FR2955106A1 - NOVEL CYCLOPROPYLATED BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

Abstract

Compounds of formula (I): in which R1 and R2, which may be identical or different, each represents a hydrogen or halogen atom, or a cyano, hydroxy, thio, nitro, alkyl, alkoxy, alkylthio, carboxy or alkoxycarbonyl group, acyloxy, amino, acylamino, aminocarbonyl, aminosulfonyl, alkylsulfonylamino or N-hydroxycarboximidamide, Drugs.

Description

The present invention relates to novel cyclopropylated benzothiadiazine derivatives, process for their preparation, pharmaceutical compositions containing them and their use as positive allosteric modulators of AMPA receptors.

It is now recognized that excitatory amino acids, and particularly glutamate, play a crucial role in the physiological processes of neural plasticity and in the mechanisms underlying learning and memory. Pathophysiological studies have clearly indicated that a deficit in glutamatergic neurotransmission is closely associated with the development of Alzheimer's disease (Neuroscience and Biobehavioral Reviews, 1992, 16, 13-24, Progress in Neurobiology, 1992, 39, 517- 545).

In addition, some studies have demonstrated in recent years the existence of receptor subtypes of excitatory amino acids and their functional interactions (Molecular Neuropharmacology, 1992, 2, 15-31).

Among these receptors, the PAMPA receptor ("α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid") appears to be the most involved in the phenomena of physiological neuronal excitability and in particular in those involved in memorization process. For example, learning has been shown to be associated with increased binding of PAMPA to its receptor in the hippocampus, one of the brain areas essential to mnemocognitive processes. Similarly, nootropic agents such as aniracetam have been described as positively modulating the AMPA receptors of neuronal cells (J. Neurochemistry, 1992, 58, 1199-1204).

In the literature, compounds of benzamide structure have been described to possess this same mechanism of action and to improve memory performance (Synapse, 1993, 15, 326-329). The compound BA 74, in particular, is the most active among these new pharmacological agents. Finally, patent EP 692 484 discloses a benzothiadiazine derivative having an AMPA current facilitating activity and the patent application WO 99/42456 describes, inter alia, certain benzothiadiazine derivatives as AMPA receptor modulators.

The benzothiadiazine derivatives, objects of the present invention, are new and are powerful modulators of AMPA receptors.

More specifically, the present invention relates to compounds of formula (I): (I) wherein,

R1 and R2, which are identical or different, each represents a hydrogen atom, a halogen atom, or a cyano group; hydroxy; thio; nitro; optionally substituted linear or branched (C1-C6) alkyl; linear or branched (C1-C6) alkoxy unsubstituted or substituted by one or more halogen atoms; linear or branched alkylthio (C1-C6); carboxy; linear or branched (C1-C6) alkoxycarbonyl; linear or branched acyloxy (C1-C6); amino unsubstituted or substituted with one or two linear or branched (C1-C6) alkyl groups, the same or different; acylamino (C1-C6) linear or branched unsubstituted or substituted on the nitrogen atom with a linear or branched (C1-C6) alkyl group; aminocarbonyl unsubstituted or substituted with one or two identical or different linear or branched (C1-C6) alkyl groups; aminosulphonyl unsubstituted or substituted with one or two linear or branched (C1-C6) alkyl groups, which are identical or different; alkylsulfonylamino (C1-C6) linear or branched unsubstituted or substituted on the nitrogen atom with a linear or branched (C1-C6) alkyl group; or N-hydroxycarboximidamide, their enantiomers and diastereoisomers when they exist, as well as their addition salts with a pharmaceutically acceptable acid or base,

it being understood that the term "optionally substituted" assigned to the term alkyl means that this group may be substituted by one or more halogen atoms, or by a cyano group; hydroxy; thio; nitro; linear or branched (C1-C6) alkoxy unsubstituted or substituted by one or more halogen atoms; linear or branched alkylthio (C1-C6); carboxy; linear or branched (C1-C6) alkoxycarbonyl; linear or branched acyloxy (C1-C6); amino unsubstituted or substituted with one or two linear or branched (C1-C6) alkyl groups, which are identical or different; acylamino (C1-C6) linear or branched unsubstituted or substituted on the nitrogen atom by a linear or branched (C1-C6) alkyl group; aminocarbonyl unsubstituted or substituted with one or two identical or different linear or branched (C1-C6) alkyl groups; aminosulfonyl unsubstituted or substituted with one or two identical or different linear or branched (C1-C6) alkyl groups; alkylsulfonylamino (C1-C6) linear or branched unsubstituted or substituted on the nitrogen atom with a linear or branched (C1-C6) alkyl group; or N-hydroxycarboximidamide.

Among the pharmaceutically acceptable acids, mention may be made, without limitation, of hydrochloric, hydrobromic, sulfuric, phosphoric, acetic, trifluoroacetic, lactic, pyruvic, malonic, succinic, glutaric, fumaric, tartaric, maleic, citric, ascorbic, oxalic and methanesulphonic acids. , benzenesulfonic, camphoric.

Among the pharmaceutically acceptable bases, mention may be made, without limitation, of sodium hydroxide, potassium hydroxide, triethylamine and tertbutylamine.

The group R 1 preferably represents a hydrogen atom or a halogen atom, and more particularly the fluorine atom. Advantageously, the group R 1 represents a hydrogen atom. The R2 group preferably represents a hydrogen atom; a halogen atom; a cyano group; an optionally substituted linear or branched (C1-C6) alkyl group; a linear or branched (C1-C6) alkoxy group; a linear or branched acylamino (C1-C6) group; an aminocarbonyl group unsubstituted or substituted with one or two linear or branched (C1-C6) alkyl groups; a linear or branched alkylsulfonylamino (C1-C6) group; or an N-hydroxycarboximidamide group.

When R2 represents a substituted alkyl group, it preferably represents a methyl or ethyl group substituted by one or more halogen atoms, or by a linear or branched (C1-C6) alkoxy group which is unsubstituted or substituted by one or more atoms. halogen; linear or branched (C1-C6) alkoxycarbonyl; linear or branched acylamino (C1-C6); aminocarbonyl unsubstituted or substituted with one or two identical or different linear or branched (C1-C6) alkyl groups; aminosulfonyl unsubstituted or substituted with one or two identical or different linear or branched (C1-C6) alkyl groups; or linear or branched alkylsulfonylamino (C1-C6).

Compounds in which R 2 represents a hydrogen atom are more particularly preferred; a fluorine, chlorine or bromine atom; a methyl group; a methoxy group; an acetylamino group; a -CONH2 group; an N-methylaminocarbonyl group; an N, N-dimethylaminocarbonyl group; a methylsulfonamide group; an acetylaminomethyl group; or a methylsulfonylaminomethyl group.

According to a preferred embodiment, R1 represents a hydrogen atom and R2 represents a hydrogen atom; a fluorine, chlorine or bromine atom; a methyl group; a methoxy group; a cyano group; an acetylamino group; a -CONH2 group; an N-methylaminocarbonyl group; an N, N-dimethylaminocarbonyl group; a methylsulfonamide group; an acetylaminomethyl group; a methylsulfonylaminomethyl group; or an N-hydroxycarboximidamide group. The R2 group is preferably in the meta or para position. Advantageously, R2 is positioned in meta.

The preferred compounds according to the invention are:

4-cyclopropyl-3,4-dihydro-7-phenoxy-2H-1,2,4-benzothiadiazine 1,1-dioxide; 7- (3-bromophenoxy) -4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide; 7- (4-bromophenoxy) -4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide; 3 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] benzonitrile; • [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] benzonitrile; 4-cyclopropyl-3,4-dihydro-7- (3-methylphenoxy) -2H-1,2,4-benzothiadiazine 1,1-dioxide; 4-cyclopropyl-3,4-dihydro-7- (4-methylphenoxy) -2H-1,2,4-benzothiadiazine 1,1-dioxide; 4-cyclopropyl-3,4-dihydro-7- (3-methoxyphenoxy) -2H-1,2,4-benzothiadiazine 1,1-dioxide; 4-cyclopropyl-3,4-dihydro-7- (4-methoxyphenoxy) -2H-1,2,4-benzothiadiazine 1,1-dioxide; N- {3 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] phenyl} acetamide; N- {4 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] phenyl} acetamide; N- {3 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] benzyl} acetamide; N- {4 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] benzyl} acetamide; 3 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] benzamide; 4 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] benzamide; 3 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] N -methylbenzamide; 4 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] N -methylbenzamide; 3 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] -N, N-dimethylbenzamide; 4 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] -N, N-dimethylbenzamide; N- {3 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] phenyl} methanesulfonamide; N- {4 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] phenyl} methanesulfonamide; N- {3 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] benzyl} methanesulfonamide; N- {4 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] benzyl} methanesulfonamide; 3 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] -N'-hydroxybenzenecarboximidamide; And 4 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] -N '-hydroxybenzenecarboximidamide.

The addition salts with an acid or a pharmaceutically acceptable base of the preferred compounds of the invention form an integral part of the invention.

The invention also extends to the process for the preparation of the compounds of formula (I) from the compound of formula (II): wherein R3 represents a linear or branched (C1-C6) alkoxy group, which is cyclized in the presence of a compound of formula (III): wherein R4 represents a linear or branched (C1-C6) alkyl group, to yield the compound of formula (IV) ): in which R3 is as defined above,

that is reacted with a reducing agent, to give the compound of formula (V), (V) wherein R3 is as defined above, which then undergoes the action of boron tribromide, to lead to the compound of formula (VI): HO which is reacted with a boronic acid derivative of formula (VII): OH (VII) in which R1 and R2 have the same meaning as in formula (I), to lead to compound of formula (I),

which can then be purified according to a conventional separation technique, which is converted, if desired, into its addition salts with an acid or a pharmaceutically acceptable base and from which the isomers are optionally separated, if they exist, according to a classical technique of separation.

The compounds of formula (II) and formula (VII) are commercially available or readily available to those skilled in the art by conventional or described chemistry reactions.

The compounds of formula (I) according to the invention have AMPA receptor activating properties which make them useful in the treatment or the prevention of mnemocognitive disorders associated with age, with anxiety or depressive syndromes, with progressive neurodegenerative diseases, with Alzheimer's disease, Parkinson's disease, Pick's disease, Huntington's disease, Korsakoff's disease, schizophrenia, the sequelae of acute neurodegenerative diseases, frontal and sub-cortical sequelae of ischemia and sequelae of epilepsy.

The invention also extends to pharmaceutical compositions containing as active ingredient at least one compound of formula (I) with one or more inert, non-toxic and suitable excipients. Among the pharmaceutical compositions according to the invention, mention may be made more particularly of those which are suitable for oral, parenteral (intravenous or subcutaneous), nasal administration, single or coated tablets, sublingual tablets, capsules, lozenges, suppositories, creams, ointments, dermal gels, injectables, and oral suspensions.

The useful dosage is adaptable according to the nature and severity of the condition, the route of administration and the age and weight of the patient. This dosage varies from 0.01 to 1000 mg per day in one or more doses.

The following examples illustrate the invention but do not limit it in any way.

The starting materials used are known products or prepared according to known preparatory methods. The structures of the compounds described in the examples were determined according to the usual spectrophotometric techniques (infrared, NMR, mass spectrometry).

EXAMPLE 1 4-cyclopropyl-3,4-dihydro-7-phenoxy-2H-1,2,4-benzothiadiazine 1,1-dioxide

