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GB1360820A - Injectable local anaesthetic - Google Patents

Injectable local anaesthetic

Info

Publication number
GB1360820A
GB1360820A GB5379571A GB5379571A GB1360820A GB 1360820 A GB1360820 A GB 1360820A GB 5379571 A GB5379571 A GB 5379571A GB 5379571 A GB5379571 A GB 5379571A GB 1360820 A GB1360820 A GB 1360820A
Authority
GB
United Kingdom
Prior art keywords
methyl
local anaesthetic
vasoconstrictor
injectable
acetanilide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5379571A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SIH Stiftung and Co Industrie Holding KG
Original Assignee
Espe Fabrik Pharmazeutischer Praeparate GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Espe Fabrik Pharmazeutischer Praeparate GmbH filed Critical Espe Fabrik Pharmazeutischer Praeparate GmbH
Publication of GB1360820A publication Critical patent/GB1360820A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1360820 An injectable local anaesthetic ESPE FABRIK PHARMAZEUTISCHER PRAPARATE GmbH 19 Nov 1971 [20 Nov 1970] 53795/71 Heading A5B Injectable local anaesthetics contain in aqueous solution a local anaesthetic active agent, a vasoconstrictor, and as a beta-receptor blocking agent, 3-t-butylamino-1-(6'-chloro-3'- methyl-phenoxy)-propan-2-ol in the form of a physiologically acceptable salt such as the hydrochloride, tartrate or lactate. The solution preferably contains 0.2 to 4% by weight of the local anaesthetic, 10 to 100 p.p.m. of the vasoconstrictor and at least 50 p.p.m. of the beta receptor blocking agent. The local anaesthetic active agent may be procaine, #-diethylamino-2,6-dimethyl-acetanilide (lidocaine), #- butyl amino-2-methyl-6-ohloro-acetanilide, rac. N - methyl - hexahydropicolinyl - 2,6 - di methyl - anilide, 3 - methyl - 2 - (diethylamino)- acetylamino benzoic acid methyl ester and/or α-(n - propylamino) - propionic acid - (2 - methyl - anilide) (Prilocaine) in free base or acid addition salt from such as a hydrochloride, phosphate or bitartrate and the vasoconstrictor may be adrenalin, noradrenalin and/or p - (2 - amino - 1 - hydroxy - propyl) - pyrocatechol (corbadrin). Specification 1,227,601 is referred to.
GB5379571A 1970-11-20 1971-11-19 Injectable local anaesthetic Expired GB1360820A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19702057174 DE2057174A1 (en) 1970-11-20 1970-11-20 Pharmaceutical product, in particular injectable local anesthetic

Publications (1)

Publication Number Publication Date
GB1360820A true GB1360820A (en) 1974-07-24

Family

ID=5788691

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5379571A Expired GB1360820A (en) 1970-11-20 1971-11-19 Injectable local anaesthetic

Country Status (3)

Country Link
DE (1) DE2057174A1 (en)
FR (1) FR2115255B1 (en)
GB (1) GB1360820A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4529601A (en) * 1977-12-01 1985-07-16 Astra Lakemedel Aktiebolag Local anesthetic mixture for topical application and method for obtaining local anesthesia
US5234957A (en) * 1991-02-27 1993-08-10 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5332576A (en) * 1991-02-27 1994-07-26 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5446070A (en) * 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4529601A (en) * 1977-12-01 1985-07-16 Astra Lakemedel Aktiebolag Local anesthetic mixture for topical application and method for obtaining local anesthesia
US4562060A (en) * 1977-12-01 1985-12-31 Astra Lakemedel Aktiebolag Local anesthetic mixture for topical application, process for its preparation, as well as method for obtaining local anesthesia
US5234957A (en) * 1991-02-27 1993-08-10 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5332576A (en) * 1991-02-27 1994-07-26 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5446070A (en) * 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents

Also Published As

Publication number Publication date
FR2115255A1 (en) 1972-07-07
FR2115255B1 (en) 1975-06-06
DE2057174A1 (en) 1972-05-25

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee