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FR3016888B1 - Synthetases de la colistine et cluster de genes correspondants - Google Patents

Synthetases de la colistine et cluster de genes correspondants Download PDF

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Publication number
FR3016888B1
FR3016888B1 FR1450641A FR1450641A FR3016888B1 FR 3016888 B1 FR3016888 B1 FR 3016888B1 FR 1450641 A FR1450641 A FR 1450641A FR 1450641 A FR1450641 A FR 1450641A FR 3016888 B1 FR3016888 B1 FR 3016888B1
Authority
FR
France
Prior art keywords
adenylation
colistine
synthetases
cluster
corresponding genes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1450641A
Other languages
English (en)
Other versions
FR3016888A1 (fr
Inventor
Romain Chevrot
Fatoumata Tambadou
Thibault Caradec
Sandrine Didelot
Cyrille Barthelemy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
La Rochelle Universite
Original Assignee
Centre National de la Recherche Scientifique CNRS
La Rochelle Universite
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, La Rochelle Universite filed Critical Centre National de la Recherche Scientifique CNRS
Priority to FR1450641A priority Critical patent/FR3016888B1/fr
Priority to US15/113,978 priority patent/US10246697B2/en
Priority to JP2016565583A priority patent/JP6637904B2/ja
Priority to EP15704379.5A priority patent/EP3099790A2/fr
Priority to CA2944826A priority patent/CA2944826A1/fr
Priority to PCT/IB2015/050571 priority patent/WO2015111013A2/fr
Publication of FR3016888A1 publication Critical patent/FR3016888A1/fr
Application granted granted Critical
Publication of FR3016888B1 publication Critical patent/FR3016888B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Synthétase PmxA impliquée dans la synthèse de polymyxine E, comprenant quatre sites d'adénylation, caractérisée en ce que le second site d'adénylation présente au moins 90% d'identité avec la séquence peptidique SEQ ID NO 1 : VTEAEKADLLGRFNDTTTEFPRGKTLIQLFEEQVERIPDAAAITLNEQE LTYRELNERVNRLARTLRSHGISKGRLVAILAERSIEMVVGMLAAHKAGAAYVPI DPEYPEERIRFLIED S GGQVMLTQ SRLRERLAGSDPVILLDDE SF YHEDGTNLNT GI EATDLACVIYT SGTTGKPKGNPV SHRNIVRVVQNTNYIDITERDHVLQL S S Y SFDG ATFDIFGALTNGARLVLVPYETLLEIGRLADLIQRERISVMFITTAFFNILVDVNVD CLRDVRAILF GGERV S VGHVRKALAHIGPGRLNHVYGPTESTVYTTYLPVDF VDE LAVTVPIGRPISNTTVYIVDSRNKLLPIGVAGELCVGGEGLVRGYNNRPELTAEKF VDNPFVPGERMYRTGDLAKWLPDGTIEYVGRTDDQVKIRGFRIELGEIEAQLQKV EGIRKTTVFARENASGEKQLCAYYEADCELPAAELKSVLSKELPAYMIPAYLIQLE RLPLTTNGKVDRRSLPAPEESLQPGGG, les acides aminés soulignés DGFFLGVVYK étant conservés et formant une poche de liaison spécifique pour un résidu leucine ou isoleucine.
FR1450641A 2014-01-27 2014-01-27 Synthetases de la colistine et cluster de genes correspondants Expired - Fee Related FR3016888B1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR1450641A FR3016888B1 (fr) 2014-01-27 2014-01-27 Synthetases de la colistine et cluster de genes correspondants
US15/113,978 US10246697B2 (en) 2014-01-27 2015-01-26 Colistin synthetases and corresponding gene cluster
JP2016565583A JP6637904B2 (ja) 2014-01-27 2015-01-26 コリスチンシンセターゼ及び対応する遺伝子のクラスター
EP15704379.5A EP3099790A2 (fr) 2014-01-27 2015-01-26 Synthetases de la colistine et cluster de genes correspondants
CA2944826A CA2944826A1 (fr) 2014-01-27 2015-01-26 Synthetases de la colistine et cluster de genes correspondants
PCT/IB2015/050571 WO2015111013A2 (fr) 2014-01-27 2015-01-26 Synthetases de la colistine et cluster de genes correspondants

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1450641A FR3016888B1 (fr) 2014-01-27 2014-01-27 Synthetases de la colistine et cluster de genes correspondants

Publications (2)

Publication Number Publication Date
FR3016888A1 FR3016888A1 (fr) 2015-07-31
FR3016888B1 true FR3016888B1 (fr) 2021-01-22

Family

ID=50489336

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1450641A Expired - Fee Related FR3016888B1 (fr) 2014-01-27 2014-01-27 Synthetases de la colistine et cluster de genes correspondants

Country Status (6)

Country Link
US (1) US10246697B2 (fr)
EP (1) EP3099790A2 (fr)
JP (1) JP6637904B2 (fr)
CA (1) CA2944826A1 (fr)
FR (1) FR3016888B1 (fr)
WO (1) WO2015111013A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111041037B (zh) * 2019-12-23 2022-08-23 天津大学 一种调控多粘菌素b同系物组分的方法
US11913731B2 (en) 2021-01-08 2024-02-27 Sanisure, Inc. Process cooling rod
EP4330269A2 (fr) * 2021-04-27 2024-03-06 The Rockefeller University Macolacines et leurs procédés d'utilisation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2242335A1 (fr) 1996-11-15 1998-05-22 Pathogenesis Corporation Colistine pure et biologiquement active, ses composants et formulation de colistine servant a traiter des infections pulmonaires
US8329430B2 (en) * 2005-12-09 2012-12-11 Korea Research Institute Of Bioscience And Biotechnology Polymyxin synthetase and gene cluster thereof
FI20085469A0 (fi) 2008-02-08 2008-05-16 Northern Antibiotics Oy Polymyksiinijohdannaiset, joissa on lyhyt rasvahappohäntä, ja niiden käyttöjä
US8193148B2 (en) * 2008-02-08 2012-06-05 Northern Antibiotics Ltd. Short fatty acid tail polymyxin derivatives and uses thereof

Also Published As

Publication number Publication date
JP2017503528A (ja) 2017-02-02
WO2015111013A3 (fr) 2015-12-23
EP3099790A2 (fr) 2016-12-07
CA2944826A1 (fr) 2015-07-30
JP6637904B2 (ja) 2020-01-29
US20160348088A1 (en) 2016-12-01
US10246697B2 (en) 2019-04-02
FR3016888A1 (fr) 2015-07-31
WO2015111013A2 (fr) 2015-07-30

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FR3016888B1 (fr) Synthetases de la colistine et cluster de genes correspondants

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