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FR2839974A1 - Derives de phenyl-furane ou de phenyl-thiophene,leur preparation et leur application a titre de medicament - Google Patents

Derives de phenyl-furane ou de phenyl-thiophene,leur preparation et leur application a titre de medicament

Info

Publication number
FR2839974A1
FR2839974A1 FR0206347A FR0206347A FR2839974A1 FR 2839974 A1 FR2839974 A1 FR 2839974A1 FR 0206347 A FR0206347 A FR 0206347A FR 0206347 A FR0206347 A FR 0206347A FR 2839974 A1 FR2839974 A1 FR 2839974A1
Authority
FR
France
Prior art keywords
halo
nr5r6
alkyl
sme
ome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR0206347A
Other languages
English (en)
Other versions
FR2839974B1 (fr
Inventor
Michel Perez
Marie Lamothe
Bridget Hill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Priority to FR0206347A priority Critical patent/FR2839974B1/fr
Priority to AU2003260566A priority patent/AU2003260566A1/en
Priority to PCT/FR2003/001567 priority patent/WO2003099812A1/fr
Publication of FR2839974A1 publication Critical patent/FR2839974A1/fr
Application granted granted Critical
Publication of FR2839974B1 publication Critical patent/FR2839974B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Composés répondant à la formule générale (I) :dans laquelle notamment : W représente : H, SO2R4, CO (CH2)n, R4, (CH2) pR5, CS (CH2)nR4 X représente : O ou SY représente : (CH2)pZ représente : Imidazole, benzimidazole ou pyridine, R1 représente : CO-NH-(CH2)q-NR5R6, ouCO-NH(CH 2)q-NR5R6R2 et R3 représentent un atome d'hydrogène R4représente un phényle ou un naphtylen représente 0 à 10p >représente 1 à 6q représente 2 à 6
FR0206347A 2002-05-24 2002-05-24 Derives de phenyl-furane ou de phenyl-thiophene,leur preparation et leur application a titre de medicament Expired - Fee Related FR2839974B1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR0206347A FR2839974B1 (fr) 2002-05-24 2002-05-24 Derives de phenyl-furane ou de phenyl-thiophene,leur preparation et leur application a titre de medicament
AU2003260566A AU2003260566A1 (en) 2002-05-24 2003-05-23 Phenyl-furan or phenyl-thiophene derivatives, their preparation and their use as medicine
PCT/FR2003/001567 WO2003099812A1 (fr) 2002-05-24 2003-05-23 Derives de phenyl-furane ou de phenyl-thiophene, leur preparation et leur application a titre de medicament

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0206347A FR2839974B1 (fr) 2002-05-24 2002-05-24 Derives de phenyl-furane ou de phenyl-thiophene,leur preparation et leur application a titre de medicament

Publications (2)

Publication Number Publication Date
FR2839974A1 true FR2839974A1 (fr) 2003-11-28
FR2839974B1 FR2839974B1 (fr) 2004-07-16

Family

ID=29415048

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0206347A Expired - Fee Related FR2839974B1 (fr) 2002-05-24 2002-05-24 Derives de phenyl-furane ou de phenyl-thiophene,leur preparation et leur application a titre de medicament

Country Status (3)

Country Link
AU (1) AU2003260566A1 (fr)
FR (1) FR2839974B1 (fr)
WO (1) WO2003099812A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10703712B2 (en) 2015-09-16 2020-07-07 Metacrine, Inc. Farnesoid X receptor agonists and uses thereof
US10927082B2 (en) 2017-03-15 2021-02-23 Metacrine, Inc. Farnesoid X receptor agonists and uses thereof
US11084817B2 (en) 2018-09-18 2021-08-10 Metacrine, Inc. Farnesoid X receptor agonists and uses thereof
US11236071B1 (en) 2017-03-15 2022-02-01 Metacrine, Inc. Farnesoid X receptor agonists and uses thereof

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP2005003319A0 (en) 2002-11-19 2005-06-30 Achillion Pharmaceitucals Inc Substituted aryl thioureas and related compounds; inhibitors of viral replication
TW200600492A (en) 2004-05-18 2006-01-01 Achillion Pharmaceuticals Inc Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
WO2024196978A2 (fr) * 2023-03-21 2024-09-26 University Of Florida Research Foundation, Inc. Composés de sulfonium et leurs procédés de fabrication et d'utilisation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997026246A1 (fr) * 1996-01-16 1997-07-24 Warner-Lambert Company Inhibiteurs substitues a base d'histidine agissant sur la farnesyltransferase proteinique
FR2796947A1 (fr) * 1999-07-30 2001-02-02 Aventis Pharma Sa Nouveaux derives 8-carbonyl chromanes, leur preparation et leur utilisation en therapeutique
FR2815032A1 (fr) * 2000-10-10 2002-04-12 Pf Medicament Nouveaux derives d'aminophenyle piperazine ou d'amino phenyle piperide inhibiteurs de proteines prenyl transferase ainsi que leurs preparations

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2825706B1 (fr) * 2001-06-06 2003-12-12 Pf Medicament Nouveaux derives de benzothienyle ou d'indole, leur preparation et leur utilisation comme inhibiteurs de proteines prenyl transferase

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997026246A1 (fr) * 1996-01-16 1997-07-24 Warner-Lambert Company Inhibiteurs substitues a base d'histidine agissant sur la farnesyltransferase proteinique
FR2796947A1 (fr) * 1999-07-30 2001-02-02 Aventis Pharma Sa Nouveaux derives 8-carbonyl chromanes, leur preparation et leur utilisation en therapeutique
FR2815032A1 (fr) * 2000-10-10 2002-04-12 Pf Medicament Nouveaux derives d'aminophenyle piperazine ou d'amino phenyle piperide inhibiteurs de proteines prenyl transferase ainsi que leurs preparations

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10703712B2 (en) 2015-09-16 2020-07-07 Metacrine, Inc. Farnesoid X receptor agonists and uses thereof
US11214538B2 (en) 2015-09-16 2022-01-04 Metacrine, Inc. Farnesoid X receptor agonists and uses thereof
US10927082B2 (en) 2017-03-15 2021-02-23 Metacrine, Inc. Farnesoid X receptor agonists and uses thereof
US10961198B2 (en) 2017-03-15 2021-03-30 Metacrine, Inc. Farnesoid X receptor agonists and uses thereof
US11236071B1 (en) 2017-03-15 2022-02-01 Metacrine, Inc. Farnesoid X receptor agonists and uses thereof
US11084817B2 (en) 2018-09-18 2021-08-10 Metacrine, Inc. Farnesoid X receptor agonists and uses thereof
US11773094B2 (en) 2018-09-18 2023-10-03 Organovo, Inc. Farnesoid X receptor agonists and uses thereof

Also Published As

Publication number Publication date
WO2003099812A8 (fr) 2004-05-27
FR2839974B1 (fr) 2004-07-16
AU2003260566A1 (en) 2003-12-12
WO2003099812A1 (fr) 2003-12-04

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20060131