FR3110414A1 - Cosmetic composition comprising at least one ceramide, at least one tyndallized microorganism and at least one plant bisabolol - Google Patents

Abstract

The present invention relates to a cosmetic composition for the care of an area of the skin, comprising at least one ceramide, at least one tyndallized microorganism and at least one plant bisabolol. The present invention also relates to a method of applying said cosmetic composition to an area of the skin, as well as the use of the cosmetic composition according to the invention for moisturizing the skin and / or protecting the skin barrier and / or reducing the skin irritations.

Description

Cosmetic composition comprising at least one ceramide, at least one tyndallized microorganism and at least one plant bisabolol

FIELD OF THE INVENTION

The present invention relates to a cosmetic composition for caring for an area of the skin, comprising at least one ceramide, at least one tyndallized microorganism and at least one plant bisabolol. The present invention also relates to a method for applying said cosmetic composition to an area of the skin, as well as the use of the cosmetic composition according to the invention for moisturizing the skin and/or protecting the skin barrier and/or reducing skin irritation.

STATE OF THE ART

The skin is an organ that is always in contact with the external environment. It protects the body against physical damage and external chemical substances, prevents bacteria, fungi and viruses from invading the skin, and acts as a protective barrier against loss of moisture from the skin. The structure of the skin consists of three layers: the epidermis, the dermis and the subcutaneous fat. The epidermis is the thinnest of the three layers and plays an important role in moisturizing and protecting the skin. In particular, the skin is elastic and softened by the moisture present in the stratum corneum of the epidermis, while it is known that a water content of 10% or more is essential to maintain the elasticity of the layer. cornea (O.K. Jacobi, Proc.Sci.Sec.Toilet Goods Assoc. 1959, 31, 22).

Over time, and in particular chronological and/or photo-induced aging, the skin undergoes numerous modifications and degradations which result, at the tissue level, in a disorganization of the architecture of the epidermis, of the dermo-dermal junction epidermal, dermis, as well as blood supply and innervation systems, and a slowing down or deregulation of various cellular metabolisms, such as those involved in balancing the barrier function or involved in melanogenesis. At the cellular level, aging thus results in an alteration of the physiology or the metabolism of the main cell types such as the fibroblasts of the dermis, of the keratinocytes of the epidermis, and also of the melanocytes.

Skin aging results from two distinct and independent processes that involve intrinsic or extrinsic factors. Intrinsic or chrono-biological aging corresponds to normal or physiological age-related aging.

Intrinsic aging is reflected in particular by a slowdown in the renewal of cells in the epidermis and the appearance of fine lines or wrinkles. In the dermis, the biosynthesis of macromolecules such as collagen decreases with age, changing the mechanical properties of the dermis, resulting in sagging skin, one of the clinical signs of ageing.

Extrinsic aging corresponds to aging generally caused by the environment and corresponds more particularly to photo-aging due to exposure to the sun and smoking. Photo-induced skin aging, that is to say caused by exposure to the sun, is also called photo-aging or heliodermia. Photoaging is the result, at the level of the dermis, of the degradation of collagen fibers resulting in particular in clinical alterations such as thick wrinkles and the formation of soft, tanned skin. Skin aging is therefore accelerated by chronic exposure to UV rays.

Chronic skin inflammation, or "inflamm'aging", is one of the major and latent causes of skin aging, which worsens over time. With age, repetitive micro-inflammations spread through the skin tissue and weaken the cells' defense systems. The visible consequences are materialized by wrinkles, dehydration, slackening of the skin, aesthetic disorders, or even neurosensory damage.

Thus, there remains a need for cosmetic alternatives for maintaining skin hydration, protecting the skin barrier effect and for soothing skin inflammation.

To do this, the Applicant has developed a cosmetic composition for caring for an area of the skin comprising at least one ceramide, at least one tyndallized microorganism, and at least one plant bisabolol.

For this purpose, according to a first aspect of the invention, a cosmetic composition is proposed for the care of an area of the skin, comprising:

• At least one ceramide, preferably chosen from sunflower oil, ceramide AP, and/or ceramide NP;
• At least one tyndallized microorganism; And
• At least one vegetable bisabolol, preferably from chamomile.

