FR2969905A1 - Composition, useful for the nutrition of farm animals, as dietary supplement, and for preventing premature aging and protecting cells against damage caused by free radicals in farm animals, comprises aerial parts of nettle and apple pomace - Google Patents
Composition, useful for the nutrition of farm animals, as dietary supplement, and for preventing premature aging and protecting cells against damage caused by free radicals in farm animals, comprises aerial parts of nettle and apple pomace Download PDFInfo
- Publication number
- FR2969905A1 FR2969905A1 FR1150081A FR1150081A FR2969905A1 FR 2969905 A1 FR2969905 A1 FR 2969905A1 FR 1150081 A FR1150081 A FR 1150081A FR 1150081 A FR1150081 A FR 1150081A FR 2969905 A1 FR2969905 A1 FR 2969905A1
- Authority
- FR
- France
- Prior art keywords
- extract
- antioxidant composition
- nettle
- farm animals
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229950005143 sitosterol Drugs 0.000 description 1
- NLQLSVXGSXCXFE-UHFFFAOYSA-N sitosterol Natural products CC=C(/CCC(C)C1CC2C3=CCC4C(C)C(O)CCC4(C)C3CCC2(C)C1)C(C)C NLQLSVXGSXCXFE-UHFFFAOYSA-N 0.000 description 1
- 235000015500 sitosterol Nutrition 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 229960001462 sodium cyclamate Drugs 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- CWVRJTMFETXNAD-NXLLHMKUSA-N trans-5-O-caffeoyl-D-quinic acid Chemical compound O[C@H]1[C@H](O)C[C@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-NXLLHMKUSA-N 0.000 description 1
- PMKQSEYPLQIEAY-UHFFFAOYSA-N trans-caffeoyl-L-malic acid Natural products OC(=O)CC(C(O)=O)OC(=O)C=CC1=CC=C(O)C(O)=C1 PMKQSEYPLQIEAY-UHFFFAOYSA-N 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
- A23K10/37—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/179—Colouring agents, e.g. pigmenting or dyeing agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Food Science & Technology (AREA)
- Birds (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Physiology (AREA)
- Fodder In General (AREA)
Abstract
La présente invention concerne une composition antioxydante destinée à la nutrition des animaux d'élevage, caractérisée en ce qu'elle comprend des parties aériennes d'ortie et du marc de pomme. La présente invention concerne également un aliment pour animal d'élevage comprenant ladite composition anti-oxydante, destinée à être distribuée à l'animal en complément de la ration et ayant un effet antioxydant pour contribuer à la protection des constituants cellulaires contre les dommages oxydatifs.The present invention relates to an antioxidant composition for the nutrition of farm animals, characterized in that it comprises aerial parts of nettle and apple pomace. The present invention also relates to a feed for livestock comprising said antioxidant composition, intended to be distributed to the animal in addition to the diet and having an antioxidant effect to contribute to the protection of cellular constituents against oxidative damage.
Description
Domaine de l'invention : La présente invention se rapporte au domaine de la nutrition animale. En particulier, la présente invention concerne une composition antioxydante à base de parties aériennes d'ortie (Urtica dioica) et de marc de pomme (Malus sylvestris ou Pyrus malus) destinée à l'alimentation animale. La présente invention concerne également un aliment comprenant ladite composition antioxydante, ainsi que son utilisation dans la nourriture des animaux d'élevage pour contribuer à la protection de leurs constituants cellulaires contre les dommages oxydatifs. Field of the Invention: The present invention relates to the field of animal nutrition. In particular, the present invention relates to an antioxidant composition based on aerial parts of nettle (Urtica dioica) and apple pomace (Malus sylvestris or Pyrus malus) intended for animal feed. The present invention also relates to a food comprising said antioxidant composition, as well as its use in the feed of farm animals to contribute to the protection of their cellular constituents against oxidative damage.
Etat de la technique : Le stress oxydant est le déséquilibre entre la production de radicaux libres et les défenses antioxydantes. En conditions normales, les radicaux libres sont produits en permanence dans l'organisme d'un animal/mammifère et sont détruits par les défenses antioxydantes. Ce processus est nocif pour l'organisme et représente une cause importante des dommages des structures cellulaires, dont les lipides, les membranes, les protéines et l'ADN. Les radicaux libres, impliqués dans un grand nombre de réactions d'oxydoréduction, sont régulièrement générés en quantité nécessaire et suffisante à la survie de la cellule. Toutefois, chez l'animal, dans certaines situations physiologiques (gestation, lactation,...), pathologiques (infections, inflammations, stéatose hépatique,...) ou alimentaires (plan d'alimentation intensif, phase de restriction, acidose...), ainsi que dans certaines conditions de stress d'origine environnementale (climatique, physique, émotionnel,...), une production excessive de radicaux libres au sein de la cellule peut se produire. Cette augmentation peut être très préjudiciable pour l'intégrité des différents constituants cellulaires de l'animal et, en particulier, des lipides membranaires. L'exposition des cellules à ces radicaux libres a conduit l'organisme à développer une série de mécanismes de défense. Les mécanismes de défense contre les radicaux libres induits par le stress oxydatif concernent: des mécanismes de prévention, des mécanismes de réparation, des défenses physiques et des défenses antioxydantes. 2 Les défenses antioxydantes en particulier enzymatiques comprennent la superoxyde dismutase (SOD), la glutathion peroxydase (GPx), la catalase (CAT). Les principaux antioxydants non enzymatiques sont l'acide ascorbique (vitamine C), l'a-tocophérol (vitamine E), le glutathion (GSH), les caroténoïdes, les flavonoïdes et autres polyphénols. Les antioxydants, synthétisés par l'organisme ou apportés par l'alimentation, sont donc nécessaires à l'homéostasie de l'organisme pour éviter un déséquilibre des radicaux libres, ce déséquilibre entraînant l'altération de la santé de l'animal, et de ce fait également une détérioration des qualités nutritionnelles et organoleptiques de la viande et du lait issu de l'animal. Dans la pratique, la nourriture des animaux d'élevage et en particulier des ruminants, ne contient pas suffisamment de micronutriments à action antioxydante et il est nécessaire d'apporter une complémentation. Pour limiter ces phénomènes d'oxydation excessive consécutifs à une des situations particulières détaillées précédemment, il est préconisé d'apporter dans la ration des animaux, des additifs capables de limiter les réactions d'oxydation, soit en neutralisant les radicaux libres (avant que ceux-ci n'attaquent les constituants cellulaires), soit en empêchant la propagation des réactions d'oxydation une fois celles-ci amorcées. STATE OF THE ART Oxidative stress is the imbalance between the production of free radicals and the antioxidant defenses. Under normal conditions, free radicals are produced continuously in the body of an animal / mammal and are destroyed by antioxidant defenses. This process is harmful to the body and is an important cause of damage to cell structures including lipids, membranes, proteins and DNA. Free radicals, involved in a large number of redox reactions, are regularly generated in the amount necessary and sufficient for the survival of the cell. However, in animals, in certain physiological situations (pregnancy, lactation, ...), pathological (infections, inflammation, hepatic steatosis, ...) or food (intensive diet, restriction phase, acidosis .. .), as well as under certain conditions of stress of environmental origin (climatic, physical, emotional, ...), excessive production of free radicals within the cell can occur. This increase can be very detrimental to the integrity of the various cellular constituents of the animal and, in particular, membrane lipids. The exposure of cells to these free radicals has led the body to develop a series of defense mechanisms. Mechanisms of defense against free radicals induced by oxidative stress include: prevention mechanisms, repair mechanisms, physical defenses and antioxidant defenses. 2 Antioxidant defenses, in particular enzymatic, include superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT). The main non-enzymatic antioxidants are ascorbic acid (vitamin C), a-tocopherol (vitamin E), glutathione (GSH), carotenoids, flavonoids and other polyphenols. Antioxidants, synthesized by the body or brought by the diet, are therefore necessary for homeostasis of the body to avoid an imbalance of free radicals, this imbalance resulting in the deterioration of the health of the animal, and this also causes a deterioration of the nutritional and organoleptic qualities of the meat and milk derived from the animal. In practice, the food of farm animals and in particular ruminants, does not contain enough micronutrients with antioxidant action and it is necessary to provide a complementation. To limit these excessive oxidation phenomena consecutive to one of the particular situations detailed above, it is recommended to add to the ration of the animals, additives capable of limiting the oxidation reactions, or by neutralizing the free radicals (before those it does not attack the cellular constituents), either by preventing the propagation of oxidation reactions once these have been initiated.
L'additif antioxydant le plus employé en nutrition animale est la vitamine E, en raison notamment de sa spécificité d'action (en particulier vis-à-vis des lipides) et de son faible coût. Toutefois, l'apport en vitamine E présente des inconvénients car celle utilisée en nutrition animale est d'origine synthétique. Son activité antioxydante présente un effet seuil au-delà duquel la vitamine E peut être non seulement moins active, mais s'avérer au contraire pro-oxydante. Ensuite, la vitamine E n'intervient que dans un nombre limité d'étapes de la chaîne de réaction de peroxydation. L'invention a donc pour but de proposer une composition antioxydante pour animal et en particulier pour le ruminant, qui soit tout au moins aussi efficace que celles existantes sur le marché à l'heure actuelle. The antioxidant additive most used in animal nutrition is vitamin E, in particular because of its specific action (especially with regard to lipids) and its low cost. However, vitamin E intake has disadvantages because that used in animal nutrition is of synthetic origin. Its antioxidant activity has a threshold effect beyond which vitamin E can be not only less active, but instead be pro-oxidant. Then, vitamin E only intervenes in a limited number of stages of the peroxidation reaction chain. The invention therefore aims to provide an antioxidant composition for animals and in particular for ruminant, which is at least as effective as those existing on the market at present.
