GB1035005A - Local anesthetic preparations and process of making same - Google Patents
Local anesthetic preparations and process of making sameInfo
- Publication number
- GB1035005A GB1035005A GB8735/64A GB873564A GB1035005A GB 1035005 A GB1035005 A GB 1035005A GB 8735/64 A GB8735/64 A GB 8735/64A GB 873564 A GB873564 A GB 873564A GB 1035005 A GB1035005 A GB 1035005A
- Authority
- GB
- United Kingdom
- Prior art keywords
- anaesthetic
- carbon dioxide
- base
- solutions
- aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Aqueous anaesthetic solutions, prepared by adding carbon dioxide to an aqueous suspension of a local anaesthetic of the basically substituted acid amide type, e.g. lidocaine, until the anaesthetic base is dissolved, are applied from pressure resistant dispensers in which the propellant may be a mixture of chlorofluorohydrocarbons.ALSO:Aqueous solutions of local anaesthetics of the basically substituted acid amide type are prepared by introducing carbon dioxide, in an amount in excess over that stoichiometrically required for carbonate salt formation, into an aqueous suspension of the anaesthetic, at a temperature not exceeding ambient temperature, until the anaesthetic base has been dissolved. In a modification, an acid addition salt of the anaesthetic base is used together with a water-soluble, acid-neutralizing agent, e.g. sodium bicarbonate, sodium carbonate or sodium hydroxide, in an amount equimolecular to the acid moiety of the addition salt, and carbon dioxide is then introduced to dissolve the liberated base. Anaesthetics specified are lidocaine, mepivacaine, a -(n-propylamino)-propionyl-toluide-(2), (n-butyl-amino)-acetyl-2-methyl-6-chloroanilide and diethylamino-acetyl-2, 6-dimethyl-4-butoxyanilide. The solutions may be used in vials, ampoules or pressure resistant dispensers and may be incorporated into jellies, ointments and creams. When used in pressurised form, the propellant may be excess carbon dioxide, nitrogen or a chloro-fluorohydrocarbon.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US177172A US3136691A (en) | 1962-03-05 | 1962-03-05 | Aqueous solution of local anesthetic maintained under pressure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1035005A true GB1035005A (en) | 1966-07-06 |
Family
ID=22647491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8735/64A Expired GB1035005A (en) | 1962-03-05 | 1963-03-05 | Local anesthetic preparations and process of making same |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3136691A (en) |
| CH (1) | CH465767A (en) |
| DE (1) | DE1220967B (en) |
| DK (1) | DK109053C (en) |
| GB (1) | GB1035005A (en) |
| SE (1) | SE315689B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4811692B1 (en) * | 1967-07-07 | 1973-04-14 | ||
| US3940483A (en) * | 1971-02-05 | 1976-02-24 | E. R. Squibb & Sons, Inc. | Antibiotic compositions and method |
| US4218477A (en) * | 1971-07-28 | 1980-08-19 | Astra Pharmaceutical Products, Inc. | Primary aminoacylanilides, methods of making the same and use as antiarrhythmic drugs |
| US4935225A (en) * | 1987-09-11 | 1990-06-19 | Curtis John P | Appetite suppresant dentifrice |
| US5331012A (en) * | 1990-07-30 | 1994-07-19 | Riddick Kenneth B | Topical pharmaceutical preparation for fever blisters and other viral infections and method of use |
| WO2005032521A2 (en) * | 2003-10-02 | 2005-04-14 | Collegium Pharmaceutical, Inc. | Non-flammable topical anesthetic liquid aerosols |
| US20060188449A1 (en) * | 2003-10-03 | 2006-08-24 | Jane Hirsh | Topical aerosol foams |
| US8652443B2 (en) * | 2008-02-14 | 2014-02-18 | Precision Dermatology, Inc. | Foamable microemulsion compositions for topical administration |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR981029A (en) * | 1949-02-17 | 1951-05-21 | Method of fine spraying a liquid | |
| US2953284A (en) * | 1957-12-06 | 1960-09-20 | Aerosol Tech Inc | Pressurized dispenser |
-
1962
- 1962-03-05 US US177172A patent/US3136691A/en not_active Expired - Lifetime
-
1963
- 1963-03-04 DE DEA42495A patent/DE1220967B/en active Pending
- 1963-03-05 SE SE2383/63A patent/SE315689B/xx unknown
- 1963-03-05 GB GB8735/64A patent/GB1035005A/en not_active Expired
- 1963-03-05 CH CH278663A patent/CH465767A/en unknown
- 1963-03-05 DK DK99763AA patent/DK109053C/en active
Also Published As
| Publication number | Publication date |
|---|---|
| DE1220967B (en) | 1966-07-14 |
| US3136691A (en) | 1964-06-09 |
| CH465767A (en) | 1968-11-30 |
| SE315689B (en) | 1969-10-06 |
| DK109053C (en) | 1968-03-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1035005A (en) | Local anesthetic preparations and process of making same | |
| ES440534A1 (en) | Blowing agent mixture | |
| SE415298B (en) | PROCEDURE FOR DETERMINATION OF AMMONIA IN A GAS MIXTURE CONTAINING PARTS OF NITROGEN OXIDE AND NITROGEN Dioxide | |
| GB1463049A (en) | Dithiobis-succinimidyl propionate | |
| GB703954A (en) | A new or improved method for the preparation of alkyl titanates | |
| MX3304E (en) | PROCEDURE FOR PREPARING AN ALPHA-AMINO ACID | |
| GB1130127A (en) | Process for the removal of hydrogen sulphide from carbon dioxide and gas mixtures containing carbon dioxide | |
| GB837338A (en) | Pyrimidinylazobenzene derivatives and their production | |
| GB939920A (en) | Process for the production of 1, 1, 1, -trifluoro-2-chloro-2-bromoethane | |
| GB1174890A (en) | Process for preparing t-Butoxycarbonyl Compounds | |
| GB918882A (en) | New alkylene-bis-n : n-nitro carbamates | |
| GB1376288A (en) | Sodium dithionite stabilization against self-ignition | |
| GB702179A (en) | Process for the manufacture of monoferro-dicalcium-citrate | |
| GB1467528A (en) | Piperazinium 1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolyl acetate | |
| AT344989B (en) | MIXTURE CONTAINING AN ORGANIC METAL COMPOUND OF AN ALKALI METAL, STABILIZED AGAINST ATMOSPHERIC EFFECTS | |
| GB1183109A (en) | Method of Photonitrosation of Cycloalkanes | |
| GB940542A (en) | Erythromycin, carbomycin or tetracycline derivatives | |
| GB1140857A (en) | New sulphonyl azide and compositions based thereon | |
| GB1132040A (en) | Complex salts of alkyl phenols and alkyl phenol sulphides | |
| ES290536A3 (en) | A method for the production of chlorine dioxide (Machine-translation by Google Translate, not legally binding) | |
| GB687099A (en) | Improvements in or relating to the generation of high quality chlorine dioxide | |
| GB1496174A (en) | Manufacture of amidosulphonic acids | |
| GB1500120A (en) | 1,2,3-trisubstituted cyclohexanes | |
| GB765673A (en) | Process for the purification of gases containing hydrogen sulphide | |
| BE813065A (en) | Alkali metal dithionites from formates - with sulphur dioxide and a basic alkali metal in 2-methoxyethanol avoiding pressure reaction |