GB1099410A - 6-fluoro-16ª‡-methyl-í¸-pregnadien-17ª‡-ol-3,20-dione and the 17-esters thereof anda process for their manufacture - Google Patents
6-fluoro-16ª‡-methyl-í¸-pregnadien-17ª‡-ol-3,20-dione and the 17-esters thereof anda process for their manufactureInfo
- Publication number
- GB1099410A GB1099410A GB2709865A GB2709865A GB1099410A GB 1099410 A GB1099410 A GB 1099410A GB 2709865 A GB2709865 A GB 2709865A GB 2709865 A GB2709865 A GB 2709865A GB 1099410 A GB1099410 A GB 1099410A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dione
- methyl
- pregnadien
- fluoro
- esters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel compounds of the general formula <FORM:1099410/C2/1> in which R represents a hydrogen atom or an acyl radical, are obtained in a process wherein a 16a - methyl - D 4 - pregnen - 17a - ol - 3,20 - dione or a 17-ester thereof containing an oxirane ring in 6,7-position is reacted with hydrogen fluoride to effect splitting of the oxirane ring and introduction of fluorine in 6-position, water is split off with formation of a double bond in 6,7-position, and, if desired, a product containing a free 17-hydroxyl group is esterified.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DESCH35421A DE1232576B (en) | 1964-07-02 | 1964-07-02 | Process for the preparation of 6-fluoro-16alpha-methyl-delta 4,6-pregnadien-17alpha-ol-3, 20-dione and its 17-esters |
| DESC036875 | 1965-04-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1099410A true GB1099410A (en) | 1968-01-17 |
Family
ID=25993192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2709865A Expired GB1099410A (en) | 1964-07-02 | 1965-06-25 | 6-fluoro-16ª‡-methyl-í¸-pregnadien-17ª‡-ol-3,20-dione and the 17-esters thereof anda process for their manufacture |
Country Status (4)
| Country | Link |
|---|---|
| CH (1) | CH460762A (en) |
| DE (2) | DE1232576B (en) |
| GB (1) | GB1099410A (en) |
| NL (1) | NL148325B (en) |
-
0
- DE DENDAT1249273D patent/DE1249273B/en active Pending
-
1964
- 1964-07-02 DE DESCH35421A patent/DE1232576B/en active Pending
-
1965
- 1965-05-07 CH CH640165A patent/CH460762A/en unknown
- 1965-06-10 NL NL6507381A patent/NL148325B/en unknown
- 1965-06-25 GB GB2709865A patent/GB1099410A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1249273B (en) | 1967-09-07 |
| NL148325B (en) | 1976-01-15 |
| CH460762A (en) | 1968-08-15 |
| NL6507381A (en) | 1966-01-03 |
| DE1232576B (en) | 1967-01-19 |
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