Description de l'invention : A cet effet, la présente invention a pour objet une composition antioxydante destinée à la nutrition des animaux d'élevage, caractérisée en ce qu'elle comprend des parties aériennes d'ortie et du marc de pomme. Description of the invention: For this purpose, the subject of the present invention is an antioxidant composition intended for the nutrition of farm animals, characterized in that it comprises aerial parts of nettle and apple pomace.
De préférence, les parties aériennes d'orties sont celles de Urtica dioica et le marc de pomme est issu d'un pommier sauvage, comme Malus sylvestris ou Pyrus malus. Le présent demandeur a découvert, de manière surprenante, que l'association d'un broyat de parties aériennes d'ortie (comme Urtica dioica) et de marc de pomme (comme Malus sylvestris, Pyrus malus...) présente une activité antioxydante supérieure à celle correspondante à la somme des activités de chacun des composants de cette composition. Celle-ci permet ainsi de réduire la quantité de radicaux libres, d'augmenter les défenses antioxydantes et de réduire les dommages cellulaires (protéines, lipides, ADN) liés au stress oxydant. La grande ortie (Urtica dioica L.) encore appelée ortie dioïque ou ortie commune convenant pour la présente invention, est une plante herbacée, vivace, de la famille des Urticacées et du genre Urtica. L'ortie se compose essentiellement de polyphénols, polysaccharides et minéraux (glucosides et rutinosides de quercétine, kaempférol et isorhamnétine, acide caffeoylmalique, acide chlorogénique, acide néochlorogénique, acide caféique, scopolétine (coumarine), sitostérol (-3-0-glucoside)). Cette plante est généralement utilisée pour des applications : alimentaires (salade, légume) aussi bien chez l'homme que l'animal, agricoles (purin de feuilles d'ortie pour tuer ou repousser les insectes et comme fertilisant), industrielles (fibres largement utilisées pour fabriquer des cordages, des fils et des vêtements), ou encore médicinales. Le marc de pomme issu par exemple des pommiers Malus sylvestris ou Pyrus malus est un sous-produit de la production du jus de pomme. Il est riche en fibres et en polyphénols. Il se compose essentiellement de cellulose, et contient des minéraux, tels que le zinc, le cuivre, le manganèse, le potassium et en moindre quantité du calcium, du phosphore et du magnésium. Preferably, the aerial parts of nettles are those of Urtica dioica and the apple pomace is derived from a wild apple tree, such as Malus sylvestris or Pyrus malus. The present Applicant has surprisingly discovered that the combination of a crushed aerial part of nettle (such as Urtica dioica) and apple pomace (such as Malus sylvestris, Pyrus malus, etc.) has superior antioxidant activity. to that corresponding to the sum of the activities of each of the components of this composition. This makes it possible to reduce the amount of free radicals, increase the antioxidant defenses and reduce the cellular damage (proteins, lipids, DNA) related to oxidative stress. The stinging nettle (Urtica dioica L.), also known as stinging nettle or common nettle suitable for the present invention, is a herbaceous perennial plant of the family Urticaceae and the genus Urtica. Nettle consists mainly of polyphenols, polysaccharides and minerals (quercetin glucosides and rutinosides, kaempferol and isorhamnetin, caffeoylmalic acid, chlorogenic acid, neochlorogenic acid, caffeic acid, scopoletin (coumarin), sitosterol (-3-O-glucoside)) . This plant is generally used for applications: food (salad, vegetable) both in humans and animals, agricultural (nettle leaf slurry to kill or repel insects and as fertilizer), industrial (widely used fiber) to make ropes, threads and clothes), or medicinal. Apple pomace, for example from Malus sylvestris or Pyrus malus apple trees, is a by-product of apple juice production. It is rich in fiber and polyphenols. It consists mainly of cellulose, and contains minerals, such as zinc, copper, manganese, potassium and lesser amounts of calcium, phosphorus and magnesium.
