GB1207246A - Process for the production of radioactive technetium-99m - Google Patents
Process for the production of radioactive technetium-99mInfo
- Publication number
- GB1207246A GB1207246A GB07816/68A GB1781668A GB1207246A GB 1207246 A GB1207246 A GB 1207246A GB 07816/68 A GB07816/68 A GB 07816/68A GB 1781668 A GB1781668 A GB 1781668A GB 1207246 A GB1207246 A GB 1207246A
- Authority
- GB
- United Kingdom
- Prior art keywords
- slurry
- solution
- radio
- molybdenum
- column
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000002285 radioactive effect Effects 0.000 title abstract 3
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 title abstract 2
- 229940056501 technetium 99m Drugs 0.000 title abstract 2
- 239000002002 slurry Substances 0.000 abstract 5
- 239000000243 solution Substances 0.000 abstract 5
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 abstract 3
- XTEGARKTQYYJKE-UHFFFAOYSA-M Chlorate Chemical compound [O-]Cl(=O)=O XTEGARKTQYYJKE-UHFFFAOYSA-M 0.000 abstract 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- YRKCREAYFQTBPV-UHFFFAOYSA-N acetylacetone Chemical compound CC(=O)CC(C)=O YRKCREAYFQTBPV-UHFFFAOYSA-N 0.000 abstract 2
- JKQOBWVOAYFWKG-UHFFFAOYSA-N molybdenum trioxide Chemical compound O=[Mo](=O)=O JKQOBWVOAYFWKG-UHFFFAOYSA-N 0.000 abstract 2
- 239000004342 Benzoyl peroxide Substances 0.000 abstract 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 abstract 1
- ZOKXTWBITQBERF-AKLPVKDBSA-N Molybdenum Mo-99 Chemical compound [99Mo] ZOKXTWBITQBERF-AKLPVKDBSA-N 0.000 abstract 1
- 229910002651 NO3 Inorganic materials 0.000 abstract 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 235000019400 benzoyl peroxide Nutrition 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 229950009740 molybdenum mo-99 Drugs 0.000 abstract 1
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 abstract 1
- 239000012286 potassium permanganate Substances 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003755 zirconium compounds Chemical class 0.000 abstract 1
- 229910001928 zirconium oxide Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
- C22B61/00—Obtaining metals not elsewhere provided for in this subclass
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/0005—Isotope delivery systems
Landscapes
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Mechanical Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
1,207,246. Separation of radio-isotopes. UNION CARBIDE CORP. 16 April, 1968 [16 June, 1967], No. 17816/68. Heading G6R. Radio-active technetium 99m is separated from a solution of molybdenum 99 by forming a slurry of the solution with an oxidized zirconium compound, adjusting the pH of the slurry to 2 to 7, heating to above 40 C., and selectively extracting Tc 99m from the slurry solids with a solvent. The radio-active Mo 99 solution may be obtained from neutronirradiated molybdenum trioxide, nitrate, sulphate, or acetylacetone, or molybdenum metal. The solution is mixed with a slurry of hydrous zirconium oxide which has been oxidized with bromine or chlorine water, potassium permanganate or chlorate, hydrogen peroxide, or benzoyl peroxide. The slurry is drained in a column, washed, and Tc 99m eluted with isotonic saline, methyl ethyl ketone, or an aqueous solution of an inorganic acid. If the column and isotonic saline are sterilized, solutions suitable for medical use are obtained.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64645367A | 1967-06-16 | 1967-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1207246A true GB1207246A (en) | 1970-09-30 |
Family
ID=24593130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB07816/68A Expired GB1207246A (en) | 1967-06-16 | 1968-04-16 | Process for the production of radioactive technetium-99m |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3468808A (en) |
| BE (1) | BE716569A (en) |
| DE (1) | DE1758118C3 (en) |
| FR (1) | FR1561828A (en) |
| GB (1) | GB1207246A (en) |
| IL (1) | IL29607A (en) |
| NL (1) | NL6804929A (en) |
