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GB1390235A - 2-amino-4,6substituted-s triazines and methods for their preparation - Google Patents

2-amino-4,6substituted-s triazines and methods for their preparation

Info

Publication number
GB1390235A
GB1390235A GB1516872A GB1516872A GB1390235A GB 1390235 A GB1390235 A GB 1390235A GB 1516872 A GB1516872 A GB 1516872A GB 1516872 A GB1516872 A GB 1516872A GB 1390235 A GB1390235 A GB 1390235A
Authority
GB
United Kingdom
Prior art keywords
amino
ethyl
triazines
compounds
pyridyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1516872A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaken Pharmaceutical Co Ltd
Original Assignee
Kakenyaku Kako KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP6006771A external-priority patent/JPS5011392B2/ja
Application filed by Kakenyaku Kako KK filed Critical Kakenyaku Kako KK
Priority to GB1516872A priority Critical patent/GB1390235A/en
Priority to CA143,155A priority patent/CA997762A/en
Priority to CH806172A priority patent/CH573418A5/xx
Priority to DE19722265083 priority patent/DE2265083A1/en
Priority to DE19722226474 priority patent/DE2226474C3/en
Publication of GB1390235A publication Critical patent/GB1390235A/en
Priority to CA243,788A priority patent/CA1026336A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
    • C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1390235 2-Amino-triazines KAKENYAKU KAKO KK 30 March 1972 15168/72 Heading C2C Novel compounds (I) in which (a) R 1 is phenyl, R 2 is ethyl and R 3 is pyridyl or C 1-4 alkyl or (b) NR 1 R 2 represents morpholino and R 3 is C 2-4 alkyl are prepared by (1) reacting a dicyanamide with a nitrile R 3 CN in the presence of a base or (2) reacting a diguanide with a carbonyl derivative R 3 -COR 4 in which R 4 is halogen, amino, hydroxyl C 1-4 alkoxy or -OCOR 3 . Compounds prepared are 2-amino- 4 - (N - ethyl(anilino) - 6 - (ethyl or 3 - pyridyl)- 1,3,5-triazine. Compounds (I) increase the secretion of induced corticoid in the hormone system and form with a carrier a pharmaceutical composition which may be administered orally or parenterally.
GB1516872A 1971-08-07 1972-03-30 2-amino-4,6substituted-s triazines and methods for their preparation Expired GB1390235A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB1516872A GB1390235A (en) 1971-08-07 1972-03-30 2-amino-4,6substituted-s triazines and methods for their preparation
CA143,155A CA997762A (en) 1971-08-07 1972-05-26 Compounds of s-triazine derivatives and their salts and process for production of said compounds
CH806172A CH573418A5 (en) 1971-08-07 1972-05-31
DE19722265083 DE2265083A1 (en) 1971-08-07 1972-05-31 2-ALKYL-4-AMINO-6-MORPHOLINO-S-TRIAZINE
DE19722226474 DE2226474C3 (en) 1971-08-07 1972-05-31 6-Substituted 2-amino-4-N äthylanilino-s-triazines, process for their preparation, and agents containing the same
CA243,788A CA1026336A (en) 1971-08-07 1976-01-19 Diamino-s-triazines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6006771A JPS5011392B2 (en) 1971-08-07 1971-08-07
GB1516872A GB1390235A (en) 1971-08-07 1972-03-30 2-amino-4,6substituted-s triazines and methods for their preparation

Publications (1)

Publication Number Publication Date
GB1390235A true GB1390235A (en) 1975-04-09

Family

ID=26251103

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1516872A Expired GB1390235A (en) 1971-08-07 1972-03-30 2-amino-4,6substituted-s triazines and methods for their preparation

Country Status (4)

Country Link
CA (1) CA997762A (en)
CH (1) CH573418A5 (en)
DE (1) DE2265083A1 (en)
GB (1) GB1390235A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001025220A1 (en) * 1999-10-07 2001-04-12 Amgen Inc. Triazine kinase inhibitors
US6864255B2 (en) 2001-04-11 2005-03-08 Amgen Inc. Substituted triazinyl amide derivatives and methods of use
US6881737B2 (en) 2001-04-11 2005-04-19 Amgen Inc. Substituted triazinyl acrylamide derivatives and methods of use

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO311614B1 (en) 1996-10-01 2001-12-17 Janssen Pharmaceutica Nv Substituted diamino-1,3,5-triazine derivatives
CR20160545A (en) 2014-04-23 2017-03-31 Basf Se DIAMINOTRIAZINE COMPOUNDS AS HERBICIDES

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001025220A1 (en) * 1999-10-07 2001-04-12 Amgen Inc. Triazine kinase inhibitors
AU770600B2 (en) * 1999-10-07 2004-02-26 Amgen, Inc. Triazine kinase inhibitors
US7074789B2 (en) 1999-10-07 2006-07-11 Amgen Inc. Kinase inhibitors
US6864255B2 (en) 2001-04-11 2005-03-08 Amgen Inc. Substituted triazinyl amide derivatives and methods of use
US6881737B2 (en) 2001-04-11 2005-04-19 Amgen Inc. Substituted triazinyl acrylamide derivatives and methods of use

Also Published As

Publication number Publication date
DE2226474A1 (en) 1973-02-22
DE2265083A1 (en) 1976-04-08
CH573418A5 (en) 1976-03-15
DE2226474B2 (en) 1977-01-13
CA997762A (en) 1976-09-28

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee