GB1358469A - Desmethyl retinoic acid homologues - Google Patents
Desmethyl retinoic acid homologuesInfo
- Publication number
- GB1358469A GB1358469A GB5733272A GB5733272A GB1358469A GB 1358469 A GB1358469 A GB 1358469A GB 5733272 A GB5733272 A GB 5733272A GB 5733272 A GB5733272 A GB 5733272A GB 1358469 A GB1358469 A GB 1358469A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- aldehyde
- coor
- ene
- trimethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 title 1
- 229930002330 retinoic acid Natural products 0.000 title 1
- 229960001727 tretinoin Drugs 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 5
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 4
- 150000002148 esters Chemical class 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 238000007239 Wittig reaction Methods 0.000 abstract 2
- HGCIXCUEYOPUTN-UHFFFAOYSA-N cyclohexene Chemical compound C1CCC=CC1 HGCIXCUEYOPUTN-UHFFFAOYSA-N 0.000 abstract 2
- 230000003301 hydrolyzing effect Effects 0.000 abstract 2
- NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Chemical compound O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 abstract 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 238000005911 haloform reaction Methods 0.000 abstract 1
- 239000012280 lithium aluminium hydride Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 229910000104 sodium hydride Inorganic materials 0.000 abstract 1
- 239000012312 sodium hydride Substances 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
- C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20762371A | 1971-12-13 | 1971-12-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1358469A true GB1358469A (en) | 1974-07-03 |
Family
ID=22771321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5733272A Expired GB1358469A (en) | 1971-12-13 | 1972-12-12 | Desmethyl retinoic acid homologues |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS562553B2 (fr) |
| BE (1) | BE792645A (fr) |
| CA (1) | CA977763A (fr) |
| DE (1) | DE2260743C3 (fr) |
| ES (1) | ES409551A1 (fr) |
| FR (1) | FR2163528B1 (fr) |
| GB (1) | GB1358469A (fr) |
| NL (1) | NL169467C (fr) |
| SE (1) | SE388417B (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3443627A1 (de) * | 1984-11-29 | 1986-05-28 | USV Pharmaceutical Corp., Tuckahoe, N.Y. | Polyolefinische (alpha)-alkylcarbonsaeuren und deren derivate, sowie diese verbindungen enthaltende arzneimittel |
-
0
- BE BE792645D patent/BE792645A/fr not_active IP Right Cessation
-
1972
- 1972-12-07 CA CA158,783A patent/CA977763A/en not_active Expired
- 1972-12-12 SE SE7216214A patent/SE388417B/xx unknown
- 1972-12-12 FR FR7244189A patent/FR2163528B1/fr not_active Expired
- 1972-12-12 DE DE2260743A patent/DE2260743C3/de not_active Expired
- 1972-12-12 GB GB5733272A patent/GB1358469A/en not_active Expired
- 1972-12-12 JP JP12404772A patent/JPS562553B2/ja not_active Expired
- 1972-12-12 ES ES409551A patent/ES409551A1/es not_active Expired
- 1972-12-13 NL NLAANVRAGE7216913,A patent/NL169467C/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPS562553B2 (fr) | 1981-01-20 |
| DE2260743A1 (de) | 1973-06-14 |
| CA977763A (en) | 1975-11-11 |
| NL7216913A (fr) | 1973-06-15 |
| BE792645A (fr) | 1973-03-30 |
| FR2163528B1 (fr) | 1976-07-02 |
| SE388417B (sv) | 1976-10-04 |
| NL169467B (nl) | 1982-02-16 |
| DE2260743B2 (de) | 1980-12-18 |
| ES409551A1 (es) | 1976-01-01 |
| AU4993872A (en) | 1974-06-13 |
| FR2163528A1 (fr) | 1973-07-27 |
| NL169467C (nl) | 1982-07-16 |
| DE2260743C3 (de) | 1981-12-24 |
| JPS4864056A (fr) | 1973-09-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |