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FR2877103B1 - SYSTEM AND METHOD FOR FIBER MULTIPHOTONIC MICROSCOPIC IMAGING OF A SAMPLE - Google Patents

SYSTEM AND METHOD FOR FIBER MULTIPHOTONIC MICROSCOPIC IMAGING OF A SAMPLE

Info

Publication number
FR2877103B1
FR2877103B1 FR0411313A FR0411313A FR2877103B1 FR 2877103 B1 FR2877103 B1 FR 2877103B1 FR 0411313 A FR0411313 A FR 0411313A FR 0411313 A FR0411313 A FR 0411313A FR 2877103 B1 FR2877103 B1 FR 2877103B1
Authority
FR
France
Prior art keywords
multiphotonic
fiber
sample
microscopic imaging
microscopic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR0411313A
Other languages
French (fr)
Other versions
FR2877103A1 (en
Inventor
Bertrand Viellerobe
Francois Lacombe
Alexandre Loiseau
Frederic Louradour
Mickael Lelek
Alain Barthelemy
Dominique Pagnoux
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Universite de Limoges
Mauna Kea Technologies SA
Original Assignee
Centre National de la Recherche Scientifique CNRS
Universite de Limoges
Mauna Kea Technologies SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0411313A priority Critical patent/FR2877103B1/en
Application filed by Centre National de la Recherche Scientifique CNRS, Universite de Limoges, Mauna Kea Technologies SA filed Critical Centre National de la Recherche Scientifique CNRS
Priority to EP05812037A priority patent/EP1817620B8/en
Priority to US11/665,768 priority patent/US8237131B2/en
Priority to JP2007537342A priority patent/JP5102622B2/en
Priority to AU2005298494A priority patent/AU2005298494B2/en
Priority to ES05812037T priority patent/ES2396426T3/en
Priority to CA2584748A priority patent/CA2584748C/en
Priority to PCT/FR2005/002630 priority patent/WO2006045936A2/en
Publication of FR2877103A1 publication Critical patent/FR2877103A1/en
Application granted granted Critical
Publication of FR2877103B1 publication Critical patent/FR2877103B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2476—Non-optical details, e.g. housings, mountings, supports
    • G02B23/2484—Arrangements in relation to a camera or imaging device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407—Optical details
    • G02B23/2461—Illumination
    • G02B23/2469—Illumination using optical fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0068—Confocal scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/08—Optical fibres; light guides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/10—Scanning
    • G01N2201/105—Purely optical scan
    • G01N2201/1053—System of scan mirrors for composite motion of beam
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/04—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings formed by bundles of fibres

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Astronomy & Astrophysics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Multimedia (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
  • Endoscopes (AREA)
FR0411313A 2004-10-22 2004-10-22 SYSTEM AND METHOD FOR FIBER MULTIPHOTONIC MICROSCOPIC IMAGING OF A SAMPLE Expired - Lifetime FR2877103B1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
FR0411313A FR2877103B1 (en) 2004-10-22 2004-10-22 SYSTEM AND METHOD FOR FIBER MULTIPHOTONIC MICROSCOPIC IMAGING OF A SAMPLE
US11/665,768 US8237131B2 (en) 2004-10-22 2005-10-21 System and method for carrying out fibre-type multiphoton microscopic imaging of a sample
JP2007537342A JP5102622B2 (en) 2004-10-22 2005-10-21 Fiber-type multi-photon microscope imaging apparatus and method for specimen
AU2005298494A AU2005298494B2 (en) 2004-10-22 2005-10-21 System and method for carrying out fibered multiphoton microscopic imagery of a sample
EP05812037A EP1817620B8 (en) 2004-10-22 2005-10-21 System and method for carrying out fibered multiphoton microscopic imagery of a sample
ES05812037T ES2396426T3 (en) 2004-10-22 2005-10-21 Diagnostic system and procedure for fibrous multifotonic microscopic image of a sample
CA2584748A CA2584748C (en) 2004-10-22 2005-10-21 System and method for carrying out fibered multiphoton microscopic imagery of a sample
PCT/FR2005/002630 WO2006045936A2 (en) 2004-10-22 2005-10-21 System and method for carrying out fibered multiphoton microscopic imagery of a sample

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0411313A FR2877103B1 (en) 2004-10-22 2004-10-22 SYSTEM AND METHOD FOR FIBER MULTIPHOTONIC MICROSCOPIC IMAGING OF A SAMPLE

Publications (2)

Publication Number Publication Date
FR2877103A1 FR2877103A1 (en) 2006-04-28
FR2877103B1 true FR2877103B1 (en) 2012-02-10

Family

ID=34951919

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0411313A Expired - Lifetime FR2877103B1 (en) 2004-10-22 2004-10-22 SYSTEM AND METHOD FOR FIBER MULTIPHOTONIC MICROSCOPIC IMAGING OF A SAMPLE

Country Status (8)

Country Link
US (1) US8237131B2 (en)
EP (1) EP1817620B8 (en)
JP (1) JP5102622B2 (en)
AU (1) AU2005298494B2 (en)
CA (1) CA2584748C (en)
ES (1) ES2396426T3 (en)
FR (1) FR2877103B1 (en)
WO (1) WO2006045936A2 (en)

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US8554087B2 (en) 2006-09-18 2013-10-08 The Trustees Of Dartmouth College System and method for imaging objects through turbid media
DE102006046925A1 (en) * 2006-09-28 2008-04-03 Jenlab Gmbh Method for laser endoscopy e.g. for medical work and for semiconductor processing, requires laser pulse for producing multi-photon processes as target ionization
JP5307439B2 (en) * 2007-04-23 2013-10-02 オリンパス株式会社 Laser microscope
US8059274B2 (en) * 2007-12-07 2011-11-15 The Spectranetics Corporation Low-loss polarized light diversion
DE102009029831A1 (en) 2009-06-17 2011-01-13 W.O.M. World Of Medicine Ag Apparatus and method for multi-photon fluorescence microscopy for obtaining information from biological tissue
US8507877B2 (en) * 2009-11-25 2013-08-13 Ofs Fitel, Llc Non-linear optical system and techniques
US9304308B2 (en) * 2009-12-09 2016-04-05 Advanced Micro Devices, Inc. Laser scanning module including an optical isolator
US20110147615A1 (en) * 2009-12-23 2011-06-23 Kintz Gregory J Method and apparatus for microscopic imaging system with wide field of view and high collection efficiency
JP5934121B2 (en) * 2010-03-05 2016-06-15 ザ ジェネラル ホスピタル コーポレイション System, method and computer accessible medium for providing a fine image of at least one anatomical structure at a specific resolution
US8792098B2 (en) 2011-06-01 2014-07-29 Digital Light Innovations System and method for hyperspectral illumination
US8891087B2 (en) 2011-06-01 2014-11-18 Digital Light Innovations System and method for hyperspectral imaging
US9356413B2 (en) * 2011-09-30 2016-05-31 Olympus Corporation Laser source apparatus and laser microscope
EP3847968A1 (en) * 2011-11-28 2021-07-14 The Board of Trustees of the Leland Stanford Junior University System and method useful for sarcomere imaging via objective-based microscopy
WO2015108991A2 (en) 2014-01-17 2015-07-23 Imra America, Inc. Laser-based modification of transparent materials
WO2015130651A1 (en) 2014-02-28 2015-09-03 Imra America, Inc. Multi-wavelength, ultrashort pulse generation and delivery, with applications in microscopy
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JP2015227778A (en) * 2014-05-30 2015-12-17 ソニー株式会社 Image acquisition device and image acquisition method
FR3030956B1 (en) * 2014-12-18 2018-03-23 Centre National De La Recherche Scientifique - Cnrs DEVICE FOR TRANSPORTING AND CONTROLLING LIGHT PULSES FOR ENDO-MICROSCOPIC IMAGING WITHOUT LENS
JP6594437B2 (en) 2015-09-15 2019-10-23 オリンパス株式会社 Microscope and microscope observation method
JP7245051B2 (en) 2016-03-08 2023-03-23 エンスペクトラ・ヘルス・インコーポレイテッド Non-invasive detection of skin diseases
US12133634B2 (en) 2016-04-06 2024-11-05 The University Court Of The University Of Edinburgh Endoscopic imaging apparatus and method
US9645291B1 (en) * 2016-04-18 2017-05-09 Ii-Vi Incorporated Voltage-tunable optical filters for instrumentation applications
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KR102567260B1 (en) * 2021-09-01 2023-08-16 연세대학교 산학협력단 Retina diagnosis system and retina diagnosis method using the same

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Also Published As

Publication number Publication date
JP5102622B2 (en) 2012-12-19
JP2008517291A (en) 2008-05-22
WO2006045936A2 (en) 2006-05-04
AU2005298494A1 (en) 2006-05-04
EP1817620A2 (en) 2007-08-15
US20070290145A1 (en) 2007-12-20
CA2584748C (en) 2015-10-13
US8237131B2 (en) 2012-08-07
EP1817620B8 (en) 2012-12-12
WO2006045936A3 (en) 2006-06-22
ES2396426T3 (en) 2013-02-21
AU2005298494B2 (en) 2011-08-11
FR2877103A1 (en) 2006-04-28
EP1817620B1 (en) 2012-09-26
CA2584748A1 (en) 2006-05-04

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