| SE (1) | SE350954B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2000361A (en) * | 1977-06-10 | 1979-01-04 | Atomic Energy Of Australia | Technetium-99m generator |
| WO2020005674A2 (en) | 2018-06-20 | 2020-01-02 | BWXT Isotope Technology Group, Inc. | SYSTEM AND METHOD FOR EVALUATING ELUTION EFFICIENCY AND RADIOPURITY OF Tc-99m GENERATORS |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL165321C (en) * | 1971-03-02 | 1981-03-16 | Byk Mallinckrodt Cil Bv | METHOD FOR THE MANUFACTURE OF A RADIO ISOTOPE GENERATOR GENERATOR. |
| US4010109A (en) * | 1973-07-02 | 1977-03-01 | Kurt Sauerwein | Device for marking fluent materials |
| US4158700A (en) * | 1976-03-08 | 1979-06-19 | Karageozian Hampar L | Method of producing radioactive technetium-99M |
| US4206358A (en) * | 1977-10-19 | 1980-06-03 | Australian Atomic Energy Commission | Technetium-99 generators |
| PL2536664T3 (en) * | 2010-02-19 | 2019-09-30 | BWXT Technical Services Group, Inc | Method and apparatus for the extraction and processing of molybdenum-99 |
| GB201112051D0 (en) * | 2011-07-13 | 2011-08-31 | Mallinckrodt Llc | Process |
| AU2013274040B2 (en) | 2012-06-15 | 2017-01-12 | Dent International Research, Inc. | Apparatus and methods for transmutation of elements |
| US9842664B2 (en) | 2013-09-26 | 2017-12-12 | Los Alamos National Security, Llc | Recovering and recycling uranium used for production of molybdenum-99 |
| US9793023B2 (en) | 2013-09-26 | 2017-10-17 | Los Alamos National Security, Llc | Recovery of uranium from an irradiated solid target after removal of molybdenum-99 produced from the irradiated target |
| AP2017009694A0 (en) * | 2014-08-06 | 2017-01-31 | Res Triangle Inst | High efficiency neutron capture product production |
| US11286172B2 (en) * | 2017-02-24 | 2022-03-29 | BWXT Isotope Technology Group, Inc. | Metal-molybdate and method for making the same |
| JP6554753B1 (en) * | 2019-03-11 | 2019-08-07 | 株式会社京都メディカルテクノロジー | Technetium 99m isolation system and technetium 99m isolation method |
| CN114121330B (en) * | 2021-11-11 | 2024-05-14 | 中国核动力研究设计院 | Molybdenum technetium generator, preparation method and device |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB896758A (en) * | 1959-11-13 | 1962-05-16 | Atomic Energy Authority Uk | Improvements in or relating to the separation of technetium from fission product solutions |
-
1967
- 1967-06-16 US US646453A patent/US3468808A/en not_active Expired - Lifetime
-
1968
- 1968-03-08 IL IL29607A patent/IL29607A/en unknown
- 1968-04-05 DE DE1758118A patent/DE1758118C3/en not_active Expired
- 1968-04-08 NL NL6804929A patent/NL6804929A/xx unknown
- 1968-04-16 GB GB07816/68A patent/GB1207246A/en not_active Expired
- 1968-05-08 FR FR1561828D patent/FR1561828A/fr not_active Expired
- 1968-06-05 SE SE07522/68A patent/SE350954B/xx unknown
- 1968-06-14 BE BE716569D patent/BE716569A/xx unknown
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2000361A (en) * | 1977-06-10 | 1979-01-04 | Atomic Energy Of Australia | Technetium-99m generator |
| GB2000361B (en) * | 1977-06-10 | 1982-06-30 | Atomic Energy Of Australia | Technetium-99m generator |
| WO2020005674A2 (en) | 2018-06-20 | 2020-01-02 | BWXT Isotope Technology Group, Inc. | SYSTEM AND METHOD FOR EVALUATING ELUTION EFFICIENCY AND RADIOPURITY OF Tc-99m GENERATORS |
| EP3811381A4 (en) * | 2018-06-20 | 2022-03-30 | BWXT Isotope Technology Group, Inc. | SYSTEM AND METHOD FOR EVALUATION OF ELUTION EFFICIENCY AND RADIATION PURITY OF TC-99M GENERATORS |
| US11391853B2 (en) | 2018-06-20 | 2022-07-19 | BWXT Isotope Technology Group, Inc. | System and method for evaluating elution efficiency and radiopurity of tc-99m generators |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1758118A1 (en) | 1970-12-23 |
| DE1758118C3 (en) | 1974-05-30 |
| BE716569A (en) | 1968-12-16 |
| IL29607A (en) | 1971-10-20 |
| US3468808A (en) | 1969-09-23 |
| DE1758118B2 (en) | 1973-10-18 |
| FR1561828A (en) | 1969-03-28 |
| NL6804929A (en) | 1968-12-17 |
| SE350954B (en) | 1972-11-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |