[go: up one dir, main page]

GB1030756A - Anti-inflammatory compositions comprising biphenylyl-alkane derivatives - Google Patents

Anti-inflammatory compositions comprising biphenylyl-alkane derivatives

Info

Publication number
GB1030756A
GB1030756A GB1284863A GB1284863A GB1030756A GB 1030756 A GB1030756 A GB 1030756A GB 1284863 A GB1284863 A GB 1284863A GB 1284863 A GB1284863 A GB 1284863A GB 1030756 A GB1030756 A GB 1030756A
Authority
GB
United Kingdom
Prior art keywords
biphenylyl
methyl
cooh
group
ch2oh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1284863A
Inventor
John Stuart Nicholson
Hugh Colin Richards
Stewart Sander Adams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boots Pure Drug Co Ltd
Original Assignee
Boots Pure Drug Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boots Pure Drug Co Ltd filed Critical Boots Pure Drug Co Ltd
Priority to GB1284863A priority Critical patent/GB1030756A/en
Publication of GB1030756A publication Critical patent/GB1030756A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/18—Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part
    • C07C33/24—Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part polycyclic without condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/26—Polyhydroxylic alcohols containing only six-membered aromatic rings as cyclic part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/34—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings containing more than one carboxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64—Acyl halides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention comprises the compounds: 4-biphenylyl-a -chloracetic acid and its ethyl ester; 4-biphenylyl-a -methoxyacetic acid; 2-41-biphenylyl -propan - 1,3 - diol; 2 - 41 - biphenylyl -propanol; and 2 - 41 - biphenylyl - malonic acid and its 2-methyl derivative and its diethyl ester; and processes for preparing them. Biphenylyl intermediates obtained are: ethyl 4 - biphenylyl - a - methoxy - acetate; and 2 - (41 - biphenylyl) - 2 - methyl - malonic acid diethyl ester.ALSO:Analgesic, anti-inflammatory and anti-pyretic compositions comprise a carrier and a compound of the general formula <FORM:1030756/A5-A6/1> wherein R represents the group-CR1R2R2 wherein R1 is H or C1-4 alkyl and R2 represents -CH2OH, -COOR1, COOM or COOH.B wherein R1 is H or C1-4 alkyl optionally substituted with an amino or dialkylamino group, M is ammonium or a single equivalent of a non-toxic cation and B is a non-toxic organic base or R represents the group A-X wherein A represents -CH2-CH2-CH(CH3)- or -CHR\yM- wherein R3 is halogen, C1-4 alkoxy, methyl or C2-3 alkenyl and X represents COOR1, COOH.B, COOM, CH2OH or CONH2 provided that X is not COOH when R3 is methyl. They may be in conventional forms suitable for oral, parenteral and topical administration.
GB1284863A 1963-04-01 1963-04-01 Anti-inflammatory compositions comprising biphenylyl-alkane derivatives Expired GB1030756A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1284863A GB1030756A (en) 1963-04-01 1963-04-01 Anti-inflammatory compositions comprising biphenylyl-alkane derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1284863A GB1030756A (en) 1963-04-01 1963-04-01 Anti-inflammatory compositions comprising biphenylyl-alkane derivatives

Publications (1)

Publication Number Publication Date
GB1030756A true GB1030756A (en) 1966-05-25

Family

ID=10012252

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1284863A Expired GB1030756A (en) 1963-04-01 1963-04-01 Anti-inflammatory compositions comprising biphenylyl-alkane derivatives

Country Status (1)

Country Link
GB (1) GB1030756A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0020230A2 (en) * 1979-05-21 1980-12-10 Pierre Fabre S.A. p-Biphenyl-4-methyl-2-butenoic acids, process for their preparation, pharmaceutical compositions containing them and their use
WO2007020381A3 (en) * 2005-08-15 2007-05-03 Syngenta Participations Ag Process for the synthesis of mandipropamid and derivatives thereof

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0020230A2 (en) * 1979-05-21 1980-12-10 Pierre Fabre S.A. p-Biphenyl-4-methyl-2-butenoic acids, process for their preparation, pharmaceutical compositions containing them and their use
FR2457275A1 (en) * 1979-05-21 1980-12-19 Fabre Sa Pierre P-BIPHENYL-4 METHYL-2 BUTEN-3 OIC ACIDS USEFUL IN THE TREATMENT OF RHUMATISMS
EP0020230A3 (en) * 1979-05-21 1981-01-07 Pierre Fabre S.A. P-biphenyl-4-methyl-2-butenoic acids, process for their preparation, pharmaceutical compositions containing them and their use
WO2007020381A3 (en) * 2005-08-15 2007-05-03 Syngenta Participations Ag Process for the synthesis of mandipropamid and derivatives thereof
US8129560B2 (en) 2005-08-15 2012-03-06 Syngenta Crop Protection, Inc. Process for the synthesis of mandipropamid and derivatives thereof
TWI399363B (en) * 2005-08-15 2013-06-21 Syngenta Participations Ag Process
KR101305928B1 (en) * 2005-08-15 2013-09-12 신젠타 파티서페이션즈 아게 Process for the synthesis of mandipropamid and derivatives thereof

Similar Documents

Publication Publication Date Title
MX9204622A (en) NEW DERIVATIVES OF 3,5-DI-TERT-BUTIL-4-HIDROXIFENILO, PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM.
ES8305298A1 (en) Analgesic and anti-inflammatory agents.
EP0143123A3 (en) Industrial products useful as intermediates in the preparation of 4-hydroxy-3 quinoleine carboxamide derivatives substituted at position 2, and the preparation of these intermediates
GB953427A (en) New oxazoline derivatives and method for the preparation thereof
GB1234490A (en)
GB1030756A (en) Anti-inflammatory compositions comprising biphenylyl-alkane derivatives
GB1049710A (en) Phenylalanine derivatives and a process for the manufacture thereof
GB1085672A (en) Substituted phthalazines
ES345835A1 (en) Substituted phenylacetamides
ES389252A1 (en) 2-substituted phenyl propionic acids
ES428673A1 (en) Substituted nitrobenzophenone derivatives
GB1324423A (en) Salicylamide derivatives
SE7908940L (en) NEW ACYL-1H-1,2,4-TRIAZOLD DERIVATIVES
DE3061435D1 (en) Process for the preparation of 5-(2,2,2,-trihalogen-ethyl)-dialkyl-tetrahydrofuran-2-ones
ES432465A1 (en) Substituted 4-biphenylyl-butenoic acids esters and amides and pharmaceutical compositions containing them
GB1262333A (en) New hydantoins their preparation and compositions containing them
JPS5283436A (en) Preparation of intermediates for synthesis of prostaglandin
GB1105007A (en) Nitrone derivatives and processes for preparation thereof
SE7713779L (en) NEW PHENYL DERIVATIVES
GB1377306A (en) Esters of 2-quinoxalinecarboxylic acid di n-oxide
GB1116608A (en) New dibenzocycloheptadiene derivatives
GB1100602A (en) N-substituted indole (3) acetic acids
FR1602630A (en) Alpha-subst hydrocinnamic acid derivatives for reducing
JPS55118452A (en) Production of alpha-cyanopropionic ester derivative
ES370226A1 (en) Cycloheptimidazolone derivatives and process for the preparation thereof