FR2961508A1 - AMINO ACID DERIVATIVES; COMPOSITIONS CONTAINING THEM; USE AS A TREATMENT AGENT FOR HUMAN PERSPIRATION - Google Patents

Abstract

The invention relates to novel amino acid derivative compounds of formula (I) as well as cosmetic or dermatological compositions containing them and their use as a treatment agent for human perspiration in a cosmetic composition. The invention also relates to a cosmetic process for treating perspiration and possibly body odors related to human perspiration, especially axillary odors.

Description

AMINO ACID DERIVATIVES; COMPOSITIONS CONTAINING THEM; The invention relates to novel compounds derived from amino acids, cosmetic or dermatological compositions containing them and their use as agents for treating human perspiration in a cosmetic composition.

The invention also relates to a cosmetic process for treating perspiration and possibly body odors related to human perspiration, especially axillary odors.

In the cosmetic field, it is well known to use topically, as antiperspirants, aluminum salts and / or zirconium which have the effect of limiting or even suppressing the flow of sweat. These products are generally available in the form of roll-on, sticks, aerosol or spray.

This type of metal salt is effective as an antiperspirant, but some people find that the application of such products causes skin irritation. On the other hand, aluminum salts block some of the perspiration by forming a partial plug in the sweat duct and giving the consumer the impression of an unnatural sweat control. In addition, they also tend to leave marks on clothing.

There remains therefore the need to seek new formulations for the treatment of perspiration does not have the disadvantages encountered with those known so far and giving a good antiperspirant effectiveness. There is therefore a need to search for new antiperspirant active agents that can replace aluminum salts and aluminum / zirconium salts, which are effective and easily formulated and well tolerated.

Application WO2006 / 094193 (Revance Therapeutics) discloses oligopeptides comprising a Glu.Glu.Met.Gln.Arg.Arg sequence for transdermal application for multiple treatments including the treatment of hyperhidrosis.

Research Disclosure Vol 519, 07 2007, p685 discloses the peptide (3-Ala-40-diaminobutyroylbenzylamide such as the product sold by Pentapharm AG which is used in the treatment of hyperhidrosis

It has been proposed in WO2010 / 003781 for the treatment of perspiration to use peptides in lamellar phase emulsions, especially oleosomes. Among the peptides recommended, this document cites the peptides comprising a Glu.Glu.Met.Gln.Arg.Arg sequence, peptide peptides comprising a Tyr.Ala.Gly.Phe.Leu sequence, the peptide (3-Ala-Prod iaminobutyroylbenzylamide .

These peptides are not fully satisfactory for the treatment of human perspiration.

The Applicant has surprisingly discovered that amino acid derivatives of formula (I) which will be given later in detail made it possible to achieve this objective and could be easily formulated in many products intended to reduce perspiration. without the need to use conventional astringent salts.

The invention relates to novel amino acid derivatives of formula (I) which will be given later in detail.

The invention also relates to a composition comprising in a cosmetically acceptable medium at least one amino acid derivative of formula (I) which will be given later in detail.

The invention also relates to the use of at least one amino acid derivative of formula (I) which will be given later in detail as a treatment agent for human perspiration in a composition comprising a cosmetically acceptable carrier.

The subject of the present invention is also a cosmetic process for treating human perspiration and possibly particularly axillary body odors, comprising applying to the surface of the skin a composition comprising, in a cosmetically acceptable medium, at least at least one derivative of amino acid of formula (I) which will be given later in detail.

By "cosmetically acceptable" is meant compatible with the skin and / or its integuments, which has a pleasant color, odor and feel and which does not generate unacceptable discomfort (tingling, tightness, redness), which can divert the consumer to use this composition.

By "sweat-treating agent" is meant any substance which has the effect of reducing the flow of sweat and / or of reducing the sensation of moisture associated with human sweat and / or of masking human sweat. .

AMINO ACID DERIVATIVES

The amino acid derivatives according to the invention are chosen from those corresponding to the following formula (I) or one of its salts, its optical isomers, stereoisomers, enantiomers and diastereoisomers or one of its geometrical isomers: (I) NH where X denotes a group chosen from: H with n = 1.2 and m = 1,2,3,4 nb O with N b with n = 1,2 H 0 HON - b O ba H 0 HN SMe ONH2 H a 0 H b 0 / H / N o N a H SM O b

ONH2 m = 1,2,3,4 a designating the point of attachment of said radical with the carbonyl group and b denotes the point of attachment of said radical with the NH group, in the formula (I).

R ~ denotes an aryl or benzyl radical or linear or branched, saturated or unsaturated C1-C18 alkyl, R2 denotes a radical -OR1 or -NR1'R2 'Ri' and R'2, which may be identical or different, denote an atom of hydrogen or a radical R ~; R3 is -OH or any of the following groups:

With n = 1, 2, 3 (y-amino-butyric acid in the case where n = 2) 35 0 * NOH H (taurine) 0 H * OH (glycine) O H N OH Me (alanine)

0 H

* NOH OH (serine) In the formula (I), among the alkyl groups, there may be mentioned especially methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, n-octyl, 2-ethylhexyl, dodecyl, hexadecyl. In the formula (I), among the aryl groups, there may be mentioned the phenyl group.

Acceptable salts of the compounds described in the present invention include conventional non-toxic salts of said compounds such as those formed from organic or inorganic acids. By way of example, mention may be made of the salts of mineral acids, such as sulfuric acid, hydrochloric acid, hydrobromic acid and phosphoric acid. Mention may also be made of organic acid salts, which may comprise one or more carboxylic acid, sulphonic acid or phosphonic acid groups. It may be linear, branched or cyclic aliphatic acids or aromatic acids. These acids may furthermore comprise one or more heteroatoms chosen from 0 and N, for example in the form of hydroxyl groups. There may be mentioned in particular propionic acid, acetic acid, terephthalic acid, citric acid and tartaric acid and lactic acid.

Organic or inorganic base salts such as ammonium salts, alkanolamine salts such as triethanolamine, aminopropanediol, alkali metal salts such as sodium, potassium, calcium.

The preferred salts are those obtained from hydrochloric, sulfuric, acetic, tartaric, citric and lactic acids. Among the compounds of formula (I), the compounds of formula (I) or one of their salts, optical isomers, stereoisomers, enantiomers and diastereoisomers or geometric isomers for which X denotes the group a NHO with a, b, n, m, R 1, R 2, R 3, R '1, R' 2 having the same meanings indicated above

Among these compounds of formula (I), the compounds of formula (I) or one of their salts, optical isomers, stereoisomers, enantiomers and diastereoisomers or geometric isomers for which R1 denotes a linear alkyl radical will be chosen more preferably. or branched, saturated or unsaturated C1-C12

Among these compounds, the compounds for which R 1 denotes a linear or branched, saturated or unsaturated C 1 -C 6 alkyl radical and R2 denotes -OH or -NH 2 will be chosen.

Among these compounds, the compounds for which R 1 denotes a saturated linear C 1 -C 4 alkyl radical, preferably a methyl radical R 2 denotes -NH 2 R 3 denotes -OH or a radical -NH- (CH 2) x CO 2 H, will advantageously be chosen, x being 1, 2, 3 or 4.

Among the compounds of formula (I), the following compounds or one of their salts, optical isomers, stereoisomers, enantiomers and diastereoisomers or geometric isomers will be chosen even more particularly.

The amino acid derivatives of formula (I) according to the present invention are peptides which may be of natural origin or may be of natural origin. can be synthesized without difficulty by those skilled in the art, using conventional solid phase or solution peptide synthesis techniques (M. Bodanszky, Principles of Peptides Synthesis, 2nd edition, 1993, Springer-Verlag Edition).

To prepare the compounds of formula (I) in solution and / or their salts, several synthetic routes are possible. For example, the peptide portion can be constructed linearly from the N-terminus to the C-terminus or conversely from the C-terminus to the N-terminus. More specifically, the peptide chain can be synthesized by reacting an N-protected amino acid with a C-protected amino acid to generate a protected N and C dipeptide which itself can lead to a tripeptide after its deprotection. N-terminal end and reaction of the NH 2 function thus liberated with an N-protected amino acid, or after deprotection of its C-terminal end and reaction of the COOH function thus released with a C-protected amino acid. This principle is repeated as much as necessary to obtain the desired peptide sequence. The reaction between two respectively N- and C-protected amino acids may require the use of an activation step and the use of a coupling reagent. Typical activating or coupling reagents in peptide synthesis are, for example, carbodiimides such as DCC (= dicyclohexylcarbodiimide) or water-soluble forms of carbodiimides such as EDC (= N-ethyl-N '- (3-dimethylaminopropyl) carbodiimide hydrochloride), phosphonium salts such as BOP (= benzotriazol-1-yloxy) tris (dimethylamino) phosphonium hexafluorophosphate), PyBOP (= (benzotriazol-1-yloxy) tripyrrolidinophosphonium hexafluorophosphate), PyBROP (= bromotripyrrolidinophosphonium hexafluorophosphate) , PyCIoP (= chlorotripyrrolidinophosphonium hexafluorophosphate), or reagents such as PyCIU (= chloro-N, N, N ', N'-bis (tetramethylene) formamidinium hexafluorophosphate), N-hydroxysuccinimide, EEDQ (= 1 ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline), CDI (= carbonyldiimidazole), or else chloroformates such as ethyl chloroformate or isobutyl chloroformate. When the coupling is carried out using coupling reagents such as carbodiimides, additives such as HOBt (= 1-hydroxybenzotriazole) or N-hydroxysuccinimide may be added during the reaction to limit the racemization.

The protective groups for the amine functions are, for example: Adoc = 1 -adamantyloxycarbonyl, Boc = t-butyloxycarbonyl-2-bromo-2-bromobenzyloxycarbonyl-2-chloro-2-chloro-benzyloxycarbonyl-Fmoc = 9 -fluorenylmethoxycarbonyl) - Formyl (H-CO-) - Nicotinoyl (pyridine-3-carbonyl) - TFA = trifluoroacetyl io - Tos = ptoluenesulfonyl

The protective groups for the acid functions are, for example: the methyl esters; ethyl; benzyl; i-propyl; t-butyl

The protective groups for the guanidine function of arginine residues are, for example: - N, N'-di (Adoc) - N, N'-di (Boc)

By way of illustration, the following scheme describes the case where the peptide chain is constructed according to this principle from the N-terminus to the C-terminus.

O H2N, ~ XOPG2 I PGZO (B) 0 HN ~ O step 1 HOMO PG ~ ^^ / BN v Tf H II Ov 7f H II O (C) step 2 O ~ OPG3H H2NN1! PG4 (D) N \ PG4 PG4 HN / N ~ 7J PG4 PG3O R1 N1R3 HO R2 (A) (1) Step 3 PG. X is a sequence of 1 or 2 amino acids such that compound (B) is a C-protected peptide having 1 or 2 amino acids.

PG1 denotes an amine protecting group or R PG2, PG3 independently denote a carboxylic acid protecting group PG4 denotes a protecting group for the guanidine function of arginine. B1 denotes a radical R3 or a radical precursor R3 as indicated later in the text. In step 1, the PG1-substituted glutamic acid derivative (A) is coupled to the C-protected peptide (or amino acid) (B) to yield the N- and C-substituted oligopeptide (VS). In step 2, after deprotection of the C-terminal end of (C), the resulting compound is coupled to a C- and N, N'-protected arginine residue (D) to yield oligopeptide N- and C-substituted (E). Step 3 includes sequential deprotection of any protective groups. Depending on its nature, the PG1 group of the peptide derivative (E) can be converted to substituent R1 in step 3 as shown above but also further upstream during the synthesis. It is thus possible for example to have R1 = PG1.

Likewise, depending on the nature of R3, the radical R3 can be introduced from B1 at the end of the reaction scheme onto the desired peptide sequence terminated or more upstream during the reaction scheme. It is thus possible for example to have R3 = Bi. In cases where R 3 is derived from an amino acid, this substituent can be introduced by coupling between the carboxylic acid function of the glutamic acid residue and the amine function of the appropriate amino acid C-protected under the conditions of a peptide coupling. This functionalization of the glutamic acid residue side chain can be performed prior to assembly of the oligopeptide chain, during this assembly or at the end of the reaction scheme on the desired finished peptide sequence.

If it has several amino acid residues, the precursor (D) can itself be obtained from the appropriate amino acids, suitably protected, under peptide coupling conditions.

In some cases, the oligopeptide sequence can be constructed linearly, by sequentially extending the peptide chain, by coupling the amino acids one by one. In some cases, the peptide sequence may be constructed by reacting a free acid function of an amino acid or N-protected peptide with the free amino function of an amino acid or C-protected peptide. For example, the pentapeptides can be constructed by coupling the free amine function of a C-protected dipeptide with the free acid function of an N-protected tripeptide. This N-protected tripeptide can itself be obtained by coupling the free amine function of a C-protected dipeptide with the free acid function of an N-protected amino acid and then deprotection of the C-terminal end.

In a preferred embodiment, the amino acid derivatives used according to the invention are synthetic peptides.

In a preferred manner, the protecting groups are chosen so as to be removed respectively under different operating conditions. The amino acid derivatives used according to the invention can also be produced by microorganisms, using bioengineering methods. In this case, it may be necessary to extract and purify the peptide producing microorganisms, before formulation. Alternatively, the producer microorganism can be applied directly to the site to be treated at the user's site.

The compound of formula (I) may in certain cases be salified by a base or an acid, preferably a base or an acid or organic, or inorganic. Acceptable salts of the compounds described in the present invention include conventional non-toxic salts of said compounds such as those formed from organic or inorganic acids. By way of example, mention may be made of the salts of mineral acids, such as sulfuric acid, hydrochloric acid, hydrobromic acid and phosphoric acid. Mention may also be made of organic acid salts, which may comprise one or more carboxylic acid, sulphonic acid or phosphonic acid groups. They may be linear, branched or cyclic aliphatic acids or aromatic acids. These acids may furthermore comprise one or more heteroatoms chosen from O and N, for example in the form of hydroxyl groups. There may be mentioned in particular propionic acid, acetic acid, terephthalic acid, citric acid and tartaric acid and lactic acid.

Organic or inorganic base salts such as ammonium salts, alkanolamine salts such as triethanolamine, aminopropanediol, alkali metal salts such as sodium, potassium.

The preferred salts are those obtained from hydrochloric, sulfuric, acetic, tartaric, citric and lactic acids. The compounds of formula (I) according to the invention are preferably used in amounts ranging from 0.001% to 20% of the total weight of the composition and more preferably in an amount representing from 0.01% to 10% by weight. total of the composition or even more preferably 0.1 to 5%. The amounts of active will be adapted according to the dosage form of the composition containing them.

Another subject of the invention consists of a cosmetic composition comprising in a cosmetically acceptable medium at least one compound of formula (I) as defined above. GALENIC FORMS

The composition according to the invention may be in any of the galenical forms conventionally used for topical application and especially in the form of aqueous gels, aqueous or aqueous-alcoholic solutions. They may also, by addition of a fatty or oily phase, be in the form of lotion-type dispersions, emulsions of liquid or semi-liquid consistency of the milk type, obtained by dispersion of a fatty phase in one phase. aqueous (O / W) or conversely (W / O), or suspensions or emulsions of soft, semi-solid or solid consistency of the cream or gel type, or multiple emulsions (W / O / W or O / W) / H), microemulsions, vesicular dispersions of ionic and / or nonionic type, or wax / aqueous phase dispersions. These compositions are prepared according to the usual methods.

The invention also relates to compositions packaged in pressurized form in an aerosol device or in a pump bottle; packaged in a device provided with a perforated wall including a grid; packaged in a device provided with a ball-on applicator, characterized in that they contain at least particles of perlite as defined above, and contain in this respect the ingredients generally used in this type. In accordance with another particular form of the invention, the compositions according to the invention can be anhydrous.

By anhydrous composition is meant a composition containing less than 2% by weight of water, or even less than 0.5% of water, and especially free of water, the water not being added during the preparation of the composition but corresponding to the residual water provided by the mixed ingredients.

The antiperspirant compositions according to the invention can also be in the form of sticks (sticks).

According to one particular form of the invention, the compositions for treating perspiration according to the invention may also be in the form of loose or compacted powder.

The compositions according to the invention intended for cosmetic use may comprise at least one aqueous phase. They are in particular formulated in aqueous lotions or in water-in-oil, oil-in-water or multiple emulsion emulsions (triple oil-in-water-in-oil or water-in-oil-in-water emulsion). such emulsions are known and described for example by C. FOX in "Cosmetics and Toiletries" - november 1986 - Vol 101 - pages 101-112).

AQUEOUS PHASE The aqueous phase of said compositions contains water and in general other solvents soluble or miscible in water. Solvents that are soluble or miscible in water include short-chain monohydric alcohols, for example C1-C4, such as ethanol or isopropanol; diols or polyols such as ethylene glycol, 1,2-propylene glycol, 1,3-butylene glycol, hexylene glycol, diethylene glycol, dipropylene glycol, 2-ethoxyethanol, diethylene glycol monomethyl ether, triethylene glycol monomethyl ether and sorbitol. Propylene glycol and glycerol, propane 1,3 diol will be used more particularly.

EMULSIFIERS a) Oil-in-water emulsifiers

Examples of emulsifiers that can be used in oil-in-water emulsions or oil-in-water-in-oil triple emulsions are, for example, nonionic emulsifiers such as oxyalkylenated fatty acid and glycerol esters (more particularly polyoxyethylenated); oxyalkylenated fatty acid and sorbitan esters; oxyalkylenated fatty acid esters (oxyethylenated and / or oxypropylenated); oxyalkylenated fatty alcohol ethers (oxyethylenated and / or oxypropylenated); sugar esters such as sucrose stearate; and their mixtures such as the mixture of glyceryl stearate and PEG-40 stearate.

Mention may also be made of the fatty alcohol / alkylpolyglycoside emulsifying mixtures as described in the applications WO92 / 06778, WO95 / 13863 and WO98 / 47610, such as the commercial products sold by the 50 company SEPPIC under the name MONTANOV®. (b) Water-in-oil emulsifiers

Among the emulsifiers that can be used in water-in-oil emulsions or triple water-in-oil-in-water-in-oil emulsions or triple emulsions, mention may be made by way of example of alkyl dimethicone copolyols corresponding to the formula (I) following 12 a CH 3 Si-CH 3 (I) CH 3 b CH 3 CH 3 in which: RI denotes a linear or branched C12-C20 and preferably C12-C18 alkyl group; R2 denotes the group: - CnH2n - (- OC2H4-) X - (- OC3H6-) y - O-R3, R3 denotes a hydrogen atom or a linear or branched alkyl radical containing from 1 to 12 atoms of carbon; a is an integer from 1 to about 500; b is an integer from 1 to about 500; n is an integer from 2 to 12 and preferably 2 to 5; x denotes an integer ranging from 1 to about 50 and preferably from 1 to 30; y denotes an integer ranging from 0 to about 49 and preferably 0 to 29 provided that when y is different from zero the ratio x / y is greater than 1 and preferably varies from 2 to 11.

Among the preferred alkyldimethicone copolyol emulsifiers of formula (I), there will be mentioned more particularly CETYL PEG / PPG-10/1 DIMETHICONE and more particularly the mixture CETYL PEG / PPG-10/1 DIMETICONE AND DIMETHICONE (INCI name) as the product sold under the trade name ABIL EM90 by GOLDSCHMIDT or the mixture (POLYGLYCERYL-4-STEARATE and CETYL PEG / PPG-10 (AND) DIMETHICONE (AND) HEXYL LAURATE) as the product sold under the trade name ABIL WE09 by the same society.

Among the water-in-oil emulsifiers, mention may also be made of dimethicone copolyols corresponding to the following formula (II) C CH 3

Si - CH 3 1 CH 3 d CH 3 Si 0 CH 3 CH 3 1 Si - O R 4 in which R 4 denotes the group: - C 1, H 2, - (- OC 2 H 4 -) s - (- OC 3 H 6 -) t - O -R5, R5 denotes a hydrogen atom or a linear or branched alkyl radical having from 1 to 12 carbon atoms; c is an integer ranging from 1 to about 500 d denotes an integer ranging from 1 to about 500, m is an integer ranging from 2 to 12 and preferably 2 to 5, s denotes an integer ranging from 1 to about 50, and preferably from 1 to 30; t denotes an integer ranging from 0 to about 50 and preferably from 0 to 30; provided that the sum s + t is greater than or equal to 1.

Among these emulsifiers dimethicone copolyols of formula (II) preferential use will particularly PEG-18IPPG-18 DIMETHICONE and more particularly the mixture CYCLOPENTASILOXANE (and) PEG-18IPPG-18 DIMETHICONE (INCI name) such as the product sold by Dow Corning under the trade name Silicone DC 5225 C or KF-6040 from Shin Etsu.

According to a particularly preferred form, use will be made of a mixture of at least one emulsifier of formula (I) and at least one emulsifier of formula (II).

More particularly, a mixture of PEG-18IPPG-18 Dimethicone and Cetyl PEG / PPG-10/1 DIMETHICONE and even more particularly a mixture of (CYCLOPENTASILOXANE (and) PEG-18IPPG-18 Dimethicone) and Cetyl PEG / PPG-1 will be used more particularly. 10/1 DIMETICONE and Dimethicone or (Polyglyceryl-4-stearate and Cetyl PEG / PPG-10 (and) Dimethicone (and) Hexyl Laurate).

Among the water-in-oil emulsifiers, mention may also be made of nonionic emulsifiers derived from fatty acid and polyol, alkylpolyglycosides (APG), sugar esters and mixtures thereof.

As nonionic emulsifiers derived from fatty acid and polyol, the fatty acid and polyol esters may in particular be used, the fatty acid having in particular a C 8 -C 24 alkyl chain, and the polyols being, for example, glycerol. and sorbitan.

Examples of fatty acid and polyol esters that may be mentioned include esters of isostearic acid and of polyols, esters of stearic acid and of polyols, and mixtures thereof, in particular esters of isostearic acid and of glycerol, and or 40 of sorbitan.

As esters of stearic acid and of polyols, mention may in particular be made of polyethylene glycol esters such as PEG-30 dipolyhydroxystearate, such as the product sold under the name Arlacel P135 by the company ICI. Examples of glycerol and / or sorbitan esters that may be mentioned are polyglycerol isostearate, such as the product sold under the name Isolan GI 34 by the company Goldschmidt; sorbitan isostearate, such as the product sold under the name Arlacel 987 by the company 50 ICI; sorbitan isostearate and glycerol, such as the product sold under the name Arlacel 986 by the company ICI, the mixture of sorbitan isostearate and polyglycerol isostearate (3 moles) sold under the name Arlacel 1690 by the Unigema company. and their mixtures.

The emulsifier may also be chosen from alkylpolyglycosides having an HLB of less than 7, for example those represented by the following general formula (1):

R-O- (G) x (1)

in which R represents a branched and / or unsaturated alkyl radical having from 14 to 24 carbon atoms, G represents a reduced sugar containing from 5 to 6 carbon atoms, and x denotes a value ranging from 1 to 10 and preferably from 1 to 4, and G particularly denotes glucose, fructose or galactose.

The unsaturated alkyl radical may comprise one or more ethylenic unsaturations, and in particular one or two ethylenic unsaturations.

As alkylpolyglycosides of this type, mention may be made of alkylpolyglucosides (G = glucose in formula (I)), and in particular compounds of formula (I) in which R represents more particularly an oleyl (unsaturated C18 radical) or isostearyl radical. (C18 saturated radical), G denotes glucose, x is a value ranging from 1 to 2, especially isostearyl glucoside, oleyl glucoside and mixtures thereof. This alkylpolyglucoside may be used in admixture with a coemulsifier, more especially with a fatty alcohol and in particular a fatty alcohol having the same fatty chain as that of the alkylpolyglucoside, that is to say comprising from 14 to 24 carbon atoms. and having a branched and / or unsaturated chain, and for example isostearyl alcohol when the alkylpolyglucoside is isostearylglucoside, and oleyl alcohol when the alkylpolyglucoside is oleylglucoside, optionally in the form of a selfemulsifying composition As described for example in WO-A-92/06778. For example, the mixture of isostearyl glucoside and isostearyl alcohol sold under the name Montanov WO 18 by the company SEPPIC and the mixture octyldodecanol and octyldodecylxyloside sold under the name FLUDANOV 20X by the company SEPPIC may be used. Mention may also be made for succinic-terminated polyolefins, such as ester-terminated polyisobutylenes and their salts, especially diethanolamine salts, such as the products sold under the names Lubrizol 2724, Lubrizol 2722 and Lubrizol 5603 by the company Lubrizol. CHEMCINNATE 2000 commercial product.

The total amount of emulsifiers in the composition will preferably be in the composition according to the invention at contents of active material ranging from 1 to 8% by weight and more particularly from 2 to 6% by weight relative to the total weight of 45%. composition.

FAT PHASE

The compositions according to the invention may contain at least one organic liquid phase that is immiscible in water. This generally comprises one or more hydrophobic compounds which render said phase immiscible in water. Said phase is liquid (in the absence of structuring agent) at room temperature (20-25. Preferably, the water-immiscible organic liquid organic phase according to the invention generally consists generally of at least one volatile oil and / or a non-volatile oil and optionally at least one structuring agent.

By "oil" is meant a fatty substance that is liquid at ambient temperature (25 ° C.) and atmospheric pressure (760 mmHg, ie 105 Pa). The oil can be volatile or non-volatile.

For the purposes of the invention, the term "volatile oil" means an oil capable of evaporating on contact with the skin or keratin fiber in less than one hour at ambient temperature and atmospheric pressure. The volatile oils of the invention are volatile cosmetic oils which are liquid at room temperature and have a non-zero vapor pressure at ambient temperature and atmospheric pressure, in particular from 0.13 Pa to 40,000 Pa (10-3). at 300 mm Hg), in particular ranging from 1.3 Pa to 13 000 Pa (0.01 to 100 mm Hg), and more particularly ranging from 1.3 Pa to 1300 Pa (0.01 to 10 mm Hg), Hg). By "non-volatile oil" is meant an oil remaining on the skin or the keratin fiber at room temperature and atmospheric pressure for at least several hours and having in particular a vapor pressure of less than 10 -3 mm Hg (0.13 Pa). ). The oil may be chosen from all physiologically acceptable and in particular cosmetically acceptable oils, in particular mineral, animal, vegetable, and synthetic oils; in particular volatile and / or nonvolatile hydrocarbon and / or silicone and / or fluorinated oils and mixtures thereof. More specifically, the term "hydrocarbon-based oil" means an oil comprising mainly carbon and hydrogen atoms and optionally one or more functions chosen from hydroxyl, ester, ether and carboxylic functions. Generally, the oil has a viscosity of 0.5 to 100,000 mPas, preferably 50 to 50,000 mPas and more preferably 100 to 300,000 mPas.

As an example of a volatile oil that may be used in the invention, mention may be made of: volatile hydrocarbon oils chosen from hydrocarbon oils having from 8 to 16 carbon atoms, and in particular the C 8 -C 16 isoalkanes of origin oil (also called isoparaffins) such as isododecane (also called 2,2,4,4,6-pentamethylheptane), isodecane, isohexadecane, and for example the oils sold under the trade names of Isopars or permetyls C8-C16 branched esters, iso-hexyl neopentanoate, and mixtures thereof. Other volatile hydrocarbon oils such as petroleum distillates, in particular those sold under the name Shell or by Shell, may also be used; volatile linear alkanes such as those described in patent application WO 2007/068371. volatile silicones, such as, for example, volatile linear or cyclic silicone oils, especially those having an 8 centistokes viscosity (8 10-6 m 2 / s), and especially having 2 to 7 silicon atoms, these silicones possibly comprising alkyl or alkoxy groups having from 1 to 10 carbon atoms. As volatile silicone oil that can be used in the invention, there may be mentioned in particular octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, heptamethylhexyltrisiloxane, heptamethyloctyltrisiloxane, hexamethylisiloxane, octamethyltrisiloxane and decamethyl tetrasiloxane, dodecamethylpentasiloxane, and mixtures thereof.

It is also possible to mention volatile alkyltrisiloxane linear oils of general formula (I): ## STR1 ## where R represents an alkyl group comprising from 2 to 4 atoms of carbon and one or more hydrogen atoms may be substituted by a fluorine or chlorine atom.

Among the oils of general formula (I), mention may be made of: 3-butyl 1,1,1,3,5,5,5-heptamethyltrisiloxane, 3-propyl 1,1,1,3,5, 5,5-heptamethyltrisiloxane, and 3-ethyl-1,1,1,3,5,5,5-heptamethyltrisiloxane, corresponding to the oils of formula (I) for which R is respectively a butyl group, a propyl group, or an ethyl group.

As an example of a non-volatile oil that may be used in the invention, mention may be made of: hydrocarbon-based oils of animal origin, such as perhydrosqualene; Vegetable hydrocarbon oils such as liquid triglycerides of fatty acids with 4 to 24 carbon atoms, for instance triglycerides of heptanoic or octanoic acids, or oils, wheat germ oils, olive oil, sweet almond, palm, colza, cotton, alfalfa, poppy, pumpkin, squash, black currant, evening primrose, millet, barley, quinoa, rye, safflower, bancoulier , passionflower, muscat rose, sunflower, maize, soya, squash, grape seed, sesame, hazelnut, apricot, macadamia, castor oil, avocado, caprylic acid triglycerides / capric such as those sold by Stearineries Dubois or those sold under the names Miglyol 810, 812 and 818 by 40 Dynamit Nobel, jojoba oil, shea butter; linear or branched hydrocarbons of mineral or synthetic origin, such as paraffin oils and their derivatives, petroleum jelly, polydecenes, polybutenes, hydrogenated polyisobutene such as Parleam or squalane; synthetic ethers having from 10 to 40 carbon atoms; Synthetic esters, especially of fatty acids, such as the oils of formula R1000R2 in which R1 represents the residue of a linear or branched higher fatty acid containing from 1 to 40 carbon atoms, and R2 represents a hydrocarbon chain, in particular a branched hydrocarbon chain, containing from 1 to 40 carbon atoms with RI + R2 such as, for example, purcellin oil (cetostearyl octanoate), isononyl isononanoate, isopropyl myristate, isopropyl palmitate, alcohol benzoate in 012 to C15, hexyl laurate, diisopropyl adipate, isononyl isononanoate, ethyl 2-hexyl palmitate, octyl 2-dodecyl stearate, octyl erucate 2- dodecyl, isostearyl isostearate, tridecyl trimellitate; octanoates, decanoates or ricinoleates of alcohols or polyalcohols such as propylene glycol dioctanoate; hydroxylated esters such as isostearyl lactate, octyl hydroxy stearate, octyl dodecyl hydroxystearate, diisostearyl malate, triisocetyl citrate, heptanoates, octanoates, decanoates of fatty alcohols; polyol esters such as propylene glycol dioctanoate, neopentyl glycol diheptanoate, diethylene glycol diisononanoate; and pentaerythritol esters such as pentaerythritol tetraisostearate; branched-chain and / or unsaturated carbon-chain liquid fatty alcohols having 12 to 26 carbon atoms, such as octyl dodecanol, isostearyl alcohol, 2-butyloctanol, 2-hexyl decanol, 2- undecyl pentadecanol, oleic alcohol; higher fatty acids such as oleic acid, linoleic acid, linolenic acid; - carbonates; Acetates; - citrates; fluorinated oils that may be partially hydrocarbon-based and / or silicone-based, such as fluorosilicone oils, fluorinated polyethers or fluorinated silicones, as described in document EP-A-847752; Silicone oils, such as non-volatile, linear or cyclic polydimethylsiloxanes (PDMSs); polydimethylsiloxanes comprising alkyl, alkoxy or phenyl groups, during or at the end of the silicone chain, groups having from 2 to 24 carbon atoms; phenyl silicones such as phenyl trimethicones, phenyl dimethicones, phenyl trimethylsiloxy diphenyl siloxanes, diphenyl dimethicones, diphenyl methyldiphenyl trisiloxanes, 2-phenylethyl trimethylsiloxysilicates, and mixtures thereof.

STRUCTURING AGENT

The compositions according to the invention comprising a fatty phase may additionally contain at least one structuring agent of said fatty phase, which may preferably be chosen from waxes, pasty compounds, mineral or organic lipophilic gelling agents and mixtures thereof.

It is understood that the amount of these compounds can be adjusted by those skilled in the art so as not to damage the desired effect in the context of the present invention. 50 Wax (s) The wax is generally a solid-state solid (25 ° C), reversible solid / liquid state solid, lipophilic compound having a melting point greater than or equal to 30 ° C. go up to 200 ° C and in particular s up to 120 ° C.

In particular, the waxes that are suitable for the invention may have a melting point greater than or equal to 45 ° C., and in particular greater than or equal to 55 ° C.

Within the meaning of the invention, the melting temperature corresponds to the temperature of the most endothermic peak observed in thermal analysis (DSC) as described in the ISO 11357-3 standard; 1999. The melting point of the wax can be measured using a differential scanning calorimeter (DSC), for example the calorimeter sold under the name "MDSC 2920" by the company TA Instruments. The measurement protocol is as follows:

A 5 mg sample of wax placed in a crucible is subjected to a first temperature rise from -20 ° C. to 100 ° C., at a heating rate of 10 ° C./minute, then is cooled by 100 ° C. at -20 ° C at a cooling rate of 10 ° C / minute and finally subjected to a second temperature rise from -20 ° C to 100 ° C at a heating rate of 5 ° C / minute. During the second temperature rise, the variation of the power difference absorbed by the empty crucible and the crucible containing the wax sample as a function of temperature is measured. The melting point of the compound is the value of the temperature corresponding to the peak apex of the curve representing the variation of the difference in power absorbed as a function of the temperature.

The waxes that may be used in the compositions according to the invention are chosen from waxes which are solid at room temperature of animal, vegetable, mineral or synthetic origin, and mixtures thereof.

Illustrative waxes suitable for the invention include, for example, hydrocarbon waxes such as beeswax, lanolin wax, and Chinese insect waxes, rice bran wax, Carnauba, Candelilla wax, Ouricury wax, Alfa wax, berry wax, shellac wax, Japanese wax and sumac wax; montan wax, orange and lemon waxes, refined sunflower wax marketed under the trademark SUNFLOWER WAX by KOSTER 40 KEUNEN, microcrystalline waxes, paraffins and ozokerite; polyethylene waxes, waxes obtained by Fisher-Tropsch synthesis and waxy copolymers and their esters.

There may also be mentioned waxes obtained by catalytic hydrogenation of animal or vegetable oils having linear or branched C8-C32 fatty chains. Among these, there may be mentioned isomerized jojoba oil such as trans isomerized partially hydrogenated jojoba oil manufactured or marketed by Desert Whale under the trade reference Iso-Jojoba-50®, sunflower oil hydrogenated hydrogenated castor oil, hydrogenated coconut oil, hydrogenated lanolin oil, and di- (1,1,1-trimethylolpropane) tetrastearate sold under the trade name Hest 2T-4S ® by the company HETERENE.

Mention may also be made of silicone waxes (C30-45 ALKYL DIMETHICONE) and fluorinated waxes.

It is also possible to use the waxes obtained by hydrogenation of castor oil esterified with cetyl alcohol sold under the names Phytowax Ricin 16L64® and 22L73® by the company SOPHIM. Such waxes are described in FR-A-2792190.

As the wax, a C20-C40 alkyl (hydroxystearyloxy) stearate (the alkyl group comprising from 20 to 40 carbon atoms), alone or in admixture, can be used. Such a wax is especially sold under the names "Kester Wax K 82 P®", "Hydroxypolyester K 82 P®" and "Kester Wax K 80 P®" by the company Koster Keunen.

As micro-waxes that can be used in the compositions according to the invention, mention may be made in particular of carnauba micro-waxes such as that marketed under the name MicroCare 350® by the company Micro Powders, synthetic wax waxes such as that marketed under the name MicroEase 114S® by MICRO POWDERS, the 25 micro waxes consisting of a mixture of carnauba wax and polyethylene wax such as those marketed under the names of Micro Care 300® and 310® by the MICRO POWDERS company, micro waxes consisting of a mixture of carnauba wax and synthetic wax such as that marketed under the name Micro Care 325® by the company MICRO 30 POWDERS, polyethylene micro-waxes such as those sold under the names of Micropoly 200®, 220®, 220L® and 250S® by the company MICRO POWDERS, the commercial products PERFOMAL EN 400 POLYETHYLENE and PERFORMALENE 500-L POLYETHYLENE from NEW PHASE TECHNOLOGIES, PERFORMALENE 655 POLYETHYLENE or paraffin waxes such as wax INCI, MICROCRYSTALLINE WAX and SYNTHETIC WAX and sold under the trade name MICROLEASE by the company SOCHIBO. ; polytetrafluoroethylene micro waxes such as those sold under the names Microslip 519® and 519 L® by the company Micro Powders. The composition according to the invention will preferably comprise a wax content (s) ranging from 3% to 20% by weight relative to the total weight of the composition, in particular from 5% to 15%, more particularly from 6% to 15%. .

