FR3007652A1 - COMPOSITION COMPRISING DOCOSAHEXAENOIC ACID AND PENTAERYTHRITYL TETRA-DI-T-BUTYL HYDROXYHYDROCINNAMATE - Google Patents

Abstract

The invention relates to a composition comprising, in a physiologically acceptable medium, docosahexaenoic acid and pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate. The invention also relates to a non-therapeutic cosmetic method for the care of keratinous substances, such as the skin, comprising the topical application to these keratin materials, of this composition.

Description

The present invention relates to a composition comprising docosahexaenoic acid and at least one antioxidant, in particular pentaerythrityl tetra-di-tbutylhydroxyhydrocinnamate, and a cosmetic treatment method for the care of keratin materials, such as the skin.

Polyunsaturated fatty acids, such as docosahexaenoic acid, are known to be very sensitive to oxidation, so they must be protected with antioxidants, in particular to avoid developing an unpleasant odor, such as a rancid odor or fish odor, which , when they are included in a composition, makes it unacceptable its use for the users. Natural oils of plant, marine or fish origin containing polyunsaturated fatty acids, especially high content, are affected by the same problem, they must also be protected from oxidation. The use of different antioxidants has been described to protect certain polyunsaturated fatty acids but without any differentiation of their potential efficacy, or their specific use for docosahexaenoic acid. However, there is a need to effectively protect this docosahexaenoic acid, and / or the natural oil comprising it, when it is formulated in a composition, in particular a cosmetic composition.

The object of the present invention is therefore to provide a composition comprising docosahexaenoic acid, in particular included in Ulkenia oil, having improved stability and exhibiting no or a slight odor variation of the composition, and which is not prohibitive for its cosmetic use.

The object of the invention is to propose the best possible protection of docosahexaenoic acid, and more specifically of the Ulkenia oil comprising it, which are included in a composition, in particular a cosmetic composition. In this respect the Applicant has surprisingly and unexpectedly discovered that the stability of such a composition is improved by combining docosahexaenoic acid, included in particular in Ulkenia oil, pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate as described below. Such a composition has a good protection of docosahexaenoic acid and has a very low variation of the olfaction over time.

More specifically, the invention therefore relates to a composition comprising, in a physiologically acceptable medium, docosahexaenoic acid and pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate.

The subject of the invention is also a non-therapeutic cosmetic treatment method for the care of keratin materials, such as the skin, comprising the application to the skin of a composition as described above.

The term "keratin materials" according to the invention is intended to mean the skin, the body, the face and / or the eye, the lips, the nails, the mucous membranes, the eyelashes, the eyebrows, the hairs, the scalp and / or the skin. hair, or any other skin area of the body. More particularly, the keratin materials according to the invention are the scalp, the hair, and / or the skin. Preferably, the keratin materials according to the invention are the scalp and / or the hair. Preferably the keratin materials according to the invention is the skin. By "the skin" is meant all of the skin of the body, and the scalp and preferably, the skin of the face, décolleté, neck, arms and forearms, or even more preferably the skin of the face (especially the forehead, nose, cheeks, breast), the neckline and the neck. The compositions according to the invention may be cosmetic or dermatological compositions. Preferably a composition according to the invention is a cosmetic composition. The composition according to the invention comprises a physiologically acceptable medium. For the purposes of the present invention, the term "physiologically acceptable medium" means a medium suitable for the administration of a composition by the topical route, and compatible with all keratin materials such as the skin, the scalp, the nails, mucous membranes, eyes and hair, or any other cutaneous zone of the body A physiologically acceptable medium may be a dermatologically or cosmetically acceptable medium, it is preferably a cosmetically acceptable medium, that is to say without odor or appearance unpleasant, and does not generate tingling, tightness or redness unacceptable to the user. Preferably, the composition according to the invention is suitable for topical administration on keratin materials. In particular, the composition according to the invention is suitable for topical application to the skin. By "care" is meant a non-therapeutic care that can produce an aesthetic effect without preventing or correcting a pathological dysfunction of the skin of the body.

In the context of the present invention the amounts of compounds indicated correspond to amounts of active material. The docosahexaenoic acid included in the compositions according to the invention (or DHA) is a polyunsaturated omega-3 fatty acid corresponding to the acid (4Z, 7Z, 10Z, 13Z, 16Z, 19Z) -docosa-4,7,10 , 13,16,19-hexaenoic, CAS number 6217-54-5. More particularly, a composition according to the invention comprising, in a physiologically acceptable medium, docosahexaenoic acid, which is included in Ulkenia oil, and pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate.

In a preferred manner, the docosahexaenoic acid is included in the oil of Ulkenia Amoeboidea. Ulkenia oil, or Ulkenia sp., Used according to the invention is produced from a renewable source, in particular a micro-seaweed of marine origin Ulkenia Amoeboidea, during a controlled process in vats. fermentation. Ulkenia Oil, especially Ulkenia Amoeboidea oil, is very rich in omega-3 fatty acids, especially docosahexaenoic acid (DHA). Advantageously, the Ulkenia oil according to the invention is an oil of Ulkenia Amoeboidea. Such an oil of Ulkenia Amoeboidea according to the invention is for example sold under the name DHAID® CL-400 by the company Lonza, in which the concentration of active ingredient of Ulkenia oil is 80%. It may also be marketed under the name DHAID® FNO-350 by the company Lonza. It may also be marketed under the name DHAID® DRY by Lonza.

The Ulkenia oil according to the invention can be obtained by a single, multi-stage vat fermentation process. Ulkenia Amoeboidea microalgae are grown in large quantities to accumulate significant volumes of DHA or docosahéxanoic acid. The active ingredient is then extracted from the dried micro-algae and refined using processes similar to those used for traditional vegetable oils.

The Ulkenia oil according to the invention can be obtained in particular by the process of obtaining described in the patent application WO2006069668. The Ulkenia oil as defined above may be present in the composition according to the invention at a content of between 0.0001% and 40% by weight of active material relative to the total weight of the composition, preferably between 0.001 and 20% by weight of active material, in particular between 0.001% and 10% by weight of active material, more particularly between 0.01% and 2% by weight of active material, more preferably between 0.05 and 2% by weight. % by weight of active material relative to the total weight of the composition. Preferably the Ulkenia oil according to the invention is present in the cosmetic composition at a content of 0.1 and 2% by weight of active material relative to the total weight of the composition. According to one aspect of the invention, the Ulkenia oil according to the invention, in particular Ulkenia Amoeboidea oil, preferably comprises docosahéxanoic acid with a content greater than 10% by weight relative to the total weight. components of said Ulkenia oil, preferably at a content of greater than 25% by weight, and more particularly at a content of greater than 40% by weight relative to the total weight of the components of said Ulkenia oil. . More preferably, the Ulkenia oil in accordance with the invention, in particular Ulkenia Amoeboidea oil, comprises docosahéxanoic acid at a content equal to approximately 40% by weight relative to the total weight of the components of said Ulkenia oil. According to another aspect of the invention, the Ulkenia oil in accordance with the invention, in particular Ulkenia Amoeboidea oil, comprises docosahexanoic acid in a content of between 30 and 60% by weight relative to the total weight of the components of said Ulkenia oil, particularly at a content of between 35% and 50%, and more particularly at a content of between 35% and 45% by weight relative to the total weight of the components of said oil of 'Ulkenia. According to another aspect of the invention preferably docosahexaenoic acid according to the invention is present in a content of between 0.00004% and 16% by weight, in particular between 0.0004 and 8% by weight, in particular between 0.0004% and 0.8% by weight, more preferably between 0.002% and 0.4% by weight relative to the total weight of the composition.

Pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate or dibutyl pentaerithrityl tetrahydroxycinnamate is a compound, which belongs to the family of cinnamic acids and their derivatives, CAS number 6683-19-8. By way of example, the pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate compound is marketed by BASF under the name Tinogard TT®.

The composition according to the invention comprises pentaerythrityl tetra-di-tert-butylhydroxyhydrocinnamate which may be present in a content of between 0.0001% and 10% by weight, in particular between 0.001% and 2% by weight, more particularly between 0%. , 01% and 1% by weight, more preferably between 0.05% and 0.5% by weight relative to the total weight of the composition. Preferably, the composition according to the invention is a topical cometic composition comprising pentaerythrityl tetra-di-t-butylhydroxyhydrocinnamate at a content of between 0.05% and 0.5% by weight relative to the total weight of the composition, and Ulkenia Amoeboidea oil at a content of between 0.1 and 2% by weight in active manner relative to the total weight of the composition, said Ulkenia oil comprising docosahexaenoic acid present at a content between 35 and 45% by weight relative to the total weight of the components of said Ulkenia oil. The composition according to the invention may comprise water which may be present in a content ranging from 5% to 80% by weight, relative to the total weight of the composition, and preferably ranging from 35% to 75% by weight. .

The composition used according to the invention may be in any galenical form normally used in the cosmetic and dermatological fields; it may especially be in the form of an aqueous solution, hydroalcoholic, optionally gelled, a dispersion of the lotion type possibly two-phase, an oil-in-water or water-in-oil or multiple emulsion, an aqueous gel , an oil dispersion in an aqueous phase using spherules, these spherules may be polymeric nanoparticles such as nanospheres and nanocapsules or, better, lipid vesicles of ionic and / or nonionic type. Advantageously, the composition is an oil-in-water emulsion.

When the composition is an emulsion, the proportion of the fatty phase can range from 5 to 80% by weight, and preferably from 5 to 50% by weight relative to the total weight of the composition. The oils and emulsifiers used in the composition in emulsion form are chosen from those conventionally used in the field under consideration. The emulsifier is present in the composition in a proportion ranging from 0.3 to 30% by weight, and preferably from 0.5 to 20% by weight relative to the total weight of the composition. This composition may be more or less fluid and have the appearance of a white or colored cream, an ointment, a milk, a lotion, a serum, a paste, a mousse . It can optionally be applied to the skin in the form of an aerosol. It can also be in solid form, and for example in the form of a stick.

The compositions according to the invention may be in any of the galenical forms conventionally used for topical application and especially in the form of aqueous, hydroalcoholic, oil-in-water (O / W) or water-in-oil emulsions (E / H) or multiple (triple: E / H / E or H / E / H), aqueous gels, or dispersions of a fatty phase in an aqueous phase using spherules, these spherules may be lipid vesicles ionic and / or nonionic type (liposomes, niosomes, oleosomes). These compositions are prepared according to the usual methods. The compositions according to the invention may also be in anhydrous form, for example in the form of an oil. The term "anhydrous composition" means a composition containing less than 1% by weight of water, or even less than 0.5% of water, and especially free of water, the water not being added during the preparation of the composition but corresponding to the residual water provided by the mixed ingredients.

Advantageously, the compositions according to the invention are in the form of a gel, or an emulsion, a powder or a paste. In addition, the composition according to the invention may be more or less fluid and have the appearance of a white or colored cream, an ointment, a milk, a lotion, a serum, a paste, a foaming gel, a treatment, a tonic or a mousse. Advantageously, the composition according to the invention can be transparent. It can optionally be applied to the skin in the form of an aerosol. It can also be in solid form, and for example in the form of a stick. The compositions used according to the invention may comprise an oily phase.

For the purposes of the invention, the term "oily phase" is intended to mean a phase comprising at least one oil and all the liposoluble and lipophilic ingredients and fatty substances used for the formulation of the compositions of the invention. The term "oil" means any fatty substance in liquid form at ambient temperature (20 ° C.) and at atmospheric pressure (760 mmHg).

