GB1141781A - Therapeutic compositions - Google Patents

Therapeutic compositions

Info

Publication number: GB1141781A
Authority: GB; United Kingdom
Prior art keywords: polymyxin; salts; toxic; jan; colistin
Prior art date: 1967-01-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

GB2883/67A

Other languages

English (en)

Inventor

Peter Acred

Robert Sutherland

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Beecham Group PLC

Original Assignee

Beecham Group PLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1967-01-19

Filing date

1967-01-19

Publication date

1969-01-29

1967-01-19 Application filed by Beecham Group PLC filed Critical Beecham Group PLC

1967-01-19 Priority to GB2883/67A priority Critical patent/GB1141781A/en

1968-01-15 Priority to DE19681692038 priority patent/DE1692038A1/de

1968-01-16 Priority to AT43868A priority patent/AT276627B/de

1968-01-18 Priority to NL6800834A priority patent/NL6800834A/xx

1968-01-18 Priority to BE709574D priority patent/BE709574A/xx

1968-01-18 Priority to FR136473A priority patent/FR7269M/fr

1969-01-29 Publication of GB1141781A publication Critical patent/GB1141781A/en

Status Expired legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title abstract 3
230000001225 therapeutic effect Effects 0.000 title abstract 2
150000003839 salts Chemical class 0.000 abstract 5
231100000252 nontoxic Toxicity 0.000 abstract 4
230000003000 nontoxic effect Effects 0.000 abstract 4
108010078777 Colistin Proteins 0.000 abstract 3
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
JORAUNFTUVJTNG-BSTBCYLQSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Polymers CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O JORAUNFTUVJTNG-BSTBCYLQSA-N 0.000 abstract 3
XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 abstract 3
108010093965 Polymyxin B Proteins 0.000 abstract 2
229960003669 carbenicillin Drugs 0.000 abstract 2
229960003346 colistin Drugs 0.000 abstract 2
229920000024 polymyxin B Polymers 0.000 abstract 2
KNIWPHSUTGNZST-UHFFFAOYSA-N polymyxin E2 Natural products CC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O KNIWPHSUTGNZST-UHFFFAOYSA-N 0.000 abstract 2
229960005266 polymyxin b Drugs 0.000 abstract 2
RDEIXVOBVLKYNT-HDZPSJEVSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-[(1r)-1-aminoethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;(2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(aminomethyl)oxan-2 Chemical compound OS(O)(=O)=O.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@@H](CN)O2)N)[C@@H](N)C[C@H]1N.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@H](O2)[C@@H](C)N)N)[C@@H](N)C[C@H]1N.O1[C@H]([C@@H](C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N RDEIXVOBVLKYNT-HDZPSJEVSA-N 0.000 abstract 1
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
BWLUMTFWVZZZND-UHFFFAOYSA-N Dibenzylamine Chemical compound C=1C=CC=CC=1CNCC1=CC=CC=C1 BWLUMTFWVZZZND-UHFFFAOYSA-N 0.000 abstract 1
CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 abstract 1
229930182566 Gentamicin Natural products 0.000 abstract 1
AFVFQIVMOAPDHO-UHFFFAOYSA-M Methanesulfonate Chemical compound CS([O-])(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 abstract 1
229930182555 Penicillin Natural products 0.000 abstract 1
108010040201 Polymyxins Proteins 0.000 abstract 1
241000589516 Pseudomonas Species 0.000 abstract 1
JVVXZOOGOGPDRZ-SLFFLAALSA-N [(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanamine Chemical compound NC[C@]1(C)CCC[C@]2(C)C3=CC=C(C(C)C)C=C3CC[C@H]21 JVVXZOOGOGPDRZ-SLFFLAALSA-N 0.000 abstract 1
150000003863 ammonium salts Chemical class 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
JUHORIMYRDESRB-UHFFFAOYSA-N benzathine Chemical compound C=1C=CC=CC=1CNCCNCC1=CC=CC=C1 JUHORIMYRDESRB-UHFFFAOYSA-N 0.000 abstract 1
FPPNZSSZRUTDAP-UWFZAAFLSA-N carbenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)C(C(O)=O)C1=CC=CC=C1 FPPNZSSZRUTDAP-UWFZAAFLSA-N 0.000 abstract 1
239000000969 carrier Substances 0.000 abstract 1
239000003085 diluting agent Substances 0.000 abstract 1
229960002518 gentamicin Drugs 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
239000007788 liquid Substances 0.000 abstract 1
YKQOSKADJPQZHB-YNWHQGOSSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1s)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Polymers CCC(C)CCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O YKQOSKADJPQZHB-YNWHQGOSSA-N 0.000 abstract 1
239000012457 nonaqueous media Substances 0.000 abstract 1
150000002960 penicillins Chemical class 0.000 abstract 1
MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 abstract 1
229960004919 procaine Drugs 0.000 abstract 1
239000000725 suspension Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

GB2883/67A 1967-01-19 1967-01-19 Therapeutic compositions Expired GB1141781A (en)

Priority Applications (6)

Application Number	Priority Date	Filing Date	Title
GB2883/67A GB1141781A (en)	1967-01-19	1967-01-19	Therapeutic compositions
DE19681692038 DE1692038A1 (de)	1967-01-19	1968-01-15	Arzneimittel
AT43868A AT276627B (de)	1967-01-19	1968-01-16	Verfahren zur Herstellung einer synergistisch wirksamen Antibiotikazusammensetzung
NL6800834A NL6800834A (de)	1967-01-19	1968-01-18
BE709574D BE709574A (de)	1967-01-19	1968-01-18
FR136473A FR7269M (de)	1967-01-19	1968-01-18

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB2883/67A GB1141781A (en)	1967-01-19	1967-01-19	Therapeutic compositions
GB2801167		1967-06-16

Publications (1)

Publication Number	Publication Date
GB1141781A true GB1141781A (en)	1969-01-29

Family

ID=26237819

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GB2883/67A Expired GB1141781A (en)	1967-01-19	1967-01-19	Therapeutic compositions

Country Status (5)

Country	Link
BE (1)	BE709574A (de)
DE (1)	DE1692038A1 (de)
FR (1)	FR7269M (de)
GB (1)	GB1141781A (de)
NL (1)	NL6800834A (de)

1967
- 1967-01-19 GB GB2883/67A patent/GB1141781A/en not_active Expired
1968
- 1968-01-15 DE DE19681692038 patent/DE1692038A1/de active Pending
- 1968-01-18 NL NL6800834A patent/NL6800834A/xx unknown
- 1968-01-18 FR FR136473A patent/FR7269M/fr not_active Expired
- 1968-01-18 BE BE709574D patent/BE709574A/xx unknown

Also Published As

Publication number	Publication date
FR7269M (de)	1969-09-15
BE709574A (de)	1968-07-18
DE1692038A1 (de)	1971-07-08
NL6800834A (de)	1968-07-22

Publication	Publication Date	Title
GB2000138A (en)	1979-01-04	Therapeutic agents
PT93313A (pt)	1990-11-07	Processo para a preparacao do acido z(2r, 5r)-3-(2-hidroxietilideno)-7-oxo-4- -oxa-1-azabiciclo{3,2,0}heptano-2-carboxilico a partir de caldos de fermentacao de streptomyces sp.
ES452361A1 (es)	1978-01-01	Un procedimiento para la preparacion de nuevos derivados delacido clavulanico.
ES408972A1 (es)	1975-10-01	Un procedimiento de preparacion de un compuesto de cefalos-porina.
GB948076A (en)	1964-01-29	Cephalosporin compounds
GB1141781A (en)	1969-01-29	Therapeutic compositions
GB1434174A (en)	1976-05-05	7-trifluoromethylsulphinylacetamido cephalosporins
GB1493676A (en)	1977-11-30	Antibiotic method and pharmaceutical compositions
ES479636A1 (es)	1980-01-16	Procedimiento para la obtencion de un antibiotico de efecto sinergistico.
GB1454399A (en)	1976-11-03	Alphaaminoacyl cephalosporin ethers
ES459945A1 (es)	1978-08-16	Un procedimiento para la preparacion de nuevos derivados de cefalosporina.
GB1464026A (en)	1977-02-09	Preparation of beta-lactam antibiotics
GB1468102A (en)	1977-03-23	Cephalosporin derivatives their preparation and compositions containing them
GB1066347A (en)	1967-04-26	New derivatives of 7-amino-cephalosporamic acid and process for their manufacture
GB1272660A (en)	1972-05-03	Therapeutic compositions
US4342758A (en)	1982-08-03	Allylsulfoxide enzyme inhibitors
GB1436977A (en)	1976-05-26	7-alkylthioacetamido cephaosporins
GB1473672A (en)	1977-05-18	Cephalosporanic acid derivatives and the preparation thereof
ES461911A1 (es)	1978-12-01	Un procedimiento para la preparacion de nuevos compuestos antibioticos de cefalosporina.
GB1464330A (en)	1977-02-09	Cephalosporin esters with antibacterial activity
GB1321815A (en)	1973-07-04	Penicillins
ES8403489A1 (es)	1984-03-16	Un procedimiento para la preparacion de derivados del acido penicilanico.
GB1074331A (en)	1967-07-05	Penicillins
JPS53104796A (en)	1978-09-12	Preparation of antibiotics
GB1477672A (en)	1977-06-22	Penicillin compositions