GB1244355A - Determining blood prothrombin time - Google Patents
Determining blood prothrombin timeInfo
- Publication number
- GB1244355A GB1244355A GB48547/68A GB4854768A GB1244355A GB 1244355 A GB1244355 A GB 1244355A GB 48547/68 A GB48547/68 A GB 48547/68A GB 4854768 A GB4854768 A GB 4854768A GB 1244355 A GB1244355 A GB 1244355A
- Authority
- GB
- United Kingdom
- Prior art keywords
- sample
- container
- field source
- prothrombin time
- magnetic field
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108010094028 Prothrombin Proteins 0.000 title abstract 4
- 102100027378 Prothrombin Human genes 0.000 title abstract 4
- 229940039716 prothrombin Drugs 0.000 title abstract 4
- 239000008280 blood Substances 0.000 title abstract 2
- 210000004369 blood Anatomy 0.000 title abstract 2
- 230000005291 magnetic effect Effects 0.000 abstract 3
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 230000005294 ferromagnetic effect Effects 0.000 abstract 2
- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 abstract 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract 1
- 206010053567 Coagulopathies Diseases 0.000 abstract 1
- 108010000499 Thromboplastin Proteins 0.000 abstract 1
- 102000002262 Thromboplastin Human genes 0.000 abstract 1
- 229910001628 calcium chloride Inorganic materials 0.000 abstract 1
- 239000001110 calcium chloride Substances 0.000 abstract 1
- 230000035602 clotting Effects 0.000 abstract 1
- 238000013500 data storage Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Ecology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
1,244,355. Determination of prothrombin time; controlling mixing by viscosity. XEROX CORP. 14 Oct., 1968 [20 Oct., 1967], No. 48547/68. Headings B1C and B1X. Apparatus for use in determining the prothrombin time of a blood sample comprises a container 10 (Fig. 4) for the sample and for reagents, for example thromboplastin and calcium chloride originally stored in solid or liquid form in upper reagent storage chambers (20) (Fig. 2), a freely movable ferromagnetic member 24 in the container, a magnetic field source which may comprise magnet 100, means for example motor 94 for producing relative movement between the magnetic field source and the container, the intensity of the field source being such that on clotting of the sample its increased resistance causes relative movement of the ferromagnetic member 24 and the magnetic field source, and means which may comprise coil 104 rotating with magnet 100 and connected to slip-rings 106, 108 for producing a signal in response to the relative movement. In automatic operation, introduction of a metered amount of sample from a sample storage tape of the kind disclosed in Specification 1,218,747 or from a circular sample conveyor into a container 10 starts a timer and the end-point signal stops the timer, the prothrombin time for the sample being stored in a data storage device for read out when desired (Fig. 3 not shown).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67682067A | 1967-10-20 | 1967-10-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1244355A true GB1244355A (en) | 1971-09-02 |
Family
ID=24716133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB48547/68A Expired GB1244355A (en) | 1967-10-20 | 1968-10-14 | Determining blood prothrombin time |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3520659A (en) |
| BE (1) | BE722360A (en) |
| BR (1) | BR6801817D0 (en) |
| DE (1) | DE1804292C3 (en) |
| ES (1) | ES359312A1 (en) |
| FR (1) | FR1588701A (en) |
| GB (1) | GB1244355A (en) |
| NL (1) | NL142783B (en) |
| SE (1) | SE345744B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006067504A2 (en) * | 2004-12-24 | 2006-06-29 | Unipath Limited | Low volume assay apparatus and method |
| WO2006070346A1 (en) * | 2004-12-27 | 2006-07-06 | Ramot At Tel-Aviv University Ltd | Method and system for determining platelet-mediated clot formation |
| US7775976B2 (en) | 1920-03-19 | 2010-08-17 | Alere Switzerland Gmbh | Method to determine a coagulation property of a fluid |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3635678A (en) * | 1969-06-13 | 1972-01-18 | Baxter Laboratories Inc | Clot-timing system and method |
| US3967934A (en) * | 1969-06-13 | 1976-07-06 | Baxter Laboratories, Inc. | Prothrombin timer |
| US3695842A (en) * | 1970-03-12 | 1972-10-03 | Intern Technidyne Corp | Method and system for analyzing a liquid |
| US3861197A (en) * | 1973-06-29 | 1975-01-21 | Technicon Instr | Method and apparatus for determining the viscosity of a liquid sample |
| US4014650A (en) * | 1975-04-25 | 1977-03-29 | Research Corporation | Ultrasonic coagulation timer |
| FR2383444A1 (en) * | 1977-03-11 | 1978-10-06 | Laborgeraete Analysensyst Gmbh | MEASURING BLOOD COAGULATION TIME |
| DE2741060C2 (en) * | 1977-09-13 | 1982-06-24 | Chemisch-pharmazeutische Industrie KG 6380 Bad Homburg Dr. Eduard Fresenius | Method and device for detecting the change in state of a liquid |
| WO1985004426A1 (en) * | 1984-03-26 | 1985-10-10 | International Health Services | A method of determining the clotting time of blood and particulate reagents therefor |
| DE3413311A1 (en) * | 1984-04-09 | 1985-10-17 | Behringwerke Ag, 3550 Marburg | REAGENT FOR DETERMINING THROMBOPLASTIN TIME |
| US4849340A (en) * | 1987-04-03 | 1989-07-18 | Cardiovascular Diagnostics, Inc. | Reaction system element and method for performing prothrombin time assay |
| US5110727A (en) * | 1987-04-03 | 1992-05-05 | Cardiovascular Diagnostics, Inc. | Method for performing coagulation assays accurately, rapidly and simply, using dry chemical reagents and paramagnetic particles |
| DE3800117A1 (en) * | 1988-01-05 | 1989-07-13 | Linhart Axel | First semiquantitative calcium assay |
| GB8912277D0 (en) * | 1989-05-27 | 1989-07-12 | Fisons Plc | Sensor device |
| FR2664982B1 (en) * | 1990-07-20 | 1994-04-29 | Serbio | APPARATUS FOR DETECTING CHANGE IN VISCOSITY, BY MEASURING RELATIVE SLIDING, PARTICULARLY FOR DETECTING BLOOD COAGULATION TIME. |
| DE4339328C1 (en) * | 1993-11-19 | 1995-02-23 | Janke & Kunkel Kg | Method and device for detecting viscosity alterations of a medium stirred by a magnetic stirrer |
| US6136271A (en) * | 1998-02-23 | 2000-10-24 | International Technidyne Corporation | Solid state apparatus employing hall effect sensors for detecting the coagulation of blood |
| DE10052548B4 (en) * | 2000-10-23 | 2008-09-18 | 3M Espe Ag | Device, its use and method for determining the end of the processing time of curable compositions |
| US9757310B2 (en) | 2013-03-12 | 2017-09-12 | 3M Innovative Properties Company | Fluorescence imparting coloring solution for dental ceramics |
| US10823743B1 (en) * | 2013-10-28 | 2020-11-03 | Ifirst Medical Technologies, Inc. | Methods of measuring coagulation of a biological sample |
| CN114384130B (en) * | 2022-01-13 | 2023-06-20 | 南京岚煜生物科技有限公司 | Electrochemical detection base and device for activating coagulation time |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2879141A (en) * | 1955-11-16 | 1959-03-24 | Technicon Instr | Automatic analyzing apparatus |
| US3053078A (en) * | 1958-04-17 | 1962-09-11 | Warren R Jewett | Apparatus for testing biological and other fluids |
| US3162038A (en) * | 1960-06-30 | 1964-12-22 | Owens Corning Fiberglass Corp | Viscometer |
-
1967
- 1967-10-20 US US676820A patent/US3520659A/en not_active Expired - Lifetime
-
1968
- 1968-08-27 BR BR201817/68A patent/BR6801817D0/en unknown
- 1968-10-14 GB GB48547/68A patent/GB1244355A/en not_active Expired
- 1968-10-15 BE BE722360D patent/BE722360A/xx unknown
- 1968-10-16 NL NL686814790A patent/NL142783B/en unknown
- 1968-10-18 SE SE14125/68A patent/SE345744B/xx unknown
- 1968-10-18 FR FR1588701D patent/FR1588701A/fr not_active Expired
- 1968-10-18 ES ES359312A patent/ES359312A1/en not_active Expired
- 1968-10-21 DE DE1804292A patent/DE1804292C3/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7775976B2 (en) | 1920-03-19 | 2010-08-17 | Alere Switzerland Gmbh | Method to determine a coagulation property of a fluid |
| WO2006067504A2 (en) * | 2004-12-24 | 2006-06-29 | Unipath Limited | Low volume assay apparatus and method |
| WO2006067504A3 (en) * | 2004-12-24 | 2006-10-05 | Unipath Ltd | Low volume assay apparatus and method |
| WO2006070346A1 (en) * | 2004-12-27 | 2006-07-06 | Ramot At Tel-Aviv University Ltd | Method and system for determining platelet-mediated clot formation |
Also Published As
| Publication number | Publication date |
|---|---|
| NL6814790A (en) | 1969-04-22 |
| DE1804292A1 (en) | 1969-05-14 |
| NL142783B (en) | 1974-07-15 |
| DE1804292B2 (en) | 1972-12-14 |
| SE345744B (en) | 1972-06-05 |
| DE1804292C3 (en) | 1973-09-13 |
| US3520659A (en) | 1970-07-14 |
| BE722360A (en) | 1969-04-15 |
| ES359312A1 (en) | 1970-06-01 |
| FR1588701A (en) | 1970-04-17 |
| BR6801817D0 (en) | 1973-01-11 |
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