By tyndallized microorganism is understood according to the invention a microorganism having undergone the process of tyndallization. Tyndallization is a process for inactivating microorganisms using a technique of discontinuous heating at low temperature: a few minutes (about thirty) every 24 hours, not exceeding 60°C. This heating is sufficient to eliminate the vegetative forms, and causes a thermal shock, which is a triggering factor for a form of resistance to germinate, and thus give vegetative forms. The intervals left between the heatings therefore allow the spores to give bacteria, which are eliminated during the next temperature increase. In this way, all the spores are gradually eliminated from the medium, which helps to sterilize it. Tyndallized microorganisms are non-living microorganisms.

Any known method of tyndallization can be used without limitation, while commercially available tyndallized dead lactic acid bacteria can also be used. A preferred method for tyndallization of a fermented lactic acid bacteria solution is a tyndallization process using an intermittent sterilization method, i.e. the separation of the fermented lactic acid bacteria from the fermented filtrate; and heating the fermented lactic acid bacteria cells at 60 to 160°C for 10 to 60 minutes, and rapidly cooling to 20 to 40°C or below 20°C to kill the fermented lactic acid bacteria.

The tyndallized microorganisms suppress or reduce the loss of moisture from the skin, possess an excellent moisturizing effect for the skin by protecting the skin barrier, and inhibit the expression level of MMP-9, which is a protein involved in the formation wrinkles. Experiments describing the effectiveness of tyndallysed microorganisms can be found in document EP3199036A1, and in particular example 1, which shows that the group treated with dead tyndallized bacteria had higher hydration than that of the UV-irradiated group, and Example 4 which demonstrates the decrease in the expression of MMP-9.

Preferably according to the invention, said composition comprises from 0.01 to 10% by weight of the composition of tyndallized microorganisms, preferably from 0.5 to 6%, even more preferably from 0.5 to 1 .5%.

The tyndallized microorganisms can be in the form of lysates.

By lysate is meant the product obtained following the cell lysis of microorganisms, which corresponds to the destruction of the cell membrane by a physical, chemical or biological agent, causing its death.

Preferably according to the invention, said at least one tyndallized microorganism is chosen from microorganisms of the genus Streptococcus, of the genus Lactococcus, of the genus Enterococcus, of the genus Lactobacillus, of the genus Pediococcus, of the genus Leuconostoc, of the genus Weissella and/or of the genus Bifidobacterium.

Preferably according to the invention, said at least one tyndallized microorganism is of the genus Lactobacillus.

Even more preferably according to the invention, said at least one tyndallized microorganism is Lactobacillus acidophilus and/or Lactobacillus casei.

Ceramides are sphingolipids resulting from the combination of a fatty acid with sphingosine via an amide bond. These molecules are found in large quantities in the cell membranes, where they enter in particular into the constitution of sphingomyelin. The term ceramides includes several compounds such as AP, EOP, NG, NP or NS ceramides.

Preferably according to the invention, said composition comprises from 0.01 to 10%, preferably from 0.5 to 6%, by weight of the composition of ceramides.

Preferably, the cosmetic composition for caring for an area of the skin comprises at least one ceramide chosen from sunflower oil, ceramide AP and/or ceramide NP.

Sunflower oil is an important source of ceramides, from which these can be derived and extracted.

Bisabolol is a monocyclic sesquiterpene alcohol possessing two isomers, α and β, in turn possessing two pairs of levorotatory and dextrorotatory enantiomers because each isomer has two stereogenic centers. It is a colorless oily liquid found in wild chamomile essential oil and bergamot oil.

Preferably according to the invention, said composition comprises from 0.01 to 10%, preferably from 0.1 to 6%, by weight of the bisabolol composition.

Preferably, said at least one vegetable bisabolol comes from chamomile.

According to one embodiment of the invention, said composition comprises:

• from 0.5 to 6% by weight of said composition of at least one ceramide, preferably chosen from sunflower oil, ceramide AP, and/or ceramide NP;
• from 0.01 to 10%, preferably from 0.5 to 6%, even more preferably from 0.5 to 1.5%, by weight of said composition of at least one tyndallized microorganism; And
• from 0.1 and 6% by weight of said composition of at least one plant bisabolol, preferably from chamomile.

Preferably according to the invention, said cosmetic composition for caring for an area of the skin comprises at least one probiotic, preferably chosen from microorganisms of the genus Streptococcus, of the genus Lactococcus, of the genus Enterococcus, of the genus Lactobacillus , of the genus Pediococcus, of the genus Leuconostoc, of the genus Weissella and/or of the genus Bifidobacterium.

Probiotics are live micro-organisms (bacteria or yeasts) naturally present in the body. These living micro-organisms participate in different functions such as digestion and immunity.

Preferably according to the invention, said composition also comprises at least one other cosmetically acceptable compound, preferably chosen from soothing agents, restructuring agents, regenerating agents, revitalizing agents, sunscreens, anti-wrinkle agents, moisturizers, anti-ageing agents, surfactants, fatty substances, organic solvents, solubilizing agents, thickening and gelling agents, smoothing agents, agents reinforcing the firmness, elasticity and/or the barrier effect of the skin, antioxidants, opacifiers, stabilizing agents, foaming agents, perfumes, ionic or non-ionic emulsifiers, fillers, sequestrants and chelators, perfumes, filters, essential oils, coloring materials, pigments, hydrophilic or lipophilic active agents, lipid vesicles encapsulating one or more active agents and/or preservatives.

Preferably according to the invention, said cosmetic composition comprises extracts of Reishi and/or apricot oil and/or jojoba seed oil and/or squalane and/or niacinamide and/or glycerin and/or punica granatum fruit extracts and/or glyceril stearate and/or glyceryl stearate and/or coconut alkanes and/or hemp oil and/or Helianthus annuus seed oil, and/or Simmondsia chinensis seed oil, and/or Pentylene glycol and/or radish root ferment filtrate and/or Sclerotic gum and/or lysolecithin and/or Coco-caprylate caprate and/or Maltodextrin, and/or xanthan gum and/or pullulan and/or butylene glycol and/or Disodium cocoyl glutamate and/or lactic acid and/or sodium cocoyl glutamate and/or sodium hyaluronate and/or tocopherol and/or squalene and/or beta-sitosterol and/or pine bark extracts and/or ginseng red and/or white hemlock and/or Cornus officinalis extracts and/or Boesenbergia rotunda extracts and/or N-acetylglucosamine and/or hyaluronic acid and/or konjac extracts and/ or collagenase digested AP peptide and/or dandelion extracts.

According to one embodiment of the invention, said composition comprises:

Example of composition according to the invention:

Ingredient % (varying between the 2 stated bounds) Water QSP 100 Glycerin 5 - 10 Lactobacillus/punica granatum fruit ferment extract 4 - 9 Glyceryl stearate 3 - 8 Coconut alkanes 3 - 8 Cannabis sativa seed oil 3 - 8 Helianthus annuus seed oil 3 - 8 Simmondsia chinensis seed oil 3 - 8 Pentylene glycol 2 - 7 Leuconostoc/radish root ferment filtrate 1 - 5 Sclerotium gum 0.5 - 6 Lysolecithin 0.5 - 6 Coco-caprylate/caprate 0.5 - 6 Lactobacillus/Ganoderma lucidum extract/lentinus edodes extract ferment filtrate 0.5 - 6 Maltodextrin 0.5 - 6 Xanthan gum 0.5 - 6 Pullulan 0.5 - 6 Butylene glycol 0.5 - 6 Disodium cocoyl glutamate 0.5 - 6 Lactobacillus ferment
(tyndallized microorganism) 0.5 - 6 lactic acid 0.5 - 6 Sodium cocoyl glutamate 0.5 - 6 Sodium hyaluronate 0.5 - 6 Ceramide NP 0.5 - 6 Tocopherol 0.5 - 6 Squalene 0.5 - 6 Beta-sitosterol 0.5 - 6 Bisabolol 0.1 - 6

Preferably according to the invention, the cosmetic composition for caring for an area of the skin is formulated in the form of a cream, a pomade, an ointment, a mask, a serum, an a milk, a lotion, a paste, a mousse, an aerosol, a stick, a deodorant, a shampoo, a conditioner, patches, an aqueous-alcoholic or oily aqueous solution, an oil-in-water or water-in-oil or multiple emulsion, an aqueous or oily gel, an anhydrous liquid, pasty or solid product, and/or a dispersion of oil in an aqueous phase using spherules, these spherules possibly being polymeric nanoparticles such as nanospheres and nanocapsules or lipid vesicles of the ionic and/or non-ionic type.

Preferably according to the invention, said area of the skin is the face, the neck and the décolleté.

According to one embodiment, said cosmetic composition for caring for an area of the skin is a moisturizing cosmetic composition for the skin.

