GB1045235A - New steroid[2,3-c]furazan compounds and preparation of the same - Google Patents
New steroid[2,3-c]furazan compounds and preparation of the sameInfo
- Publication number
- GB1045235A GB1045235A GB2552265A GB2552265A GB1045235A GB 1045235 A GB1045235 A GB 1045235A GB 2552265 A GB2552265 A GB 2552265A GB 2552265 A GB2552265 A GB 2552265A GB 1045235 A GB1045235 A GB 1045235A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- preparation
- formula
- same
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- JKFAIQOWCVVSKC-UHFFFAOYSA-N furazan Chemical class C=1C=NON=1 JKFAIQOWCVVSKC-UHFFFAOYSA-N 0.000 title 1
- 150000003431 steroids Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 239000002904 solvent Substances 0.000 abstract 4
- 239000003513 alkali Substances 0.000 abstract 2
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 abstract 2
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 235000010288 sodium nitrite Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0057—Nitrogen and oxygen
- C07J71/0063—Nitrogen and oxygen at position 2(3)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises a compound of the formula <FORM:1045235/C2/1> wherein R is a hydrogen atom or a methyl radical and a process for the preparation thereof by contacting a compound of the formula <FORM:1045235/C2/2> with sodium nitrite in the presence of an acid and a solvent, or an acidic solvent to produce a compound of the formula <FORM:1045235/C2/3> contacting this compound with hydroxylamine in a solvent made slightly alkaline by the addition of an alkali agent to afford a compound of the formula <FORM:1045235/C2/4> and heating this compound in a solvent in the presence of an alkali.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3408864 | 1964-06-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1045235A true GB1045235A (en) | 1966-10-12 |
Family
ID=12404496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2552265A Expired GB1045235A (en) | 1964-06-18 | 1965-06-16 | New steroid[2,3-c]furazan compounds and preparation of the same |
Country Status (7)
| Country | Link |
|---|---|
| AT (1) | AT253144B (en) |
| CH (1) | CH451947A (en) |
| DE (1) | DE1296627B (en) |
| ES (1) | ES314256A1 (en) |
| FR (1) | FR1545559A (en) |
| GB (1) | GB1045235A (en) |
| NL (2) | NL6507627A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995018821A3 (en) * | 1994-01-06 | 1995-08-31 | Stanford Res Inst Int | Novel antiandrogenic agents and related pharmaceutical compositions and methods of use |
-
0
- NL NL126026D patent/NL126026C/xx active
-
1965
- 1965-06-15 NL NL6507627A patent/NL6507627A/xx unknown
- 1965-06-15 CH CH830665A patent/CH451947A/en unknown
- 1965-06-15 AT AT541365A patent/AT253144B/en active
- 1965-06-16 GB GB2552265A patent/GB1045235A/en not_active Expired
- 1965-06-16 ES ES0314256A patent/ES314256A1/en not_active Expired
- 1965-06-18 DE DE1965D0047545 patent/DE1296627B/en active Pending
- 1965-06-18 FR FR1545559D patent/FR1545559A/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995018821A3 (en) * | 1994-01-06 | 1995-08-31 | Stanford Res Inst Int | Novel antiandrogenic agents and related pharmaceutical compositions and methods of use |
| US5723455A (en) * | 1994-01-06 | 1998-03-03 | Sri International | Antiandrogenic agents and related pharmaceutical compositions and methods of use |
| US5854230A (en) * | 1994-01-06 | 1998-12-29 | Sri International | Antiandrogenic agents and related pharmaceutical compositions and methods of use |
| US6083940A (en) * | 1994-01-06 | 2000-07-04 | Sri International | Method and composition for effecting contraception in a mammalian male |
Also Published As
| Publication number | Publication date |
|---|---|
| AT253144B (en) | 1967-03-28 |
| NL126026C (en) | |
| FR1545559A (en) | 1968-11-15 |
| NL6507627A (en) | 1965-12-20 |
| CH451947A (en) | 1968-05-15 |
| ES314256A1 (en) | 1966-03-01 |
| DE1296627B (en) | 1969-06-04 |
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