FR2817242A1 - Recipient for cosmetics, pharmaceuticals and foodstuffs comprising an inner layer of organic material or varnish comprising a biocide and an agent regulating release of the biocide - Google Patents
Recipient for cosmetics, pharmaceuticals and foodstuffs comprising an inner layer of organic material or varnish comprising a biocide and an agent regulating release of the biocide Download PDFInfo
- Publication number
- FR2817242A1 FR2817242A1 FR0015520A FR0015520A FR2817242A1 FR 2817242 A1 FR2817242 A1 FR 2817242A1 FR 0015520 A FR0015520 A FR 0015520A FR 0015520 A FR0015520 A FR 0015520A FR 2817242 A1 FR2817242 A1 FR 2817242A1
- Authority
- FR
- France
- Prior art keywords
- biocidal substance
- organic material
- substance
- biocidal
- flexible tube
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003115 biocidal effect Effects 0.000 title claims abstract description 49
- 239000003795 chemical substances by application Substances 0.000 title claims abstract description 20
- 239000011368 organic material Substances 0.000 title claims abstract description 16
- 239000002966 varnish Substances 0.000 title claims description 8
- 239000003139 biocide Substances 0.000 title abstract description 11
- 230000001105 regulatory effect Effects 0.000 title abstract description 4
- 239000002537 cosmetic Substances 0.000 title description 5
- 239000003814 drug Substances 0.000 title 1
- 239000000126 substance Substances 0.000 claims description 53
- 229920003023 plastic Polymers 0.000 claims description 18
- 239000004033 plastic Substances 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 11
- 239000004698 Polyethylene Substances 0.000 claims description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- -1 polyethylene Polymers 0.000 claims description 7
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 6
- 229910052751 metal Inorganic materials 0.000 claims description 5
- 239000002184 metal Substances 0.000 claims description 5
- 239000008601 oleoresin Substances 0.000 claims description 5
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 4
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 4
- 239000004814 polyurethane Substances 0.000 claims description 4
- 229930003427 Vitamin E Natural products 0.000 claims description 3
- 239000005038 ethylene vinyl acetate Substances 0.000 claims description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 3
- 229940107702 grapefruit seed extract Drugs 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 229920000728 polyester Polymers 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 229920000098 polyolefin Polymers 0.000 claims description 3
- 235000013311 vegetables Nutrition 0.000 claims description 3
- 235000019165 vitamin E Nutrition 0.000 claims description 3
- 229940046009 vitamin E Drugs 0.000 claims description 3
- 239000011709 vitamin E Substances 0.000 claims description 3
- HFOCAQPWSXBFFN-UHFFFAOYSA-N 2-methylsulfonylbenzaldehyde Chemical compound CS(=O)(=O)C1=CC=CC=C1C=O HFOCAQPWSXBFFN-UHFFFAOYSA-N 0.000 claims description 2
- KEPNSIARSTUPGS-UHFFFAOYSA-N 2-n,4-n,6-n-trichloro-1,3,5-triazine-2,4,6-triamine Chemical compound ClNC1=NC(NCl)=NC(NCl)=N1 KEPNSIARSTUPGS-UHFFFAOYSA-N 0.000 claims description 2
- 239000005711 Benzoic acid Substances 0.000 claims description 2
- 241000218631 Coniferophyta Species 0.000 claims description 2
- 241000196324 Embryophyta Species 0.000 claims description 2
- 239000004593 Epoxy Substances 0.000 claims description 2
- 239000004743 Polypropylene Substances 0.000 claims description 2
- 239000004793 Polystyrene Substances 0.000 claims description 2
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 2
- 230000002009 allergenic effect Effects 0.000 claims description 2
- 235000010233 benzoic acid Nutrition 0.000 claims description 2
- 239000001722 capsicum frutescens oleoresin Substances 0.000 claims description 2
- 229940050948 capsicum oleoresin Drugs 0.000 claims description 2
- 235000020971 citrus fruits Nutrition 0.000 claims description 2
- 238000005520 cutting process Methods 0.000 claims description 2
- 239000001941 cymbopogon citratus dc and cymbopogon flexuosus oil Substances 0.000 claims description 2
- 239000000284 extract Substances 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 231100000252 nontoxic Toxicity 0.000 claims description 2
- 230000003000 nontoxic effect Effects 0.000 claims description 2
- 235000011837 pasties Nutrition 0.000 claims description 2
- 229940116257 pepper extract Drugs 0.000 claims description 2
- 229920000058 polyacrylate Polymers 0.000 claims description 2
- 229920006122 polyamide resin Polymers 0.000 claims description 2
- 229920000647 polyepoxide Polymers 0.000 claims description 2
- 229920001225 polyester resin Polymers 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 229920001296 polysiloxane Polymers 0.000 claims description 2
- 229920002223 polystyrene Polymers 0.000 claims description 2
- 229920002635 polyurethane Polymers 0.000 claims description 2
- 229920005749 polyurethane resin Polymers 0.000 claims description 2
- 238000005096 rolling process Methods 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- 235000010199 sorbic acid Nutrition 0.000 claims description 2
- 239000004334 sorbic acid Substances 0.000 claims description 2
- 229940075582 sorbic acid Drugs 0.000 claims description 2
- 239000010677 tea tree oil Substances 0.000 claims description 2
- 229940111630 tea tree oil Drugs 0.000 claims description 2
- 229960003500 triclosan Drugs 0.000 claims description 2
- 229920002554 vinyl polymer Polymers 0.000 claims description 2
- 238000003466 welding Methods 0.000 claims description 2
- 229940043810 zinc pyrithione Drugs 0.000 claims description 2
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000000047 product Substances 0.000 claims 4
- 238000000748 compression moulding Methods 0.000 claims 1
- 238000001746 injection moulding Methods 0.000 claims 1
- 239000012263 liquid product Substances 0.000 claims 1
- 239000005416 organic matter Substances 0.000 claims 1
- WSWCOQWTEOXDQX-MQQKCMAXSA-N sorbic acid group Chemical group C(\C=C\C=C\C)(=O)O WSWCOQWTEOXDQX-MQQKCMAXSA-N 0.000 claims 1
- 239000010410 layer Substances 0.000 description 25
- 229920000219 Ethylene vinyl alcohol Polymers 0.000 description 5
- 239000004715 ethylene vinyl alcohol Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- UFRKOOWSQGXVKV-UHFFFAOYSA-N ethene;ethenol Chemical compound C=C.OC=C UFRKOOWSQGXVKV-UHFFFAOYSA-N 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 229920002457 flexible plastic Polymers 0.000 description 2
- RZXDTJIXPSCHCI-UHFFFAOYSA-N hexa-1,5-diene-2,5-diol Chemical compound OC(=C)CCC(O)=C RZXDTJIXPSCHCI-UHFFFAOYSA-N 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- 230000000050 nutritive effect Effects 0.000 description 2
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- PZWQOGNTADJZGH-SNAWJCMRSA-N (2e)-2-methylpenta-2,4-dienoic acid Chemical compound OC(=O)C(/C)=C/C=C PZWQOGNTADJZGH-SNAWJCMRSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 229910000838 Al alloy Inorganic materials 0.000 description 1
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 229960002798 cetrimide Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 229920001903 high density polyethylene Polymers 0.000 description 1
- 239000004700 high-density polyethylene Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229920001684 low density polyethylene Polymers 0.000 description 1
- 239000004702 low-density polyethylene Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
- B65D81/28—Applications of food preservatives, fungicides, pesticides or animal repellants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D35/00—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor
- B65D35/24—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor with auxiliary devices
- B65D35/36—Pliable tubular containers adapted to be permanently or temporarily deformed to expel contents, e.g. collapsible tubes for toothpaste or other plastic or semi-liquid material; Holders therefor with auxiliary devices for applying contents to surfaces
- B65D35/38—Nozzles
Landscapes
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Mechanical Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Tubes (AREA)
Abstract
Description
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TUBES SOUPLES CONTENANT DES AGENTS BIOCIDES
DOMAINE TECHNIQUE L'invention concerne des tubes souples destinés à stocker et distribuer des produits liquides à pâteux susceptibles de s'altérer au cours du temps par attaque bactérienne, cryptogamique ou virale. FLEXIBLE TUBES CONTAINING BIOCIDAL AGENTS
TECHNICAL FIELD The invention relates to flexible tubes intended for storing and distributing liquid to pasty products liable to deteriorate over time by bacterial, cryptogamic or viral attack.