Préférentiellement, la composition anti-oxydante comprend en poids, par rapport au poids total de ladite composition, 0,1% à 85% de parties aériennes d'ortie et 0,1% à 85% de marc de pomme. De manière encore plus préférentielle, la composition anti-oxydante comprend en poids, par rapport au poids total de ladite composition, 10% à 65 %, de préférence de 15% à 35% de parties aériennes d'ortie et de 30% à 85%, de préférence 65% à 85% de marc de pomme. Avantageusement, la composition comprend en outre un des actifs ou extraits choisis parmi : des vitamines comme la vitamine E et C ; des caroténoïdes comme le bêta-carotène et la lutéine ; le coenzyme Q10 ; l'acide alpha-lipoïque ; des oligoéléments/ minéraux comme le sélénium, le chrome, le bore, le magnésium, le calcium, le fer, le molybdène ; l'extrait de romarin ; l'extrait de thym ; l'extrait de mélisse ; l'extrait de basilic ; l'extrait de thé ; l'extrait de tagète ; l'extrait de curcuma ; l'extrait d'ail ; l'extrait de raisin ; l'extrait de chardon marie ; l'extrait de baies ; l'extrait d'orthosiphon ; l'extrait de camu camu ; l'extrait d'ascophyllum ; des polyphénols, ou un de leurs mélanges. D'autres agents acceptables sur les plans pharmaceutique et/ou alimentaire peuvent être rajoutés à la composition antioxydante, tels que des agents de charge, des fluidisants, des extraits naturels, d'autres vitamines, des acides aminés, des acides gras, des anti-agglomérants, des huiles naturelles, des colorants, des acidifiants, des épaississants, des conservateurs, des édulcorants, des adjuvants, des colorants, des agents pour améliorer la croissance, des arômes, des céréales broyées, des semoules et/ou du son de blé. Preferably, the antioxidant composition comprises, by weight, relative to the total weight of said composition, 0.1% to 85% aerial parts of nettle and 0.1% to 85% of apple pomace. Even more preferably, the antioxidant composition comprises, by weight, relative to the total weight of said composition, from 10% to 65%, preferably from 15% to 35% aerial parts of nettle and from 30% to 85% by weight. %, preferably 65% to 85% of apple pomace. Advantageously, the composition further comprises one of the active agents or extracts chosen from: vitamins such as vitamin E and C; carotenoids such as beta-carotene and lutein; coenzyme Q10; alpha lipoic acid; trace elements / minerals such as selenium, chromium, boron, magnesium, calcium, iron, molybdenum; rosemary extract; thyme extract; melissa extract; basil extract; tea extract; tagete extract; turmeric extract; garlic extract; grape extract; the milk thistle extract; berry extract; orthosiphon extract; camu camu extract; ascophyllum extract; polyphenols, or a mixture thereof. Other pharmaceutically and / or food acceptable agents may be added to the antioxidant composition, such as bulking agents, fluidizers, natural extracts, other vitamins, amino acids, fatty acids, -Conductants, natural oils, colorants, acidifiers, thickeners, preservatives, sweeteners, adjuvants, colorants, agents for improving growth, flavorings, ground cereals, semolina and / or bran corn.
Les charges sont avantageusement la cellulose microcristalline, la maltodextrine de pomme de terre ou de maïs. L'épaississant utilisé de préférence est l'amidon de pomme de terre, l'hydroxypropylméthylcellulose, la pectine de citrus, la gomme de guar, de caroube, l'agar-agar, le konjac, les huiles hydrogénées, la cire d'abeille. The fillers are advantageously microcrystalline cellulose, maltodextrin potato or corn. The thickener preferably used is potato starch, hydroxypropyl methylcellulose, citrus pectin, guar gum, locust bean, agar-agar, konjac, hydrogenated oils, beeswax .
Les fluidisants peuvent être du silicate de magnésium, du stéarate de magnésium, de la silice colloïdale. The fluidizers may be magnesium silicate, magnesium stearate, colloidal silica.
Les anti-agglomérants sont ceux utilisés usuellement dans l'industrie alimentaire, tels que le stéarate de magnésium, la silice colloïdale. Les autres vitamines sont choisies parmi, entre autres, les vitamines B6, B1, B2, B3, B5, B8. Anti-caking agents are those usually used in the food industry, such as magnesium stearate, colloidal silica. The other vitamins are selected from, among others, vitamins B6, B1, B2, B3, B5, B8.
En tant qu'acidifiant, de l'acide citrique peut être utilisé dans la composition selon la présente invention. Les stabilisants employés dans la fabrication de ladite composition sont ceux usuellement utilisés dans l'industrie alimentaire, dérivés de sucre et de céréale, tels que le sorbitol. As an acid, citric acid may be used in the composition of the present invention. The stabilizers used in the manufacture of said composition are those usually used in the food industry, derived from sugar and cereals, such as sorbitol.
Les arômes qui peuvent être utilisés sont variés, tels que l'arôme de café, de citron, de pomme, de pêche, de chocolat, de vanille, de fraise. Les édulcorants utilisés sont, entre autres, l'inuline, le xylitol, l'aspartame, le sirop de glucose, le sirop de fructo-oligosaccharide, le maltitol en poudre ou en sirop, l'acésulfame de potassium, le fructooligosaccharide, le sucralose, la néohespéridine, les stéviosides et le cyclamate de sodium. Des acides gras peuvent également être ajoutés à la composition, tels que oméga 3, oméga 6, galactolipides, mais aussi des acides aminés, tels que tryptophane, leucine, arginine et glycine. Les conservateurs sont utiles afin que ladite composition se conserve dans le temps. Les conservateurs utilisés peuvent être par exemple le sorbate de potassium, les parabènes, le benzoate de sodium, l'acide citrique, l'acide benzoïque, le romarin ou le palmitate d'ascorbyle (antioxydant). Tous ces composés ne sont nullement limitatifs, des agents acceptables sur les plans pharmaceutique et/ou alimentaire pouvant être ajoutés à la composition antioxydante selon la présente invention. La composition antioxydante destinée à l'animal peut se présenter sous forme d'un complément ou supplément alimentaire, c'est-à-dire sous la forme d'une solution ou d'une suspension aqueuse à apporter dans l'eau de boisson ou un aliment liquide, ou à l'état sec de comprimé nus ou enrobés, de gélules, de dragées, de capsules, de poudre, de granules, de sticks, de pastilles, de pâte et toute autre forme d'apport à l'alimentation animale. The aromas that can be used are varied, such as aroma of coffee, lemon, apple, peach, chocolate, vanilla, strawberry. The sweeteners used are, inter alia, inulin, xylitol, aspartame, glucose syrup, fructo-oligosaccharide syrup, maltitol powder or syrup, acesulfame potassium, fructooligosaccharide, sucralose , neohesperidin, steviosides and sodium cyclamate. Fatty acids may also be added to the composition, such as omega 3, omega 6, galactolipids, but also amino acids, such as tryptophan, leucine, arginine and glycine. Preservatives are useful so that said composition is preserved over time. The preservatives used may be, for example, potassium sorbate, parabens, sodium benzoate, citric acid, benzoic acid, rosemary or ascorbyl palmitate (antioxidant). All of these compounds are in no way limiting, pharmaceutically and / or food acceptable agents may be added to the antioxidant composition of the present invention. The antioxidant composition intended for the animal may be in the form of a supplement or dietary supplement, that is to say in the form of a solution or an aqueous suspension to be introduced into the drinking water or a liquid food, or in the dry state of naked or coated tablets, capsules, dragees, capsules, powder, granules, sticks, lozenges, paste and any other form of food intake animal.
Le procédé de fabrication de la composition anti-oxydante comprend les étapes consistant à : - broyer et sécher les parties aériennes d'orties pour en récupérer une poudre - presser les pommes pour en récupérer le marc de pomme, - et mélanger simultanément ou non, la poudre d'ortie et le marc de pomme avec éventuellement d'autres actifs, tels que ceux mentionnés ci-dessus, afin d'obtenir un mélange homogène. Le marc de pomme obtenu comprend de préférence, de 150 mg à 600 mg/ 100 g de polyphénols totaux, et notamment de 200 mg à 300 mg. Lors d'une étape supplémentaire, les constituants de la composition antioxydante peuvent être stérilisés, notamment par chauffage avec ou sans pression et/ou par passage sur une membrane. Ces constituants peuvent également être désinfectés, notamment par chauffage avec ou sans pression ou encore par l'intermédiaire d'un agent désinfectant. The method of manufacturing the antioxidant composition comprises the steps of: - grinding and drying the aerial parts of nettles to recover a powder - squeezing the apples to recover the apple pomace, - and mix simultaneously or not, stinging powder and apple pomace with possibly other active ingredients, such as those mentioned above, to obtain a homogeneous mixture. The apple pomace obtained preferably comprises from 150 mg to 600 mg / 100 g of total polyphenols, and in particular from 200 mg to 300 mg. In an additional step, the constituents of the antioxidant composition can be sterilized, in particular by heating with or without pressure and / or by passage over a membrane. These constituents can also be disinfected, in particular by heating with or without pressure or by means of a disinfecting agent.
La présente invention a également pour but, l'utilisation de la composition anti-oxydante telle que décrite ci-dessus, pour prévenir le vieillissement prématuré des cellules et les protéger contre les dommages causés par les radicaux libres chez les animaux d'élevage, et en particulier chez le ruminant. La présente invention a aussi pour objet, l'utilisation de la composition anti-oxydante telle que décrite ci-dessus, pour être distribuée en complément d'une ration alimentaire et/ou d'une boisson d'un animal d'élevage du type polygastrique (bovin, ovin, caprin,...), ou monogastrique (porc, volaille, lapin,...). Comme mentionné ci-dessus et pour plus de facilité, la composition antioxydante peut se présenter sous la forme d'un complément alimentaire ou d'un supplément alimentaire. The present invention also aims at the use of the antioxidant composition as described above, for preventing the premature aging of cells and protecting them against damage caused by free radicals in farm animals, and especially in the ruminant. The present invention also relates to the use of the antioxidant composition as described above, to be distributed in addition to a food ration and / or a drink of a farm animal of the type polygastric (bovine, ovine, goat, ...), or monogastric (pork, poultry, rabbit, ...). As mentioned above and for convenience, the antioxidant composition may be in the form of a dietary supplement or a dietary supplement.
