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GB1111929A - Injectable colloidal iron preparations and their production - Google Patents

Injectable colloidal iron preparations and their production

Info

Publication number
GB1111929A
GB1111929A GB5194066A GB5194066A GB1111929A GB 1111929 A GB1111929 A GB 1111929A GB 5194066 A GB5194066 A GB 5194066A GB 5194066 A GB5194066 A GB 5194066A GB 1111929 A GB1111929 A GB 1111929A
Authority
GB
United Kingdom
Prior art keywords
polysaccharide
solution
complex
ferric
chelating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5194066A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of GB1111929A publication Critical patent/GB1111929A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/295—Iron group metal compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

An iron-polysaccharide complex is made by heating a polysaccharide with hydrogen peroxide, and at a pH above 8, with a non-toxic ferric compound and bringing the resulting complex into colloidal solution. The polysaccharide may have been heated under alkaline, neutral or weakly acid conditions with the hydrogen peroxide, prior to effecting complex formation. The product may be dried, and formed into solution with a chelating hydroxyacid. Specified polysaccharides are starch, dextran, levan, insulin, mannan and pullulan; specified ferric compounds are the nitrate, chloride, acetate or ferric ammonium chloride or a ferric oxy-salt. The chelating acid may be citric, tartaric, lactic, glycolic or salicylic acid.ALSO:An iron-polysaccharide complex which has been prepared by reacting, at a pH above 8, a polysaccharide which has been treated with hydrogen peroxide and a non-toxic ferric compound and which has been brought into colloidal suspension, may be used in the preparation of an injectable preparation. In examples, the complex is brought into solution using secondary sodium citrate as a chelating agent, the pH is adjusted to 6.3, the solution rendered isotonic e.g. with NaCl, and then sterilized at 105 DEG C. for 1/2 -hour, yielding a solution containing 100 mg Fe/ml. Specified polysaccharides are starch, dextran, mannan, inulin, pullulan and levan. Other chelating agents are citric, lactic, tartaric, glycolic or salicylic acids.
GB5194066A 1965-11-20 1966-11-21 Injectable colloidal iron preparations and their production Expired GB1111929A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEF0047736 1965-11-20
DEF0049667 1966-07-11

Publications (1)

Publication Number Publication Date
GB1111929A true GB1111929A (en) 1968-05-01

Family

ID=25977057

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5194066A Expired GB1111929A (en) 1965-11-20 1966-11-21 Injectable colloidal iron preparations and their production

Country Status (4)

Country Link
BE (1) BE689779A (en)
DE (1) DE1617463A1 (en)
GB (1) GB1111929A (en)
NL (1) NL6616205A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002046241A2 (en) * 2000-12-07 2002-06-13 Ad 'zdravlje' Farmaceutsko - Hemijska Industrija, Centar Za Istrazivanje I Razvoj Polynuclear complex fe(iii) with pullulan oligomers, process of its obtaining, and pharmaceutical preparations on the basis of the complex
WO2004037865A1 (en) * 2002-10-23 2004-05-06 Vifor (International) Ag Water-soluble iron-carbohydrate complexes, production thereof, and medicaments containing said complexes
US7060302B1 (en) 1999-08-31 2006-06-13 Remedy Research Limited Metal-containing compositions, preparations and uses
EP1947120A1 (en) * 2007-01-19 2008-07-23 Vifor (International) Ag Iron-carbohydrate complex compounds
CN109134683A (en) * 2018-09-25 2019-01-04 武汉轻工大学 A kind of preparation method and applications of pyracantha fortuneana Nu-Iron

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU187167B (en) * 1982-10-15 1985-11-28 Richter Gedeon Vegyeszet Process for producing pharmaceutical solution of new type polynuclear iron/iii/ mixed complex activity
DE10040707A1 (en) * 2000-08-17 2002-03-14 Braun Melsungen Ag Injectable aqueous medicament, containing colloid, e.g. hydroxyethyl starch, to modulate mobility, diffusion, pharmacokinetic and electrophoretic properties of active agent and improve effectiveness

