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FR3115606B1 - Optical system for detecting at least one target compound present in an aerosol exhaled by a breath fluid - Google Patents

Optical system for detecting at least one target compound present in an aerosol exhaled by a breath fluid Download PDF

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Publication number
FR3115606B1
FR3115606B1 FR2010994A FR2010994A FR3115606B1 FR 3115606 B1 FR3115606 B1 FR 3115606B1 FR 2010994 A FR2010994 A FR 2010994A FR 2010994 A FR2010994 A FR 2010994A FR 3115606 B1 FR3115606 B1 FR 3115606B1
Authority
FR
France
Prior art keywords
target compound
detecting
optical system
substrate
compound present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR2010994A
Other languages
French (fr)
Other versions
FR3115606A1 (en
Inventor
Guillaume Nesa
Cyril Chappaz
Valentin Leveque
Julien Babic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Olythe SAS
Original Assignee
Olythe SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olythe SAS filed Critical Olythe SAS
Priority to FR2010994A priority Critical patent/FR3115606B1/en
Priority to EP21811407.2A priority patent/EP4236787A1/en
Priority to PCT/FR2021/000123 priority patent/WO2022090635A1/en
Publication of FR3115606A1 publication Critical patent/FR3115606A1/en
Application granted granted Critical
Publication of FR3115606B1 publication Critical patent/FR3115606B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/097—Devices for facilitating collection of breath or for directing breath into or through measuring devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/948—Sedatives, e.g. cannabinoids, barbiturates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4845—Toxicology, e.g. by detection of alcohol, drug or toxic products
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7756—Sensor type
    • G01N2021/7763—Sample through flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G01N2021/8578—Gaseous flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/165—Coronaviridae, e.g. avian infectious bronchitis virus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Surgery (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Physiology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L’invention concerne un système optique de détection d’au moins un composé cible présent dans un aérosol exhalé par un fluide d’haleine, comportant : (a) un substrat amovible comprenant deux faces opposées appelées face inférieure et face supérieure, le fluide d’haleine étant exhalé sur tout ou partie dudit substrat,(b) un émetteur d’un rayonnement optique dirigé vers la face supérieure dudit substrat,(c) un détecteur de tout ou partie du rayonnement optique émis par l’émetteur,et dans lequel tout ou partie du substrat est fonctionnalisé par une molécule ayant une affinité chimique spécifique au(x) composé(s) cible(s) de sorte que l’intensité du rayonnement optique détecté soit sensiblement différente en présence ou en l’absence du(es)dit(s) composé(s) cible(s).The invention relates to an optical system for detecting at least one target compound present in an aerosol exhaled by a breath fluid, comprising: (a) a removable substrate comprising two opposite faces called the lower face and the upper face, the breath fluid being exhaled on all or part of said substrate, (b) an emitter of optical radiation directed towards the upper face of said substrate, (c) a detector of all or part of the optical radiation emitted by the emitter, and in which all or part of the substrate is functionalized by a molecule having a specific chemical affinity to the target compound(s) such that the intensity of the detected optical radiation is substantially different in the presence or absence of said target compound(s).

FR2010994A 2020-10-27 2020-10-27 Optical system for detecting at least one target compound present in an aerosol exhaled by a breath fluid Active FR3115606B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR2010994A FR3115606B1 (en) 2020-10-27 2020-10-27 Optical system for detecting at least one target compound present in an aerosol exhaled by a breath fluid
EP21811407.2A EP4236787A1 (en) 2020-10-27 2021-10-28 Optical system for detecting at least one target compound present in an aerosol exhaled through a breath fluid
PCT/FR2021/000123 WO2022090635A1 (en) 2020-10-27 2021-10-28 Optical system for detecting at least one target compound present in an aerosol exhaled through a breath fluid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR2010994A FR3115606B1 (en) 2020-10-27 2020-10-27 Optical system for detecting at least one target compound present in an aerosol exhaled by a breath fluid
FR2010994 2020-10-27

Publications (2)

Publication Number Publication Date
FR3115606A1 FR3115606A1 (en) 2022-04-29
FR3115606B1 true FR3115606B1 (en) 2025-01-17

Family

ID=74871474

Family Applications (1)

Application Number Title Priority Date Filing Date
FR2010994A Active FR3115606B1 (en) 2020-10-27 2020-10-27 Optical system for detecting at least one target compound present in an aerosol exhaled by a breath fluid

Country Status (3)

Country Link
EP (1) EP4236787A1 (en)
FR (1) FR3115606B1 (en)
WO (1) WO2022090635A1 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9134247B2 (en) * 2011-12-16 2015-09-15 Real-Time Analyzers, Inc. Method and apparatus for two-step surface-enhanced raman spectroscopy
US10309876B2 (en) * 2013-10-03 2019-06-04 Hitachi, Ltd. Cartridge for airborne substance sensing device, and airborne substance sensing device
US9726684B1 (en) * 2015-01-18 2017-08-08 Hound Labs, Inc. Compositions for target substance detection and measurement
US10969333B2 (en) * 2017-08-02 2021-04-06 Vox Biomedical Llc Sensing cannabis and opioids in exhaled breath by infrared spectroscopy
US11977086B2 (en) * 2019-03-21 2024-05-07 Hound Labs, Inc. Biomarker detection from breath samples

Also Published As

Publication number Publication date
WO2022090635A1 (en) 2022-05-05
EP4236787A1 (en) 2023-09-06
FR3115606A1 (en) 2022-04-29

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