GB1298771A - Carboxylic esters of hydroxyphenylalkanolamines - Google Patents
Carboxylic esters of hydroxyphenylalkanolaminesInfo
- Publication number
- GB1298771A GB1298771A GB03690/70A GB1369070A GB1298771A GB 1298771 A GB1298771 A GB 1298771A GB 03690/70 A GB03690/70 A GB 03690/70A GB 1369070 A GB1369070 A GB 1369070A GB 1298771 A GB1298771 A GB 1298771A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbon atoms
- cycloalkyl
- alkyl
- hydrogen
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001733 carboxylic acid esters Chemical class 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 14
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000002252 acyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- -1 phenoxyacetyl Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 230000001975 sympathomimetic effect Effects 0.000 abstract 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 2
- 239000000150 Sympathomimetic Substances 0.000 abstract 1
- 206010062119 Sympathomimetic effect Diseases 0.000 abstract 1
- 239000000443 aerosol Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229940124630 bronchodilator Drugs 0.000 abstract 1
- 239000012050 conventional carrier Substances 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000003380 propellant Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB129972A GB1298772A (en) | 1969-04-01 | 1970-03-20 | Ester of alpha-aminomethyl-3-(hydroxymethyl)-4-hydroxybenzyl ketones |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81237069A | 1969-04-01 | 1969-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1298771A true GB1298771A (en) | 1972-12-06 |
Family
ID=25209368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB03690/70A Expired GB1298771A (en) | 1969-04-01 | 1970-03-20 | Carboxylic esters of hydroxyphenylalkanolamines |
Country Status (17)
| Country | Link |
|---|---|
| JP (2) | JPS5314544B1 (xx) |
| AT (1) | AT300762B (xx) |
| BE (1) | BE748178A (xx) |
| CH (1) | CH522589A (xx) |
| DE (1) | DE2015573C3 (xx) |
| DK (1) | DK131459B (xx) |
| ES (1) | ES378092A1 (xx) |
| FI (1) | FI54796C (xx) |
| FR (1) | FR2042295B1 (xx) |
| GB (1) | GB1298771A (xx) |
| IE (1) | IE34583B1 (xx) |
| IL (2) | IL34148A (xx) |
| NL (1) | NL171155C (xx) |
| NO (1) | NO129903B (xx) |
| PH (2) | PH9407A (xx) |
| SE (2) | SE381039B (xx) |
| ZA (1) | ZA702065B (xx) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4046913A (en) | 1973-08-18 | 1977-09-06 | Boehringer Ingelheim Gmbh | 1-(M-alkanoyloxy-phenyl)-1-hydroxy-2-(N-lower alkyl-amino)-ethanes and salts thereof |
| GB2135883A (en) * | 1983-03-04 | 1984-09-12 | Bristol Myers Co | Anti-inflammatory B2 agonists |
| US5011845A (en) * | 1990-06-13 | 1991-04-30 | Schering Corporation | Cyclic diesters of 4-hydroxy-1,3-benzenedimethanol and compositions and methods employing such compounds |
| US5118683A (en) * | 1990-06-13 | 1992-06-02 | Schering Corporation | Esters of 4-hydroxy-1,3-benzenedimethanol and compositions and methods employing such compounds |
| US8906908B2 (en) | 2010-05-21 | 2014-12-09 | Research Triangle Institute | Hydroxybupropion analogues for treating drug dependence |
| US9562001B2 (en) | 2009-04-15 | 2017-02-07 | Research Triangle Institute | Monoamine reuptake inhibitors |
| US9617229B2 (en) | 2010-05-21 | 2017-04-11 | Research Triangle Institute | Phenylmorpholines and analogues thereof |
| CN108997261A (zh) * | 2017-06-07 | 2018-12-14 | 东莞市凯法生物医药有限公司 | 一类化合物及其制备方法与应用 |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4138581A (en) | 1969-04-01 | 1979-02-06 | Sterling Drugs Inc. | 3(Hydroxy or hydroxymethyl)-4(hydroxy)-α-(aminomethyl)benzyl alcohols |
| US3809714A (en) * | 1972-08-31 | 1974-05-07 | Interx Research Corp | Novel ester of ((methylamino)methyl) benzyl alcohol |
| US3868461A (en) * | 1972-11-22 | 1975-02-25 | Interx Research Corp | Ester of 3,4-dihydroxy-alpha (isopropylamino) methyl benzyl alcohol, composition and anti-asthma use thereof |
| LU71637A1 (xx) * | 1974-01-15 | 1975-06-17 | ||
| US3957849A (en) * | 1974-09-09 | 1976-05-18 | Zoecon Corporation | Cyclopropane esters |
| US4000315A (en) * | 1974-09-09 | 1976-12-28 | Zoecon Corporation | Cyclopropane esters for the control of mites |
| EP0043807B1 (en) | 1980-07-09 | 1984-05-30 | Aktiebolaget Draco | 1-(dihydroxyphenyl)-2-amino-ethanol derivatives; preparation, compositions and intermediates |
| CY1271A (en) * | 1980-07-09 | 1985-03-08 | Draco Ab | Therapeutically active derivatives of phenylethanol amines |
| US4614830A (en) * | 1985-08-09 | 1986-09-30 | Sterling Drug Inc. | Esterification process |
| IT1229846B (it) * | 1989-04-20 | 1991-09-13 | Simes | Esteri di catecolammine. |
| WO2014108449A1 (en) | 2013-01-08 | 2014-07-17 | Atrogi Ab | A screening method, a kit, a method of treatment and a compound for use in a method of treatment |
| GB201714736D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714745D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714734D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714740D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB202205895D0 (en) | 2022-04-22 | 2022-06-08 | Atrogi Ab | New medical uses |
| WO2024153813A1 (en) | 2023-01-20 | 2024-07-25 | Atrogi Ab | Beta 2-adrenergic receptor agonists for treatment or prevention of muscle wasting |
| GB202302225D0 (en) | 2023-02-16 | 2023-04-05 | Atrogi Ab | New medical uses |
| GB202303229D0 (en) | 2023-03-06 | 2023-04-19 | Atrogi Ab | New medical uses |
-
1970
- 1970-03-20 GB GB03690/70A patent/GB1298771A/en not_active Expired
- 1970-03-20 NO NO01048/70A patent/NO129903B/no unknown
- 1970-03-24 IL IL34148A patent/IL34148A/xx unknown
- 1970-03-24 IL IL42029A patent/IL42029A/xx unknown
- 1970-03-25 PH PH11270*UA patent/PH9407A/en unknown
- 1970-03-26 ZA ZA702065A patent/ZA702065B/xx unknown
- 1970-03-26 CH CH467070A patent/CH522589A/fr not_active IP Right Cessation
- 1970-03-27 BE BE748178D patent/BE748178A/xx not_active IP Right Cessation
- 1970-03-31 ES ES378092A patent/ES378092A1/es not_active Expired
- 1970-03-31 SE SE7004367A patent/SE381039B/xx unknown
- 1970-03-31 DK DK160470AA patent/DK131459B/da not_active IP Right Cessation
- 1970-04-01 JP JP2779370A patent/JPS5314544B1/ja active Pending
- 1970-04-01 NL NLAANVRAGE7004671,A patent/NL171155C/xx not_active IP Right Cessation
- 1970-04-01 DE DE2015573A patent/DE2015573C3/de not_active Expired
- 1970-04-01 AT AT296170A patent/AT300762B/de not_active IP Right Cessation
- 1970-04-01 FR FR707011697A patent/FR2042295B1/fr not_active Expired
- 1970-04-01 FI FI908/70A patent/FI54796C/fi active
- 1970-04-01 IE IE394/70A patent/IE34583B1/xx unknown
-
1972
- 1972-07-14 PH PH13731A patent/PH14377A/en unknown
-
1973
- 1973-03-23 SE SE7304162A patent/SE413503B/xx unknown
- 1973-07-31 JP JP8630073A patent/JPS5414096B1/ja active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4046913A (en) | 1973-08-18 | 1977-09-06 | Boehringer Ingelheim Gmbh | 1-(M-alkanoyloxy-phenyl)-1-hydroxy-2-(N-lower alkyl-amino)-ethanes and salts thereof |
| GB2135883A (en) * | 1983-03-04 | 1984-09-12 | Bristol Myers Co | Anti-inflammatory B2 agonists |
| US5011845A (en) * | 1990-06-13 | 1991-04-30 | Schering Corporation | Cyclic diesters of 4-hydroxy-1,3-benzenedimethanol and compositions and methods employing such compounds |
| US5118683A (en) * | 1990-06-13 | 1992-06-02 | Schering Corporation | Esters of 4-hydroxy-1,3-benzenedimethanol and compositions and methods employing such compounds |
| US9562001B2 (en) | 2009-04-15 | 2017-02-07 | Research Triangle Institute | Monoamine reuptake inhibitors |
| US10919841B2 (en) | 2009-04-15 | 2021-02-16 | Research Triangle Institute | Monoamine reuptake inhibitors |
| US8906908B2 (en) | 2010-05-21 | 2014-12-09 | Research Triangle Institute | Hydroxybupropion analogues for treating drug dependence |
| US9527823B2 (en) | 2010-05-21 | 2016-12-27 | Research Triangle Institute | Hydroxybupropion analogues for treating drug dependence |
| US9617229B2 (en) | 2010-05-21 | 2017-04-11 | Research Triangle Institute | Phenylmorpholines and analogues thereof |
| CN108997261A (zh) * | 2017-06-07 | 2018-12-14 | 东莞市凯法生物医药有限公司 | 一类化合物及其制备方法与应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA702065B (en) | 1971-01-27 |
| IE34583L (en) | 1970-10-01 |
| DK131459B (da) | 1975-07-21 |
| CH522589A (fr) | 1972-06-30 |
| IL34148A (en) | 1974-01-14 |
| SE381039B (sv) | 1975-11-24 |
| SE413503B (sv) | 1980-06-02 |
| FR2042295B1 (xx) | 1974-06-14 |
| IL34148A0 (en) | 1970-07-19 |
| PH9407A (en) | 1975-11-06 |
| JPS5414096B1 (xx) | 1979-06-05 |
| FR2042295A1 (xx) | 1971-02-12 |
| FI54796C (fi) | 1979-03-12 |
| DE2015573B2 (de) | 1978-03-16 |
| IE34583B1 (en) | 1975-06-25 |
| IL42029A (en) | 1974-01-14 |
| JPS5314544B1 (xx) | 1978-05-18 |
| DE2015573C3 (de) | 1978-11-02 |
| PH14377A (en) | 1981-06-17 |
| BE748178A (fr) | 1970-09-28 |
| AT300762B (de) | 1972-08-10 |
| NO129903B (xx) | 1974-06-10 |
| NL171155C (nl) | 1983-02-16 |
| FI54796B (fi) | 1978-11-30 |
| ES378092A1 (es) | 1973-01-01 |
| DE2015573A1 (de) | 1970-10-08 |
| NL171155B (nl) | 1982-09-16 |
| NL7004671A (xx) | 1970-10-05 |
| DK131459C (xx) | 1975-12-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |