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GB1340334A - Synthesis of benzazetropolones and hence of kynurenic acids - Google Patents

Synthesis of benzazetropolones and hence of kynurenic acids

Info

Publication number
GB1340334A
GB1340334A GB1340334DA GB1340334A GB 1340334 A GB1340334 A GB 1340334A GB 1340334D A GB1340334D A GB 1340334DA GB 1340334 A GB1340334 A GB 1340334A
Authority
GB
United Kingdom
Prior art keywords
alkyl
formula
benzazetropolones
hence
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rees A H
Original Assignee
Rees A H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rees A H filed Critical Rees A H
Publication of GB1340334A publication Critical patent/GB1340334A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1340334 Benzazepine derivatives R H REES 5 July 1971 [6 July 1970] 32594/70 Heading C2C Compounds of the formula wherein R is H or alkyl, R<SP>1</SP> is H, halogen or alkyl, and n is 1 or 2, may be obtained by reacting a 2-alkoxy-1,4-naphthoquinone of the formula wherein R<SP>1</SP> is as defined above and R is alkyl, in sulphuric acid with sodium azide, and optionally dealkylating the product where R is alkyl. The dealkylation reaction may also be effected by choosing appropriate conditions during work up. The products wherein R is H may be converted to kynurenic acid derivatives of the formula by covering with dilute caustic alkali.
GB1340334D 1970-07-06 1970-07-06 Synthesis of benzazetropolones and hence of kynurenic acids Expired GB1340334A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3259470 1970-07-06

Publications (1)

Publication Number Publication Date
GB1340334A true GB1340334A (en) 1973-12-12

Family

ID=10341068

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1340334D Expired GB1340334A (en) 1970-07-06 1970-07-06 Synthesis of benzazetropolones and hence of kynurenic acids

Country Status (1)

Country Link
GB (1) GB1340334A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2251616A (en) * 1991-01-02 1992-07-15 Ici Plc Benzazepine derivatives.
WO1993025534A1 (en) * 1992-06-10 1993-12-23 Zeneca Limited 2,5-DIOXO-2,5-DIHYDRO-1H-BENZ[b]AZEPINES AS NMDA RECEPTOR ANTAGONISTS
US5502048A (en) * 1993-06-10 1996-03-26 Zeneca Limited Substituted nitrogen heterocycles
WO1996015112A1 (en) * 1994-11-16 1996-05-23 Acea Pharmaceuticals, Inc. Azepine synthesis via a diels-alder reaction
US5801168A (en) * 1994-06-09 1998-09-01 Zeneca Limited Substituted nitrogen heterocycles

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2251616A (en) * 1991-01-02 1992-07-15 Ici Plc Benzazepine derivatives.
WO1992011854A1 (en) * 1991-01-02 1992-07-23 Imperial Chemical Industries Plc Therapeutic benzazepine compounds
US5254683A (en) * 1991-01-02 1993-10-19 Imperial Chemical Industries Plc Therapeutic benzazarine compounds
US5541319A (en) * 1991-01-02 1996-07-30 Zeneca Limited Therapeutic benzazapine compounds
GB2251616B (en) * 1991-01-02 1995-01-11 Ici Plc Therapeutic benzazapine compounds
US5446039A (en) * 1991-01-02 1995-08-29 Imperial Chemical Industries, Plc Therapeutic benzazapine compounds
WO1993025534A1 (en) * 1992-06-10 1993-12-23 Zeneca Limited 2,5-DIOXO-2,5-DIHYDRO-1H-BENZ[b]AZEPINES AS NMDA RECEPTOR ANTAGONISTS
US5492905A (en) * 1992-06-10 1996-02-20 Zeneca Limited 1-bolizazepin-2,5-diones
US5654295A (en) * 1992-06-10 1997-08-05 Zeneca Limited Therapeutic compositions
KR100298377B1 (en) * 1992-06-10 2001-12-01 사라 엔 람베쓰 (NMDA) receptor antagonist, 2,5-dioxo-2,5-dihydro-1H-benz (b)
US5712272A (en) * 1992-06-10 1998-01-27 Zeneca Limited Therapeutic compositions
US5502048A (en) * 1993-06-10 1996-03-26 Zeneca Limited Substituted nitrogen heterocycles
US5656626A (en) * 1993-06-10 1997-08-12 Zeneca Limited Substituted nitrogen heterocycles
US5801168A (en) * 1994-06-09 1998-09-01 Zeneca Limited Substituted nitrogen heterocycles
WO1996015112A1 (en) * 1994-11-16 1996-05-23 Acea Pharmaceuticals, Inc. Azepine synthesis via a diels-alder reaction
US5708168A (en) * 1994-11-16 1998-01-13 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Azepine compounds

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee