GB1051382A - - Google Patents
Info
- Publication number
- GB1051382A GB1051382A GB1051382DA GB1051382A GB 1051382 A GB1051382 A GB 1051382A GB 1051382D A GB1051382D A GB 1051382DA GB 1051382 A GB1051382 A GB 1051382A
- Authority
- GB
- United Kingdom
- Prior art keywords
- red blood
- cells
- aldehyde
- surface active
- blood cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- AIJULSRZWUXGPQ-UHFFFAOYSA-N Methylglyoxal Chemical compound CC(=O)C=O AIJULSRZWUXGPQ-UHFFFAOYSA-N 0.000 abstract 4
- 150000001299 aldehydes Chemical class 0.000 abstract 4
- 210000003743 erythrocyte Anatomy 0.000 abstract 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 3
- 239000006285 cell suspension Substances 0.000 abstract 3
- 229920002521 macromolecule Polymers 0.000 abstract 3
- 239000004094 surface-active agent Substances 0.000 abstract 3
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000012736 aqueous medium Substances 0.000 abstract 2
- 239000008363 phosphate buffer Substances 0.000 abstract 2
- 229940120731 pyruvaldehyde Drugs 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- 244000215068 Acacia senegal Species 0.000 abstract 1
- 235000006491 Acacia senegal Nutrition 0.000 abstract 1
- 241000416162 Astragalus gummifer Species 0.000 abstract 1
- 241000283690 Bos taurus Species 0.000 abstract 1
- 241000282693 Cercopithecidae Species 0.000 abstract 1
- 229920002307 Dextran Polymers 0.000 abstract 1
- 241000287828 Gallus gallus Species 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 229920000084 Gum arabic Polymers 0.000 abstract 1
- 241000282414 Homo sapiens Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 241001494479 Pecora Species 0.000 abstract 1
- 229920001615 Tragacanth Polymers 0.000 abstract 1
- 235000010489 acacia gum Nutrition 0.000 abstract 1
- 239000000872 buffer Substances 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- SQYNKIJPMDEDEG-UHFFFAOYSA-N paraldehyde Chemical compound CC1OC(C)OC(C)O1 SQYNKIJPMDEDEG-UHFFFAOYSA-N 0.000 abstract 1
- 229960003868 paraldehyde Drugs 0.000 abstract 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 abstract 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 abstract 1
- 229920000053 polysorbate 80 Polymers 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
- G01N33/555—Red blood cell
- G01N33/556—Fixed or stabilised red blood cell
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2496/00—Reference solutions for assays of biological material
- G01N2496/05—Reference solutions for assays of biological material containing blood cells or plasma
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2496/00—Reference solutions for assays of biological material
- G01N2496/25—Reference solutions for assays of biological material containing added polymers to stabilise biological material against degradation or maintain viscosity or density, e.g. gelatin, polyacrylamides or polyvinyl alcohol
- G01N2496/35—Polyvinylpyrrolidone, e.g. PVP
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
1,051,382. Stabilized red blood cell suspension. WARNER-LAMBERT PHARMACEUTICAL CO. Feb. 11, 1965 [March 10, 1964], No. 6075/65. Heading B1X. A stabilized red blood cell suspension comprises aldehyde-treated red blood cells in a buffered iso-tonic aqueous medium containing a macromolecular compound compatible with said cells, and a surface active agent. The cells may be derived from warm-blooded animals including chicken, sheep, bovine species, and monkeys, and from human beings; the aldehyde employed may be formaldehyde, pyruvaldehyde or paraldehyde; the buffer may be phosphate buffer; the macromolecular compound may be polyvinyl pyrrolidone, dextran, gum acacia, gum tragacanth or gelatin; and the surface active agent may be polyoxyethylene sorbitan monooleate. The invention also comprises a method of producing stabilized red blood cell suspensions comprising mixing in a phosphate buffer of pH7, a suspension of said cells in isotonic saline solution with an aldehyde, allowing to stand at 4-10‹C., washing with isotonic saline to free from aldehyde and resuspending in an aqueous medium comprising a macromolecular compound. In the Example, pyruvaldehyde, adjusted to pH7 with Na 2 CO 3 , is used, and sodium azide is added as a preservative with the surface active compound, to the final suspension.
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1051382A true GB1051382A (en) | 1900-01-01 |
Family
ID=1756358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1051382D Expired GB1051382A (en) |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1051382A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2408838A1 (en) * | 1977-11-22 | 1979-06-08 | Louderback Allan | BLOOD CONTROL STANDARD AND PROCESS FOR ITS PREPARATION |
| FR2884717A1 (en) * | 2005-04-25 | 2006-10-27 | Erytech Pharma Soc Par Actions | Use of erythrocytes containing arginine deiminase for preparing a drug to decrease the in vivo plasma concentration of arginine |
| US9364504B2 (en) | 2007-08-08 | 2016-06-14 | Erytech Pharma | Compostition and therapeutic anti-tumour vaccine |
| US11613759B2 (en) | 2015-09-04 | 2023-03-28 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to cells comprising a cell wall |
| US12201652B2 (en) | 2016-05-03 | 2025-01-21 | Stemcell Technologies Canada Inc. | Intracellular delivery of biomolecules to induce tolerance |
-
0
- GB GB1051382D patent/GB1051382A/en not_active Expired
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2408838A1 (en) * | 1977-11-22 | 1979-06-08 | Louderback Allan | BLOOD CONTROL STANDARD AND PROCESS FOR ITS PREPARATION |
| FR2884717A1 (en) * | 2005-04-25 | 2006-10-27 | Erytech Pharma Soc Par Actions | Use of erythrocytes containing arginine deiminase for preparing a drug to decrease the in vivo plasma concentration of arginine |
| US9125876B2 (en) | 2005-04-25 | 2015-09-08 | Erytech Pharma | Erythrocytes containing arginine deiminase |
| US9364504B2 (en) | 2007-08-08 | 2016-06-14 | Erytech Pharma | Compostition and therapeutic anti-tumour vaccine |
| US9950049B2 (en) | 2007-08-08 | 2018-04-24 | Erytech Pharma | Composition and therapeutic anti-tumour vaccine |
| US10780151B2 (en) | 2007-08-08 | 2020-09-22 | Erytech Pharma | Composition and therapeutic anti-tumour vaccine |
| US11613759B2 (en) | 2015-09-04 | 2023-03-28 | Sqz Biotechnologies Company | Intracellular delivery of biomolecules to cells comprising a cell wall |
| US12201652B2 (en) | 2016-05-03 | 2025-01-21 | Stemcell Technologies Canada Inc. | Intracellular delivery of biomolecules to induce tolerance |
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