Un autre but de l'invention concerne un aliment pour animal, caractérisé en ce qu'il comprend la composition anti-oxydante telle que définie ci-dessus. Another object of the invention relates to an animal feed, characterized in that it comprises the antioxidant composition as defined above.
Outre la composition antioxydante, l'aliment comprend les ingrédients usuellement utilisés pour l'alimentation des animaux d'élevage, par exemple, du maïs, de la paille, du foin de luzerne pour une vache laitière ; des céréales, du foin pour une brebis... In addition to the antioxidant composition, the food includes the ingredients usually used for feeding farm animals, for example corn, straw, alfalfa hay for a dairy cow; cereals, hay for a sheep ...
De préférence, l'aliment en poids sec, par rapport au poids total de l'aliment à sec, est de l'ordre de 0,05 à 95 %, de préférence, de 0,002 à 2 % de la composition anti-oxydante. Les différents ingrédients de l'aliment antioxydant pour animal peuvent être apportés individuellement ou ensemble selon les facilités de fabrication. 10 Les exemples A à G selon la présente invention sont donnés à titre illustratif : Preferably, the food by dry weight, relative to the total weight of the dry food, is of the order of 0.05 to 95%, preferably from 0.002 to 2% of the antioxidant composition. The different ingredients of the antioxidant food for animals can be provided individually or together depending on the manufacturing facilities. Examples A to G according to the present invention are given by way of illustration:
Les exemples A à c concernent des exemples de composition 15 antioxydante selon l'invention.10 Exemple A : Ingrédients Quantité en pourcentage Partie aérienne d'ortie 35,00 Marc de pomme 65,00 Exemple B : Ingrédients Quantité en pourcentage Partie aérienne d'ortie 35,00 Marc de pomme 55,00 Vitamine C 8,00 Extrait de basilic 2,00 Exemple C : Ingrédients quantité en pourcentage Partie aérienne d'ortie 65,00 Marc de pomme 32,00 Extrait de romarin 2,00 Extrait de tagète 1,00 Les exemples D à F concernent des aliments pour animal domestique comprenant ladite composition antioxydante. 810 Exemple D: Ingrédients quantité en pourcentage Partie aérienne d'ortie 0,02 Marc de pomme 0,02 Ensilage de maïs 53 Paille 15 Foin de luzerne 30 Aliment minéral 1,96 On obtient une ration pour vache laitière. 5 Exemple E : Ingrédients quantité en pourcentage Parties aériennes d'ortie 0,16 Marc de pomme 0,08 Foin de graminées 80 Complément azoté 12 Céréales 7,76 On obtient une ration pour brebis. Exemple F : Ingrédients Ration 1 quantité en Ration 2 quantité en pourcentage pourcentage Parties aériennes d'ortie 0,004 0,004 Marc de pomme 0,006 0,005 Pulpes de betteraves - 77 Ensilage de luzerne 75 - 9 Foin de luzerne 21 18 Tourteau d'arachide - 2 Orge 3 2 Aliment minéral 0,99 0,99 On obtient des rations pour des boeufs. Examples A to C relate to examples of the antioxidant composition according to the invention. Example A: Ingredients Percentage content Aerial part of nettle 35.00 Apple root 65.00 Example B: Ingredients Percentage quantity Aerial part of nettle 35.00 Marc apple 55.00 Vitamin C 8.00 Basil extract 2.00 Example C: Ingredients amount in percentage Aerial part of nettle 65.00 Marc of apple 32.00 Rosemary extract 2.00 Extract of Tagete 1.00 Examples D to F relate to pet foods comprising said antioxidant composition. 810 Example D: Ingredients amount in percent Aerial part of nettle 0.02 Apple mark 0.02 Corn silage 53 Straw 15 Alfalfa hay 30 Mineral feed 1.96 A ration for dairy cows is obtained. Example E: Ingredients amount in percent Nettle parts 0.16 Potato Marc 0.08 Grass Hay 80 Nitrogen Supplement 12 Cereals 7.76 A sheep ration is obtained. Example F: Ingredients Ration 1 amount in Ration 2 amount in percent percentage Nettle parts 0.004 0.004 Potato Marc 0.006 0.005 Beet Pulps - 77 Alfalfa Silage 75 - 9 Alfalfa Hay 21 18 Peanut Cake - 2 Barley 3 2 Mineral Food 0.99 0.99 Rations are obtained for cattle.
Le présent demandeur a analysé la teneur en polyphénols dans le marc de pomme qui contient 209.8 mg de polyphénols (exprimés en équivalent catéchines) pour 100 g d'extrait de marc de pomme, ce qui correspond à une valeur attendue pour ce type de produit. The present applicant has analyzed the content of polyphenols in apple pomace which contains 209.8 mg of polyphenols (expressed in catechin equivalent) per 100 g of apple pomace extract, which corresponds to a value expected for this type of product.