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7060302B1 (en) 1999-08-31 2006-06-13 Remedy Research Limited Metal-containing compositions, preparations and uses
WO2002046241A3 (en) * 2000-12-07 2002-08-08 Ad Zdravlje Farmaceutsko Hemij Polynuclear complex fe(iii) with pullulan oligomers, process of its obtaining, and pharmaceutical preparations on the basis of the complex
WO2002046241A2 (en) * 2000-12-07 2002-06-13 Ad 'zdravlje' Farmaceutsko - Hemijska Industrija, Centar Za Istrazivanje I Razvoj Polynuclear complex fe(iii) with pullulan oligomers, process of its obtaining, and pharmaceutical preparations on the basis of the complex
US11590097B2 (en) 2002-10-23 2023-02-28 Vifor (International) Ag Aqueous iron carbohydrate complexes, their production and medicaments containing them
JP2006505638A (en) * 2002-10-23 2006-02-16 ヴィフォー・インターナショナル・アーゲー Water-soluble iron-carbohydrate complex, process for producing the same, and drug containing the same
WO2004037865A1 (en) * 2002-10-23 2004-05-06 Vifor (International) Ag Water-soluble iron-carbohydrate complexes, production thereof, and medicaments containing said complexes
US10519252B2 (en) 2002-10-23 2019-12-31 Vifor (International) Ag. Aqueous iron carbohydrate complexes, their production and medicaments containing them
AU2003278111B2 (en) * 2002-10-23 2009-05-28 Vifor (International) Ag Water-soluble iron-carbohydrate complexes, production thereof, and medicaments containing said complexes
AU2003278111B8 (en) * 2002-10-23 2009-06-04 Vifor (International) Ag Water-soluble iron-carbohydrate complexes, production thereof, and medicaments containing said complexes
US7612109B2 (en) 2002-10-23 2009-11-03 Vifor (International) Ag Water-soluble iron-carbohydrate complexes, production thereof, and medicaments containing said complexes
AU2003278111C1 (en) * 2002-10-23 2010-12-02 Vifor (International) Ag Water-soluble iron-carbohydrate complexes, production thereof, and medicaments containing said complexes
EP2287204A1 (en) * 2002-10-23 2011-02-23 Vifor (International) Ag Water-soluble iron-carbohydrate complexes, production thereof, and medicaments containing said complexes
US11291645B2 (en) 2002-10-23 2022-04-05 Vifor (International) Ag Aqueous iron carbohydrate complexes, their production and medicaments containing them
US11123321B2 (en) 2002-10-23 2021-09-21 Vifor (International) Ag Aqueous iron carbohydrate complexes, their production and medicaments containing them
US9376505B2 (en) 2002-10-23 2016-06-28 Vifor (International) Ag. Aqueous iron carbohydrate complexes, their production and medicaments containing them
EP1947120A1 (en) * 2007-01-19 2008-07-23 Vifor (International) Ag Iron-carbohydrate complex compounds
AU2008206969B2 (en) * 2007-01-19 2012-12-06 Vifor (International) Ag Iron-carbohydrate complex compounds
US8263564B2 (en) 2007-01-19 2012-09-11 Vifor (International) Ag Iron-carbohydrate complex compounds
WO2008087135A1 (en) * 2007-01-19 2008-07-24 Vifor (International) Ag Iron-hydrocarbon complex compounds
CN109134683A (en) * 2018-09-25 2019-01-04 武汉轻工大学 A kind of preparation method and applications of pyracantha fortuneana Nu-Iron
CN109134683B (en) * 2018-09-25 2021-01-15 武汉轻工大学 Preparation method and application of pyracantha polysaccharide-iron complex

Also Published As

Publication number Publication date
DE1617463A1 (en) 1971-04-08
NL6616205A (en) 1967-05-22
BE689779A (en) 1967-05-16

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