GB1068497A - New tertiary amine and process for its manufacture - Google Patents
New tertiary amine and process for its manufactureInfo
- Publication number
- GB1068497A GB1068497A GB547166A GB547166A GB1068497A GB 1068497 A GB1068497 A GB 1068497A GB 547166 A GB547166 A GB 547166A GB 547166 A GB547166 A GB 547166A GB 1068497 A GB1068497 A GB 1068497A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- dimethylaminomethyl
- diphenyl
- acid addition
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Remote Monitoring And Control Of Power-Distribution Networks (AREA)
Abstract
The invention comprises 1,2-diphenyl-2-propionyloxy - 3 - (dimethylaminomethyl) - 3-butene; acid addition salts thereof; and their preparation by propionylating 1,2-diphenyl-3-(dimethylaminomethyl)-3-buten-2-ol or a salt thereof, e.g. an O-alkali metal or O-magnesium halide salt, and, if desired, converting a resulting-acid addition salt into the free base or converting the resulting free base into an acid addition salt. 1,2 - Diphenyl - 3 - (dimethylaminomethyl) - 3-buten-2-ol is prepared by reacting 2,3-dibromopropene with dimethylamine to form N,N - dimethyl-2-bromoallylamine, treating this compound with magnesium to form the corresponding Grignard compound, reacting this compound with desoxybenzoin and decomposing the resulting complex. Pharmaceutical compositions having analgesic and antitussive activity, for oral, parenteral or topical administration, comprise a compound of the invention together with a pharmaceutical carrier.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH267765A CH465584A (en) | 1965-02-26 | 1965-02-26 | Process for the preparation of new tertiary amines |
| CH902865 | 1965-06-28 | ||
| CH1311165 | 1965-09-22 | ||
| CH1811965 | 1965-12-30 | ||
| CH1811865 | 1965-12-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1068497A true GB1068497A (en) | 1967-05-10 |
Family
ID=27509073
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB547366A Expired GB1117623A (en) | 1965-02-26 | 1966-02-08 | New tertiary amines and process for their manufacture |
| GB547166A Expired GB1068497A (en) | 1965-02-26 | 1966-02-08 | New tertiary amine and process for its manufacture |
| GB547266A Expired GB1117622A (en) | 1965-02-26 | 1966-02-08 | New tertiary amines and process for their manufacture |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB547366A Expired GB1117623A (en) | 1965-02-26 | 1966-02-08 | New tertiary amines and process for their manufacture |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB547266A Expired GB1117622A (en) | 1965-02-26 | 1966-02-08 | New tertiary amines and process for their manufacture |
Country Status (16)
| Country | Link |
|---|---|
| BE (3) | BE677035A (en) |
| BR (3) | BR6677337D0 (en) |
| CH (2) | CH465584A (en) |
| CY (1) | CY556A (en) |
| DE (2) | DE1793640B1 (en) |
| DK (3) | DK118601B (en) |
| FI (1) | FI44601C (en) |
| FR (4) | FR1468479A (en) |
| GB (3) | GB1117623A (en) |
| IL (1) | IL25127A (en) |
| LU (1) | LU50473A1 (en) |
| MY (1) | MY7000162A (en) |
| NL (3) | NL6602537A (en) |
| NO (1) | NO115389B (en) |
| SE (3) | SE348724B (en) |
| SU (1) | SU372806A3 (en) |
-
1965
- 1965-02-26 CH CH267765A patent/CH465584A/en unknown
- 1965-02-26 CH CH1401167A patent/CH475190A/en not_active IP Right Cessation
-
1966
- 1966-02-07 IL IL2512766A patent/IL25127A/en unknown
- 1966-02-08 GB GB547366A patent/GB1117623A/en not_active Expired
- 1966-02-08 GB GB547166A patent/GB1068497A/en not_active Expired
- 1966-02-08 GB GB547266A patent/GB1117622A/en not_active Expired
- 1966-02-16 LU LU50473A patent/LU50473A1/xx unknown
- 1966-02-17 FR FR50039A patent/FR1468479A/en not_active Expired
- 1966-02-17 DE DE19661793640 patent/DE1793640B1/en active Pending
- 1966-02-17 FR FR50038A patent/FR1468478A/en not_active Expired
- 1966-02-17 DE DE19661568254 patent/DE1568254A1/en active Pending
- 1966-02-23 FI FI44866A patent/FI44601C/en active
- 1966-02-24 BR BR17733766A patent/BR6677337D0/en unknown
- 1966-02-24 BR BR17734466A patent/BR6677344D0/en unknown
- 1966-02-24 BR BR17733666A patent/BR6677336D0/en unknown
- 1966-02-25 BE BE677035D patent/BE677035A/xx unknown
- 1966-02-25 DK DK98566A patent/DK118601B/en unknown
- 1966-02-25 NL NL6602537A patent/NL6602537A/xx unknown
- 1966-02-25 NL NL6602535A patent/NL6602535A/xx unknown
- 1966-02-25 SE SE246666A patent/SE348724B/xx unknown
- 1966-02-25 SE SE246566A patent/SE325266B/xx unknown
- 1966-02-25 DK DK98766A patent/DK122878B/en unknown
- 1966-02-25 SE SE246766A patent/SE348454B/xx unknown
- 1966-02-25 NL NL6602536A patent/NL6602536A/xx unknown
- 1966-02-25 DK DK98666A patent/DK123023B/en unknown
- 1966-02-25 BE BE677034D patent/BE677034A/xx unknown
- 1966-02-25 BE BE677036D patent/BE677036A/xx unknown
- 1966-02-25 NO NO16185366A patent/NO115389B/no unknown
- 1966-03-29 SU SU1064790A patent/SU372806A3/ru active
- 1966-05-10 FR FR60914A patent/FR5348M/fr not_active Expired
- 1966-05-10 FR FR60915A patent/FR5349M/fr not_active Expired
-
1970
- 1970-08-19 CY CY55670A patent/CY556A/en unknown
- 1970-12-31 MY MY7000162A patent/MY7000162A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE677036A (en) | 1966-08-25 |
| CH475190A (en) | 1969-07-15 |
| CH465584A (en) | 1968-11-30 |
| FI44601B (en) | 1971-08-31 |
| GB1117622A (en) | 1968-06-19 |
| FR5349M (en) | 1967-09-04 |
| FI44601C (en) | 1971-12-10 |
| DK123023B (en) | 1972-05-08 |
| DE1793640B1 (en) | 1973-04-26 |
| DE1568254A1 (en) | 1970-03-19 |
| MY7000162A (en) | 1970-12-31 |
| DK122878B (en) | 1972-04-24 |
| CY556A (en) | 1970-08-19 |
| DK118601B (en) | 1970-09-14 |
| GB1117623A (en) | 1968-06-19 |
| NL6602535A (en) | 1966-08-29 |
| DE1568253B1 (en) | 1971-07-29 |
| SE325266B (en) | 1970-06-29 |
| LU50473A1 (en) | 1966-04-18 |
| DE1568252B2 (en) | 1973-01-04 |
| BE677034A (en) | 1966-08-25 |
| NL6602537A (en) | 1966-08-29 |
| BE677035A (en) | 1966-08-25 |
| NO115389B (en) | 1968-09-30 |
| BR6677337D0 (en) | 1973-09-06 |
| FR1468479A (en) | 1967-02-03 |
| IL25127A (en) | 1969-12-31 |
| SU372806A3 (en) | 1973-03-01 |
| FR5348M (en) | 1967-09-04 |
| DE1568252A1 (en) | 1971-06-24 |
| SE348724B (en) | 1972-09-11 |
| BR6677336D0 (en) | 1973-09-20 |
| BR6677344D0 (en) | 1973-09-06 |
| FR1468478A (en) | 1967-02-03 |
| SE348454B (en) | 1972-09-04 |
| NL6602536A (en) | 1966-08-29 |
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