Step A: 4-cyclopropyl-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide

The solution of 2-amino-5-methoxybenzenesulfonamide (4.9 mmol) in methanol (20 mL) is added with (1-ethoxycyclopropyloxy) trimethylsilane (4 mL) and glacial acetic acid (4 mL) and then brought to reflux. for 18 hours. After this time, the medium is evaporated to dryness under vacuum. The oil obtained is taken up in water (30 ml) and extracted with chloroform (3 × 30 ml). The chloroform phases are combined and dried over anhydrous MgSO 4. After filtration, the filtrate is evaporated to dryness and the residual oil is engaged as it is in the next step. The solution of the residual oil from the previous step in THF (50 mL) is treated with NaBH4 (2 g) and boron trifluoride etherate (2 mL) and refluxed for 18 hours. Then, the solvent is removed by evaporation under reduced pressure and the residue is taken up in water (30 ml), adjusted to a slightly acidic pH by addition of 6 N HCl, and then extracted with chloroform (3 × 30 ml). The chloroform phases are combined and dried over anhydrous MgSO 4. After filtration, the filtrate is evaporated to dryness and the residual oil is engaged as it is in the next step. In a flask, the compound of the previous step (2.5 g) and ethyl orthoformate (25 mL) was heated in an open vessel at 150 ° C for 1 hour. The suspension obtained is cooled on an ice bath and the insoluble material is collected by filtration, washed with ether and dried. The solid is redissolved in a mixture of acetone and hot methanol and the hot solution is treated with absorbent charcoal, then filtered and concentrated to dryness. The residue is recrystallized from methanol to give the title product as a white solid. Melting Point: 216-219 ° C Step B: 4-Cyclopropyl-3,4-dihydro-7-methoxy-2H-1,2,4-benzothiadiazine 1,1-dioxide

The solution of 4-cyclopropyl-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide of the previous step (1.9 g) in isopropanol (50 mL) is added with NaBH4 (1 g). g) finely ground and then heated for 5-10 minutes at 50-55 ° C. The solvent is removed by evaporation under vacuum. The residue is taken up in water (50 mL) and brought to acidic pH by the addition of 6N HCl. The title product is extracted with dichloromethane (3 x 30 mL). The organic phase is dried over MgSO4 and filtered. The filtrate is evaporated to dryness and the resulting residue is recrystallized from 1: 1 methanol / water (60 mL).

Melting point: 154-156 ° C

Stage C: 4-Cyclopropyl-3,4-dihydro-7-hydroxy-2H-1,2,4-benzothiadiazine 1,1-dioxide

The solution of 4-cyclopropyl-3,4-dihydro-7-methoxy-2H-1,2,4-benzothiadiazine 1,1-dioxide (50 mg) in chloroform (3 mL) is cooled on an ice bath, then added with boron tribromide (0.15 mL). After stirring for 20 hours, the medium is added with water (5 mL), then concentrated under vacuum to remove chloroform, and then extracted with ethyl acetate (3 × 20 mL). The organic phases are combined and dried over anhydrous MgSO4. After filtration, the filtrate is evaporated to dryness and the residue is dissolved in ethyl acetate (1 mL) and then hexane (5 mL) is added. The precipitate obtained is collected by filtration, washed with hexane and dried to yield the title product as a white solid. Melting point: 187-189 ° C

Stage D: 4-cyclopropyl-3,4-dihydro-7-p-phenoxy-2H-1,2,4-benzothiadiazine 1,1-dioxide The solution of 4-cyclopropyl-3,4-dihydro-7-hydroxy-2H -1,2,4-benzothiadiazine 1,1-dioxide (400 mg, 1.7 mmol) in dichloromethane (60 mL) is added with pyridine (10 drops), 4A molecular sieve (16 g), phenylboronic acid (300 mg, 2.5 mmol) and cupric acetate (450 mg, 2.5 mmol). The suspension is stirred for 5 hours at 40 ° C. Then, a supplement of dichloromethane is added (40 mL) and the suspension is filtered. The filtrate is evaporated to dryness under vacuum and the residue obtained is taken up in water (50 mL) slightly acidified with HCl. The suspension is extracted with three portions of ethyl acetate (3 x 50 mL). The organic phases are combined and dried over anhydrous MgSO4. After filtration, the filtrate is concentrated to dryness and the residue is purified by chromatography on silica gel (dichloromethane). After recrystallization from dichloromethane / petroleum ether (5/15), the title product is obtained as a white solid. Melting Point: 198-200 ° C.

