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GB1211721A - Laboratory reagent for assay of acid or alkaline phosphatase - Google Patents

Laboratory reagent for assay of acid or alkaline phosphatase

Info

Publication number
GB1211721A
GB1211721A GB49698/67A GB4969867A GB1211721A GB 1211721 A GB1211721 A GB 1211721A GB 49698/67 A GB49698/67 A GB 49698/67A GB 4969867 A GB4969867 A GB 4969867A GB 1211721 A GB1211721 A GB 1211721A
Authority
GB
United Kingdom
Prior art keywords
acid
alkaline phosphatase
nov
mixture
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB49698/67A
Inventor
D H Deutsch
J D Murray
S E Green
E W Saleeby
B M Steciw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of GB1211721A publication Critical patent/GB1211721A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • C12Q2334/10—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases p-Nitrophenol derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

1,211,721. Determination of acid or alkaline phosphatases. SMITH KLINE & FRENCH LABORATORIES. 1 Nov., 1967 [14 Nov., 1966; 31 March, 1967], No. 49698/67. Heading B1X. A stable assay material for dissolving in water for assaying acid or alkaline phosphatase comprises a mixture of an amine salt of p-nitrophenyl phosphoric acid, a dry buffer capable of maintaining the pH between 4 and 11, and a water-soluble magnesium salt, for example magnesium aspartate or glutamate as activator. -The mixture may include also a polyhydric linear alcohol or a polymer of a polyhydric linear alcohol having 1 to 5 hydroxyl groups per monomer unit, for example mannitol, sorbitol, inositol, lactose, sucrose. Preferred amine salts are the dicyclohexyl ammonium and tris (hydroxy methyl) amino methane salts; others are named. The dry assay material may be packed in unit amounts in for example foil capsules.
GB49698/67A 1966-11-14 1967-11-01 Laboratory reagent for assay of acid or alkaline phosphatase Expired GB1211721A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59374066A 1966-11-14 1966-11-14
US62743067A 1967-03-31 1967-03-31

Publications (1)

Publication Number Publication Date
GB1211721A true GB1211721A (en) 1970-11-11

Family

ID=27081784

Family Applications (2)

Application Number Title Priority Date Filing Date
GB49698/67A Expired GB1211721A (en) 1966-11-14 1967-11-01 Laboratory reagent for assay of acid or alkaline phosphatase
GB35174/69A Expired GB1211722A (en) 1966-11-14 1967-11-01 Amine salts of an aromatic phosphoric ester

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB35174/69A Expired GB1211722A (en) 1966-11-14 1967-11-01 Amine salts of an aromatic phosphoric ester

Country Status (10)

Country Link
US (1) US3425912A (en)
CA (1) CA930655A (en)
CH (1) CH497702A (en)
DE (1) DE1673047C2 (en)
DK (1) DK140267B (en)
GB (2) GB1211721A (en)
IL (1) IL28842A (en)
NL (1) NL6715288A (en)
SE (2) SE336687B (en)
SU (1) SU444376A3 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2325046A1 (en) * 1975-09-22 1977-04-15 Chembro Holdings Pty Ltd MEASURING ALKALINE PHOSPHATASE LEVELS IN HUMORS
FR2393310A1 (en) * 1977-06-03 1978-12-29 Modrovich Ivan STABILIZED LIQUID DIAGNOSTIC COMPOSITION CONTAINING A PHOSPHATE AND PROCESS FOR THE PREPARATION OF THE SAME

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3791929A (en) * 1968-09-08 1974-02-12 Searle & Co Phosphatase assay using lyophilized aryl phosphate monesters
US3723579A (en) * 1969-09-08 1973-03-27 Searle & Co Lyophilized aryl phosphate monoesters and process therefor
US3926735A (en) * 1971-10-20 1975-12-16 Mallinckrodt Inc Alkaline phosphatase assay
US3896008A (en) * 1971-10-28 1975-07-22 Owens Illinois Inc Electrochemical potentiometric method for selectively determining alkaline phosphatase content in aqueous fluids
IT1065125B (en) * 1975-08-20 1985-02-25 Boehringer Mannheim Gmbh PROCESS TO KEEP THE ACTIVITY OF ALKALINE PHOSPHATASE AND CONTROL SERUM CONTAINING SUCH PHOSPHATASE CONSTANT
CH625833A5 (en) * 1975-12-24 1981-10-15 Hoffmann La Roche Method for the determination of acid phosphatase
US4206280A (en) * 1975-12-24 1980-06-03 Hoffmann-La Roche Inc. Determination of acid phosphatase
JPS5377015A (en) * 1976-12-16 1978-07-08 Asahi Glass Co Ltd Preparation of fluorine-containing phosphoric acid ester
IT1108964B (en) * 1978-01-20 1985-12-16 Sclavo Inst Sieroterapeut COMPOSITION SUITABLE FOR THE ANALYSIS OF ALKALINE PHOSPHATASE AND METHOD USING THE SAME
US4472499A (en) * 1982-01-22 1984-09-18 American Hoechst Corporation Reagents for the determination of enzymes
US4555484A (en) * 1983-07-25 1985-11-26 Eastman Kodak Company Analytical element and method for alkaline phosphatase assay
CN102297962B (en) * 2011-05-23 2014-01-08 董理 Kit for detecting alkaline phosphatase

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2359052A (en) * 1940-07-01 1944-09-26 Scharer Harry Method for detecting enzyme activity
US3002893A (en) * 1958-11-13 1961-10-03 Warner Lambert Pharmaceutical Method for the determination of serum acid phosphatase and diagnostic preparation therefor
US3069330A (en) * 1960-08-30 1962-12-18 Warner Lambert Pharmaceutical Method of determining glutamic-oxal-acetic transaminase and composition therefor

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2325046A1 (en) * 1975-09-22 1977-04-15 Chembro Holdings Pty Ltd MEASURING ALKALINE PHOSPHATASE LEVELS IN HUMORS
FR2393310A1 (en) * 1977-06-03 1978-12-29 Modrovich Ivan STABILIZED LIQUID DIAGNOSTIC COMPOSITION CONTAINING A PHOSPHATE AND PROCESS FOR THE PREPARATION OF THE SAME

Also Published As

Publication number Publication date
US3425912A (en) 1969-02-04
SE375384B (en) 1975-04-14
DK140267C (en) 1979-12-10
DE1673047B1 (en) 1972-06-08
GB1211722A (en) 1970-11-11
DK140267B (en) 1979-07-16
CA930655A (en) 1973-07-24
SE336687B (en) 1971-07-12
CH497702A (en) 1970-10-15
NL6715288A (en) 1968-05-15
IL28842A (en) 1972-11-28
SU444376A3 (en) 1974-09-25
DE1673047C2 (en) 1973-01-04

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PE20 Patent expired after termination of 20 years