45 Paste compounds

For the purposes of the present invention, the term "pasty compound" is intended to mean a lipophilic fat compound having a reversible solid / liquid state change, having in the solid state an anisotropic crystalline organization and having at a temperature of 50 ° C. liquid fraction and a solid fraction.

The pasty compound is preferably chosen from synthetic compounds and compounds of plant origin. A pasty compound can be obtained synthetically from starting materials of plant origin.

The pasty compound may advantageously be chosen from: lanolin and its derivatives, silicone compounds which may or may not be polymeric, fluorinated compounds which are polymeric or non-polymeric, vinyl polymers, in particular: homopolymers of olefins, copolymers of olefins, - homopolymers and copolymers of hydrogenated dienes, - linear or branched oligomers, homo or copolymers of alkyl (meth) acrylates preferably having a C8-C30 alkyl group, - homo and copolymer oligomers of vinyl esters having C 8 -C 30 alkyl groups; and homo- and copolymer oligomers of vinyl ethers having C 8 -C 30 alkyl groups; liposoluble polyethers resulting from the polyetherification between one or more C2-C100 diols, preferably C2-050, - the esters, - their mixtures.

Among the esters, the following are particularly preferred: esters of an oligomeric glycerol, in particular diglycerol esters, in particular adipic acid and glycerol condensates, for which part of the hydroxyl groups of the glycerols have reacted with a mixture of fatty acids such as stearic acid, capric acid, stearic acid and isostearic acid and 12-hydroxystearic acid, especially in the image of those marketed under the brand name Softisan 649 by the company Sasol, - arachidyl propionate sold under the trademark Waxenol 801 by Alzo, - phytosterol esters, - triglycerides of fatty acids and their derivatives, - pentaerythritol esters, - non-crosslinked polyesters resulting from the polycondensation between a linear or branched C 4 -C 50 dicarboxylic acid or polycarboxylic acid and a C2-050 diol or polyol; - the ester aliphatic esters resulting from the esterification of a 40 h acid ester aliphatic carboxylic acid with an aliphatic carboxylic acid, - polyesters resulting from the esterification, by a polycarboxylic acid, of an aliphatic hydroxycarboxylic acid ester, said ester comprising at least two hydroxyl groups such as Risocast DA-H ® products , and Risocast DA-L

The esters of diol dimer and diacid dimer, if appropriate, esterified on their (their) function (s) alcohol (s) or acid (s) free (s) by acidic radicals or alcohols such as Plandool-G - their mixtures.

Among the pasty compounds of plant origin, a mixture of soy sterols and oxyethylenated (5OE) oxypropylene pentaerythritol (5 PO), marketed under the reference Lanolide by the company VEVY, will preferably be chosen.

Lipophilic gelling agents Mineral gelling agents

As the mineral lipophilic gelling agent, there may be mentioned optionally modified clays, such as hectorites modified with a C10 to C22 ammonium chloride, such as hectorite modified with di-stearyl dimethyl ammonium chloride such as, for example, that marketed under the name Bentone 38V® by the company ELEMENTIS.

It is also possible to mention the optionally hydrophobic fumed silica surface with a particle size of less than 1 μm. It is indeed possible to chemically modify the surface of the silica, by chemical reaction generating a decrease in the number of silanol groups present on the surface of the silica. In particular, it is possible to substitute silanol groups with hydrophobic groups 20: a hydrophobic silica is then obtained. The hydrophobic groups may be trimethylsiloxyl groups, which are especially obtained by treatment of fumed silica in the presence of hexamethyldisilazane. Silicas thus treated are called "Silica silylate" according to the CTFA (8th edition, 2000). They are for example sold under the references Aerosil 25 R812® by the company Degussa, Cab-O-Sil TS-530® by the company Cabot, dimethylsilyloxyl or polydimethylsiloxane groups, which are especially obtained by treatment of fumed silica in the presence of polydimethylsiloxane or dimethyldichlorosilane. Silicas thus treated are called "Silica dimethyl silylate" according to the CTFA (8th edition, 2000). They are for example marketed under the references Aerosil R972®, and Aerosil R974® by the company DEGUSSA, CAB-O-SIL TS-610® and CAB-O-SIL TS-720® by CABOT.

In particular, the hydrophobic fumed silica has a particle size which may be nanometric to micrometric, for example from about 5 to 200 nm.

Organic gelling agents

The polymeric organic lipophilic gelling agents are, for example, partially or fully crosslinked elastomeric organopolysiloxanes of three-dimensional structure, such as those marketed under the names KSG6®, KSG16® and KSG18® by the company SHIN-ETSU, by Trefil E-505C®. and Trefil E-506C® by DOW-CORNING, Gransil SR-CYC®, 45 SR DMF10®, SR-DC556®, SR 5CYC gel®, SR DMF 10 gel® and SR DC 556 gel® by the company GRANT INDUSTRIES, SF 1204® and JK 113® by the company GENERAL ELECTRIC; ethylcellulose such as that sold under the name Ethocel® by Dow Chemical; galactomannans having from one to six, and in particular from two to four, hydroxyl groups per sac, substituted by a saturated or unsaturated alkyl chain, such as guar gum alkylated by C1-C6 alkyl chains, and in particular C1 C3 and mixtures thereof. Block copolymers of the "diblock", "triblock" or "radial" type of the polystyrene / polyisoprene, polystyrene / polybutadiene type, such as those sold under the name Luvitol HSB® by the company BASF, of the polystyrene / copoly (ethylene-propylene) type such as those sold under the name Kraton® by Shell Chemical Co., or else from the polystyrene / copoly (ethylene-butylene) type, mixtures of triblock and radial (star) copolymers in isododecane, such as those marketed by the company PENRECO company under the name Versagel® such as, for example, the mixture of butylene / ethylene / styrene triblock copolymer and ethylene / propylene / styrene star copolymer in isododecane (Versagel M 5960).

As the lipophilic gelling agent, mention may also be made of polymers having a weight average molecular weight of less than 100,000, comprising a) a polymeric backbone having hydrocarbon-based repeating units provided with at least one heteroatom, and optionally b) at least one chain pendent fat and / or at least one optionally functionalized terminal fatty chain having from 6 to 120 carbon atoms and being bonded to these hydrocarbon moieties, as disclosed in WO-A-02/056847, WO-A-02 / 47619, the contents of which are incorporated by reference; in particular polyamide resins (especially comprising alkyl groups having from 12 to 22 carbon atoms) such as those described in US-A-5783657 whose contents are incorporated by reference. Among the lipophilic gelling agents that can be used in the compositions according to the invention, mention may also be made of dextrin and fatty acid esters, such as dextrin palmitates, in particular such as those sold under the names Rheopearl TL® or Rheopearl KL® by the company CHIBA FLOUR. Silicone polyamides of the polyorganosiloxane type such as those described in US-A-5,874,069, US-A-5,919,441, US-A-6,051,216 and US-A-5,981,680 may also be used.

These silicone polymers may belong to the following two families: polyorganosiloxanes comprising at least two groups capable of establishing hydrogen interactions, these two groups being located in the polymer chain, and / or polyorganosiloxanes comprising at least two groups capable of to establish hydrogen interactions, these two groups being located on grafts or branches.

SALTS OR COMPLEXES OF ALUMINUM AND / OR ZIRCONIUM

The compositions according to the invention may additionally contain one or more salts or complexes of aluminum and / or zirconium.

