FR2915748B1 - Acides polyglutamiques fonctionnalises par des groupes cationiques et des groupements hydrophobes et leurs applications, notamment therapeutiques - Google Patents

Acides polyglutamiques fonctionnalises par des groupes cationiques et des groupements hydrophobes et leurs applications, notamment therapeutiques

Info

Publication number: FR2915748B1
Authority: FR; France
Prior art keywords: groups; applications; particular therapeutic; polyglutamic acids; acids functionalized
Prior art date: 2007-05-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

FR0703185A

Other languages

English (en)

Other versions

FR2915748A1 (fr

Inventor

You Ping Chan

Olivier Breyne

Gonnet Cecile Bonnet

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Flamel Technologies SA

Original Assignee

Flamel Technologies SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-05-03

Filing date

2007-05-03

Publication date

2012-10-19

2007-05-03 Priority to FR0703185A priority Critical patent/FR2915748B1/fr

2007-05-03 Application filed by Flamel Technologies SA filed Critical Flamel Technologies SA

2008-05-05 Priority to EA200901481A priority patent/EA016911B1/ru

2008-05-05 Priority to BRPI0809208A priority patent/BRPI0809208A2/pt

2008-05-05 Priority to PCT/EP2008/055507 priority patent/WO2008135563A1/fr

2008-05-05 Priority to EP08750064A priority patent/EP2152782A1/fr

2008-05-05 Priority to NZ580906A priority patent/NZ580906A/en

2008-05-05 Priority to AU2008248604A priority patent/AU2008248604B2/en

2008-05-05 Priority to JP2010504757A priority patent/JP2010529214A/ja

2008-05-05 Priority to US12/149,542 priority patent/US8716217B2/en

2008-05-05 Priority to CA002683741A priority patent/CA2683741A1/fr

2008-05-05 Priority to CN2008800125724A priority patent/CN101663346B/zh

2008-05-05 Priority to KR1020097023191A priority patent/KR20100016280A/ko

2008-05-05 Priority to MX2009011813A priority patent/MX2009011813A/es

2008-11-07 Publication of FR2915748A1 publication Critical patent/FR2915748A1/fr

2009-09-17 Priority to IL201017A priority patent/IL201017A/en

2009-10-06 Priority to ZA2009/06941A priority patent/ZA200906941B/en

2012-10-19 Application granted granted Critical

2012-10-19 Publication of FR2915748B1 publication Critical patent/FR2915748B1/fr

Status Expired - Fee Related legal-status Critical Current

2027-05-03 Anticipated expiration legal-status Critical

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/48—Polymers modified by chemical after-treatment
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Inorganic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Medicinal Preparation (AREA)
Polyamides (AREA)
Cosmetics (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

FR0703185A 2007-05-03 2007-05-03 Acides polyglutamiques fonctionnalises par des groupes cationiques et des groupements hydrophobes et leurs applications, notamment therapeutiques Expired - Fee Related FR2915748B1 (fr)

Priority Applications (15)

Application Number	Priority Date	Filing Date	Title
FR0703185A FR2915748B1 (fr)	2007-05-03	2007-05-03	Acides polyglutamiques fonctionnalises par des groupes cationiques et des groupements hydrophobes et leurs applications, notamment therapeutiques
CN2008800125724A CN101663346B (zh)	2007-05-03	2008-05-05	由阳离子基团和疏水基团官能化的聚谷氨酸及其应用，特别是其治疗应用
PCT/EP2008/055507 WO2008135563A1 (fr)	2007-05-03	2008-05-05	Acides polyglutamiques fonctionnalises par des groupements cationiques et des groupements hydrophobes et leurs applications, notamment therapeutiques
EP08750064A EP2152782A1 (fr)	2007-05-03	2008-05-05	Acides polyglutamiques fonctionnalises par des groupements cationiques et des groupements hydrophobes et leurs applications, notamment therapeutiques
NZ580906A NZ580906A (en)	2007-05-03	2008-05-05	Polyglutamic acids functionalized by cationic groups and hydrophobic groups and applications thereof, in particular therapeutic applications thereof
AU2008248604A AU2008248604B2 (en)	2007-05-03	2008-05-05	Polyglutamic acids functionalized by cationic groups and hydrophobic groups and applications thereof, in particular therapeutic applications thereof
JP2010504757A JP2010529214A (ja)	2007-05-03	2008-05-05	カチオン性基及び疎水性基により官能基化したポリグルタミン酸及びその応用、特にはその治療への応用
US12/149,542 US8716217B2 (en)	2007-05-03	2008-05-05	Polyglutamic acids functionalized by cationic groups and hydrophobic groups and applications thereof, in particular therapeutic applications thereof
EA200901481A EA016911B1 (ru)	2007-05-03	2008-05-05	Полиглутаминовые кислоты, функционализированные катионными и гидрофобными группами, и их применения, в частности терапевтические применения
BRPI0809208A BRPI0809208A2 (pt)	2007-05-03	2008-05-05	ácidos poliglutâmicos funcionalizados por grupos catiônicos e grupos hidrofóbios e aplicações dos mesmos, em particular, aplicações terapêuticas dos mesmos.
KR1020097023191A KR20100016280A (ko)	2007-05-03	2008-05-05	양이온성 기 및 소수성 기로 작용기화된 폴리글루탐산 및 이의 용도, 특히 이의 치료적 용도
MX2009011813A MX2009011813A (es)	2007-05-03	2008-05-05	Acidos poliglutamicos funcionalizados con grupos cationicos y grupos hidrofobicos y aplicaciones de los mismos, en particular aplicaciones terapeuticas de los mismos.
CA002683741A CA2683741A1 (fr)	2007-05-03	2008-05-05	Acides polyglutamiques fonctionnalises par des groupements cationiques et des groupements hydrophobes et leurs applications, notamment therapeutiques
IL201017A IL201017A (en)	2007-05-03	2009-09-17	Polyglutamic acids functionalized by cationic groups and hydrophobic groups and compositions thereof, in particular pharmaceuticalcompositions
ZA2009/06941A ZA200906941B (en)	2007-05-03	2009-10-06	Polyglutamic acids functionalized by cationic groups and hydrophobic groups and applications thereof,in particular therapeutic applications thereof

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0703185A FR2915748B1 (fr)	2007-05-03	2007-05-03	Acides polyglutamiques fonctionnalises par des groupes cationiques et des groupements hydrophobes et leurs applications, notamment therapeutiques

Publications (2)

Publication Number	Publication Date
FR2915748A1 FR2915748A1 (fr)	2008-11-07
FR2915748B1 true FR2915748B1 (fr)	2012-10-19

Family

ID=38792517

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR0703185A Expired - Fee Related FR2915748B1 (fr)	2007-05-03	2007-05-03	Acides polyglutamiques fonctionnalises par des groupes cationiques et des groupements hydrophobes et leurs applications, notamment therapeutiques

Country Status (15)

Country	Link
US (1)	US8716217B2 (fr)
EP (1)	EP2152782A1 (fr)
JP (1)	JP2010529214A (fr)
KR (1)	KR20100016280A (fr)
CN (1)	CN101663346B (fr)
AU (1)	AU2008248604B2 (fr)
BR (1)	BRPI0809208A2 (fr)
CA (1)	CA2683741A1 (fr)
EA (1)	EA016911B1 (fr)
FR (1)	FR2915748B1 (fr)
IL (1)	IL201017A (fr)
MX (1)	MX2009011813A (fr)
NZ (1)	NZ580906A (fr)
WO (1)	WO2008135563A1 (fr)
ZA (1)	ZA200906941B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2822834B1 (fr)	2001-04-02	2005-02-25	Flamel Tech Sa	Suspension colloidale de nanoparticules a base de copolymeres amphiphile pour la vectorisation de principes actifs et leur mode de preparation
FR2840614B1 (fr) *	2002-06-07	2004-08-27	Flamel Tech Sa	Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques
FR2843117B1 (fr)	2002-07-30	2004-10-15	Flamel Tech Sa	Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques
FR2860516B1 (fr) *	2003-10-03	2006-01-13	Flamel Tech Sa	Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
FR2862536B1 (fr)	2003-11-21	2007-11-23	Flamel Tech Sa	Formulations pharmaceutiques pour la liberation prolongee de principe(s) actif(s), ainsi que leurs applications notamment therapeutiques
FR2915683B1 (fr)	2007-05-03	2009-08-07	Flamel Technologies Sa	Formulations pharmaceutiques auto-precipitantes pour la liberation modifiee de principe actif
FR2915684B1 (fr)	2007-05-03	2011-01-14	Flamel Tech Sa	Particules a base de polyelectrolytes et de principe actif a liberation modifiee et formulations pharmaceutiques contenant ces particules
GB0814519D0 (en) *	2008-08-08	2008-09-17	Imp Innovations Ltd	Process
GB0820865D0 (en) *	2008-11-14	2008-12-24	Membrane Extraction Tech Ltd	Degradable supports for tide synthesis
FR2940619B1 (fr)	2008-12-31	2012-02-10	Flamel Technologies Sa	Composition comprenant un actif de solubilite aqueuse faible ou moyenne
WO2011130577A1 (fr) *	2010-04-14	2011-10-20	Intezyne Technologies, Incorporated	Ensemble de polyplexes contrôlés
JP2013234207A (ja) *	2010-08-31	2013-11-21	Jsr Corp	新規重合体及び新規ｎ−カルボキシアミノ酸無水物、ならびにそれらの製造方法
WO2012051457A1 (fr) *	2010-10-14	2012-04-19	Nitto Denko Corporation	Composés pour l'administration d'acides nucléiques
FR2968993B1 (fr)	2010-12-17	2012-12-28	Flamel Tech Sa	Nanoparticules comportant au moins un actif et au moins deux polyelectrolytes
FR2968994B1 (fr)	2010-12-17	2012-12-28	Flamel Tech Sa	Procede de preparation de nanoparticules
US9272020B2 (en)	2011-05-20	2016-03-01	Ares Trading S.A.	IFN-beta compositions, preparation methods and uses thereof
FR2975912B1 (fr)	2011-05-30	2013-06-14	Flamel Tech Sa	Composition a liberation controlee de buprenorphine
EP2554161A1 (fr) *	2011-08-02	2013-02-06	LFB Biotechnologies	Composition pharmaceutique comprenant factor VII encapsulé dans des micelles
CN102698279B (zh) *	2012-07-03	2013-12-04	南京医科大学	一种两亲性γ-聚谷氨酸纳米药物载体的制备方法
US9357772B2 (en)	2013-04-09	2016-06-07	International Business Machines Corporation	Antimicrobial cationic polycarbonates
US9999633B2 (en)	2013-04-09	2018-06-19	International Business Machines Corporation	Antimicrobial cationic polycarbonates
WO2014169153A1 (fr) *	2013-04-10	2014-10-16	Echogen, Inc.	Complexes peptidiques et utilisations thérapeutiques
KR101507119B1 (ko) *	2013-05-31	2015-03-30	주식회사 바이오리더스	점막 점착성 폴리감마글루탐산 나노마이셀 및 이를 이용한 약물 전달체
CN103590133B (zh) *	2013-10-11	2015-09-16	华东理工大学	一种利用静电纺丝制备聚肽共聚物多孔纳米纤维的方法
WO2015133449A1 (fr) *	2014-03-07	2015-09-11	日本化薬株式会社	Composition pour administration d'acide nucléique
JP6513635B2 (ja) *	2014-03-26	2019-05-15	日本化薬株式会社	核酸送達用組成物及び核酸含有医薬組成物
CN111698999A (zh) *	2017-12-06	2020-09-22	阿道恰公司	包含至少一种pi在5.8与8.5之间的基础胰岛素和带有羧酸根电荷及疏水基的共聚氨基酸的ph为7的可注射溶液
CN111683674A (zh) *	2017-12-07	2020-09-18	阿道恰公司	包含胰淀素、胰淀素激动剂受体或胰淀素类似物和共聚氨基酸的可注射水溶液形式的组合物
CN108465104A (zh) *	2018-03-07	2018-08-31	佛山实瑞先导材料研究院（普通合伙）	一种生长激素控释包衣及其制备方法
CN110903410B (zh) *	2019-12-05	2021-07-23	南京大学	聚阳离子型多糖及其应用
CN111804151B (zh) *	2020-07-27	2021-08-27	上海恩捷新材料科技有限公司	一种用于生活污水处理的mbr平板滤膜及其制备方法
CN115975185B (zh) *	2022-12-15	2024-07-26	广州微冠生物科技有限公司	一种含多肽的可溶性微针贴及其制备方法
CN119081105A (zh) *	2024-11-01	2024-12-06	浙江大学长三角智慧绿洲创新中心	一种聚谷氨酸-维生素e两亲性偶联物及其制备方法和应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4351337A (en)	1973-05-17	1982-09-28	Arthur D. Little, Inc.	Biodegradable, implantable drug delivery device, and process for preparing and using the same
JPS60100516A (ja)	1983-11-04	1985-06-04	Takeda Chem Ind Ltd	徐放型マイクロカプセルの製造法
DE3581471D1 (de)	1984-10-19	1991-02-28	Battelle Memorial Institute	Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten.
KR940003548U (ko)	1992-08-14	1994-02-21	김형술	세탁물 건조기
US6153193A (en)	1993-04-28	2000-11-28	Supratek Pharma Inc.	Compositions for targeting biological agents
FR2732218B1 (fr)	1995-03-28	1997-08-01	Flamel Tech Sa	Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s) et leurs procedes de preparation
US6686446B2 (en) *	1998-03-19	2004-02-03	The Regents Of The University Of California	Methods and compositions for controlled polypeptide synthesis
EP0963758A3 (fr)	1998-05-07	2000-03-22	Universiteit Gent	Synthetique polyaminoacide complexes pour l'apport des acides nucleiques aux celles cibles
GB9811059D0 (en)	1998-05-23	1998-07-22	Univ Strathclyde	Polyamino acid vesicles
FR2786098B1 (fr)	1998-11-20	2003-05-30	Flamel Tech Sa	Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s), suspension colloidale les comprenant et leurs procedes de fabrication
FR2801226B1 (fr)	1999-11-23	2002-01-25	Flamel Tech Sa	Suspension colloidale de particules submicroniques de vectorisation de principes actifs et son mode de preparation
JP2002069177A (ja) *	2000-06-12	2002-03-08	Mitsui Chemicals Inc	重合体及びその製造方法
JP4585114B2 (ja) *	2000-12-27	2010-11-24	三井化学株式会社	重合体及びその製造方法
FR2840614B1 (fr) *	2002-06-07	2004-08-27	Flamel Tech Sa	Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques
FR2843117B1 (fr) *	2002-07-30	2004-10-15	Flamel Tech Sa	Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques
JP4970731B2 (ja)	2002-12-04	2012-07-11	フラメル・テクノロジー	少なくとも１つの（オリゴ）アミノ酸基によって官能性をもたせたポリアミノ酸およびこれらの適用、特に医療適用
FR2855521B1 (fr) *	2003-05-28	2005-08-05	Flamel Tech Sa	Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques.
FR2873703B1 (fr) *	2004-07-30	2006-12-08	Flamel Technologies Sa	Polyaminoacides branches, fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
JP4735933B2 (ja)	2004-09-03	2011-07-27	独立行政法人産業技術総合研究所	ｐＨ応答性両性イオン微粒子状ポリマー及びその用途
FR2892725B1 (fr) *	2005-10-31	2011-03-04	Flamel Tech Sa	Acides polyglutamiques fonctionnalises par des derives de l'histidine et des groupements hydrophobes et leurs applications notamment therapeutiques
EP1969031B1 (fr) *	2005-12-05	2009-06-03	Nitto Denko Corporation	Conjugues acides amino-polyglutamate et procedes
JP2009007547A (ja) *	2007-05-25	2009-01-15	Tokyo Metropolitan Univ	核酸キャリア及び核酸デリバリー方法

2007
- 2007-05-03 FR FR0703185A patent/FR2915748B1/fr not_active Expired - Fee Related
2008
- 2008-05-05 US US12/149,542 patent/US8716217B2/en not_active Expired - Fee Related
- 2008-05-05 EP EP08750064A patent/EP2152782A1/fr not_active Withdrawn
- 2008-05-05 AU AU2008248604A patent/AU2008248604B2/en not_active Ceased
- 2008-05-05 CA CA002683741A patent/CA2683741A1/fr not_active Abandoned
- 2008-05-05 JP JP2010504757A patent/JP2010529214A/ja active Pending
- 2008-05-05 EA EA200901481A patent/EA016911B1/ru not_active IP Right Cessation
- 2008-05-05 WO PCT/EP2008/055507 patent/WO2008135563A1/fr active Application Filing
- 2008-05-05 BR BRPI0809208A patent/BRPI0809208A2/pt not_active IP Right Cessation
- 2008-05-05 KR KR1020097023191A patent/KR20100016280A/ko not_active Abandoned
- 2008-05-05 NZ NZ580906A patent/NZ580906A/en not_active IP Right Cessation
- 2008-05-05 MX MX2009011813A patent/MX2009011813A/es active IP Right Grant
- 2008-05-05 CN CN2008800125724A patent/CN101663346B/zh not_active Expired - Fee Related
2009
- 2009-09-17 IL IL201017A patent/IL201017A/en not_active IP Right Cessation
- 2009-10-06 ZA ZA2009/06941A patent/ZA200906941B/en unknown

Also Published As

Publication number	Publication date
AU2008248604A1 (en)	2008-11-13
BRPI0809208A2 (pt)	2016-11-16
CN101663346A (zh)	2010-03-03
US20090012028A1 (en)	2009-01-08
MX2009011813A (es)	2009-11-13
IL201017A0 (en)	2010-05-17
EP2152782A1 (fr)	2010-02-17
CN101663346B (zh)	2012-03-21
JP2010529214A (ja)	2010-08-26
EA016911B1 (ru)	2012-08-30
EA200901481A1 (ru)	2010-04-30
KR20100016280A (ko)	2010-02-12
US8716217B2 (en)	2014-05-06
IL201017A (en)	2013-03-24
FR2915748A1 (fr)	2008-11-07
ZA200906941B (en)	2010-12-29
CA2683741A1 (fr)	2008-11-13
WO2008135563A1 (fr)	2008-11-13
AU2008248604B2 (en)	2012-11-08
NZ580906A (en)	2011-07-29

Publication	Publication Date	Title
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