Exemple comparatif G Le présent demandeur a démontré l'activité antioxydante de ladite composition comprenant un broyat de parties aériennes d'ortie et du marc de pomme, par une analyse de la capacité antioxydante par la méthode ORAC (Oxygen Radical Absorbance Capacity). La composition analysée correspond à la composition de l'exemple A, à savoir une composition comprenant 35% de partie aérienne d'ortie et 65% de marc de pomme (en poids par rapport au poids total de la composition selon l'invention). La méthode ORAC permet une mesure globale du pouvoir antioxydant de substances pures ou en mélange comme dans les produits finis. La première étape consiste en une extraction des principes actifs dans un mélange d'eau et d'éthanol pour les molécules hydrosolubles et dans l'éthanol pour les lipophiles. Le test est réalisé en spectrofluorimétrie. Il consiste en une mesure de la protection exercée par une molécule donnée contre l'oxydation de la fluorescéine par un radical libre stable, I'AAPH (2,2-azobis- (diméthylaminopropane chlorohydrate). Il s'agit donc à proprement parler de la mesure d'un pouvoir anti-radicalaire. Les résultats sont exprimés par rapport à la protection exercée par un antioxydant de référence, le Trolox® qui est l'équivalent hydrosoluble de la vitamine E et ramenés par gramme du produit testé. L'avantage majeur du test ORAC est de proposer une mesure standardisée et largement acceptée du pouvoir antioxydant. Plus particulièrement, le protocole qui a été suivi est celui du laboratoire Brunswick, USA, (laboratoire de référence en la matière),II a été publié dans la publication de Ou et al. (Hampsch-Woodill M, Prior RL. Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe. J Agric Food Chem. 2001 Oct;49(10):4619-26). Ainsi, 0,5g d'un premier échantillon comprenant des parties aériennes d'orties, 0,5 g d'un second échantillon comprenant du marc de pomme et 0,5 g de la composition selon l'exemple A ont été repris chacun dans 20m1 de tampon d'extraction (mélange acétone/eau, 1:1). Puis des dilutions adéquates de chaque échantillon ont été effectuées afin qu'il puisse être comparé dans la gamme de réponse du Trolox. L'acquisition de la cinétique a été faite sur un lecteur de microplaque en fluorescence et les résultats obtenus sont exprimés en pmol d'équivalent Trolox / g de produit. Echantillons Résultats (pmoles d'équivalents Trolox®/g d'échantillon) Parties aériennes d'orties 1600 Marc de pomme 170 Composition antioxydante (invention) 1960 > 1770 Ainsi, la composition selon l'invention présente une activité antioxydante supérieure à celle correspondant à la somme des activités de chacun des composants de cette composition, à savoir 1960 contre 1770 (pmoles d'équivalents Trolox®/g d'échantillon) lorsqu'on additionne l'effet des parties aériennes d'orties et celui du marc de pomme. 12 La présente invention a également pour but l'utilisation de l'aliment tel que décrit ci-dessus, pour prévenir le vieillissement prématuré des cellules et les protéger contre les dommages causés par les radicaux libres chez les animaux d'élevage, en particulier le ruminant. En effet, le présent demandeur a trouvé que la composition antioxydante ou l'aliment comprenant ladite composition est efficace chez le ruminant, (en particulier le bovin, l'ovin et le caprin), attendu que les produits qui sont efficaces chez le monogastrique ne le sont pas forcément chez le polygastrique. La quantité totale de ladite composition antioxydante administrée à l'animal est préférentiellement de 0,02 mg à 200 g par jour et par kg de poids corporel. La composition antioxydante selon l'invention présente ainsi l'avantage de limiter efficacement l'oxydation des composants cellulaires (ADN, protéines, lipides) causée par les radicaux libres et par le stress oxydant, et ce de manière à préserver les performances zootechniques, le bien-être et la santé de l'animal ainsi que les qualités nutritionnelles et organoleptiques de ses produits (viande, lait et dérivés laitiers, oeufs). Comparative Example G The present applicant has demonstrated the antioxidant activity of said composition comprising ground mashed nettle and apple pomace, by Oxygen Radical Absorbance Capacity (ORAC) analysis of the antioxidant capacity. The composition analyzed corresponds to the composition of Example A, namely a composition comprising 35% of aerial part of nettle and 65% of apple pomace (by weight relative to the total weight of the composition according to the invention). The ORAC method allows a global measurement of the antioxidant power of pure or mixed substances as in finished products. The first step consists in extracting the active ingredients in a mixture of water and ethanol for the water-soluble molecules and in ethanol for the lipophilic ones. The test is carried out in spectrofluorimetry. It consists of a measurement of the protection exerted by a given molecule against the oxidation of fluorescein by a stable free radical, AAPH (2,2-azobis (dimethylaminopropane chlorohydrate). The results are expressed