GB1113600A - Tris-(hydroxymethyl)-aminomethane salts - Google Patents
Tris-(hydroxymethyl)-aminomethane saltsInfo
- Publication number
- GB1113600A GB1113600A GB7186/67A GB718667A GB1113600A GB 1113600 A GB1113600 A GB 1113600A GB 7186/67 A GB7186/67 A GB 7186/67A GB 718667 A GB718667 A GB 718667A GB 1113600 A GB1113600 A GB 1113600A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydroxymethyl
- tris
- aminomethane
- aminomethane salts
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical class OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 title abstract 4
- 150000003839 salts Chemical class 0.000 abstract 2
- AGBQKNBQESQNJD-SSDOTTSWSA-M (R)-lipoate Chemical compound [O-]C(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-M 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 abstract 1
- 229940106978 pangamate Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Tris - (hydroxymethyl) - aminomethane derivatives, having antiacidotic action, are produced by reaction of monocarboxylic aminated organic acids or inorganic salts thereof with tris - (hydroxymethyl) - aminomethane or acid addition salts thereof. Specified novel derivatives are the theophylline-7-N-acetate, 6,8-thioctate, orotate and pangamate of tris-(hydroxymethyl)-aminomethane.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES0323195A ES323195A1 (en) | 1966-02-17 | 1966-02-17 | Tris (hydroxymethyl) aminomethane theophylline acetate |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1113600A true GB1113600A (en) | 1968-05-15 |
Family
ID=8442738
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB7186/67A Expired GB1113600A (en) | 1966-02-17 | 1967-02-15 | Tris-(hydroxymethyl)-aminomethane salts |
Country Status (7)
Country | Link |
---|---|
US (1) | US3562273A (en) |
BE (1) | BE694127A (en) |
CH (1) | CH469659A (en) |
DE (1) | DE1695358A1 (en) |
ES (1) | ES323195A1 (en) |
FR (1) | FR1511911A (en) |
GB (1) | GB1113600A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2805752C2 (en) * | 2022-03-01 | 2023-10-23 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Co-crystalline forms of theophylline |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL162361C (en) * | 1974-09-10 | Dufour Claude Etude | PROCESS FOR PREPARING A SALT OF THEOPHYLLINACETIC ACID AND OF A PHARMACEUTICAL PREPARATION WITH MUCOLYTIC ACTION CONTAINING THIS SALT, AND PHARMACEUTICAL OBJECTS. | |
GB2024087B (en) * | 1978-06-29 | 1982-08-25 | Yoshino Kogyosho Co Ltd | Blow moulding polyester container |
ATE70974T1 (en) * | 1987-12-04 | 1992-01-15 | Asta Pharma Ag | INJECTABLE SOLUTION OF THIOCT ACID SALT WITH TROMETAMOLE AND/OR BASIC AMINO ACIDS. |
US5136096A (en) * | 1989-08-31 | 1992-08-04 | University Of South Florida | Multifunctional synthons as used in the preparation of cascade polymers or unimolecular micelles |
DE4433764A1 (en) * | 1994-09-22 | 1996-03-28 | Asta Medica Ag | Dosage forms containing alpha-lipoic acid, solid salts of R-thioctic acid with improved release and bioavailability |
DE10137381A1 (en) * | 2001-07-31 | 2003-02-13 | Viatris Gmbh | New crystalline modifications of R-thioctic acid trometamol salt, useful as antiinflammatory agent, for treating diabetes mellitus or as appetite suppressant |
WO2007095117A2 (en) * | 2006-02-10 | 2007-08-23 | Multi Formulations Ltd. | Method for improving the oral administration of alpha-lipoic acid |
US8334402B2 (en) * | 2008-04-17 | 2012-12-18 | Thomas Daly | Biological buffers with wide buffering ranges |
US8822728B2 (en) | 2008-04-17 | 2014-09-02 | Thomas Daly | Biological buffers with wide buffering ranges |
US8519141B2 (en) | 2008-04-17 | 2013-08-27 | Thomas Daly | Biological buffers with wide buffering ranges |
US20170313920A1 (en) | 2010-10-06 | 2017-11-02 | Thomas P. Daly | Biological Buffers with Wide Buffering Ranges |
US9090638B2 (en) | 2008-04-17 | 2015-07-28 | Thomas Daly | Biological buffers with wide buffering ranges |
US9447310B2 (en) | 2008-04-17 | 2016-09-20 | Thomas P. Daly | Biological buffers with wide buffering ranges |
US7635791B2 (en) * | 2008-04-17 | 2009-12-22 | Tpat Ip Llc | Biological buffers with wide buffering ranges |
US8034951B2 (en) * | 2008-04-17 | 2011-10-11 | Thomas Daly | Biological buffers with wide buffering ranges |
US7939659B2 (en) * | 2008-04-17 | 2011-05-10 | Thomas Daly | Biological buffers with wide buffering ranges |
KR100935554B1 (en) | 2009-06-24 | 2010-01-07 | 주식회사 셀트리온제약 | Piperazine dithioctate and pharmaceutical composition including the same |
US9475754B2 (en) | 2011-10-06 | 2016-10-25 | Thomas P. Daly | Biological buffers with wide buffering ranges |
CN103360393B (en) * | 2013-07-29 | 2016-01-06 | 上海万巷制药有限公司 | The preparation method of theophylline acetic acid |
CN113200959A (en) * | 2020-12-16 | 2021-08-03 | 南京海融制药有限公司 | Lipoic acid tromethamine salt crystal form and preparation method thereof |
-
1966
- 1966-02-17 ES ES0323195A patent/ES323195A1/en not_active Expired
-
1967
- 1967-02-15 GB GB7186/67A patent/GB1113600A/en not_active Expired
- 1967-02-16 BE BE694127D patent/BE694127A/xx unknown
- 1967-02-16 DE DE19671695358 patent/DE1695358A1/en active Pending
- 1967-02-17 CH CH240367A patent/CH469659A/en unknown
- 1967-02-17 FR FR95468A patent/FR1511911A/en not_active Expired
- 1967-02-17 US US616780A patent/US3562273A/en not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2805752C2 (en) * | 2022-03-01 | 2023-10-23 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Co-crystalline forms of theophylline |
Also Published As
Publication number | Publication date |
---|---|
US3562273A (en) | 1971-02-09 |
FR1511911A (en) | 1968-02-02 |
ES323195A1 (en) | 1966-12-01 |
CH469659A (en) | 1969-03-15 |
BE694127A (en) | 1967-07-31 |
DE1695358A1 (en) | 1972-04-13 |
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