The antiperspirant salts or complexes in accordance with the invention are generally chosen from aluminum or zirconium salts or complexes. They are preferably chosen from aluminum halohydrates; aluminum and zirconium halohydrates, complexes of zirconium hydroxychloride and aluminum hydroxychloride with or without an amino acid such as those described in US-3792068.

Among the aluminum salts, mention may in particular be made of aluminum chlorohydrate in activated or non-activated form, aluminum chlorohydrex, chlorohydrex polyethylene glycol aluminum complex, aluminum chlorohydrexpropyleneglycol complex, aluminum dichlorohydrate, aluminum dichlorohydrex complex polyethylene glycol, aluminum dichlorohydrexpropyleneglycol complex, sesquichlorohydrate aluminum, sesquichlorohydrex polyethyleneglycol aluminum complex, sesquichlorohydrexpropyleneglycol aluminum complex, aluminum sulphate buffered with sodium lactate and aluminum.

Among the aluminum and zirconium salts, there may be mentioned in particular aluminum zirconium octachlorohydrate, aluminum zirconium pentachlorohydrate, aluminum zirconium tetrachlorohydrate, aluminum zirconium trichlorohydrate.

Complexes of zirconium hydroxychloride and aluminum hydroxychloride with an amino acid are generally known as ZAG (when the amino acid is glycine). Among these products, mention may be made of aluminum complexes of zirconium octachlorohydrex glycine, aluminum zirconium pentachlorohydrex glycine, aluminum zirconium tetrachlorohydrex glycine and aluminum zirconium trichlorohydrex glycine.

The antiperspirant salts or complexes may be present in the composition according to the invention in a proportion of approximately 0.5 to 25% by weight relative to the total weight of the composition.

DEODORANT ASSETS The compositions according to the invention may additionally contain one or more deodorant active agents.

The deodorant active agents may be bacteriostatic agents or bactericidal agents acting on the germs of axillary odors, such as 2,4,4'-trichloro-2'-hydroxydiphenyl ether (®Triclosan), 2,4-dichloro-2 ' 3-hydroxydiphenyl ether, 3 ', 4', 5'-trichlorosalicylanilide, 1- (3 ', 4'-dichlorophenyl) -3- (4'-chlorophenyl) urea (®Triclocarban) or 3,7,11-trimethyldodeca -2,5,10-trienol (®Farnesol); quaternary ammonium salts such as cetyltrimethylammonium salts, cetylpyridinium salts, DPTA (1,3-diaminopropanetetraacetic acid), 1,2 decanediol (SYMCLARIOL from Symrise), glycerine derivatives, for example Caprylic / Capric Glycerides (CAPMUL MCM from Abitec), Caprylate or Glycerol caprate (DERMOSOFT GMCY and DERMOSOFT GMC respectively from STRAETMANS), 45 Polyglyceryl-2 Caprate (DERMOSOFT DG ™ from STRAETMANS) Biguanide derivatives such as polyhexamethylene salts biguanide. - chlorhexidine and its salts; 4-Phenyl-4,4-dimethyl-2-butanol (SYMDEO MPP from Symrise). Among the deodorant active agents according to the invention, mention may also be made of zinc salts such as zinc salicylate, zinc gluconate and zinc pidolate; zinc sulphate, zinc chloride, zinc lactate, zinc phenolsulfonate; zinc ricinoleate - sodium bicarbonate; salicylic acid and its derivatives such as n-octanoyl-5-salicylic acid; silver zeolites or without silver; alum. In the event of incompatibility or to stabilize them, some of the above-mentioned active agents may be incorporated into spherules, in particular ionic or non-ionic vesicles and / or nanoparticles (nanocapsules and / or nanospheres).

The deodorant active agents may preferably be present in the compositions according to the invention in weight concentrations ranging from 0.01 to 5% by weight relative to the total weight of the composition.

SUSPENSION AGENTS

In order to improve the homogeneity of the product, one or more suspending agents may also be used, which are preferably selected from hydrophobic modified montmorillonite clays, such as hydrophobic modified bentonites or hectorites. Mention may be made, for example, of the product Stearalkonium Bentonite (CTFA name) (reaction product of bentonite and of quaternary ammonium stearalkonium chloride), such as the commercial product sold under the name Tixogel MP 250 by the company Sud Chemie Rheologicals, United Catalysts Inc. or the product Disteardimonium Hectorite (CTFA name) (reaction product of hectorite and distearyldimium chloride) sold under the name Bentone 38 or Bentone Gel by Elementis Specialties.

The suspending agents are preferably present in amounts ranging from 0.1 to 5% by weight and more preferably from 0.2 to 2% by weight relative to the total weight of the composition.

ORGANIC POWDER According to one particular form of the invention, the antiperspirant compositions according to the invention will also contain an organic powder.

As used herein, the term "organic powder" means any solid that is insoluble in the medium at room temperature (25 ° C.).

Organic powders that may be used in the composition of the invention include, for example, polyamide particles and especially those sold under the names ORGASOL by Atochem; 45 powders of polyethylene; microspheres based on acrylic copolymers, such as those made of ethylene glycol dimethacrylate / lauryl methacrylate copolymer sold by Dow Corning under the name Polytrap; polymethyl methacrylate microspheres, sold under the name MICROSPHERE M-100 by the company Matsumoto or under the name COVABEAD LH85 by the company Wackherr; hollow polymethyl methacrylate microspheres (particle size: 6.5-10.5 μ) sold under the name Ganzpearl GMP 0800 by Ganz Chemical; Methyl methacrylate / ethylene glycol dimethacrylate copolymer microbeads (size: 6.5-10.5 μ) sold under the name Ganzpearl GMP 0820 by Ganz Chemical or Microsponge 5640 by the company Amcol Health & Beauty Solutions; ethyleneacrylate copolymer powders, such as those sold under the name FLOBEADS by Sumitomo Seika Chemicals; expanded powders such as hollow microspheres and in particular microspheres formed of a terpolymer of vinylidene chloride, acrylonitrile and methacrylate and sold under the name Expancel by the company Kemanord Piast under the references 551 DE 12 (particle size distribution d about 12 μm and density 40 kg / m 3), 551 DE (particle size about 30 μm and density 65 kg / m 3), 551 DE 50 (particle size about 40 μm), or the microspheres marketed under the name MICROPEARL F 80 ED by the company Matsumoto; powders of natural organic materials such as starch powders, especially corn starch, wheat or rice, crosslinked or otherwise, such as starch powders crosslinked with octenylsuccinate anhydride, sold under the name DRY -FLO by the company National Starch; Silicone resin microbeads such as those sold under the name Tospearl by Toshiba Silicone, especially Tospearl 240; amino acid powders such as the Lauroyllysine powder marketed under the name Amihope LL-11 by the Ajinomoto Company; the wax microdispersion particles, which preferably have average dimensions of less than 1 μm and in particular from 0.02 μm to 1 μm, and which consist essentially of a wax or a mixture of waxes, such as the products marketed under the name Aquacer by Byk Cera, and in particular: Aquacer 520 (mixture of synthetic and natural waxes), Aquacer 514 or 513 (polyethylene wax), Aquacer 511 (polymeric wax), or such as the products sold under the name Jonwax 120 by Johnson Polymer (a blend of polyethylene waxes and paraffin wax) and under the name Ceraflour 961 by Byk Cera (micronized modified polyethylene wax); and their mixtures.

