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GB1214093A - Purification of deoxycholic acid - Google Patents

Purification of deoxycholic acid

Info

Publication number
GB1214093A
GB1214093A GB5584668A GB5584668A GB1214093A GB 1214093 A GB1214093 A GB 1214093A GB 5584668 A GB5584668 A GB 5584668A GB 5584668 A GB5584668 A GB 5584668A GB 1214093 A GB1214093 A GB 1214093A
Authority
GB
United Kingdom
Prior art keywords
deoxycholic acid
solution
evaporating
adduct
urea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5584668A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of GB1214093A publication Critical patent/GB1214093A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47J—KITCHEN EQUIPMENT; COFFEE MILLS; SPICE MILLS; APPARATUS FOR MAKING BEVERAGES
    • A47J45/00—Devices for fastening or gripping kitchen utensils or crockery
    • A47J45/06—Handles for hollow-ware articles
    • A47J45/08—Heat-insulating handles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

1,214,093. Deoxycholic acid. RIGHTER GEDEON VEGYESZETI GYAR RT. 25 Nov., 1968 [19 Dec., 1967], No. 55846/68. Heading C2U. Pure deoxycholic acid is prepared from a fatty acid adduct thereof by treating a solution of the adduct in an organic solvent with urea, separating the precipitated fatty acid-urea complex and recovering deoxycholic acid from the solution. The initial adduct may be obtained by working up raw bile. The organic solvent may be methanol. The urea may be added in solid form, and charcoal may also be added. The treatment is preferably effected at reflux and the precipitate removed by filtration or centrifuging after cooling to about 5‹ C. Deoxycholic acid is isolated from the solution by evaporating, dissolving the residue in aqueous NaOH and precipitating the product with H 2 SO 4 . Sodium deoxycholate is obtained by evaporating the NaOH solution or by dissolving the final product in aqueous NaOH and evaporating, e.g. by spray-drying.
GB5584668A 1967-12-19 1968-11-25 Purification of deoxycholic acid Expired GB1214093A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HURI000333 1967-12-19

Publications (1)

Publication Number Publication Date
GB1214093A true GB1214093A (en) 1970-12-02

Family

ID=11000823

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5584668A Expired GB1214093A (en) 1967-12-19 1968-11-25 Purification of deoxycholic acid

Country Status (4)

Country Link
DE (1) DE1810033A1 (en)
FR (1) FR1602556A (en)
GB (1) GB1214093A (en)
NL (1) NL6817632A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2452358A (en) * 2008-04-25 2009-03-04 Kythera Biopharmaceuticals Inc Preparation of bile acids and intermediates thereof
US8242294B2 (en) 2007-06-19 2012-08-14 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
US9522155B2 (en) 2007-06-19 2016-12-20 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
US9683008B2 (en) 2010-08-12 2017-06-20 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9949986B2 (en) 2007-06-19 2018-04-24 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
US11202786B2 (en) 2007-06-19 2021-12-21 Allergan Sales, Llc Synthetic bile acid compositions and methods
US11026955B2 (en) 2007-06-19 2021-06-08 Allergan Sales, Llc Synthetic bile acid compositions and methods
US10434108B2 (en) 2007-06-19 2019-10-08 Allergan Sales, Llc Synthetic bile acid compositions and methods
US8242294B2 (en) 2007-06-19 2012-08-14 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
US10434107B2 (en) 2007-06-19 2019-10-08 Allergan Sales, Llc Synthetic bile acid compositions and methods
US9987291B2 (en) 2007-06-19 2018-06-05 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
US8461140B2 (en) 2007-06-19 2013-06-11 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
US8546367B2 (en) 2007-06-19 2013-10-01 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
US9050349B2 (en) 2007-06-19 2015-06-09 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
US9522155B2 (en) 2007-06-19 2016-12-20 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
US9636349B2 (en) 2007-06-19 2017-05-02 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
US8362285B2 (en) 2008-04-25 2013-01-29 Kythera Biopharmaceuticals, Inc. Preparation of bile acids and intermediates thereof
US8367852B2 (en) 2008-04-25 2013-02-05 Kythera Biopharmaceuticals, Inc. Preparation of bile acids and intermediates thereof
US10053486B2 (en) 2008-04-25 2018-08-21 Kythera Biopharmaceuticals, Inc. Preparation of bile acids and intermediates thereof
GB2452358A (en) * 2008-04-25 2009-03-04 Kythera Biopharmaceuticals Inc Preparation of bile acids and intermediates thereof
US7994351B2 (en) 2008-04-25 2011-08-09 Kythera Biopharmaceuticals, Inc. Preparation of bile acids and intermediates thereof
US10633412B2 (en) 2008-04-25 2020-04-28 Allergan Sales, Llc Preparation of bile acids and intermediates thereof
US11008363B2 (en) 2008-04-25 2021-05-18 Allergan Sales, Llc Preparation of bile acids and intermediates thereof
US7902387B2 (en) 2008-04-25 2011-03-08 Kythera Biopharmaceuticals, Inc. Preparation of bile acids and intermediates thereof
GB2452358B (en) * 2008-04-25 2009-12-09 Kythera Biopharmaceuticals Inc Preparation of bile acids
US9683008B2 (en) 2010-08-12 2017-06-20 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
US10144757B2 (en) 2010-08-12 2018-12-04 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods

Also Published As

Publication number Publication date
DE1810033A1 (en) 1969-07-10
NL6817632A (en) 1969-06-23
FR1602556A (en) 1970-12-28

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees