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FR3003171B1 - Nouveaux medicaments comprenant une composition d'anticorps enrichie en isoforme de charge majoritaire - Google Patents

Nouveaux medicaments comprenant une composition d'anticorps enrichie en isoforme de charge majoritaire

Info

Publication number
FR3003171B1
FR3003171B1 FR1352360A FR1352360A FR3003171B1 FR 3003171 B1 FR3003171 B1 FR 3003171B1 FR 1352360 A FR1352360 A FR 1352360A FR 1352360 A FR1352360 A FR 1352360A FR 3003171 B1 FR3003171 B1 FR 3003171B1
Authority
FR
France
Prior art keywords
antibody composition
enhanced antibody
novel medicaments
enforcement
majority load
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1352360A
Other languages
English (en)
Other versions
FR3003171A1 (fr
Inventor
Guillaume Chevreux
Nicolas Bihoreau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LFB SA
Original Assignee
LFB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR1352360A priority Critical patent/FR3003171B1/fr
Application filed by LFB SA filed Critical LFB SA
Priority to KR1020157029822A priority patent/KR20150132522A/ko
Priority to CN201480024699.3A priority patent/CN105163758B/zh
Priority to PCT/EP2014/055179 priority patent/WO2014140322A1/fr
Priority to CA2907358A priority patent/CA2907358A1/fr
Priority to EP14709977.4A priority patent/EP2968533A1/fr
Priority to MX2015012812A priority patent/MX2015012812A/es
Priority to BR112015023209A priority patent/BR112015023209A8/pt
Priority to AU2014230134A priority patent/AU2014230134A1/en
Priority to US14/776,725 priority patent/US20160046722A1/en
Priority to JP2015562236A priority patent/JP2016512216A/ja
Publication of FR3003171A1 publication Critical patent/FR3003171A1/fr
Application granted granted Critical
Publication of FR3003171B1 publication Critical patent/FR3003171B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Analytical Chemistry (AREA)
FR1352360A 2013-03-15 2013-03-15 Nouveaux medicaments comprenant une composition d'anticorps enrichie en isoforme de charge majoritaire Expired - Fee Related FR3003171B1 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FR1352360A FR3003171B1 (fr) 2013-03-15 2013-03-15 Nouveaux medicaments comprenant une composition d'anticorps enrichie en isoforme de charge majoritaire
AU2014230134A AU2014230134A1 (en) 2013-03-15 2014-03-14 Novel medicaments comprising an antibody composition enriched with predominant charge isoform
PCT/EP2014/055179 WO2014140322A1 (fr) 2013-03-15 2014-03-14 Nouveaux médicaments comprenant une composition d'anticorps enrichie en isoforme de charge majoritaire
CA2907358A CA2907358A1 (fr) 2013-03-15 2014-03-14 Nouveaux medicaments comprenant une composition d'anticorps enrichie en isoforme de charge majoritaire
EP14709977.4A EP2968533A1 (fr) 2013-03-15 2014-03-14 Nouveaux médicaments comprenant une composition d'anticorps enrichie en isoforme de charge majoritaire
MX2015012812A MX2015012812A (es) 2013-03-15 2014-03-14 Medicamentos novedosos que comprenden una composicion de anticuerpo enriquecida con isoforma de carga mayor.
KR1020157029822A KR20150132522A (ko) 2013-03-15 2014-03-14 주요 전하 아이소폼이 풍부한 항체 조성물을 포함하는 신규 의약품
CN201480024699.3A CN105163758B (zh) 2013-03-15 2014-03-14 包含富集主要电荷同工型的抗体组合物的药物
US14/776,725 US20160046722A1 (en) 2013-03-15 2014-03-14 Novel medicaments comprising an antibody composition enriched with predominant charge isoform
JP2015562236A JP2016512216A (ja) 2013-03-15 2014-03-14 主要電荷アイソフォームに富んだ抗体組成物を含む新規な薬剤
BR112015023209A BR112015023209A8 (pt) 2013-03-15 2014-03-14 novos medicamentos compreendendo uma composição de anticorpo enriquecida com uma carga principal de isoforma

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1352360A FR3003171B1 (fr) 2013-03-15 2013-03-15 Nouveaux medicaments comprenant une composition d'anticorps enrichie en isoforme de charge majoritaire

Publications (2)

Publication Number Publication Date
FR3003171A1 FR3003171A1 (fr) 2014-09-19
FR3003171B1 true FR3003171B1 (fr) 2015-04-10

Family

ID=48771615

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1352360A Expired - Fee Related FR3003171B1 (fr) 2013-03-15 2013-03-15 Nouveaux medicaments comprenant une composition d'anticorps enrichie en isoforme de charge majoritaire

Country Status (11)

Country Link
US (1) US20160046722A1 (fr)
EP (1) EP2968533A1 (fr)
JP (1) JP2016512216A (fr)
KR (1) KR20150132522A (fr)
CN (1) CN105163758B (fr)
AU (1) AU2014230134A1 (fr)
BR (1) BR112015023209A8 (fr)
CA (1) CA2907358A1 (fr)
FR (1) FR3003171B1 (fr)
MX (1) MX2015012812A (fr)
WO (1) WO2014140322A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013004841A1 (fr) * 2011-07-06 2013-01-10 Genmab A/S Modulation de la cytotoxicité dépendante du complément par des modifications de l'extrémité c-terminale des chaînes lourdes d'anticorps
WO2017192093A1 (fr) 2016-05-04 2017-11-09 Delaval Holding Ab Cartouche pour gobelet trayeur, et gobelet trayeur
FR3053688A1 (fr) 2016-07-06 2018-01-12 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Mutants fc a activite fonctionnelle amelioree
EP3498293A1 (fr) 2017-12-15 2019-06-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Traitement de maladies monogéniques avec un anticorps anti-cd45rc
EP3626265A1 (fr) 2018-09-21 2020-03-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Anticorps anti-cd45rc anti-humains et leurs utilisations
KR20210119448A (ko) 2019-01-23 2021-10-05 앙세파 Cd31 경쟁인자(competitor) 및 이의 용도
KR20220012263A (ko) * 2019-05-23 2022-02-03 리제너론 파아마슈티컬스, 인크. 항체의 도메인-특이적 전하 변이체의 특징규명
WO2021057726A1 (fr) * 2019-09-23 2021-04-01 南开大学 CRIBLAGE DE LIAISON SPÉCIFIQUE FC À FCγR AU MOYEN D'UNE PRÉSENTATION DE MAMMIFÈRES
JP2024535060A (ja) 2021-09-16 2024-09-26 アボレリス ファーマ 抗ヒトｃｄ４５ｒｃ結合ドメインおよびその使用
CN114236010A (zh) * 2021-12-18 2022-03-25 苏州莱奥生物技术有限公司 一种生物活性药物的药代动力学分析方法
CN115073548A (zh) * 2022-08-01 2022-09-20 上海蓝析生物技术有限公司 一种用于重组蛋白药物电荷异构体制备的缓冲体系

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX353234B (es) * 1999-01-15 2018-01-08 Genentech Inc Variantes de polipeptidos con función efectora alterada.
FR2807767B1 (fr) * 2000-04-12 2005-01-14 Lab Francais Du Fractionnement Anticorps monoclonaux anti-d
FR2844513B1 (fr) * 2002-09-13 2007-08-03 Lab Francais Du Fractionnement Anticorps pour adcc et induisant la production de cytokines.
ATE541857T1 (de) * 2002-09-27 2012-02-15 Xencor Inc Optimierte fc-varianten und herstellungsverfahren dafür
ES2524694T3 (es) * 2002-10-17 2014-12-11 Genmab A/S Anticuerpos monoclonales humanos contra CD20
US7355008B2 (en) * 2003-01-09 2008-04-08 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
FR2861078B1 (fr) * 2003-10-16 2007-09-21 Lab Francais Du Fractionnement NOUVELLES IgG3 UTILES POUR STIMULER LA PHAGOCYTOSE
IL296666A (en) * 2005-03-23 2022-11-01 Genmab As Antibodies against 38cd for the treatment of multiple myeloma
WO2013004841A1 (fr) * 2011-07-06 2013-01-10 Genmab A/S Modulation de la cytotoxicité dépendante du complément par des modifications de l'extrémité c-terminale des chaînes lourdes d'anticorps

Also Published As

Publication number Publication date
EP2968533A1 (fr) 2016-01-20
MX2015012812A (es) 2016-05-09
AU2014230134A1 (en) 2015-10-29
JP2016512216A (ja) 2016-04-25
KR20150132522A (ko) 2015-11-25
CA2907358A1 (fr) 2014-09-18
BR112015023209A2 (pt) 2017-07-18
FR3003171A1 (fr) 2014-09-19
CN105163758B (zh) 2017-11-17
WO2014140322A1 (fr) 2014-09-18
US20160046722A1 (en) 2016-02-18
BR112015023209A8 (pt) 2018-01-23
CN105163758A (zh) 2015-12-16

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