According to one embodiment, said cosmetic composition for the care of an area of the skin is a cosmetic composition making it possible to reinforce the protection of the cutaneous barrier of the skin.

According to one embodiment, said cosmetic composition for caring for an area of the skin is a skin-soothing cosmetic composition.

According to one embodiment, said cosmetic composition for caring for an area of the skin is an anti-redness cosmetic composition for the skin.

According to a second aspect, the invention relates to a method for cosmetic care comprising a step of applying the composition according to the invention to an area of the skin.

Preferably, an amount of 0.1 to 50 mg/cm2, preferably 0.25 to 2.5 mg/cm2, of cosmetic composition according to the invention is applied to the area of the skin.

Preferably, said application step is carried out on the face, neck and décolleté.

Preferably, the cosmetic composition according to the invention is applied once or twice a day, preferably twice a day, for at least 7 days, preferably at least 15 days, more preferably at least one month, from particularly preferably at least 2 months, and more particularly preferably at least 3 months. Very particularly preferably, the cosmetic composition is applied in the process according to the invention twice a day for at least 3 months.

According to a third aspect, the invention relates to the use of the cosmetic composition according to the invention for moisturizing the skin.

According to a fourth aspect, the invention relates to the use of the cosmetic composition according to the invention to protect the skin barrier.

According to a fifth aspect, the invention relates to the use of the cosmetic composition according to the invention to reduce skin irritation.

According to a sixth aspect, the invention relates to the use of the cosmetic composition according to the invention as anti-redness of the skin.

According to a seventh aspect, the invention relates to the use of the cosmetic composition according to the invention for moisturizing the skin and/or protecting the skin barrier and/or reducing skin irritation, and/or anti-redness of the skin .

EXAMPLES

Example 1: Evaluation of skin tolerance, perceived efficacy and acceptability of the composition according to the invention

The evaluation of the product is made through two types of data:

• tolerance data, obtained on the one hand by the comparison of clinical signs rated by a dermatologist on D0 and on D21 (=clinical symptomatology), and on the other hand by the collection of inconveniences and feelings of discomfort due to the product on during the 21 days of use (= functional symptomatology),
• data on perceived efficacy and acceptability, obtained by a questionnaire at the end of the study.

Course of the study: The composition according to the invention is applied once a day in the morning to the face, the neck and the décolleté.

Inclusion criteria:

• Caucasian female, 18-70 years old
• Person declaring to have skin that lacks firmness and radiance on the face
• Person declaring to wear make-up daily
• All skin types were represented in the panel (dry to very dry, combination to oily, normal)
• Person declaring to have sensitive skin (about 50% of the panel)

Non-inclusion criteria:

• Pregnant or breastfeeding woman
• Person who expressed opposition to the conditions of the study
• Person with a history of allergies to cosmetics
• Person with allergies with skin reactions
• Person with "hyper irritable" skin
• Person with a dermatological disease*
  • psoriasis, eczema, urticaria, mycosis, vitiligo, oedema, recurrent herpes, shingles, pityriasis versicolor, significant juvenile acne in inflammatory flare-up or nodular or cystic acne, lichen planus, chronic lupus erythematosus, significant pigmentary disorders
• Person with an immune deficiency
• Person on medication
  • by immunosuppressants or corticosteroids,
  • by antihistamines, anti-inflammatories,
  • by retinoids.

Restrictions for participants: Volunteers must not change their cosmetic habits during the study (apart from the use of the tested product). They should also avoid significant exposure to the sun. No aesthetic care at the product application area should be performed during the study, either by the panelist himself or in a beauty salon.

Evaluation criteria :

Tolerance: clinical and functional symptomatology

The tolerance of the test product is assessed during 2 visits at the start and end of the test (D0 and D21). The parameters evaluated being:

• objective data through a dermatological examination on D0 and D21 (clinical symptoms),
• subjective data by collecting the sensations felt and the signs observed by the volunteers while using the product (functional symptomatology).

Clinical symptomatology

The dermatologist observes the skin condition of each volunteer on the face (forehead, cheeks, chin), neck and décolleté, on D0 and D21, taking into account various clinical signs.

The importance of the various clinical signs observed in the different areas is rated from 0 (absence of sign) to 10 (severe sign), passing through 5 (moderate).