35 ADDITIVES

The cosmetic compositions according to the invention may furthermore comprise cosmetic adjuvants chosen from softeners, antioxidants, opacifiers, stabilizers, moisturizing agents, vitamins, bactericides, preservatives, polymers, perfumes, agents and the like. thickeners, propellants or any other ingredient usually used in cosmetics for this type of application.

Of course, those skilled in the art will take care to choose this or these optional complementary compounds in such a way that the advantageous properties intrinsically attached to the cosmetic composition according to the invention are not, or not substantially, impaired by the addition or additions. considered.

The thickeners, preferably nonionic, can be chosen from 50 guar gums and modified or unmodified celluloses such as hydroxypropyl guar gum, cetylhydroxyethylcellulose, silicas such as Bentone Gel MIO sold by the company NL INDUSTRIES or the Veegum Ultra, sold by the company POLYPLASTIC.

The thickeners may also be cationic, for example POLYQUATERNIUM-37 sold under the name Salcare SC95 (Polyquaternium-37 (And) Mineral Oil (And) PPG-1 Trideceth-6) or Salcare SC96 (Polyquaternium-37 (And) Propylene Glycol Dicaprylate / Dicaprate (And) PPG-1-Trideceth-6) or other crosslinked cationic polymer such as, for example, those of the CTFA name Ethylacrylate / Dimethylamino Ethyl Methacrylate Cationic Emulsion Copolymer.

The amounts of these various constituents that may be present in the cosmetic composition according to the invention are those conventionally used in compositions for the treatment of perspiration.

AEROSOLS

The compositions according to the invention may also be pressurized and packaged in an aerosol device consisting of: (A) a container comprising an antiperspirant composition as defined above, (B) at least one propellant and a dispensing means of said aerosol composition. Propellants generally used in this type of product and well known to those skilled in the art are, for example, dimethyl ether (DME); volatile hydrocarbons such as n-butane, propane, isobutane, and mixtures thereof, optionally with at least one chlorinated and / or fluorinated hydrocarbon; Among these are the compounds sold by the company Dupont de Nemours under the names Freon® and Dymel®, and in particular monofluorotrichloromethane, difluorodichloromethane, tetrafluorodichloroethane and 1,1-difluoroethane sold in particular under the trade name DYMEL 152 A by the company DUPONT. Carbon dioxide, nitrous oxide, nitrogen or compressed air can also be used as the propellant.

The compositions containing the perlite particles as defined above and the propellant (s) may be in the same compartment or in different compartments in the aerosol container. According to the invention, the concentration of propellant generally varies from 5 to 95% by weight pressurized and more preferably from 50 to 85% by weight relative to the total weight of the pressurized composition.

The dispensing means, which forms part of the aerosol device, is generally constituted by a dispensing valve controlled by a dispensing head, itself comprising a nozzle through which the aerosol composition is vaporized. The container containing the pressurized composition may be opaque or transparent. It may be made of glass, polymeric material or metal, possibly covered with a layer of protective varnish.

The following examples serve to illustrate the present invention. The amounts are given as a percentage by weight relative to the total weight of the composition. EXAMPLES Example 1: Anhydrous Stick L-POLYETHYLENE WAX (PERFORMALENE 500-L 4.1% POLYETHYLENENEW PHASE TECHNOLOGY) 15-HOMOPOLYMER OF ETHYLENE (PERFORMALENE 400 POLYETHYLENE - NEW PHASE TECHNOLOGY) 8.3% - CYCLOHEXA DIMETHYLSILOXANE 26.4 0/0 DOW CORNING 246 FLUID -DOW CORNING) 20 - PHENYL TRIMETHICONE (DOW CORNING 556 COSMETIC GRADE FLUID-DOW CORNING) 19.6% - ISO-HEXADECANE 19.6% - METHYL METHACRYLATE CROSSPOLYMER 15.0 0/0 GANZPEARL GMP 0820 - GANZ CHEMICAL) 25 - COMPOUND 1 6,5 0/0 - PYRROLIDONE 0.5 MICROZINC ZINC CARBOXYLATE (UCIB -SOLABIA) 30 Procedure:

The cyclopentasiloxane is heated to 65 ° C. The other ingredients (one by one) are added remaining at 65-10 ° C. The whole (transparent solution) is homogenized for 15 minutes. Perlite or superabsorbent polymer is added. Cooled to about 55 ° C (a few ° C above the thickening of the mixture) and poured into the sticks. It is put at 4 ° C for 30 minutes. Examples 2 and 3: Aerosols Ingredients Ex 2 Ex3 TRIETHYL CITRATE 1.0 1.0 (CITROFLEX 2 (REILLY CHEMICALS) STEARALKONIUM BENTONITE 0.2 0.2 TIXOGEL MP250 (SOUTH CHEMIE RHEOLOG.) ISOPROPYL PALMITATE 0.9 0, 9 COMPOUND 2 2,6 COMPOUND 3 - 2,6 CYCLOPENTASILOXANE (and) 1,3 1,3 DIMETHICONOL (DOW CORNING 1501 FLUID) ISOBUTANE (A-31 -AEROPRES) qs 100 qs 100

Claims (9)

REVENDICATIONS1. Compound corresponding to the following formula (I) and CLAIMS1. Compound corresponding to the following formula (I) as well as its salts, its optical isomers, stereoisomers, enantiomers and diastereoisomers or one of its geometric isomers: ## STR2 ## where X denotes a group chosen from: H with n = 1,2 and m = 1,2,3,4 nb O ba N 15 withn = 1,2 H 0 0 H b HON - b O a H m SMe ONH2 H a 0 H b 0 / H Wherein m = 1,2,3,4a denotes the point of attachment of said radical with the carbonyl group and b denotes the point of attachment of said radical with the NH group, in formula (I). R1 denotes an aryl or benzyl radical or linear or branched, saturated or unsaturated C1-C13 alkyl; R2 denotes a radical -OR1 or -NR1'R2 'Ri' and R'2, which may be identical or different, denote a hydrogen atom; or a radical R ~ R3 denotes -OH or one of the following groups: ## STR2 ## with n = 1, 2, 3 0 * OH OH OH 2. Compound according to claim 1, wherein X denotes the group O and R1 denotes a linear or branched, saturated or unsaturated C1-C12 alkyl radical with a, b, n, m, R2, R3, R'1, R 2 having the meanings given in claim 1. 25 3. Compound according to claim 2, wherein RI denotes a linear or branched, saturated or unsaturated C 1 -C 12 alkyl radical. 4. A compound according to claim 3, wherein R1 denotes a linear or branched, saturated or unsaturated C1-C6 alkyl radical R2 denotes -OH or -NH2. 10 5. Compound according to claim 4, wherein R1 denotes a linear C1-C4 saturated alkyl radical, preferably a methyl radical R2 denotes -NH2 R3 denotes -OH or a radical -NH- (CH2) x CO2H, x being 1, 2, 3 or 4. 6. A compound according to any one of claims 1 to 4, selected from the following compounds or one of their salts, optical isomers, stereoisomers, enantiomers and diastereoisomers or geometric isomers o HN o NH Compound 1 HN H2N NH HO 15 HN O Compound 2 o CONH2 N \ NH H2N 20 HN 25 Compound 3 7. Composition comprising in a cosmetically acceptable medium at least one compound as defined according to any one of claims 1 to 6. 8. Use of at least one compound as defined in any one of claims 1 to 6 as a treatment agent for transpiration in a cosmetic composition. 9. A cosmetic process for treating human perspiration and possibly human body odors, comprising applying to the surface of the skin a composition comprising in a cosmetically acceptable medium at least one compound as defined according to any one of claims 1 to 65.