[go: up one dir, main page]

GB1400985A - X-ray contrast agent - Google Patents

X-ray contrast agent

Info

Publication number
GB1400985A
GB1400985A GB4394273A GB4394273A GB1400985A GB 1400985 A GB1400985 A GB 1400985A GB 4394273 A GB4394273 A GB 4394273A GB 4394273 A GB4394273 A GB 4394273A GB 1400985 A GB1400985 A GB 1400985A
Authority
GB
United Kingdom
Prior art keywords
acetylamino
reacting
ether
group
butanedioldiglycide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4394273A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
Pharmacia AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia AB filed Critical Pharmacia AB
Publication of GB1400985A publication Critical patent/GB1400985A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442—Polymeric X-ray contrast-enhancing agent comprising a halogenated group
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G59/00—Polycondensates containing more than one epoxy group per molecule; Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups
    • C08G59/18—Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups ; e.g. general methods of curing
    • C08G59/40—Macromolecules obtained by polymerising compounds containing more than one epoxy group per molecule using curing agents or catalysts which react with the epoxy groups ; e.g. general methods of curing characterised by the curing agents used
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Epoxy Resins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

1400985 Polymers containing iodine PHARMACIA AB 19 Sept 1973 [19 Sept 1972] 43942/73 Heading C3R A polymer for use as an X-ray contrast material contains iodine-substituted aromatic groups bound in or to the polymer by covalent bonds and also contains hydrophilic groups, the polymer being in the form of a three-dimensional network held together by covalent bonds and being insoluble in water but which swells in water to form a gel containing from 10 to 99% by weight of water. The polymers are obtained by reacting one or more at least monofunctional iodine-substituted aromatic compounds having X-ray contrast properties and one or more at least bifunctional cross-linking agents with each other in one or more steps, at least one of the reactants containing or giving rise to at least one hydrophilic group. The iodinesubstituted aromatic group may be a triiodobenzene group and the hydrophilic group may be a carboxyl, hydroxyl or amino group. In examples polymers are obtained by reacting 5 - acetylamino - 2,4,6 - triiodo - N - methylisophthalic acid monoamide with 1,4- butanedioldiglycide ether, by reacting 3 - acetylamino - 5 - acetylamino - 2,4,6 - triiodobenzoic acid with 1,4-butanedioldiglycide ether, by reacting 3-acetylamino-5-acetylmethylamino-2,4,6-triiodobenzoic acid with 1,4-butanediol-diglycide ether and by reacting 3-acetylamino-2,4,6-triiodobenzoic acid with 1,4-butanedioldiglycide ether.
GB4394273A 1972-09-19 1973-09-19 X-ray contrast agent Expired GB1400985A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE1207672A SE403255B (en) 1972-09-19 1972-09-19 X-RAY CONTRAST AGENT IN WHICH AN X-RAY CONTRASTING SUBSTANCE CONSISTS OF A POLYMER WHICH DOES NOT INCLUDE IODO-SUBSTITUTED AROMATIC GROUPS

Publications (1)

Publication Number Publication Date
GB1400985A true GB1400985A (en) 1975-07-16

Family

ID=20295106

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4394273A Expired GB1400985A (en) 1972-09-19 1973-09-19 X-ray contrast agent

Country Status (9)

Country Link
JP (1) JPS4969799A (en)
AU (1) AU475204B2 (en)
BE (1) BE805017A (en)
CA (1) CA1028788A (en)
DE (1) DE2346774A1 (en)
FR (1) FR2200018B1 (en)
GB (1) GB1400985A (en)
NL (1) NL7312905A (en)
SE (1) SE403255B (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984004888A1 (en) * 1983-06-09 1984-12-20 Field Group Chemicals Radiopaque medium
FR2574297A1 (en) * 1984-12-12 1986-06-13 Ceskoslovenska Akademie Ved SPHERICAL, CONTRAST EFFECT HYDROGEL PARTICLES BASED ON POLYMERS AND COPOLYMERS OF ACRYLATES AND METHACRYLATES AND PROCESS FOR THEIR PREPARATION
EP0354836A1 (en) * 1988-08-10 1990-02-14 Guerbet S.A. Iodopolymers with a dextran skeleton, their processes of preparation and their applications as contrast agents
EP0374266A1 (en) * 1988-07-05 1990-06-27 Manac Incorporated Solid x-ray contrast medium
US5271923A (en) * 1988-07-05 1993-12-21 Manac Incorporated Solid radiographic contrast medium
WO1994025075A1 (en) * 1993-04-26 1994-11-10 Sterling Winthrop Inc. Polymeric x-ray contrast compositions containing iodinated polymeric beads
WO1996000088A1 (en) * 1994-06-24 1996-01-04 The General Hospital Corporation Hydrophobic polymers capable of forming a micelle for x-ray imaging
EP1299718A1 (en) * 2000-05-10 2003-04-09 Hydromer, Inc. Radio-opaque polymeric compositions
WO2009081169A2 (en) * 2007-12-21 2009-07-02 Iopharma Technologies Ab Biodegradable contrast agents
US10561746B2 (en) 2013-05-24 2020-02-18 Danmarks Tekniske Universitet Gel formulations for guiding radiotherapy

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6884698B2 (en) 2014-11-21 2021-06-09 テクニカル ユニバーシティ オブ デンマークＴｅｃｈｎｉｃａｌ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｄｅｎｍａｒｋ Gel formulation for topical drug release

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984004888A1 (en) * 1983-06-09 1984-12-20 Field Group Chemicals Radiopaque medium
FR2574297A1 (en) * 1984-12-12 1986-06-13 Ceskoslovenska Akademie Ved SPHERICAL, CONTRAST EFFECT HYDROGEL PARTICLES BASED ON POLYMERS AND COPOLYMERS OF ACRYLATES AND METHACRYLATES AND PROCESS FOR THEIR PREPARATION
EP0374266A1 (en) * 1988-07-05 1990-06-27 Manac Incorporated Solid x-ray contrast medium
US5271923A (en) * 1988-07-05 1993-12-21 Manac Incorporated Solid radiographic contrast medium
EP0374266A4 (en) * 1988-07-05 1991-04-17 Manac Incorporated Solid x-ray contrast medium
WO1990001500A1 (en) * 1988-08-10 1990-02-22 Guerbet S.A. Iodine-containing polymers with dextrane skeleton, preparation methods and applications as contrast products
FR2635327A1 (en) * 1988-08-10 1990-02-16 Guerbet Sa IODIC POLYMERS, DEXTRANE SKELETON, PROCESSES FOR THEIR PREPARATION AND THEIR APPLICATIONS AS CONTRAST PRODUCTS
US5126440A (en) * 1988-08-10 1992-06-30 Guerbert S.A. Iodinated polymers with dextran skeleton, processes for their preparation and their uses as contrast products
EP0354836A1 (en) * 1988-08-10 1990-02-14 Guerbet S.A. Iodopolymers with a dextran skeleton, their processes of preparation and their applications as contrast agents
WO1994025075A1 (en) * 1993-04-26 1994-11-10 Sterling Winthrop Inc. Polymeric x-ray contrast compositions containing iodinated polymeric beads
WO1996000088A1 (en) * 1994-06-24 1996-01-04 The General Hospital Corporation Hydrophobic polymers capable of forming a micelle for x-ray imaging
US5567410A (en) * 1994-06-24 1996-10-22 The General Hospital Corporation Composotions and methods for radiographic imaging
US5746998A (en) * 1994-06-24 1998-05-05 The General Hospital Corporation Targeted co-polymers for radiographic imaging
EP1299718A1 (en) * 2000-05-10 2003-04-09 Hydromer, Inc. Radio-opaque polymeric compositions
EP1299718A4 (en) * 2000-05-10 2009-04-29 Hydromer Inc Radio-opaque polymeric compositions
WO2009081169A2 (en) * 2007-12-21 2009-07-02 Iopharma Technologies Ab Biodegradable contrast agents
WO2009081169A3 (en) * 2007-12-21 2009-12-10 Iopharma Technologies Ab Biodegradable contrast agents
US10561746B2 (en) 2013-05-24 2020-02-18 Danmarks Tekniske Universitet Gel formulations for guiding radiotherapy

Also Published As

Publication number Publication date
AU6034873A (en) 1975-03-20
DE2346774A1 (en) 1974-03-28
FR2200018B1 (en) 1977-07-15
BE805017A (en) 1974-03-19
FR2200018A1 (en) 1974-04-19
SE403255B (en) 1978-08-07
NL7312905A (en) 1974-03-21
AU475204B2 (en) 1976-08-12
CA1028788A (en) 1978-03-28
JPS4969799A (en) 1974-07-05

Similar Documents

Publication Publication Date Title
Arima et al. The effects of cross-linking agents on some properties of HEMA-based resins
GB1400985A (en) X-ray contrast agent
TR27895A (en) Powdered polymers that can absorb liquids in water, a process for the production of these polymers and their use as absorbents.
CS5939290A2 (en) Cross-linked hydrogels, method of their production and their application as wound tegmentum
EP0324985A3 (en) Process for the preparation of water-absorbent and water-swellable polysaccharide graft polymers
ES432150A1 (en) Suture or ligature carrying on the exposed surface thereof a coating of a polyester resin
JPS58500287A (en) Hydrophilic water-swellable polymeric composition
ES373282A1 (en) Moulding compositions
DE59105884D1 (en) CYCLODEXTRIN POLYMERISATES AND METHOD FOR THE PRODUCTION THEREOF.
ATE115864T1 (en) POLYETHER-SUBSTITUTED TUMOR AGENTS.
GB1530178A (en) Water-insoluble hydrophilic gels and a method for the preparation of the same
ES8203398A1 (en) Copolymers having bactericidal activity, process for the preparation thereof and pharmaceutical compositions therefor.
NO881917L (en) EXTINGUISHING WATER ADDING.
GB2084585B (en) The preparation of high molecular weight hydrophilic polymer gels
JP2000309519A (en) Aqueous composition having completed use preparation for bleaching of keratin fiber and containing combination of nonionic or anionic amphiphatic polymer having aliphatic chain and water-soluble solvent
FI861553A0 (en) Use of a swollen macromolecule containing water mixing system as extinguishing water
ES411117A1 (en) Triiodoisophthalic acid monoamino acid amides
JPS5493089A (en) Preparation of acrylamide polymer
GB1204862A (en) Water-soluble polymers and their use in x-ray visualization
Su Preparation and properties of novel dental adhesives based upon pentaerythritol
DE3061224D1 (en) Chlorobrominated dicarboxylic acids, process for their preparation and their use in making synthetic materials flame-resistant
CA2096622A1 (en) Ionomers of low molecular weight copolymer amides
DE3776357D1 (en) COATING COMPOSITION.
FR2320112A1 (en) Disinfectant contg iodine complexed with polymer - esp. reticulated e.g. polymerised saccharides treated with epihalohydrin, usually in gel form
HU9203289D0 (en) Water-soluble non-ionic contrast material for radiography and method for producing it

Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee