GB1071170A - Method of manufacturing minute capsules - Google Patents
Method of manufacturing minute capsulesInfo
- Publication number
- GB1071170A GB1071170A GB4819165A GB4819165A GB1071170A GB 1071170 A GB1071170 A GB 1071170A GB 4819165 A GB4819165 A GB 4819165A GB 4819165 A GB4819165 A GB 4819165A GB 1071170 A GB1071170 A GB 1071170A
- Authority
- GB
- United Kingdom
- Prior art keywords
- wall
- forming polymer
- liquid vehicle
- solution
- coacervate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002775 capsule Substances 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 229920000642 polymer Polymers 0.000 abstract 18
- 239000007788 liquid Substances 0.000 abstract 10
- 239000000243 solution Substances 0.000 abstract 9
- 239000011162 core material Substances 0.000 abstract 6
- 238000000034 method Methods 0.000 abstract 6
- 238000005354 coacervation Methods 0.000 abstract 5
- 229920000609 methyl cellulose Polymers 0.000 abstract 5
- 239000001923 methylcellulose Substances 0.000 abstract 5
- 235000010981 methylcellulose Nutrition 0.000 abstract 5
- 230000000295 complement effect Effects 0.000 abstract 4
- 230000003247 decreasing effect Effects 0.000 abstract 4
- 238000000926 separation method Methods 0.000 abstract 4
- 229920002307 Dextran Polymers 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 238000010438 heat treatment Methods 0.000 abstract 3
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 abstract 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- 229920000896 Ethulose Polymers 0.000 abstract 2
- 239000001859 Ethyl hydroxyethyl cellulose Substances 0.000 abstract 2
- 239000004372 Polyvinyl alcohol Substances 0.000 abstract 2
- 229960001138 acetylsalicylic acid Drugs 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 235000019326 ethyl hydroxyethyl cellulose Nutrition 0.000 abstract 2
- -1 hydroxypropyldextran Polymers 0.000 abstract 2
- 238000005191 phase separation Methods 0.000 abstract 2
- 229920002432 poly(vinyl methyl ether) polymer Polymers 0.000 abstract 2
- 229920002451 polyvinyl alcohol Polymers 0.000 abstract 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 abstract 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 abstract 1
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 abstract 1
- 239000001263 FEMA 3042 Substances 0.000 abstract 1
- 235000019501 Lemon oil Nutrition 0.000 abstract 1
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 abstract 1
- 238000013019 agitation Methods 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 1
- 238000005538 encapsulation Methods 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 239000003350 kerosene Substances 0.000 abstract 1
- 239000010501 lemon oil Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229940041616 menthol Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000000049 pigment Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 239000000600 sorbitol Substances 0.000 abstract 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 abstract 1
- 229940033123 tannic acid Drugs 0.000 abstract 1
- 235000015523 tannic acid Nutrition 0.000 abstract 1
- 229920002258 tannic acid Polymers 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/10—Complex coacervation, i.e. interaction of oppositely charged particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
- B41M—PRINTING, DUPLICATING, MARKING, OR COPYING PROCESSES; COLOUR PRINTING
- B41M5/00—Duplicating or marking methods; Sheet materials for use therein
- B41M5/124—Duplicating or marking methods; Sheet materials for use therein using pressure to make a masked colour visible, e.g. to make a coloured support visible, to create an opaque or transparent pattern, or to form colour by uniting colour-forming components
- B41M5/165—Duplicating or marking methods; Sheet materials for use therein using pressure to make a masked colour visible, e.g. to make a coloured support visible, to create an opaque or transparent pattern, or to form colour by uniting colour-forming components characterised by the use of microcapsules; Special solvents for incorporating the ingredients
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Manufacture And Refinement Of Metals (AREA)
Abstract
In a process for the production of coated capsules by coacervation, the core material and a coacervate solution of the wall-forming polymer are dispersed as minute entities in an agitated liquid vehicle, the solubility of the wall-forming polymer decreasing with increasing temperature, and the system is heated above the gel point of the wall-forming polymer to harden the walls deposited about the entities of core material. In order to produce phase separation to effect an emergence of a coacervate phase of the wall-forming polymer a complementary polymer may be added to the system. Separation of the capsules from the liquid vehicle is carried out at the elevated temperature, unless agents are added to the system to accelerate the hardening process, in which case separation can be carried out after recooling. In the one form a coacervate solution of the wall-forming polymer is formed separately from the liquid vehicle in which it is insoluble, and the system is made up by combining the component phases and agitating and heating as required. Incomplete systems, lacking one or more component, may be stored for future use. In cases where the liquid vehicle is used as the solvent for the wall-forming polymer coacervation may be induced by, in conjunction with the property of decreasing solubility at elevated temperature, changing conditions such as microion concentration. Examples of wall-forming polymers having the requisite solubility properties are methyl cellulose, polyvinylmethyl ether, and ethylhydroxyethyl cellulose. Suitable complementary polymers to assist in formation of a coacervate solution of methyl cellulose include dextran, hydroxypropyldextran, polyvinyl alcohol or polyvinylpyrrolidone. The method is particularly suited to the coating of core materials which are insoluble in the liquid vehicle, including chloroform, chlorinated biphenyl, kerosene, acetylated monoglyceride, lemon oil, menthol, aspirin, resins, pigments and dies. In particular examples described, aqueous dextran solution is used to facilitate coacervation of methyl cellulose aqueous wall-forming solution when various materials are coated, agitation and heating to 50-60 DEG C. producing the required particle size and encapsulation. An example of a wall-hardening agent is a mixture of aqueous sorbitol solution; mono-and di-glycerides of fat forming fatty acids, and an aqueous solution of tannic acid.ALSO:In a process for the production of coated capsules of, for example, aspirin, by coacervation, the core material and a coacervate solution of the wall-forming polymer are dispersed as minute entities in an agitated liquid vehicle, the solubility of the wall-forming polymer decreasing with increasing temperature, and the system is heated above the gel point of the wall-forming polymer to harden the walls deposited about the entities of core material. In order to produce phase separation to effect an emergence of a coacervate phase of the wall-forming polymer a complementary polymer may be added to the system. Separation of the capsules from the liquid vehicle is carried out at the elevated temperature, unless agents are added to the system to accelerate the hardening process, in which case separation can be carried out after recooling. In the one form a coacervate solution of the wall-forming polymer is formed separately from the liquid vehicle in which it is insoluble, and the system is made up by combining the component phases and agitating and heating as required. Incomplete systems, lacking one or more component, may be stored for future use. In cases where the liquid vehicle is used as the solvent for the wall-forming polymer coacervation may be induced by, in conjunction with the property of decreasing solubility at elevated temperature, changing conditions such as microion concentration. Examples of wallforming polymers having the requisite solubility properties are methyl cellulose, polyvinylmethyl ether, and ethylhydroxyethyl cellulose. Suitable complementary polymers to assist in formation of a coacervate solution of methyl cellulose include dextran, hydroxypropyldextran, polyvinyl alcohol or polyvinylpyrrolidone. The method is particularly suited to the coating of core materials which are insoluble in the liquid vehicle.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41334864A | 1964-11-23 | 1964-11-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1071170A true GB1071170A (en) | 1967-06-07 |
Family
ID=23636893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4819165A Expired GB1071170A (en) | 1964-11-23 | 1965-11-12 | Method of manufacturing minute capsules |
Country Status (10)
| Country | Link |
|---|---|
| AT (1) | AT262937B (en) |
| BE (1) | BE672621A (en) |
| CH (1) | CH458294A (en) |
| DE (1) | DE1283191B (en) |
| DK (1) | DK109893C (en) |
| FR (1) | FR1453745A (en) |
| GB (1) | GB1071170A (en) |
| NL (1) | NL6515181A (en) |
| NO (1) | NO123781B (en) |
| SE (1) | SE303733B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0232512A3 (en) * | 1985-12-13 | 1989-06-14 | E.I. Du Pont De Nemours And Company | Encapsulated pigment in silver halide wash-off film |
| WO2003105786A3 (en) * | 2002-06-14 | 2004-06-03 | Firmenich & Cie | Non-crystalline perfume or flavour delivery system |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5515681A (en) * | 1978-07-21 | 1980-02-02 | Kuraray Co Ltd | Production of microcapsule |
-
1965
- 1965-11-12 GB GB4819165A patent/GB1071170A/en not_active Expired
- 1965-11-16 FR FR38479A patent/FR1453745A/en not_active Expired
- 1965-11-19 SE SE1496565A patent/SE303733B/xx unknown
- 1965-11-19 DE DEN27644A patent/DE1283191B/en active Pending
- 1965-11-19 NO NO16055065A patent/NO123781B/no unknown
- 1965-11-22 DK DK599065A patent/DK109893C/en active
- 1965-11-23 CH CH1610865A patent/CH458294A/en unknown
- 1965-11-23 NL NL6515181A patent/NL6515181A/xx unknown
- 1965-11-23 AT AT1051265A patent/AT262937B/en active
- 1965-12-01 BE BE672621D patent/BE672621A/xx unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0232512A3 (en) * | 1985-12-13 | 1989-06-14 | E.I. Du Pont De Nemours And Company | Encapsulated pigment in silver halide wash-off film |
| WO2003105786A3 (en) * | 2002-06-14 | 2004-06-03 | Firmenich & Cie | Non-crystalline perfume or flavour delivery system |
| CN1327823C (en) * | 2002-06-14 | 2007-07-25 | 弗门尼舍有限公司 | Non-crystalline perfume or flavour delivery system |
Also Published As
| Publication number | Publication date |
|---|---|
| CH458294A (en) | 1968-06-30 |
| BE672621A (en) | 1966-04-01 |
| SE303733B (en) | 1968-09-09 |
| FR1453745A (en) | 1966-06-03 |
| AT262937B (en) | 1968-07-10 |
| DK109893C (en) | 1968-07-29 |
| NL6515181A (en) | 1966-05-24 |
| NO123781B (en) | 1972-01-17 |
| DE1283191B (en) | 1968-11-21 |
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