The clinical signs of the skin observed by the dermatologist are erythema, dryness, desquamation and hyperkeratosis.

The dermatologist specifies any other clinical sign observed (oedema, vesicles, etc.).

If several skin areas are scored, an overall score (= sum of the scores for each area) is calculated.

Data on clinical symptoms are processed using the non-parametric Wilcoxon rank test (see paragraph 2.3.3).

Functional symptomatology

If the volunteers observe an intolerance reaction during the study, the volunteers complete a tolerance collection form. They then specify the area concerned by the intolerance, the date and duration and the importance (weak, moderate, strong, very strong) of the reaction.

This tolerance collection form is checked by the study director during the end-of-study visit. The volunteers are questioned about possible intolerance reactions to the product.

In the event of a significant intolerance reaction during the study, the volunteers must contact the laboratory so that an observation by a dermatologist can be carried out quickly.

Overall functional tolerance is assessed according to the following scale:

EXCELLENT – VERY GOOD – GOOD - FAIRLY GOOD – MODERATE – FAIRLY BAD – BAD

Overall tolerance

Overall tolerance is assessed based on clinical symptomatology and functional symptomatology.

Taking into account the results obtained for each symptomatology (clinical and functional), overall tolerance is assessed on the following 7-point scale:

EXCELLENT – VERY GOOD – GOOD - FAIRLY GOOD – MODERATE – FAIRLY BAD – BAD

Perceived effectiveness and acceptability

At the end of the test, the volunteers complete a questionnaire concerning the perceived effectiveness and acceptability of the product being tested. The volunteers answer questions according to a 4-point scale.

The responses are grouped into two groups: positive responses and negative responses.

Efficacy and acceptability data are reported as a percentage and illustrated using graphical representations.

Statistical data processing

Data on clinical dermatological symptoms are processed using the non-parametric Wilcoxon rank test with the null hypothesis H0: (A) = (B), and the alternative hypothesis H1: (A) ≠ (B).

(A): clinical symptoms at D0

(B): clinical symptoms at D21

If the significance level obtained (p) is < 0.05, the null hypothesis H0 is rejected. We then accept an alternative hypothesis H1 of a significant difference between the clinical symptomatology observed on D21 and that on D0.

The statistical software used is the XLSTAT software.

Experimental plan

Selection of a group of 20 people according to the inclusion and non-inclusion criteria.

D0: skin observations of the volunteers by the dermatologist. Verification of inclusion and non-inclusion criteria. Distribution of the test product.

D21: skin observations of the volunteers by the dermatologist. Evaluation of perceived effectiveness and acceptability through a questionnaire. Verification of the tolerance collection form.

Data processing.

RESULTS :

Population

22 volunteers (22 women) are included on D0. The average age is 49 years (± 12 years) between 31 and 70 years.

Skin type:

• Dry to very dry: 10 (46%)
• Normal: 4 (18%)
• Combination to oily: 8 (36%)

11 volunteers (50%) have sensitive skin.

Dermatological clinical symptomatology

Based on the dermatological examinations and the D21/D0 comparative analysis, the test product is well tolerated.

Functional symptomatology

The 22 volunteers did not feel any inconvenience during the study. For these 22 volunteers (i.e. 100% of the panel), individual functional tolerance can be considered excellent.

According to the collection of feelings of intolerance, the overall functional tolerance is excellent.

Overall tolerance

After 21 days of use of the product, considering the observations of the dermatologist and the comparative analyzes D21/D0, good clinical tolerance is demonstrated.

Moreover, the functional tolerance is excellent.

Overall, the tolerance of the product is excellent during the 21 days of use.

Perceived effectiveness and acceptability

The results of the questionnaire are positive in particular for the following aspects:

• The complexion is brighter
• The product has a tightening effect
• The skin is lifted
• The product seems to act on the visible signs of aging
• The skin is revitalized
• The skin is regenerated
• The product improves the firmness of the skin
• The product improves the elasticity of the skin
• The skin is hydrated,
• The skin barrier is reinforced
• Signs of irritation / redness / inflammation are reduced

CONCLUSION

The protocol carried out (use test under dermatological control) demonstrates excellent tolerance of the product according to the invention and excellent efficacy.

Claims (9)

Cosmetic composition for the care of an area of the skin, comprising:

• At least one ceramide, preferably chosen from sunflower oil, ceramide AP, and/or ceramide NP;
• At least one tyndallized microorganism; And
• At least one vegetable bisabolol, preferably from chamomile.

Cosmetic composition for caring for an area of the skin according to the preceding claim, characterized in that the said at least one tyndallized microorganism is chosen from microorganisms of the genus Streptococcus, of the genus Lactococcus, of the genus Enterococcus, of the genus Lactobacillus, genus Pediococcus, genus Leuconostoc, genus Weissella and/or genus Bifidobacterium. Cosmetic composition for caring for an area of the skin according to the preceding claim, characterized in that the said at least one tyndallized microorganism is Lactobacillus acidophilus and/or Lactobacillus casei. Cosmetic composition for the care of an area of the skin according to any one of the preceding claims, characterized in that the said composition comprises:

• from 0.5 to 6% by weight of said composition of at least one ceramide, preferably chosen from sunflower oil, ceramide AP, and/or ceramide NP;
• from 0.01 to 10%, preferably from 0.5 to 6%, even more preferably from 0.5 to 1.5%, by weight of said composition of at least one tyndallized microorganism; And
• from 0.1 to 6% by weight of said composition of at least one vegetable bisabolol, preferably originating from chamomile.

Cosmetic composition for caring for an area of the skin according to any one of the preceding claims, characterized in that it comprises at least one probiotic, preferably chosen from microorganisms of the genus Streptococcus, of the genus Lactococcus, of genus Enterococcus, genus Lactobacillus, genus Pediococcus, genus Leuconostoc, genus Weissella and/or genus Bifidobacterium. Cosmetic composition for caring for an area of the skin according to any one of the preceding claims, characterized in that the said composition also comprises at least one other cosmetically acceptable compound, preferably chosen from soothing agents, restructuring agents, regenerating agents, revitalizing agents, sun filters, anti-wrinkle agents, moisturizing agents, anti-aging agents, surfactants, fatty substances, organic solvents, solubilizing agents, thickening and gelling agents, smoothing agents, agents reinforcing the firmness, elasticity and/or barrier effect of the skin, antioxidants, opacifiers, stabilizing agents, foaming agents, perfumes, ionic or non-ionic emulsifiers, fillers, sequestrants and chelators, perfumes, filters, essential oils, coloring matter, pigments, hydrophilic or lipophilic active ingredients, lipid vesicles encapsulating one or more active agents and/or the preservatives. Cosmetic composition for the care of an area of the skin according to any one of the preceding claims, characterized in that it comprises extracts of Reishi and/or apricot oil and/or jojoba seed and/or squalane and/or niacinamide and/or glycerine and/or punica granatum fruit extracts and/or glyceryl stearate and/or glyceryl stearate and/or alkanes from the nut coconut and/or hemp oil and/or Helianthus annuus seed oil, and/or Simmondsia chinensis seed oil, and/or Pentylene glycol and/or ferment filtrate radish root and/or sclerotic gum and/or lysolecithin and/or coco-caprylate caprate and/or maltodextrin, and/or xanthan gum and/or pullulan and/or butylene glycol and/or disodium cocoyl glutamate and/or lactic acid and/or sodium cocoyl glutamate and/or sodium hyaluronate and/or tocopherol and/or squalene and/or Beta-sitosterol and/or extracts of pine bark and/or red ginseng and/or white hemlock and/or extracts of Cornus officinalis and/or extracts of Boesenbergia rotunda and/or N -acetylglucosamine and/or hyaluronic acid and/or konjac extracts and/or collagenase-digested AP peptide and/or dandelion extracts. Cosmetic composition for the care of an area of the skin according to any one of the preceding claims, characterized in that the said composition is formulated in the form of a cream, a pomade, an ointment, a mask, a serum, a milk, a lotion, a paste, a mousse, an aerosol, a stick, a deodorant, a shampoo, an after - shampoos, patches, a hydroalcoholic or oily aqueous solution, an oil-in-water or water-in-oil or multiple emulsion, an aqueous or oily gel, an anhydrous liquid, pasty or solid, and/or a dispersion of oil in an aqueous phase using spherules, these spherules possibly being polymeric nanoparticles such as nanospheres and nanocapsules or lipid vesicles of the ionic and/or non-ionic type . Composition according to any one of Claims 1 to 8, for use in the treatment of skin irritations and/or skin redness and/or in the hydration of the skin and/or in the protection of the skin barrier.