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GB1206995A - Indoline-2-ones - Google Patents

Indoline-2-ones

Info

Publication number
GB1206995A
GB1206995A GB2182768A GB2182768A GB1206995A GB 1206995 A GB1206995 A GB 1206995A GB 2182768 A GB2182768 A GB 2182768A GB 2182768 A GB2182768 A GB 2182768A GB 1206995 A GB1206995 A GB 1206995A
Authority
GB
United Kingdom
Prior art keywords
benzyl
chlorobenzyl
ones
chloro
indolin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2182768A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR106179A external-priority patent/FR1529901A/en
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Publication of GB1206995A publication Critical patent/GB1206995A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,206,995. Substituted indolin-2-ones. CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE. 8 May, 1968 [12 May, 1967; 24 April, 1968], No. 21827/68. Heading C2C. The invention comprises indolin-2-ones substituted as follows: (a) 3-(3,4-dichlorobenzyl); (b) 3-benzyl-4-chloro; (c) 3-benzyl-6-trifluoromethyl; (d) 6-amino-3-ethyl; (e) 3-(2-chlorobenzyl); (f)3-(4-chlorobenzyl)-6-trifluoromethyl; (g) 3-benzyl-6-methyl; (h) 1-carboxymethyl-3- (4-chlorobenzyl)-6-methoxy; (i) 3-methyl-6- chloro; (j) 3-benzyl-6-chloro; (k) 3-(4-chlorobenzyl )-6-chloro; (1) 1-benzyl-3-methyl; (m) 1-carboxymethyl-3-(4-chlorobenzyl); (n) 1- carboxymethyl - 3 - benzyl - 6 - methoxy. These compounds are prepared by hydrolysing and decarboxylating the corresponding indolin-2-ones containing an additional 3-CO 2 R substituent (R = alkyl or aralkyl); where the desired products contain a 1-carboxymethyl group, the corresponding 1-alkoxycarbonylmethyl-3-alkoxycarbonyl-indolin-2-ones are used. Starting material.-XEtC(CO 2 Et) 2 (X = 2,4- dinitrophenyl) is prepared from XCl and NaEtC(Co 2 Et) 2 .
GB2182768A 1967-05-12 1968-05-08 Indoline-2-ones Expired GB1206995A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR106179A FR1529901A (en) 1967-05-12 1967-05-12 Process for the preparation of lactams bound to indolinone and oxoquinoline
FR149311 1968-04-24

Publications (1)

Publication Number Publication Date
GB1206995A true GB1206995A (en) 1970-09-30

Family

ID=26176394

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2182768A Expired GB1206995A (en) 1967-05-12 1968-05-08 Indoline-2-ones

Country Status (4)

Country Link
BE (1) BE714717A (en)
CH (1) CH485715A (en)
DE (1) DE1770372A1 (en)
GB (1) GB1206995A (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US4569942A (en) * 1984-05-04 1986-02-11 Pfizer Inc. N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
US4658037A (en) * 1984-02-07 1987-04-14 Pfizer Inc. Intermediates for 1,3-disubstituted 2-oxindoles as analgesic and antiinflammatory agents
US4690943A (en) * 1984-09-19 1987-09-01 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
US4721712A (en) * 1984-06-12 1988-01-26 Pfizer Inc. 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents
US4752609A (en) * 1985-06-20 1988-06-21 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
US4808601A (en) * 1984-09-19 1989-02-28 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
US4963686A (en) * 1984-05-12 1990-10-16 Boehringer Mannheim Gmbh Certain pyridinoylamino-indolin-2-one derivatives
US5358949A (en) * 1986-03-05 1994-10-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
CN108096244A (en) * 2018-01-25 2018-06-01 昆明医科大学 The new application of 1- hydrogen -2- indolones -3- benzyls/substituted benzyl -3- formic ether compounds

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4658037A (en) * 1984-02-07 1987-04-14 Pfizer Inc. Intermediates for 1,3-disubstituted 2-oxindoles as analgesic and antiinflammatory agents
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
US4569942A (en) * 1984-05-04 1986-02-11 Pfizer Inc. N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
US4963686A (en) * 1984-05-12 1990-10-16 Boehringer Mannheim Gmbh Certain pyridinoylamino-indolin-2-one derivatives
US4721712A (en) * 1984-06-12 1988-01-26 Pfizer Inc. 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents
US4690943A (en) * 1984-09-19 1987-09-01 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
US4808601A (en) * 1984-09-19 1989-02-28 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
US4752609A (en) * 1985-06-20 1988-06-21 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
US5358949A (en) * 1986-03-05 1994-10-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
CN108096244A (en) * 2018-01-25 2018-06-01 昆明医科大学 The new application of 1- hydrogen -2- indolones -3- benzyls/substituted benzyl -3- formic ether compounds
CN108096244B (en) * 2018-01-25 2020-11-24 昆明医科大学 Use of 1-hydro-2-indolone-3-benzyl/substituted benzyl-3-carboxylate compounds

Also Published As

Publication number Publication date
CH485715A (en) 1970-02-15
BE714717A (en) 1968-09-30
DE1770372A1 (en) 1971-10-21

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees