GB1234625A - - Google Patents
Info
- Publication number
- GB1234625A GB1234625A GB1234625DA GB1234625A GB 1234625 A GB1234625 A GB 1234625A GB 1234625D A GB1234625D A GB 1234625DA GB 1234625 A GB1234625 A GB 1234625A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- conh
- compound
- alkoxy
- conversion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1,234,625. Oxazinoisoquinoline derivatives. CIBA-GEIGY A.G. 30 April, 1968 [1 May, 1967], No. 1625/71. Divided out of 1,234,624. Heading C2C. Compounds of the general formula (Z=CN, COOH, C 2-5 alkoxycarbonyl; R 1 =H, C 1-3 alkoxy; R 2 , 3 =C 1-3 alkoxy or (when R 1 = H) R 2+3 =OCH 2 O) and their mineral acid addition salts are prepared by cyclizing a compound of the formula (R=CN, CONH 2 ) and reducing the product or dehydrating a compound of the formula (A= CONH 2 ), optionally followed by conversion to the acid, an ester or a salt and/or racemate separation or resolution. The morpholinone starting materials are prepared by reacting substituted phenethylamines with glycidamide and reacting the resulting compound of the formula with ethyl chloroacetate in the presence of a base or with chloroacetyl chloride followed by treatment with a base, optionally followed by conversion of the CONH 2 group to CN.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63485667A | 1967-05-01 | 1967-05-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1234625A true GB1234625A (en) | 1971-06-09 |
Family
ID=24545439
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1234625D Expired GB1234625A (en) | 1967-05-01 | 1968-04-30 | |
| GB1234624D Expired GB1234624A (en) | 1967-05-01 | 1968-04-30 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1234624D Expired GB1234624A (en) | 1967-05-01 | 1968-04-30 |
Country Status (12)
| Country | Link |
|---|---|
| AT (3) | AT277271B (en) |
| BE (1) | BE714508A (en) |
| CH (1) | CH499538A (en) |
| DE (1) | DE1770304A1 (en) |
| DK (1) | DK125422B (en) |
| ES (3) | ES353394A1 (en) |
| FR (3) | FR1578899A (en) |
| GB (2) | GB1234625A (en) |
| IE (1) | IE32045B1 (en) |
| IL (1) | IL29920A (en) |
| NL (1) | NL6805805A (en) |
| SE (1) | SE343586B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU191301B (en) * | 1984-03-23 | 1987-02-27 | Richter Gedeon Vegyeszeti Gyar Rt,Hu | Process for preparing 1-/hydroxy-methyl/-1,6,7,11b-tetrahydro-2h,4h-/1,3/-oxazino- or -thiazino/4,3-a/isoquinoline -derivatives |
-
1968
- 1968-04-24 SE SE5540/68A patent/SE343586B/xx unknown
- 1968-04-24 NL NL6805805A patent/NL6805805A/xx unknown
- 1968-04-24 DK DK185068AA patent/DK125422B/en unknown
- 1968-04-30 GB GB1234625D patent/GB1234625A/en not_active Expired
- 1968-04-30 IE IE506/68A patent/IE32045B1/en unknown
- 1968-04-30 BE BE714508D patent/BE714508A/xx unknown
- 1968-04-30 AT AT419468A patent/AT277271B/en not_active IP Right Cessation
- 1968-04-30 DE DE19681770304 patent/DE1770304A1/en active Pending
- 1968-04-30 CH CH638268A patent/CH499538A/en not_active IP Right Cessation
- 1968-04-30 AT AT00989/69A patent/AT277273B/en active
- 1968-04-30 AT AT00988/69A patent/AT277272B/en not_active IP Right Cessation
- 1968-04-30 ES ES353394A patent/ES353394A1/en not_active Expired
- 1968-04-30 ES ES353393A patent/ES353393A1/en not_active Expired
- 1968-04-30 IL IL29920A patent/IL29920A/en unknown
- 1968-04-30 GB GB1234624D patent/GB1234624A/en not_active Expired
- 1968-04-30 ES ES353395A patent/ES353395A1/en not_active Expired
- 1968-05-02 FR FR1578899D patent/FR1578899A/fr not_active Expired
- 1968-07-30 FR FR161145A patent/FR7645M/fr not_active Expired
- 1968-07-30 FR FR161146A patent/FR7706M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1234624A (en) | 1971-06-09 |
| SE343586B (en) | 1972-03-13 |
| DE1770304A1 (en) | 1971-10-21 |
| IE32045B1 (en) | 1973-03-21 |
| ES353395A1 (en) | 1969-10-01 |
| IE32045L (en) | 1968-11-01 |
| DK125422B (en) | 1973-02-19 |
| NL6805805A (en) | 1968-11-04 |
| AT277271B (en) | 1969-12-29 |
| FR1578899A (en) | 1969-08-22 |
| IL29920A0 (en) | 1968-06-20 |
| FR7706M (en) | 1970-02-23 |
| ES353394A1 (en) | 1969-10-01 |
| ES353393A1 (en) | 1969-09-01 |
| FR7645M (en) | 1970-02-02 |
| AT277273B (en) | 1969-12-29 |
| AT277272B (en) | 1969-12-29 |
| BE714508A (en) | 1968-10-30 |
| CH499538A (en) | 1970-11-30 |
| IL29920A (en) | 1972-04-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |