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GB1249261A - Mannich-bases - Google Patents

Mannich-bases

Info

Publication number
GB1249261A
GB1249261A GB1244970A GB1244970A GB1249261A GB 1249261 A GB1249261 A GB 1249261A GB 1244970 A GB1244970 A GB 1244970A GB 1244970 A GB1244970 A GB 1244970A GB 1249261 A GB1249261 A GB 1249261A
Authority
GB
United Kingdom
Prior art keywords
group
groups
formula
alkyl
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1244970A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Publication of GB1249261A publication Critical patent/GB1249261A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,249,261. Mannich bases. BEIERSDORF A.G. 16 March, 1970 [15 March, 1969], No. 12449/70. Heading C2C. Novel compounds of formula in which R 1 and R 2 are hydrogen, hydroxyl, lower alkyl, alkoxy or acyloxy groups, n is 0, 1 or 2 and A is a methylene group or a group R 3 R 4 C< where one or both of R 3 and R 4 are alkyl groups, or n is 1 and A is oxygen or sulphur, and R 5 is an arylalkyl, aryloxyalkyl or arylthioalkyl group, in which the alkyl portion is constituted by a straight or branched chain alkyl residue containing 2 to 4 carbon atoms, optionally substituted by a hydroxyl group, and the aryl portion comprises a phenyl, naphthalene or thiophene residue optionally substituted by one or more substituents, selected from halogen atoms, hydroxyl groups. lower alkyl and alkoxy groups, or in which two neighbouring carbon atoms of the said residue are linked in a ring via a methylene dioxy group, or R 5 is a group of the formula wherein m is 1 or 2 and acid addition salts thereof, are prepared by reaction of formaldehyde or a polymeric form thereof, an amine H 2 NR 5 and a compound of formula optionally with salt formation. Pharmaceutical compositions in conventional forms for oral or parenteral administration and having strong α-sympathicolytic activity comprise an above novel compound or salt and a carrier therefore.
GB1244970A 1969-03-15 1970-03-16 Mannich-bases Expired GB1249261A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19691913199 DE1913199C3 (en) 1969-03-15 1969-03-15 Mannich bases from alpha-tetralone or its derivatives and arylalkylamines and their salts

Publications (1)

Publication Number Publication Date
GB1249261A true GB1249261A (en) 1971-10-13

Family

ID=5728218

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1244970A Expired GB1249261A (en) 1969-03-15 1970-03-16 Mannich-bases

Country Status (9)

Country Link
AT (1) AT296971B (en)
CH (1) CH530370A (en)
CS (1) CS158270B2 (en)
DE (1) DE1913199C3 (en)
DK (1) DK134396B (en)
FR (1) FR2034968B1 (en)
GB (1) GB1249261A (en)
NL (1) NL161434C (en)
SE (1) SE369415B (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0127143A2 (en) * 1983-05-25 1984-12-05 Merrell Dow Pharmaceuticals Inc. Novel aryloxycycloalkanolaminoalkylene aryl ketones
US4777176A (en) * 1985-06-18 1988-10-11 Imperial Chemical Industries Plc Fungicidal compositions containing piperidine compounds
US4868315A (en) * 1983-05-25 1989-09-19 Merrell Dow Pharmaceuticals Inc. Novel aryloxycycloalkanolaminoalkylene aryl ketones
WO1992005143A1 (en) * 1990-09-22 1992-04-02 The Wellcome Foundation Limited Anti-hypertensive tetralins
EP1018879A1 (en) * 1996-02-02 2000-07-19 Nitromed, Inc. Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
US7297704B2 (en) 2005-02-17 2007-11-20 Wyeth Cycloalkyfused indole, benzothiophene, benzofuran and idene derivatives
US7858613B2 (en) 2005-05-20 2010-12-28 Gruenenthal Gmbh Substituted benzo-condensed cycloheptanone derivatives and their use for producing drugs
CN106565508A (en) * 2016-11-14 2017-04-19 烟台智本知识产权运营管理有限公司 Mannich base quaternary ammonium salt oil removing agent for binary compound flooding sewage and preparation method thereof

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2301247A1 (en) * 1975-02-20 1976-09-17 Jouillie International Sa CHROMANONE-4 DERIVATIVES
DE3151046A1 (en) * 1981-12-23 1983-07-21 Karl 4802 Halle Beintmann Sign for an unroadworthy vehicle
US5508306A (en) * 1992-11-13 1996-04-16 Synaptic Pharmaceutical Corporation Aromatic amine derivatives
DE102005039145A1 (en) 2005-05-20 2006-11-23 Grünenthal GmbH Substituted benzo-fused cyclohexanone derivatives and their use for the preparation of medicaments

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0127143A2 (en) * 1983-05-25 1984-12-05 Merrell Dow Pharmaceuticals Inc. Novel aryloxycycloalkanolaminoalkylene aryl ketones
EP0127143A3 (en) * 1983-05-25 1985-05-29 Merrell Dow Pharmaceuticals Inc. Novel aryloxycycloalkanolaminoalkylene aryl ketones
US4868315A (en) * 1983-05-25 1989-09-19 Merrell Dow Pharmaceuticals Inc. Novel aryloxycycloalkanolaminoalkylene aryl ketones
US4777176A (en) * 1985-06-18 1988-10-11 Imperial Chemical Industries Plc Fungicidal compositions containing piperidine compounds
WO1992005143A1 (en) * 1990-09-22 1992-04-02 The Wellcome Foundation Limited Anti-hypertensive tetralins
US5405872A (en) * 1990-09-22 1995-04-11 Burroughs Wellcome Co. Anti-hypertensive tetralins
EP1018879A1 (en) * 1996-02-02 2000-07-19 Nitromed, Inc. Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
EP1018879A4 (en) * 1996-02-02 2002-07-24 Nitromed Inc Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
US7297704B2 (en) 2005-02-17 2007-11-20 Wyeth Cycloalkyfused indole, benzothiophene, benzofuran and idene derivatives
US7858613B2 (en) 2005-05-20 2010-12-28 Gruenenthal Gmbh Substituted benzo-condensed cycloheptanone derivatives and their use for producing drugs
CN106565508A (en) * 2016-11-14 2017-04-19 烟台智本知识产权运营管理有限公司 Mannich base quaternary ammonium salt oil removing agent for binary compound flooding sewage and preparation method thereof

Also Published As

Publication number Publication date
AT296971B (en) 1972-03-10
FR2034968B1 (en) 1974-05-24
DE1913199C3 (en) 1975-11-27
DK134396C (en) 1977-03-28
DE1913199B2 (en) 1975-01-16
CH530370A (en) 1972-11-15
NL161434C (en) 1980-02-15
CS158270B2 (en) 1974-10-15
NL7003634A (en) 1970-09-17
NL161434B (en) 1979-09-17
DE1913199A1 (en) 1970-09-24
SE369415B (en) 1974-08-26
DK134396B (en) 1976-11-01
FR2034968A1 (en) 1970-12-18

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