GB1002665A - Improvements in or relating to muscle relaxant and analgesic compositions - Google Patents
Improvements in or relating to muscle relaxant and analgesic compositionsInfo
- Publication number
- GB1002665A GB1002665A GB2920063A GB2920063A GB1002665A GB 1002665 A GB1002665 A GB 1002665A GB 2920063 A GB2920063 A GB 2920063A GB 2920063 A GB2920063 A GB 2920063A GB 1002665 A GB1002665 A GB 1002665A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydrogen
- lower alkyl
- amino
- halogen
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises carbostyril compounds of the general formula <FORM:1002665/C2/1> wherein Y is -CH=CH- or -CH2-CH2-; X is oxygen or sulphur and R2 is lower alkyl, or, when Y is -CH2-CH2-, hydrogen. Compounds of the above general formula, may be prepared by the reaction schemes outlined below <FORM:1002665/C2/2> R represents trifluoromethyl, R1 is hydrogen, and X is an anion. The term "lower" refers to groups having 1 to 4 carbon atoms. The N-oxide of 6-trifluoromethylquinoline is prepared by action of hydrogen peroxide on quinoline and then treated with acetic anhydride before hydrogenation to give 3,4-dihydro-6-trifluoromethylcarbostyril.ALSO:Pharmaceutical compositions having muscle relaxant and analgesic activity comprise a pharmaceutical carrier in association with a carbostyril compound <FORM:1002665/A5-A6/1> wherein Y is -CH = CH- or -CH2-CH2-; X is O or S; R is hydrogen, halogen, hydroxy, nitro, amino, mono-lower alkyl amino, di-lower alkyl amino, acetamido, trifluoromethyl, lower alkyl, lower alkoxy or ethoxycarbonyl; R1 is hydrogen or, together with R, dihalogen, dihydroxy, diloweralkoxy or methylene-dioxy; and R2 is lower alkyl or, when R is -CH2-CH2-, hydrogen. "Lower" refers to groups having 1 to 4 carbon atoms and "halogen" denotes chlorine, bromine or fluorine. Conventional solid or liquid carriers may be used, together with a sustained release material. The compositions may be used in the forms of a tablet, capsule, troche or lozenge, and their administration may be effected parenterally or orally.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21552362A | 1962-08-08 | 1962-08-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1002665A true GB1002665A (en) | 1965-08-25 |
Family
ID=22803314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2920063A Expired GB1002665A (en) | 1962-08-08 | 1963-07-23 | Improvements in or relating to muscle relaxant and analgesic compositions |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE634894A (en) |
| CH (1) | CH411885A (en) |
| DE (1) | DE1470250A1 (en) |
| DK (1) | DK105646C (en) |
| GB (1) | GB1002665A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3462438A (en) * | 1967-10-16 | 1969-08-19 | Smithkline Corp | 1,2,2alpha,8beta-tetrahydrocyclobuta(c) quinolines |
-
1963
- 1963-07-12 BE BE634894A patent/BE634894A/en unknown
- 1963-07-12 DK DK334863A patent/DK105646C/en active
- 1963-07-23 GB GB2920063A patent/GB1002665A/en not_active Expired
- 1963-07-30 CH CH947263A patent/CH411885A/en unknown
- 1963-08-08 DE DE19631470250 patent/DE1470250A1/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3462438A (en) * | 1967-10-16 | 1969-08-19 | Smithkline Corp | 1,2,2alpha,8beta-tetrahydrocyclobuta(c) quinolines |
Also Published As
| Publication number | Publication date |
|---|---|
| CH411885A (en) | 1966-04-30 |
| BE634894A (en) | 1964-01-13 |
| DE1470250A1 (en) | 1969-05-29 |
| DK105646C (en) | 1966-10-24 |
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