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GB1097054A - Acid-soluble veterinary medicaments - Google Patents

Acid-soluble veterinary medicaments

Info

Publication number
GB1097054A
GB1097054A GB8207/66A GB820766A GB1097054A GB 1097054 A GB1097054 A GB 1097054A GB 8207/66 A GB8207/66 A GB 8207/66A GB 820766 A GB820766 A GB 820766A GB 1097054 A GB1097054 A GB 1097054A
Authority
GB
United Kingdom
Prior art keywords
copolymer
methyl methacrylate
ruminants
soluble
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8207/66A
Inventor
Wulf Von Bonin
Manfred Federmann
Reimer Strufe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of GB1097054A publication Critical patent/GB1097054A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
    • A23K40/35—Making capsules specially adapted for ruminants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
    • C08F20/02—Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
    • C08F20/52—Amides or imides
    • C08F20/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F20/60—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Fodder In General (AREA)

Abstract

N-(3-dimethyl aminopropyl)-methacrylamide is copolymerized with methyl methacrylate in solution in ethyl acetate or chloroform using azodiisobutyronitrile as initiator. The copolymer is also prepared in emulsion by polymerizing the hydrochloride salt of the above-mentioned amide monomer, together with methyl methacrylate, in water containing a paraffin sulphonate and ammonium persulphate; the product is treated with NaOH to convert the polymer from salt form to free-base form. The copolymer is used in preparing enteric-type medicaments for ruminants (see Division A5).ALSO:Medicaments suitable for oral administration to ruminants and which are insoluble in the rumen but soluble in the abomasum, comprise a pharmaceutically active material coated with or embedded in a protective material which is acid soluble but alkaline resistant, the protective material being essentially composed of a copolymer of a substituted acrylamide of the formula CH2=CR-CO-NH(CH2)n-NR1R11 where R is H or C1-C4 alkyl, R1 and R11 are the same or different C1-C4 alkyl and n is 2, 3 or 4. The acrylamide compound may be copolymerised with, for example, styrene, methylstyrene, vinyl acetate or propionate, ethyl or n-butyl acrylate, acrylonitrile or, preferably, methyl methacrylate. 2,2\sv-dihydroxy-3,3\sv-dinitro -5,5\sv-dichlorodiphenyl is specified as active material.
GB8207/66A 1965-02-24 1966-02-24 Acid-soluble veterinary medicaments Expired GB1097054A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEF45339A DE1219175B (en) 1965-02-24 1965-02-24 Process for the production of active ingredient preparations protected against the action of rumen juices from ruminants

Publications (1)

Publication Number Publication Date
GB1097054A true GB1097054A (en) 1967-12-29

Family

ID=7100447

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8207/66A Expired GB1097054A (en) 1965-02-24 1966-02-24 Acid-soluble veterinary medicaments

Country Status (3)

Country Link
BR (1) BR6677288D0 (en)
DE (1) DE1219175B (en)
GB (1) GB1097054A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2273934A (en) * 1992-12-14 1994-07-06 Witco Gmbh Improvements in and relating to polymeric resins and binders for antifouling paints
US8790693B2 (en) 2007-08-02 2014-07-29 Basf Se Aqueous polymer dispersion based on N,N-diethylaminoethyl methacrylate, its preparation and use
US8865250B2 (en) 2011-02-28 2014-10-21 Basf Se Production of pulverulent coating compositions for stable protective coatings for pharmaceutical dosage forms
US8962064B2 (en) 2011-02-28 2015-02-24 Basf Se Production of pulverulent coating compositions for stable protective coatings for pharmaceutical dosage forms
US10912835B2 (en) 2012-03-09 2021-02-09 Basf Se Production of pharmaceutical protective coatings with good resistance in a neutral environment

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011051155A2 (en) 2009-10-28 2011-05-05 Basf Se Stable protective coatings for pharmaceutical dosage forms
JP2013536821A (en) 2010-09-07 2013-09-26 ビーエーエスエフ ソシエタス・ヨーロピア Use of copolymers based on amino-containing polymers as matrix binders in the preparation of active compound-containing granules and dosage forms
JP6012604B2 (en) 2010-09-27 2016-10-25 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ Protective coating for acidic active ingredients
CN103403069B (en) 2011-02-28 2017-06-13 巴斯夫欧洲公司 The method for preparing the powder coating agent of stable protective coating for pharmaceutical dosage form
CN103347931B (en) 2011-02-28 2016-02-17 巴斯夫欧洲公司 For the preparation of the powder coated agent of the stable protectiveness clothing layer of pharmaceutical dosage form
EP2636403A1 (en) 2012-03-09 2013-09-11 Basf Se Production of pharmaceutical protective overalls with good resistance in a neutral environment

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2273934A (en) * 1992-12-14 1994-07-06 Witco Gmbh Improvements in and relating to polymeric resins and binders for antifouling paints
GB2273934B (en) * 1992-12-14 1996-12-11 Witco Gmbh Improvements in and relating to polymeric resins and binders for antifouling paints
US8790693B2 (en) 2007-08-02 2014-07-29 Basf Se Aqueous polymer dispersion based on N,N-diethylaminoethyl methacrylate, its preparation and use
US9732200B2 (en) 2007-08-02 2017-08-15 Basf Se Aqueous polymer dispersion based on N,N-diethylaminoethyl methacrylate, its preparation and use
US8865250B2 (en) 2011-02-28 2014-10-21 Basf Se Production of pulverulent coating compositions for stable protective coatings for pharmaceutical dosage forms
US8962064B2 (en) 2011-02-28 2015-02-24 Basf Se Production of pulverulent coating compositions for stable protective coatings for pharmaceutical dosage forms
US10912835B2 (en) 2012-03-09 2021-02-09 Basf Se Production of pharmaceutical protective coatings with good resistance in a neutral environment

Also Published As

Publication number Publication date
DE1219175B (en) 1966-06-16
BR6677288D0 (en) 1973-09-06

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