As oils that can be used in the composition of the invention, mention may be made, for example, of: hydrocarbon-based oils of animal origin, such as perhydrosqualene; hydrocarbon oils of plant origin, such as liquid triglycerides of fatty acids containing from 4 to 10 carbon atoms, for instance triglycerides of heptanoic or octanoic acids or, for example, sunflower, corn, soya, squash, grape seed, sesame, hazelnut, apricot, macadamia, arara, sunflower, castor oil, avocado, caprylic / capric acid triglycerides as sold by the company Stearineries Dubois or those sold under the names Miglyol 810, 812 and 818 by the company CREMER OLEO, jojoba oil, shea butter oil; esters and synthetic ethers, in particular of fatty acids, such as the oils of formulas R'COOR2 and R'OR2 in which R 'represents the residue of a fatty acid containing from 8 to 29 carbon atoms, and R2 represents a hydrocarbon chain, branched or unbranched, containing from 3 to 30 carbon atoms, for example Purcellin oil, isononyl isononanoate, isopropyl myristate, 2-ethylhexyl palmitate, octyl-2-dodecyl stearate, octy-2-dodecyl erucate, isostearyl isostearate; hydroxyl esters such as isostearyl lactate, octyl hydroxystearate, octyldodecyl hydroxystearate, diisostearyl malate, triisocetyl citrate, heptanoates, octanoates, decanoates of fatty alcohols; polyol esters, such as propylene glycol dioctanoate, neopentyl glycol diheptanoate and diethylene glycol diisononanoate; and pentaerythritol esters such as pentaerythrityl tetraisostearate; linear or branched hydrocarbons of mineral or synthetic origin, such as paraffin oils, volatile or not, and their derivatives, petroleum jelly, polydecenes, hydrogenated polyisobutene such as parleam oil; fatty alcohols having from 8 to 26 carbon atoms, such as cetyl alcohol, stearyl alcohol and their mixture (cetylstearyl alcohol), octyldodecanol, 2-butyloctanol, 2-hexyldecanol, 2-undecylpentadecanol, oleic alcohol or linoleic alcohol; partially fluorinated hydrocarbon oils and / or silicone oils such as those described in document JP-A-2-295912; silicone oils such as volatile or non-volatile polymethylsiloxanes (PDMS) with a linear or cyclic silicone chain, which are liquid or pasty at room temperature, in particular cyclopolydimethylsiloxanes (cyclomethicones) such as cyclohexasiloxane; poly-dimethylsiloxanes comprising alkyl, alkoxy or phenyl groups, during or at the end of the silicone chain, groups having from 2 to 24 carbon atoms; phenyl silicones such as phenyltrimethicones, phenyldimethicones, phenyltrimethylsiloxydiphenylsiloxanes, diphenyl-dimethicones, diphenylmethyldiphenyltrisiloxanes, 2-phenylethyltrimethylsiloxysilicates, and polymethylphenylsiloxanes; - their mixtures. By hydrocarbon oil is meant in the list of oils mentioned above, any oil predominantly comprising carbon and hydrogen atoms, and optionally ester, ether, fluoro, carboxylic acid and / or alcohol groups. The other fatty substances that may be present in the oily phase are, for example, fatty acids containing from 8 to 30 carbon atoms, such as stearic acid, auric acid, palmitic acid and oleic acid; such as lanolin, beeswax, carnauba or candelilla wax, paraffin waxes, lignite waxes or micro-crystalline waxes, ceresin or ozokerite, synthetic waxes such as polyethylene waxes, Fischer-Tropsch waxes, silicone resins such as trifluoromethyl-C1-4-alkyldimethicone and trifluoropropyldimethicone, and silicone elastomers such as the products sold under the names KSG by Shin-Etsu under the names "Trefil" "," BY29 "or" EPSX "by the company Dow Corning or under the names" Gransil "by the company Grant Industries.These fats can be chosen in a variety of ways by those skilled in the art to prepare a c omposition having the properties, for example of consistency or texture, desired.

According to a particular embodiment of the invention, the composition according to the invention is a water-in-oil (W / O) or oil-in-water (O / W) emulsion, or a triple water / oil / water emulsion. Water. The proportion of the oily phase of the emulsion can range from 5 to 90% by weight, and preferably from 5 to 60% by weight relative to the total weight of the composition. The emulsions generally contain at least one emulsifier chosen from amphoteric, anionic, cationic or nonionic emulsifiers, used alone or as a mixture, and optionally a co-emulsifier. The emulsifiers are suitably selected according to the emulsion to be obtained (W / O or O / W). The emulsifier and the coemulsifier are generally present in the composition, in a proportion ranging from 0.3 to 30% by weight, and preferably from 0.5 to 20% by weight relative to the total weight of the composition. For W / O emulsions, examples of emulsifiers that may be mentioned include dimethicone copolyols such as the mixture of cyclomethicone and dimethicone copolyol, sold under the name "DC 5225 C" by Dow Corning, and the alkyl-dimethicone copolyols. lyols such as Laurylmethicone copolyol sold under the name "Dow Corning 5200 Formulation Aid" by Dow Corning and Cetyl dimethicone copolyol sold under the name Abil EM 90R by Goldschmidt. It is also possible to use, as surfactant of W / O emulsions, a crosslinked solid elastomeric organopolysiloxane comprising at least one oxyalkylene group, such as those obtained according to the procedure of Examples 3, 4 and 8 of US Pat. No. 5,412,004 and examples US-A-5,811,487, especially the product of Example 3 (synthetic example) of US-A-5,412,004, and such as that sold under the reference KSG 21 by Shin Etsu. Examples of O / W emulsions which may be mentioned as emulsifiers are nonionic emulsifiers such as oxyalkylenated fatty acid and glycerol esters (more particularly polyoxyethylenated); oxyalkylenated fatty acid and sorbitan esters; oxyalkylenated fatty acid esters (oxyethylenated and / or oxypropylenated); oxyalkylenated fatty alcohol ethers (oxyethylenated and / or oxypropylenated); sugar esters such as sucrose stearate; and mixtures thereof such as the mixture of glyceryl stearate and PEG-40 stearate. The composition according to the invention may also contain adjuvants which are customary in the cosmetic field, such as hydrophilic or lipophilic gelling agents, preservatives, water, solvents, perfumes, fillers, waxes, pasty fatty substances, sun protection or UV filter, odor absorbers, dyestuffs, basic agents, acids, sequestering agents, polyols, nonionic, anionic, cationic surfactants. The amounts of these various adjuvants are those conventionally used in the field in question, and for example from 0.01 to 20% of the total weight of the composition. These adjuvants, depending on their nature, can be introduced into the fatty phase, into the aqueous phase and / or into the lipid vesicles. The compositions according to the invention may further comprise at least one aqueous phase.

The aqueous phase contains water, and optionally other organic solvents that are soluble or miscible with water. An aqueous phase that is suitable for the invention may comprise, for example, a water chosen from natural spring water, such as La Roche-Posay water, Vittel water, or Vichy waters, or water. floral.

Of course, those skilled in the art will take care to choose this or these optional ingredients and / or additional active ingredients, and / or their quantity, in such a way that the advantageous properties of an Ulkenia oil according to the invention are not , or substantially not, impaired by the addition contemplated.

The compositions according to the invention may be applied directly to the skin or, alternatively, to occlusive or non-occlusive type cosmetic supports intended to be applied in a localized manner to the skin. As examples of non-limiting cosmetic media, there may be mentioned a patch, a wipe, a roll-on and a pen.

The composition according to the present invention may comprise, according to a particular embodiment, in addition to the Ulkenia oil as defined above, at least one additional active ingredient for the care of keratinous substances, and more particularly of the skin.

The compositions of the invention may contain additional active agents chosen from antioxidants, dermo-relaxants or dermodecontracting agents, anti-aging agents, depigmenting agents, anti-glycation agents, stimulating agents and the synthesis of macromolecules. dermal or epidermal agents and / or preventing their degradation, agents stimulating proliferation of fibroblasts or keratinocytes and / or differentiation of keratinocytes, agents promoting the maturation of the horny envelope, inhibitors of NO synthase, stimulating agents energy metabolism of cells and desquamating agents.

The additional asset for the care of keratin materials, such as the skin, used in the composition according to the invention may represent from 0.0001% to 20%, preferably from 0.01% to 10% and better still, from 0.01% to 5% by weight relative to the total weight of the composition.

The cosmetic composition can be rinsed or not after being applied to the skin. Furthermore, after application of the cosmetic composition according to the invention, it is possible to apply to the surface of the skin a composition comprising one or more active agents chosen from antibacterials, antifungals and / or powders.

According to a particular embodiment of the invention, it is also possible to add other agents to the appearance and / or the texture of the skin in the composition that is suitable for the invention. Preferably, the composition according to the invention is a composition in the form of an oil-in-water emulsion. The composition used according to the invention may be intended for a cosmetic application. It can be used for the care or makeup of keratin materials.

The invention also relates to a non-therapeutic cosmetic treatment method for the care of keratin materials, such as the skin, comprising the application to the skin of a composition as described above. Preferably, a method according to the invention comprises topical administration, that is to say by surface application of the keratin material in question, and more particularly of the skin in question. Preferably, a method according to the invention comprises the topical application of a composition according to the invention on the skin, in particular on the skin of the face.

Throughout the description, including the claims, the phrase "having one" should be understood as being synonymous with "having at least one", unless the opposite is specified.

The expressions "more than", "between ... and ..." and "from ... to ..." must be understood to include limits, unless the opposite is specified. The expression "greater than" must be understood to be an included bound, that is, "greater than or equal to".

The following examples and figures are presented for illustrative and non-limiting purposes of the invention. The compounds are, as the case may be, listed in chemical names or CTFA names (International Cosmetic Ingredient Dictionary and Handbook). The following examples illustrate the invention.

EXAMPLE 1 Compositions according to the invention in the form of an oil-in-water emulsion for the care of the skin by topical application. The process for obtaining these compositions prepared in the form of an oil-in-water emulsion comprises various stages: 1 / In the manufacturing tank, heat phase A at 75 ° C. until all the raw materials have been solubilized. 2 / In an additional tank, heat phase B to 75 ° C until all solids are solubilized. 3 / At 75 ° C, introduce phase B into A. Emulsify for 10 minutes. 4 / At 75 ° C, introduce phase D and homogenize with vigorous stirring for 10 minutes. 5 / Cool to 25 ° C 6 / Below 40 ° C, introduce phase C and homogenize for 5 minutes with stirring. 7 / Stop production at 25 ° C. Two compositions in the form of an oil-in-water emulsion having the following compositions were prepared, the contents below being expressed in percentages by weight.

Phase Chemical name Composition A Composition BA WATER qsp A TETRA HYDROXYCINNAMATE OF DIBUTYL PENTAERITHRITYLE (TINOGARD TT® from BASF) 0.07 0.1 A CO-PRESERVATIVES 2.35 2.35 A GLYCERIN OF VEGETABLE ORIGIN, INCLUDING PALM 7 7 ACID ETHYLENE DIAMINE 0.15 0.15 TETRACETIC, SALT DISODIUM, 2 H2O TO CO-TENSIOACTIVE 0.8 0.8 B MIXTURE OF SORBITAN STEARATE, COCOATE OF SUCROSE 2.5 2.5 B ISO-HEXADECAN 3 3 B POLY DIMETHYLSILOXANE (VISCOSITY) : 10 CST) 7.7 7.7 C ULKENIA OIL Amoeboidea (DHAID CL-400® from Lonza) 0.625 0.625 D THICKENING POLYMERS 1.1 1.1 These compositions applied topically to keratin materials, such as the skin, allow a care these keratin materials, including a skin care.

Example 2 Predictive Oxidation Study In order to determine whether a compound makes it possible to provide optimum protection for the docosahexaenoic acid (or DHA) which is formulated in a composition, and thus also for the Ulkenia oil comprising it, it was determined if the composition shows an alteration of the odor according to the following protocol. Three compositions were prepared: one according to the invention (composition A) and two outside the invention (compositions C and D) described in the table below; Phase Chemical Name Composition A Composition Composition WATER qA qs qsp qs TETRA 0.07 HYDROXYCINNAMATE OF DIBUTYL PENTAERITHRITYLE (TINOGARD TT® from BASF) A DL-TOCOPHEROL (marketed under the name COPHEROL F 1300 CO by the company BASF) A CO-PRESERVATIVES 2.35 2.35 2.35 A GLYCERIN OF ORIGIN 7 7 7 VEGETABLE ACID PALM ETHYLENE DIAMINE 0.15 0.15 0.15 TETRACETIC, SALT DISODIUM, 2 H2O TO CO-TENSIOACTIVE 0.8 0.8 0, 8 B MIXTURE OF SORBITANE STEARATE, SUCROSE COCOATE 2,5 2,5 2,5 B ISO-HEXADECAN 3 3 3 B POLY DIM ETHYLSI LOXANE 7.7 7.7 7.7 (VISCOSITY: 10 CST) C OIL ULKENIA Amoeboidea (DHAID CL-400® from Lonza) 0.625 0.625 0.625 D THICKENING POLYMERS 1.1 1.1 1.1 The compositions tested comprise Ulkenia Amoeboidea oil comprising 40% min. in docosahéxanoic acid (marketed under the name DHAID CL-400® by Lonza), at a content of 80% by weight of active ingredient relative to the weight of the composition. DL-alpha-tocopherol or Vitamin E (marketed under the name COPHEROL F 1300 CO by the company BASF) is mentioned in the literature as being an antioxidant compound.

Each composition was stored for 1 year and 5 months at room temperature. After storage, the olfaction of the composition, which represents the stability and the oxidation state docosahexaenoic acid (or DHA) included in this composition, was evaluated. The following results were obtained: Composition C / No added antioxidant Composition D / Composition A / TETRA HYDROXYCINNAMATE DL-ALPHA-DIBUTYL TOCOPHEROL Composition / or Vitamin E PENTAERITHRITYLE An antioxidant compound added to the composition (marketed under the trademark - nation (marketed under the name TINOGARD TT® by the company BASF) COPHEROL F 1300 CO by the company BASF) Significant alteration Strong alteration - Olfactory evolution ac- Olfaction odor samples - Odor As- Odor of poison- able - Not The results obtained show that the compositions C and D respectively comprising no added antioxidant compound or DL-alpha-tocopherol at a temperature of about 1 year and 5 months at room temperature as determined by the test with Tocopherol. amount of 0.45% by weight relative to the total weight of the composition, associated with docosahexaenoic acid present at a content of about 40% by weight relative to the total weight of the components of Ulkenia oil, have a significant alteration of their odor which is not acceptable for a cosmetic composition. These results therefore show that in these compositions C and D, docosahexaneonic acid present in Ulkenia Amoeboidea oil is not stable in the odor and is not protected from oxidation. These results also show, surprisingly, that the composition comprising docosahexaenoic acid present at a content of 40% by weight relative to the total weight of the components of Ulkenia oil combined with pentaerythrityl tetra-di-t - Butyl hydroxyhydrocinnamate at a content of 0.07% by weight relative to the total weight of the composition, has a stable odor over time without any unacceptable odor. Unexpectedly pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate allows optimal stabilization in a cosmetic composition of docosahexaenoic acid included in the oil of Ulkenia Amoeboidea, avoiding an oxidation of it and any unacceptable odor of said composition .

Claims (13)

REVENDICATIONS1. A composition comprising, in a physiologically acceptable medium, docosahexaenoic acid and pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate. 2. Composition according to claim 1 characterized in that said docosahexaenoic acid is included in the oil of Ulkenia. 3. Composition according to any one of the preceding claims, characterized in that said Ulkenia oil is an oil of Ulkenia Amoeboidea. 4. Composition according to any one of claims 2 and 3, characterized in that the docosahexaenoic acid is present at a content greater than 10% by weight, preferably greater than 25% by weight, and more particularly greater than 40%. by weight relative to the total weight of the components of said Ulkenia oil. 5. Composition according to any one of claims 2 to 3, characterized in that the docosahexaenoic acid is present in a content of between 30% and 60% by weight, particularly between 35% and 50% by weight, more particularly between 35% and 45% relative to the total weight of the components of said Ulkenia oil. 6. Composition according to any one of claims 1 to 3, characterized in that the docosahexaenoic acid is present in a content of between 0.00004% and 16% by weight, in particular between 0.0004 and 8% by weight. in particular between 0.0004 and 4% by weight, more particularly between 0.0004% and 0.8% by weight, more preferably between 0.002 and 0.4% by weight relative to the total weight of the composition. 7. Composition according to any one of the preceding claims, characterized in that the composition is a cosmetic or dermatological composition. 8. Composition according to any one of the preceding claims, characterized in that said composition is suitable for topical administration. 9. Composition according to any one of claims 2 to 8, characterized in that said Ulkenia oil is present in the composition at a content between 0.0001% and 40% by weight of active material, preferably between 0.001%. and 20% by weight of active material, in particular between 0.001% and 10% by weight of active material, more particularly between 0.01% and 2% by weight of active material, more preferably between 0.05 and 2% by weight of active material, more preferably between 0.1 and 2% by weight of active material, relative to the total weight of the composition. 10. Composition according to any one of the preceding claims, characterized in that pentaerythrityl tetra-di-t-butylhydroxyhydrocinnamate is present in a content of between 0.0001% and 10% by weight, in particular between 0.001 and 2%. by weight, more particularly between 0.01% and 1% by weight, more preferably between 0.05% and 0.5% by weight relative to the total weight of the composition. 11. Composition according to any one of the preceding claims, characterized in that the said composition is a topical cometic composition comprising pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate at a content of between 0.05% and 0.5. % by weight relative to the total weight of the composition, and Ulkenia Amoeboidea oil at a content of between 0.1 and 2% by weight of active ingredient relative to the total weight of the composition, said oil of Ulkenia comprising docosahexaenoic acid present at a content of between 35 and 45% by weight relative to the total weight of the components of said Ulkenia oil. 12. Composition according to any one of the preceding claims, characterized in that it is in the form of oil-in-water emulsion. 13. Non-therapeutic cosmetic process for the care of keratin materials, such as the skin, characterized in that it comprises the topical application to these keratin materials of at least one composition according to any one of claims 1 to 11.