EXAMPLE 2 4-cyclopropyl-3,4-dihydro-7- (3-methoxyphenoxy) -2H-1,2,4-benzothiadiazine 1,1-dioxide

The title product is obtained according to the protocol described in Example 1 using 3-methoxyphenylboronic acid instead of phenylboronic acid. Melting point: 148-150 ° C

EXAMPLE 3 3 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] benzonitrile

The title product is obtained according to the protocol described in Example 1 using 3-cyanophenylboronic acid instead of phenylboronic acid. Melting point: 198-200 ° C

EXAMPLE 4 N- {3 - [(4-Cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] phenyl} methanesulfonamide

The title product is obtained according to the protocol described in Example 1 using 3 - [(methylsulfonyl) amino] phenylboronic acid in place of phenylboronic acid. The compounds of Examples 5 to 25, mentioned below, are obtained according to the protocol described in Example 1, using the corresponding boronic acid in place of phenylboronic acid.

EXAMPLE 5 7- (3-bromophenoxy) -4-cyclopropyl-3,4-dihydro-2H-1,2,4-5 benzothiadiazine 1,1-dioxide

EXAMPLE 6 7- (4-bromophenoxy) -4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide

EXAMPLE 7 4 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] benzonitrile

EXAMPLE 8: 4-Cyclopropyl-3,4-dihydro-7- (3-methylphenoxy) -2H-1,2,4-benzothiadiazine 1,1-dioxide

EXAMPLE 9 4-cyclopropyl-3,4-dihydro-7- (4-methylphenoxy) -2H-1,2,4-benzothiadiazine 1,1-dioxide

EXAMPLE 10 4-cyclopropyl-3,4-dihydro-7- (4-methoxyphenoxy) -2H-1,2,4-15 benzothiadiazine 1,1-dioxide

EXAMPLE 11 N- {3 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] phenyl} acetamide

EXAMPLE 12: N- {4 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiazin-7-yl) oxy] phenyl} acetamide

EXAMPLE 13: N- {3 - [(4-Cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiazin-7-yl) oxy] benzyl} acetamide 2955106 -14 EXAMPLE 14 N- {4- [(4-Cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] benzyl} acetamide

EXAMPLE 15 3 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] benzamide

EXAMPLE 16: 4 - [(4-Cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] benzamide

EXAMPLE 17: 3 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] -N-methylbenzamide

EXAMPLE 18 4 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] -N-methylbenzamide

EXAMPLE 19 3 - [(4-Cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] -N, N-dimethylbenzamide

EXAMPLE 20 4 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] -N, N-dimethylbenzamide

EXAMPLE 21: N- {4 - [(4-Cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] phenyl} methanesulfonamide

EXAMPLE 22 N- {3 - [(4-Cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] benzyl} methanesulfonamide

EXAMPLE 23 N- {4 - [(4-Cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4,20-benzothiadiazin-7-yl) oxy] benzyl} methanesulfonamide

EXAMPLE 24: 3 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] -N'-hydroxybenzenecarboximidamide EXAMPLE 25 : 4 - [(4-Cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] -N'-hydroxybenzenecarboximidamide - 16 - PHARMACOLOGICAL STUDY

EXAMPLE A Study of the effect of the products on PAMPA-induced membrane depolarization on primary cultures of rat neurons.

The test consists in the in vitro fluorescence measurement of the membrane depolarization induced on rat embryonic neurons in culture, by the joint action of PAMPA and the tested product, in comparison with the action of PAMPA alone. Brain cells are cultured and maintained in a cell culture incubator for 18 days. After incubation, the culture medium is removed and replaced with fluorescence probe loading medium for measuring the membrane potential (20 μl Molecular Devices membrane potential kit) and left at room temperature for 1 hour. The basic fluorescence of the wells is read (Hamamatsu FDSS apparatus), then PAMPA is injected onto the cells (20 μl, concentration range 3 to 100 μM) and the action of PAMPA is measured in kinetics. The test product is then introduced into the wells (20 .mu.l in concentration range, crossed with that of PAMPA) and the action of the product is measured in kinetics. At the end of each of the two measurement periods in kinetics, the value used for each well is the average of the reading over the last 15 seconds of the period. The PAMPA effect curves are shown at different product concentrations. For each product concentration, the value retained is the area under the AMPA curve at that concentration and EC2X, a product concentration that doubles the PAMPA-induced membrane potential, is calculated.

The compounds of the invention strongly potentiate the excitatory effects of PAMPA. By way of example, the compound of Example 1 has an EC2X of 0.3 μM. EXAMPLE B Pharmaceutical Composition

Preparation formula for 1000 tablets dosed at 10 mg with 4-cyclopropyl-3,4-dihydro-7-phenoxy-2H-1,2,4-benzothiadiazine 1,1-dioxide (Example 1) 10 g Hydroxypropylcellulose 2 g starch Wheat 10 g Lactose 100 g Magnesium stearate 3 g Talc 3 g

Claims (12)

REVENDICATIONS1. Compounds of formula (I): (I) in which: R1 and R2, identical or different, each represent a hydrogen atom, a halogen atom, or a cyano group; hydroxy; thio; nitro; optionally substituted linear or branched (C1-C6) alkyl; linear or branched (C1-C6) alkoxy unsubstituted or substituted by one or more halogen atoms; linear or branched alkylthio (C1-C6); carboxy; linear or branched (C1-C6) alkoxycarbonyl; linear or branched acyloxy (C1-C6); amino unsubstituted or substituted with one or two linear or branched (C1-C6) alkyl groups, which are identical or different; acylamino (C1-C6) linear or branched unsubstituted or substituted on the nitrogen atom with a linear or branched (C1-C6) alkyl group; aminocarbonyl unsubstituted or substituted with one or two identical or different linear or branched (C1-C6) alkyl groups; aminosulfonyl unsubstituted or substituted with one or two identical or different linear or branched (C1-C6) alkyl groups; alkylsulfonylamino (C1-C6) linear or branched unsubstituted or substituted on the nitrogen atom with a linear or branched (C1-C6) alkyl group; or N-hydroxycarboximidamide, it being understood that the term "optionally substituted" for the term alkyl means that this group may be substituted by one or more halogen atoms, or by a cyano group; hydroxy; thio; nitro; linear or branched (C1-C6) alkoxy, unsubstituted or substituted by one or more halogen atoms; linear or branched alkylthio (C1-C6); carboxy; linear or branched (C1-C6) alkoxycarbonyl; linear or branched acyloxy (C1-C6); amino unsubstituted or substituted with one or two linear or branched (C1-C6) alkyl groups, which are identical or different; linear or branched acylamino (C1-C6) unsubstituted or substituted on the nitrogen atom with a linear or branched (C1-C6) alkyl group; aminocarbonyl unsubstituted or substituted with one or two identical or different linear or branched (C1-C6) alkyl groups; aminosulfonyl unsubstituted or substituted with one or two identical or different linear or branched (C1-C6) alkyl groups; linear or branched alkylsulfonylamino (C1-C6) unsubstituted or substituted on the nitrogen atom with a linear or branched (C1-C6) alkyl group; or N-hydroxycarboximidamide, their enantiomers and diastereoisomers when they exist, as well as their addition salts with a pharmaceutically acceptable acid or base. 2. Compounds of formula (I) according to claim 1, characterized in that RI represents a hydrogen atom. 3. Compounds of formula (I) according to claim 1, characterized in that RI represents a halogen atom. 4. Compounds of formula (I) according to claim 1, characterized in that R2 represents a hydrogen atom; a halogen atom; a cyano group; an optionally substituted linear or branched (C1-C6) alkyl group; a linear or branched (C1-C6) alkoxy group; a linear or branched acylamino (C1-C6) group; an aminocarbonyl group unsubstituted or substituted with one or two linear or branched (C1-C6) alkyl groups; a linear or branched alkylsulfonylamino (C1-C6) group; or an N-hydroxycarboximidamide group. 5. Compounds of formula (I) according to claim 1, characterized in that R2 represents a hydrogen atom, a bromine atom, a methyl group; a methoxy group; an acetylamino group; a -CONH2 group; a N-methylaminocarbonyl group; an N, N-dimethylaminocarbonyl group; a methylsulfonamide group; an acetylaminomethyl group; or a methylsulfonylaminomethyl group. 