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GB1144215A - Process for treating erythrocytes and the manufacture of tablet therefrom - Google Patents

Process for treating erythrocytes and the manufacture of tablet therefrom

Info

Publication number
GB1144215A
GB1144215A GB2896366A GB2896366A GB1144215A GB 1144215 A GB1144215 A GB 1144215A GB 2896366 A GB2896366 A GB 2896366A GB 2896366 A GB2896366 A GB 2896366A GB 1144215 A GB1144215 A GB 1144215A
Authority
GB
United Kingdom
Prior art keywords
erythrocytes
drying
sensitized
starch
auxiliaries
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2896366A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Laboratories Ltd
Original Assignee
Organon Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Laboratories Ltd filed Critical Organon Laboratories Ltd
Publication of GB1144215A publication Critical patent/GB1144215A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
    • G01N33/555—Red blood cell
    • G01N33/556—Fixed or stabilised red blood cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Mycology (AREA)
  • Reproductive Health (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

1,144,215. Preparing erythrocytes for immunochemical use. ORGANON LABORATORIES Ltd. 28 June, 1966 [28 July, 1965], No. 28963/66. Heading B1X. An aqueous suspension of erythrocytes treated with one or more tanning agents, is dried and heated at above 30‹C, to provide a product which can be compressed into tablets for storage and use in immunochemical determination. The erythrocytes may first be sensitized with an antigen or this may be done subsequently. Other materials may be present in the suspension, e.g. tableting auxiliaries such as fillers (saccharose, mannitol, lactose, urea), lubricants (boric acid, starch, carbowax (Trade Mark) and magnesium stearate), disintegration agents (starch, alginic acid) and substances used in the determination e.g. buffers (monopotassium and disodium phosphate), sodium chloride, EDTA and albumin. Alternatively, these auxiliaries may be mixed individually or as a spray-dried mixture, with the treated ethythrocytes before tableting. The drying may be performed by lyophilisation, and the heating by fluidisation in a dry gas stream at 50- 120‹C for 1-10 mins, but preferably drying and heating are performed simultaneously by spray drying e.g. at 75-140‹C. In the Examples the erythrocytes were tanned with formalin with or without tannin, but the use of inulin, hydroquinine, bis-diazo benzidine, acetaldehyde, pyruvic acid aldehyde and glyoxal as tanning agents (mordants) is mentioned. In the Examples, the erythrocytes are sensitized with HCG, but serum gonadotrophin, growth hormone, serium albumins, gamma globulins, insulin, luteinizing hormone and tetanus toxoid are other antigens mentioned.
GB2896366A 1965-07-28 1966-06-28 Process for treating erythrocytes and the manufacture of tablet therefrom Expired GB1144215A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL6509726A NL6509726A (en) 1965-07-28 1965-07-28

Publications (1)

Publication Number Publication Date
GB1144215A true GB1144215A (en) 1969-03-05

Family

ID=19793749

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2896366A Expired GB1144215A (en) 1965-07-28 1966-06-28 Process for treating erythrocytes and the manufacture of tablet therefrom

Country Status (4)

Country Link
BE (1) BE684720A (en)
DE (1) DE1617666A1 (en)
GB (1) GB1144215A (en)
NL (1) NL6509726A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2328189A1 (en) * 1975-10-15 1977-05-13 Behringwerke Ag TANNED THROMBOCYTES, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS AS DIAGNOSIS AGENTS
FR2448150A1 (en) * 1979-01-31 1980-08-29 Takeda Chemical Industries Ltd REAGENT AND METHOD USING THE SAME FOR LATEX AGGLUTINATION REACTION
US4874690A (en) * 1988-08-26 1989-10-17 Cryopharm Corporation Lyophilization of red blood cells
WO1992010208A1 (en) * 1990-12-04 1992-06-25 Microtek Research And Development Ltd. Spray-dried antigenic products and method of preparation
US5425951A (en) * 1988-05-18 1995-06-20 Cryopharm Corporation Method of reconstituting lyophilized cells
CN113588501A (en) * 2015-12-08 2021-11-02 生物马特里卡公司 Reducing erythrocyte sedimentation rate

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2328189A1 (en) * 1975-10-15 1977-05-13 Behringwerke Ag TANNED THROMBOCYTES, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS AS DIAGNOSIS AGENTS
FR2448150A1 (en) * 1979-01-31 1980-08-29 Takeda Chemical Industries Ltd REAGENT AND METHOD USING THE SAME FOR LATEX AGGLUTINATION REACTION
US5425951A (en) * 1988-05-18 1995-06-20 Cryopharm Corporation Method of reconstituting lyophilized cells
US4874690A (en) * 1988-08-26 1989-10-17 Cryopharm Corporation Lyophilization of red blood cells
US5648206A (en) * 1988-08-26 1997-07-15 Cobe Laboratories, Inc. Lyophilization of cells
WO1992010208A1 (en) * 1990-12-04 1992-06-25 Microtek Research And Development Ltd. Spray-dried antigenic products and method of preparation
US5616329A (en) * 1990-12-04 1997-04-01 Microtek Research And Development Ltd. Spray-dried antigenic products
CN113588501A (en) * 2015-12-08 2021-11-02 生物马特里卡公司 Reducing erythrocyte sedimentation rate

Also Published As

Publication number Publication date
BE684720A (en) 1967-01-30
NL6509726A (en) 1967-01-30
DE1617666A1 (en) 1971-04-01

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