GB1235667A - Improvements in or relating to sustained release preparations - Google Patents
Improvements in or relating to sustained release preparationsInfo
- Publication number
- GB1235667A GB1235667A GB2314668A GB2314668A GB1235667A GB 1235667 A GB1235667 A GB 1235667A GB 2314668 A GB2314668 A GB 2314668A GB 2314668 A GB2314668 A GB 2314668A GB 1235667 A GB1235667 A GB 1235667A
- Authority
- GB
- United Kingdom
- Prior art keywords
- emulsion
- prolonged release
- july
- oil
- aqueous phase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003405 delayed action preparation Substances 0.000 title 1
- 239000000839 emulsion Substances 0.000 abstract 4
- 239000013543 active substance Substances 0.000 abstract 3
- 230000002035 prolonged effect Effects 0.000 abstract 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 239000008346 aqueous phase Substances 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 229930013930 alkaloid Natural products 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- -1 chemotherapeutics Substances 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000012071 phase Substances 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229940088594 vitamin Drugs 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 abstract 1
- 235000013343 vitamin Nutrition 0.000 abstract 1
- 239000011782 vitamin Substances 0.000 abstract 1
- 239000007762 w/o emulsion Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
1,235,667. Prolonged release medicaments. NATIONAL RESEARCH DEVELOPMENT CORP. 8 July, 1968 [19 July, 1967; 15 May, 1968], Nos. 33255/67 and 23146/68. Heading A5B. An injectable medicament having prolonged release is formulated by preparing a primary water-in-oil emulsion containing a watersoluble, sparing oil-soluble, active substance (which is not solely or primarily antigenic) and another physiologically acceptable substance, e.g. NaCl or glucose, in the aqueous phase, the quantities thereof being such that the osmolarity of the aqueous medium and internal phase volume of the emulsion, together with the concentration of detergent used to prepare the emulsion are so selected that prolonged release of the active substance is achieved in vivo when the primary emulsion is injected in the form of a double emulsion in an outermost aqueous phase. A wide range of active substances are referred to including antibiotics, vitamins, chemotherapeutics, anti-coagulants and alkaloids.
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL30320A IL30320A0 (en) | 1967-07-19 | 1968-07-05 | Biologically active compositions having a slow rate of release of active component |
| LU56490D LU56490A1 (en) | 1967-07-19 | 1968-07-15 | |
| BE718199D BE718199A (en) | 1967-07-19 | 1968-07-17 | |
| FR159745A FR8416M (en) | 1967-07-19 | 1968-07-18 | |
| DE19681792067 DE1792067A1 (en) | 1967-07-19 | 1968-07-18 | Biologically active emulsion and process for its preparation |
| FR1603602D FR1603602A (en) | 1967-07-19 | 1968-07-18 | Oil-based depot compsns - mainly for parenteral administration |
| ES356274A ES356274A1 (en) | 1967-07-19 | 1968-07-19 | Procedure for the preparation of a biologically active composition. (Machine-translation by Google Translate, not legally binding) |
| NL6810301A NL6810301A (en) | 1967-07-19 | 1968-07-19 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3325567 | 1967-07-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1235667A true GB1235667A (en) | 1971-06-16 |
Family
ID=10350555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2314668A Expired GB1235667A (en) | 1967-07-19 | 1967-07-19 | Improvements in or relating to sustained release preparations |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1235667A (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5246382A (en) * | 1975-10-11 | 1977-04-13 | Lion Corp | Method of preparing compound emulsion |
| US4254105A (en) * | 1975-10-11 | 1981-03-03 | The Lion Dentifrice Co., Ltd. | Multiple emulsion having a form of water/oil/water phase and process for preparation thereof, and multiple emulsion type cosmetics |
| US4714566A (en) * | 1984-03-02 | 1987-12-22 | Meiji Milk Products Company Limited | Process for producing W/O/W type multiple emusion |
| AU571171B2 (en) * | 1981-05-08 | 1988-04-14 | Schering Wien Ges. M.B.H. | Cosmetic oil/water - water/oil emulsion |
| US4988456A (en) * | 1984-03-26 | 1991-01-29 | Meiji Milk Products Company Limited | Process for producing W/O/W type multiple emulsion for medicines |
| US5750124A (en) * | 1993-12-22 | 1998-05-12 | Beiersdorf Ag | W/O/W emulsions |
| US5834539A (en) * | 1991-10-15 | 1998-11-10 | Krivohlavek; Dennis | Multiple phase emulsions in burner fuel, combustion, emulsion and explosives applications |
| WO2004082670A1 (en) * | 2003-03-14 | 2004-09-30 | Xanodyne Pharmaceuticals, Inc. | Methadone-containing compositions for parenteral administration and use thereof |
| EP3274548A4 (en) * | 2015-03-23 | 2019-01-16 | President and Fellows of Harvard College | METHODS AND COMPOSITIONS FOR INJECTING ACTIVE SOLUTIONS OF HIGH CONCENTRATION AND / OR HIGH VISCOSITY |
| US11540984B2 (en) | 2018-05-23 | 2023-01-03 | Conopco, Inc. | Nanoemulsions and a method for making the same |
-
1967
- 1967-07-19 GB GB2314668A patent/GB1235667A/en not_active Expired
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5246382A (en) * | 1975-10-11 | 1977-04-13 | Lion Corp | Method of preparing compound emulsion |
| JPS5523087B2 (en) * | 1975-10-11 | 1980-06-20 | ||
| US4254105A (en) * | 1975-10-11 | 1981-03-03 | The Lion Dentifrice Co., Ltd. | Multiple emulsion having a form of water/oil/water phase and process for preparation thereof, and multiple emulsion type cosmetics |
| AU571171B2 (en) * | 1981-05-08 | 1988-04-14 | Schering Wien Ges. M.B.H. | Cosmetic oil/water - water/oil emulsion |
| US4714566A (en) * | 1984-03-02 | 1987-12-22 | Meiji Milk Products Company Limited | Process for producing W/O/W type multiple emusion |
| US4988456A (en) * | 1984-03-26 | 1991-01-29 | Meiji Milk Products Company Limited | Process for producing W/O/W type multiple emulsion for medicines |
| US5834539A (en) * | 1991-10-15 | 1998-11-10 | Krivohlavek; Dennis | Multiple phase emulsions in burner fuel, combustion, emulsion and explosives applications |
| US5750124A (en) * | 1993-12-22 | 1998-05-12 | Beiersdorf Ag | W/O/W emulsions |
| WO2004082670A1 (en) * | 2003-03-14 | 2004-09-30 | Xanodyne Pharmaceuticals, Inc. | Methadone-containing compositions for parenteral administration and use thereof |
| EP3274548A4 (en) * | 2015-03-23 | 2019-01-16 | President and Fellows of Harvard College | METHODS AND COMPOSITIONS FOR INJECTING ACTIVE SOLUTIONS OF HIGH CONCENTRATION AND / OR HIGH VISCOSITY |
| US11540984B2 (en) | 2018-05-23 | 2023-01-03 | Conopco, Inc. | Nanoemulsions and a method for making the same |
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