6. Compounds of formula (I) according to claim 1, which are: 4-cyclopropyl-3,4-dihydro-7-phenoxy-2H-1,2,4-benzothiadiazine 1,1-dioxide; • the 7- (3-bromophenoxy) -4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide; 7- (4-bromophenoxy) -4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide; 3 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] benzonitrile; • [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] benzonitrile; 4-cyclopropyl-3,4-dihydro-7- (3-methylphenoxy) -2H-1,2,4-benzothiadiazine 1,1-dioxide; 4-cyclopropyl-3,4-dihydro-7- (4-methylphenoxy) -2H-1,2,4-benzothiadiazine 1,1-dioxide; 4-cyclopropyl-3,4-dihydro-7- (3-methoxyphenoxy) -2H-1,2,4-benzothiadiazine 1,1-dioxide; 4-cyclopropyl-3,4-dihydro-7- (4-methoxyphenoxy) -2H-1,2,4-benzothiadiazine 1,1-dioxide; N- {3 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] phenyl} acetamide; N- {4 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] phenyl} acetamide; N- {3 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] benzyl} acetamide; N- {4 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] benzyl} acetamide; 3 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] benzamide; • [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] benzamide; 3 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] N -methylbenzamide; 4 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] N -methylbenzamide; 3 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] -N, N-dimethylbenzamide; 4 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] -N, N-dimethylbenzamide; N- {3 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] phenyl} methanesulfonamide; N- {4 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] phenyl} methanesulfonamide; N- {3 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] benzyl} methanesulfonamide; N- {4 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] benzyl} methanesulfonamide; 3 - [(4-Cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] -N'-hydroxybenzenecarboximidamide; And 4 - [(4-cyclopropyl-1,1-dioxido-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-yl) oxy] -N '-hydroxybenzenecarboximidamide, and salts thereof addition to a pharmaceutically acceptable acid or base. 7. Process for the preparation of the compounds of formula (I) according to claim 1, characterized in that a compound of formula (II) is used as starting material: ## STR2 ## in which R 3 represents an alkoxy group ( C1-C6) linear or branched, which is cyclized in the presence of a compound of formula (III): wherein R4 represents a linear or branched (C1-C6) alkyl group, to yield the compound of formula (IV): wherein R 3 is as defined above, which is reacted with a reducing agent, to yield the compound of formula (V), - (-) wherein R3 is as defined above, which then undergoes the action of boron tribromide, to yield the compound of formula (VI): which is reacted with a boronic acid derivative of formula (VII): in which RI and R2 have the same meaning as in formula (I), HO OH 1 B, OH (VII) to yield the compound of formula (I), 295 5106 - 24 - which can then be purified according to a conventional separation technique, which, if desired, is converted into its addition salts with a pharmaceutically acceptable acid or base and the isomers are optionally separated therefrom. they exist, according to a classical technique of separation. 5 8. Pharmaceutical composition containing as active ingredient a compound according to any one of claims 1 to 6, in combination with one or more inert, non-toxic and pharmaceutically acceptable vehicles. Pharmaceutical compositions according to claim 8 useful as modulators of the AMPA receptor. 10. Pharmaceutical compositions according to claim 8, useful for the treatment or the prevention of mnemocognitive disorders associated with age, with anxiety or depressive syndromes, with progressive neurodegenerative diseases, with Alzheimer's disease, with Parkinson's disease, with Parkinson's disease. Pick's disease, Huntington's disease, Korsakoff's disease, schizophrenia, sequelae of acute neurodegenerative diseases, frontal and subcortical dementia, sequelae of ischemia and sequelae of epilepsy. 11. Use of the compounds of formula (I) according to any one of claims 1 to 6 for the manufacture of medicaments useful as modulators of the AMPA receptor. 12. Use of the compounds of formula (I) according to any one of claims 1 to 6 for the manufacture of medicaments useful for the treatment or prevention of mnemocognitive disorders associated with age, anxiety or depressive syndromes, neurodegenerative diseases Alzheimer's disease, Parkinson's disease, Pick's disease, Huntington's disease, Korsakoff's disease, schizophrenia, the sequelae of acute neurodegenerative diseases, frontal dementia, and -cortical, sequelae of ischemia and sequelae of epilepsy.