in relation to the protection exerted by a reference antioxidant, Trolox®, which is the water-soluble equivalent of vitamin E and reduced by gram of the test product. ORAC test is to propose a standardized and widely accepted measure of antioxidant power, in particular, the protocol that has been followed is that of the Brunswick, USA laboratory (reference laboratory in the field), II was published in the publication et al (Hampsch-Woodill M, Prior RL, Development and validation of an improved oxygen radical absorbance capacity using fluorescein as the fluorescent probe.) J Agric Food Chem., 2001 Oct; 49 (10): 461 9-26) Thus, 0.5 g of a first sample comprising aerial parts of nettles, 0.5 g of a second sample comprising apple pomace and 0.5 g of the composition according to Example A were each taken up in 20 ml of extraction buffer (acetone / water mixture, 1: 1). Then adequate dilutions of each sample were made so that it could be compared in the Trolox response range. The acquisition of the kinetics was made on a fluorescence microplate reader and the results obtained are expressed in pmol of Trolox equivalent / g of product. Samples Results (pmoles of Trolox® equivalents / g of sample) Aerial parts of nettles 1600 Marc of apple 170 Antioxidant composition (invention) 1960> 1770 Thus, the composition according to the invention has an antioxidant activity greater than that corresponding to the sum of the activities of each of the components of this composition, namely 1960 versus 1770 (pmoles of Trolox® equivalents / g of sample) when the effect of aerial parts of nettles and that of apple pomace is added. The present invention also aims at the use of the food as described above, to prevent the premature aging of cells and to protect them against the damage caused by free radicals in farm animals, in particular the ruminant. Indeed, the present applicant has found that the antioxidant composition or the feed comprising said composition is effective in ruminants, (in particular cattle, sheep and goats), since the products which are effective in the monogastric are not necessarily in the polygastric. The total amount of said antioxidant composition administered to the animal is preferably from 0.02 mg to 200 g per day and per kg of body weight. The antioxidant composition according to the invention thus has the advantage of effectively limiting the oxidation of cellular components (DNA, proteins, lipids) caused by free radicals and by oxidative stress, so as to preserve the zootechnical performances, the well-being and the health of the animal as well as the nutritional and organoleptic qualities of its products (meat, milk and dairy products, eggs).
Bien que l'invention ait été décrite en relation avec un mode de réalisation particulier, il est bien évident qu'elle n'y est nullement limitée et qu'elle comprend tous les équivalents techniques des moyens décrits ainsi que leurs combinaisons si celles-ci entrent dans le cadre de l'invention.25 Although the invention has been described in connection with a particular embodiment, it is obvious that it is not limited thereto and that it comprises all the technical equivalents of the means described and their combinations if they fall within the scope of the invention.
Claims (11)
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| CN102907576A (en) * | 2012-09-26 | 2013-02-06 | 齐鲁动物保健品有限公司 | Feed additive capable of improving oestrus and lactescence of sows and eggshell quality |
| CN106721374A (en) * | 2017-03-21 | 2017-05-31 | 道真自治县云庄农牧业发展有限公司 | A kind of feed for rabbit food |
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| US20020006445A1 (en) * | 2000-02-23 | 2002-01-17 | Daniel Gelber | Composition and method for treating the effects of diseases and maladies |
| US20030143292A1 (en) * | 2002-01-04 | 2003-07-31 | Cho Suk H. | Dietary supplements and methods for treating pain and inflammation |
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| US20020006445A1 (en) * | 2000-02-23 | 2002-01-17 | Daniel Gelber | Composition and method for treating the effects of diseases and maladies |
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| MAVI A ET AL: "Antioxidant properties of some medicinal plants: Prangos ferulacea (Apiaceae), Sedum sempervivoides (Crassulaceae), Malva neglecta (Malvaceae), Cruciata taurica (Rubiaceae), Rosa pimpinellifolia (Rosaceae), Galium verum subsp. verum (Rubiaceae), Urtica dioica (Urticaceae)", MEDICINAL & AROMATIC PLANTS ABSTRACTS, SCIENTIFIC PUBLISHERS, NEW DELHI - INDIA, vol. 26, no. 6, 1 December 2004 (2004-12-01), XP018002396 * |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102907576A (en) * | 2012-09-26 | 2013-02-06 | 齐鲁动物保健品有限公司 | Feed additive capable of improving oestrus and lactescence of sows and eggshell quality |
| CN106721374A (en) * | 2017-03-21 | 2017-05-31 | 道真自治县云庄农牧业发展有限公司 | A kind of feed for rabbit food |
| CN106721374B (en) * | 2017-03-21 | 2020-08-07 | 青岛凯立德生物科技有限公司 | Feed for rabbits |
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