FR3070010A1 - METHOD AND SYSTEM FOR CONDITIONING A COMPOSITION OF DRY EXTRACTS OF PLANTS, AND COMPOSITION OF DRY EXTRACTS OF PLANTS THUS IMPLEMENTED. - Google Patents

Abstract

Process for conditioning a composition of dry extracts of plants, comprising the following steps: - preparation (1) of a selection of dry extracts of plants (ESP1, ESP2, ESP3, ESP4, ..., ESPn) in respective amounts predetermined, - combination (2) of a hydrophilic compound with said selection to obtain a dry solids composition of plants, - filling (3) of a capsule (GE) by a determined quantity of said composition, and - coating ( 4) of said capsule thus filled, with a controlled dissolution material.

Description

"Method and system for conditioning a composition of dry plant extracts, and composition of dry plant extracts thus implemented"

Technical area

The present invention relates to a method for packaging dry extracts of plants. It also relates to a conditioning system implementing the method, as well as compositions of dry extracts of plants thus conditioned.

This process relates more particularly to the field of food supplements.

State of the art

The physiological and saprophytic intestinal microbiota of a human or animal subject may present developmental abnormalities to become dysbiotic and / or pathogenic. The most notable morphological change is a thickening by the production of a hydrated matrix which ultimately decreases the size of the intestinal lumen and creates dysbiotic and treatment-resistant ecosystems. It thus constitutes a dysbiotic intestinal biofilm.

To eliminate this biofilm, several methods of elimination can be considered. Chemical elimination can be achieved by having the patient ingest enzymes that chemically disrupt this matrix.

The elimination of biofilm can be carried out hydrically in the terminal parts of the intestine by carrying out hydrations of the colon. Biofilm can also be removed mechanically by surgery.

These methods of eliminating intestinal biofilm each have drawbacks that limit their application, whether chemical, water or surgical.

The aim of the present invention is to propose a process which makes it possible to condition dry extracts of plants in such a way that they

-2 are easily ingested by a patient or an animal and that they effectively contribute to an elimination of the pathogenic intestinal biofilm.

Statement of the invention

This objective is achieved by proposing a process for conditioning a composition of dry plant extracts, comprising the following steps:

- preparation of a selection of dry plant extracts in respective predetermined quantities,

- association of a hydrophilic compound with said selection to obtain a composition of dry plant extracts,

filling of a capsule with a determined quantity of said composition, and

- coating of the capsule thus filled, with a coating material with controlled dissolution.

The hydrophilic compound preferably comprises a gelling powder. This gelling powder is advantageously chosen from natural origin and can consist, for example and without limitation of guar gum, which can be organic and gluten-free.

The coating material preferably comprises a material resistant to gastric juices present in the stomach of humans or animals.

Given the number of different plant extracts necessary for effective removal of intestinal biofilm, a large container is necessary.

In a first option, a single large capsule, in particular size 000, can be used to contain the entire composition of dry plant extracts. This unique container ensures sufficient therapeutic volume.

In a second option, capsules of smaller size, in particular of size 0, which may contain a partial selection of dry plant extracts, can be used. In this case, an effective dose will be reached when the patient has taken several capsules containing all of the dry plant extracts. Furthermore, it is

-3 Imperative that the capsules are not opened by the patient before ingestion, which would cause a loss of gastric protection. By way of nonlimiting example, the choice of four small capsules will then be easier for the prescription.

Thus, in a particular embodiment of the invention, the preparation step comprises a plurality of steps for the preparation of partial selections of dry extracts of plants with each of which a hydrophilic compound is then associated to carry out as many separate compositions of dry plant extracts, and the filling step comprises a plurality of stages of filling as many capsules as separate compositions of dry plant extracts.

The capsules filled respectively from partial selections of dry plant extracts can advantageously have distinct visual characteristics. These visual characteristics may in particular include respective respective coating colors.

In a third embodiment of the invention, the preparation step comprises a plurality of steps for preparing dry extracts of a given plant from a selection of plants intended for a given composition, each preparation step being followed a step for associating with the dry extracts of said specific plant a hydrophilic compound so as to obtain a composition of dry extracts of the specific plant.

The filling step comprises a plurality of filling steps for each composition of dry extracts of a specific plant in a capsule dedicated to this composition.

Preparations can thus be made more easily which can be applied to the food types and / or to the drug treatments responsible for biofilm disorders. In addition, it is also thus possible to select more specifically the part or parts of the digestive tract to be treated. Individualization of a patient's treatment is then possible.

The capsules filled respectively with separate compositions of dry extracts of a given plant have distinct visual characteristics.

-4 Distinct visual features include distinct coating colors.

According to another aspect of the invention, a system is proposed for conditioning a composition of dry plant extracts, for the implementation of the conditioning process according to any one of the preceding claims, comprising:

means for preparing a selection of dry plant extracts (ESP1, ESP2, ESP4, .., ESPn) in respective predetermined quantities,

means for associating a hydrophilic compound with said selection in order to obtain a composition of dry plant extracts,

means for filling a capsule (G) with a determined quantity of said composition, and

- Means for coating said capsule (G) thus filled, with a material with controlled dissolution.

In a particular embodiment of the invention, the preparation means are arranged to prepare partial selections (SA, SB, SC) of dry extracts of plants with each of which a hydrophilic compound is then associated (2A, 2B, 2C ) to make as many separate compositions of dry plant extracts, and the filling means are arranged to perform a plurality of fillings (3A, 3B, 3C) as many capsules as separate compositions of dry plant extracts.

In another particular embodiment of the invention, the preparation means are arranged to ensure a plurality of preparations of dry extracts of a given plant from a selection of plants intended for a given composition, the means of association are arranged to associate with the dry extracts of each specific plant a hydrophilic compound so as to obtain a plurality of distinct compositions of dry extracts of each said specific plant, and the filling means are arranged to fill each said composition of dry extracts with a specific plant in a separate capsule dedicated to said composition.

According to yet another aspect of the invention, a composition of dry plant extracts is proposed, used in the packaging process according to the invention, comprising:

- a selection of dry plant extracts in respective predetermined quantities,

- a hydrophilic compound providing a support function for said dry extracts of plants.

The selection of dry plant extracts can advantageously include all or part of the following plant extracts: dehydrated grape marc, dry spicy nettle leaf, psyllium, dehydrated garlic, berberine, cinnamon, vanilla, ginkgo biloba, emodin, coumarin , boswellia.

Thus, with the conditioning method according to the invention, it becomes possible to contribute to a mechanical elimination of the pathogenic intestinal biofilm by absorption of capsules with programmed release of extracts of dry plants.

The composition according to the invention also contributes, by reducing the thickness of the biofilm and by facilitating absorption at the level of the intestinal villi, to promote food assimilation, the assimilation of food supplements and / or drugs taken by the oral.

The method according to the invention allows the production of coated capsules containing extracts of selected dry plants and having as a vector a gel released precisely in the intestine. This contributes to the release of dry plant extracts within the intestine and to the creation of a flexible vector for these extracts.

The innovative principle implemented in the method according to the invention is the association of a coated container so that the vector is not altered by the gastric juices during passage through the stomach and a dry multi-component container.

As regards the content, it represents the association of a natural or non-hydrophilic gelling powder and dry plant extracts, ensuring during the change of state of the gel powder the production of a recurrent volume surface.

In certain cases of dysbiosis and in particular chronic or very old, the efficiency of the mechanical treatment of the capsules can be advantageously increased by the addition within the capsule or capsules either of essential oils, or of enzymes for example. In addition to the mechanical action, a targeted chemical action is thus added.

Examples include the treatment of chronic intestinal candidiasis. It is understood that the mechanical scouring action caused by the passage of the abrasive vector carrying the plants eliminates the three-dimensional aspect of the candidosic network. The addition, for example and without limitation, of stabilized oregano oil or concentrated grapefruit seed extract will reduce the micellar forms (in two dimensions this time) to bring this population back to its saprophytic state.

Description of the figures and embodiments

Other advantages and particularities of the invention will appear on reading the detailed description of implementations and embodiments in no way limiting, and the following appended drawings:

- Figure 1 schematically shows the essential steps of a first mode of implementation of the packaging method according to the invention;

- Figure 2 schematically illustrates the essential steps of a second mode of implementation of the packaging method according to the invention; and

- Figure 3 schematically illustrates the essential steps of a third mode of implementation of the packaging method according to the invention.

Description of embodiments

We will now describe, with reference to FIGS. 1 and 2, two particular modes of implementing the process for packaging a composition of dry plant extracts.

In a first embodiment illustrated by the figure, a first step 1 consists in preparing a selection of dry extracts of plants ESP1, ESP2, EPSP3, ESP4, ... ESPn.

These dry plant extracts, chosen for their properties as food supplements can for example include dry plants that are not pulverized, regularly crushed to ensure easy filling of the capsules.

By way of example, there may be mentioned and without implied limitation:

- dehydrated organic grape marc

- organic dry spicy nettle leaves,

- organic psyllium

- organic dehydrated garlic

- berberine

- cinnamon

- vanilla

- ginkgo biloba,

- emodin,

- coumarin,

- Boswellia ...

This selection of dry plant extracts is then combined (step 2) with a hydrophilic compound support agent such as, for example and without limitation, gluten-free organic guar gum.

The composition of dry plant extracts thus obtained is then used to fill (step 3) a capsule G, for example of large size 000.

At this stage, it is optionally possible to provide a step for adding one or more essential oils and / or one or more enzymes to the capsule G.

By way of nonlimiting example, the proportion of essential oil added to the composition of dry extracts can be chosen equal to one third of the volume. In reference to a classic treatment of mixing essential oils of 7 drops to be taken 3 times a day for the treatment of intestinal candidiasis, which corresponds to approximately 0.35 g per intake in total.

By way of nonlimiting example, the proportion of enzyme added to the composition of dry extracts can be chosen equal to 10% of the volume. With reference to the dosages of enzyme supplementation treatments offered by different manufacturers, for example ENZYNUTRICS from METAGENICS.

A step may also be provided for adding mineral and / or metallic particles to the capsule G, for example in a proportion of 10% of the volume. Referring to the dosage of silica supplements, for example 10 ml at each meal.

Then the capsule G thus filled is coated (step 4) with a controlled dissolution material of the known gastro-resistant type, such as for example and without limitation, an EUDRAGUARD® for the coating of certain pharmaceutical capsules. We then obtain a GE coated capsule ready to use.

The process which has just been described can of course be automated (5) in its filling and coating stages, using automation techniques widely used in the pharmaceutical industry and food supplements.

The determination of the respective amounts of dry plant extracts in the composition is carried out from known and published studies.

We can thus cite for example:

Vikram A, et.al. Suppression of bacterial cell-cell signaling, biofilm formation and type III secretion System by citrus flavonoids, J Microbiol 2010; 109: 515-27.,

- Raja AF, Ali F, Khan IA, et al. Antistaphylococcal and biofilm inhibitory activities of acetyl-ll-keto-p-boswellic acid from Boswellia serrata. BMC Microbiology 2011; 11:54.,

- Partiwi SU, Lagendijk EL, Hertiani T. Antimicrobial effects of Indonesian medicinal plants extracts on planktonic and biofilm growth on of Pseudomonas aeruginosa and Staphylococcus aureus. Intl J Pharm Pharmaceut Sci 2015; 7: 183-91., And

- Shan B, Cai Y, Brooks JD, Corke H. The in vitro antibacterial activity of dietary spice and medicinal herb extracts. Int J Food Microbiol 2007; 117: 112-9.

It should be recalled that these references are concerned with the chemical components of the plant or plants described.

The present invention combines this phytotherapeutic aspect with mechanical cleaning within the intestinal tract.

In a practical example of making a composition of dry plant extracts, the following quantities of dry plant extracts were used:

. 0.5 g guar. 0.04 g garlic,. 0.3 g of nettle leaves,. 0.5 g of grape marc,. 0.25 g psyllium

We will now describe, with reference to FIG. 2, a second embodiment of the method for packaging dry plant extracts according to the invention, in which the single capsule is replaced by a batch of several capsules (2, 3, 4, 5, ....) small.

In this embodiment, partial selections of dry extracts of plants SA = ESP1 + ESP2, SB = ESP3 + ESP4, SC = ESP4 + ... ESPN are carried out. These partial selections can be chosen as a function of known information on certain compatibility of plants or on certain positive effects of combinations of plants. Separate steps (IA, IB, IC) are thus carried out for the preparation of these partial selections SA, SB, SC, then a hydrophilic compound is combined with them (2A, 2B, 2C) to obtain three compositions of dry plant extracts.

A filling of capsules GA, GB, GC each is then carried out with a composition. These capsules are preferably provided with distinct colors or distinctive signs, so that their administration can be carried out without ambiguity on the respective contents of the capsules.

Each GA, GB, GC capsule is then subjected to an enteric coating (steps 4A, 4B, 4C). A batch 6 of complementary capsules is thus obtained, the administration of which is equivalent to taking a single capsule which would comprise the complete composition of dry plant extracts as described with reference to FIG. 1.

In a third embodiment illustrated by FIG. 3, separate preparations are made (11-15) for each plant of the composition. Each quantity of dry extract (ESP1-ESP5) of a given plant thus prepared is associated (21-25) with an amount of the hydrophilic gelling support.

We then carry out (31-35) a filling of capsules each dedicated to a given plant, with compositions of dry extracts of the corresponding plants. These capsules, which are then coated (41-45) with a material with selective dissolution, are preferably provided with distinct colors or distinctive signs, so that their administration can be carried out without ambiguity on the respective contents of the capsules.

L1-L5 batches each containing G1E-G5E capsules filled with the same dry plant extracts are thus formed. These capsules are identified by distinctive visual signs identifying the type of dry extract of the plant.

From therapeutic indications and specific conditions experienced by the human or animal subject, selections 50 of capsules are ordered to carry out an individualized treatment. This results in selective sampling from the lots of capsules L1-L5 to make individualized combinations TA, ΤΒ,.,. Τη each containing a plurality of capsules.

The method of packaging in multiple capsules which has just been described, with reference to FIGS. 2 and 3, can of course be the subject of automation 5 within an automatic packaging system, using techniques of automation well known in the pharmaceutical industry or food supplements.

This automatic packaging system typically includes:

- technical preparation units intended to prepare dry extracts of plants by selecting, sorting and homogenizing them so that these dry extracts can be processed

- technical units to associate with these dry extracts thus prepared a hydrophilic gelling support and thus produce compositions of dry plant extracts,

- technical units for filling capsules with these compositions, and

- technical units for coating these capsules thus filled, with a material with controlled dissolution.

These embodiments being in no way limitative, it will be possible in particular to consider variants of the invention comprising only a selection of characteristics described or illustrated subsequently isolated from the other characteristics described or illustrated (even if this selection is isolated within a sentence including these other characteristics), if this selection of characteristics is sufficient to confer a technical advantage or to differentiate the invention from the state of the prior art. This selection comprises at least one characteristic, preferably functional, without structural details, and / or with only part of the structural details if this part only is sufficient to confer a technical advantage or to differentiate the invention from the state of the art. earlier.

Of course, the invention is not limited to the examples which have just been described and numerous modifications can be made to these examples without departing from the scope of the invention. The different characteristics, forms, variants and embodiments of the invention can be combined with one another in various combinations as long as they are not incompatible or mutually exclusive of each other. In particular, all the variants and embodiments described above can be combined with one another.

Furthermore, it is important to note that the compositions of dry plant extracts according to the invention which have just been described can also be used in other galenical forms and be offered, by way of nonlimiting example , in toothpaste, a mouthwash, a solution for contact lenses, wipes, suppositories, skin topicals in all forms or sprays.

Claims (22)

1. Method for packaging a composition of dry plant extracts, comprising the following steps: - preparation (1) of a selection of dry plant extracts (ESP1, ESP2, ESP4, .., ESPn) in respective predetermined quantities, - association (2) of a hydrophilic compound with said selection to obtain a composition of dry plant extracts, filling (3) of a capsule (G) with a determined quantity of said composition, and - coating (4) of said capsule (G) thus filled, with a controlled dissolution material. 2. Method according to claim 1, characterized in that it further comprises a step for adding to the capsule at least one essential oil. 3. Method according to one of claims 1 or 2, characterized in that it further comprises a step for adding to the capsule at least one enzyme. 4. Method according to any one of the preceding claims, characterized in that it further comprises a step for adding mineral and / or metallic particles to the capsule. 5. Method according to any one of the preceding claims, characterized in that the hydrophilic compound comprises a gelling powder. 6. Method according to claim 5, characterized in that the gelling powder is of natural origin. 7. Method according to one of the preceding claims, characterized in that the coating material comprises a material resistant to gastric juices present in the stomach of human or animal subjects. 8. Method according to any one of the preceding claims, characterized in that the preparation step comprises a plurality of steps (IA, IB, IC) for the preparation of partial selections (SA, SB, SC) of dry extracts plants to each of which a hydrophilic compound is then associated (2A, 2B, 2C) to produce as many separate compositions of dry extracts of plants, and in that the filling step comprises a plurality of filling steps (3A , 3B, 3C) as many capsules as separate compositions of dry plant extracts. 9. Method according to claim 8, characterized in that the capsules (Ga, Gb, Gc) filled respectively from partial selections of dry extracts of plants have distinct visual characteristics. 10. Method according to claim 9, characterized in that the capsules (Ga, Gb, Gc) filled respectively from partial selections of dry extracts of plants have respective respective coating colors. 11. Method according to any one of claims 1 to 7, characterized in that the preparation step comprises a plurality of steps (11-15) of preparation of dry extracts of a determined plant from a selection of plants , each preparation step (11-15) being followed by a step (21-25) for associating the dry extracts of said specific plant with a hydrophilic compound so as to obtain a composition of dry extracts of said specific plant, and in that the filling step comprises a plurality of steps (31-35) of filling each composition of dry extracts of a specific plant in a capsule dedicated to said composition. - ΜΙΣ. Method according to claim 11, characterized in that the capsules (G1E-G5E) filled respectively with separate compositions of dry extracts of a given plant have distinct visual characteristics. 13. Method according to claim 12, characterized in that the distinct visual characteristics include distinct coating colors. 14. System for conditioning a composition of dry plant extracts, for implementing the packaging method according to any one of the preceding claims, comprising: means for preparing a selection of dry plant extracts (ESP1, ESP2, ESP4, .., ESPn) in respective predetermined quantities, means for associating a hydrophilic compound with said selection in order to obtain a composition of dry plant extracts, means for filling a capsule (G) with a determined quantity of said composition, and - Means for coating said capsule (G) thus filled, with a material with controlled dissolution. 15. Conditioning system according to claim 14, characterized in that the preparation means are arranged to prepare partial selections (SA, SB, SC) of dry extracts of plants with each of which a hydrophilic compound is then associated (2A, 2B, 2C) to make as many separate compositions of dry plant extracts, and in that the filling means are arranged to carry out a plurality of fillings (3A, 3B, 3C) as many capsules as of separate compositions of 'dry extracts of plants. 16. Packaging system according to claim 14, characterized in that the preparation means are arranged to ensure a plurality of preparations of dry extracts of a specific plant - 15 from a selection of plants intended for a given composition, the association means are arranged to associate with the dry extracts of each given plant a hydrophilic compound so as to obtain a plurality of distinct compositions of dry extracts of each said given plant , and in that the filling means are arranged to fill each said composition with dry extracts of a given plant in a separate capsule dedicated to said composition. 17. Composition of dry plant extracts, used in the packaging process according to any one of the preceding claims, comprising: - a selection of dry plant extracts in respective predetermined quantities, a hydrophilic compound providing a support function for said dry extracts of plants, said composition being adapted to contribute, after ingestion by a human or animal subject, to an elimination of a pathogenic intestinal biofilm. 18. Composition according to claim 17, characterized in that the selection of dry plant extracts comprises all or part of the following plant extracts: dehydrated grape marc, dry spicy nettle leaf, psyllium, dehydrated garlic, berberine, cinnamon, vanilla, ginkgo biloba, emodin, coumarin, boswellia. 19. Composition according to one of claims 17 or 18, characterized in that the hydrophilic compound comprises a guar gum. 20. Composition according to claim 19, characterized in that the hydrophilic compound comprises a gluten-free guar gum. 21. Composition according to any one of claims 17 to 20, characterized in that it further comprises at least one essential oil in a predetermined proportion. 22. Composition according to any one of claims 17 to 21, characterized in that it also comprises at least one enzyme in a predetermined proportion. 23. Composition according to any one of claims 17 to 22, characterized in that it further comprises mineral and / or metallic particles in predetermined proportions.