Cette invention s'applique plus particulièrement aux tubes conditionnant les produits d'hygiène, cosmétiques, pharmaceutiques ou alimentaires. Pour ces produits, les tubes suivant l'invention permettent d'éviter que la présence éventuelle de bactéries ou de ferments à l'intérieur du tube ou au sein du produit même ne provoque une détérioration de celui-ci. This invention applies more particularly to tubes conditioning hygiene, cosmetic, pharmaceutical or food products. For these products, the tubes according to the invention make it possible to prevent the possible presence of bacteria or ferments inside the tube or within the product itself from causing deterioration of the latter.
ETAT DE LA TECHNIQUE
Habituellement, les tubes conditionnant de tels produits sont soit métalliques soit plastiques. Dans ce dernier cas, ils comportent en général plusieurs couches en matières plastiques différentes, ce qui permet en combinant certaines propriétés physiques, chimiques ou physico-chimiques, d'obtenir les caractéristiques désirées sur le plan de la résistance mécanique, de la résistance aux ultra-violets et des diverses contraintes liées à l'étanchéité (risque de perte de produit, risque de perte d'arôme, risque d'oxydation du produit conditionné, etc...). Lorsque les tubes sont métalliques, ils sont en général en alliage d'aluminium, typiquement du 1050, et l'intérieur du tube est protégé par un vernis. Lorsque les tubes sont plastiques ou métalloplastiques, ils comportent en général au moins une jupe multicouche avec des couches internes et externes en polyoléfine-typiquement du polyéthylène-ou en polyester et une couche intermédiaire en métal ou en une matière plastique à effet barrière à la diffusion, typiquement un copolymère (éthylène-alcool vinylique) (EVOH). STATE OF THE ART
Usually, the tubes conditioning such products are either metallic or plastic. In the latter case, they generally comprise several layers of different plastic materials, which makes it possible, by combining certain physical, chemical or physico-chemical properties, to obtain the desired characteristics in terms of mechanical strength, resistance to ultra -violets and various constraints related to sealing (risk of loss of product, risk of loss of aroma, risk of oxidation of the packaged product, etc.). When the tubes are metallic, they are generally made of aluminum alloy, typically 1050, and the inside of the tube is protected by a varnish. When the tubes are plastic or metalloplastic, they generally comprise at least one multilayer skirt with internal and external layers of polyolefin - typically polyethylene - or polyester and an intermediate layer of metal or of a plastic material with a diffusion barrier effect. , typically a copolymer (ethylene-vinyl alcohol) (EVOH).
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Malgré les soins apportés à la confection de ces tubes, il est difficile d'opérer dans des conditions d'asepsie parfaites, et il peut arriver au cours du stockage avant le remplissage ou pendant le remplissage ou encore à un stade ultérieur, que des bactéries pénètrent à l'intérieur et se développent ensuite au contact du produit ; contenu. Un tel développement détériore le produit et peut le rendre inapte à l'emploi. Pour éviter ces accidents, la stérilisation des tubes et des dispositifs de remplissage n'est pas toujours suffisante. Despite the care taken in making these tubes, it is difficult to operate under perfect aseptic conditions, and it can happen during storage before filling or during filling or at a later stage, that bacteria penetrate inside and then develop on contact with the product; content. Such a development deteriorates the product and can make it unfit for use. To avoid these accidents, sterilization of tubes and filling devices is not always sufficient.
PROBLEME POSE
Une solution plus sûre consiste à incorporer des substances bactéricides dans les produits eux-mêmes mais la concentration nécessaire pour que leur action soit efficace peut augmenter sensiblement le prix du produit conditionné et surtout modifier ses propriétés dans un sens défavorable. PROBLEM
A safer solution is to incorporate bactericidal substances into the products themselves, but the concentration necessary for their action to be effective can significantly increase the price of the packaged product and, above all, modify its properties in an unfavorable way.
On connaît par ailleurs l'incorporation dans des films plastiques pour emballage de molécules actives à base d'éléments chlorés ou contenant des ions métalliques tels que l'argent et le cuivre. Mais tous ces produits présentent des risques sanitaires vis à vis des produits conditionnés ce qui en limite l'utilisation, en particulier pour les produits alimentaires et les produits cosmétiques, où la présence d'ions métalliques ou d'éléments halogénés est à l'origine d'un grand nombre d'allergies. D'autre part, certaines substances testées sont potentiellement extrêmement toxiques de par leur nature même (en général des composés à base d'arsenic) et en raison de leur concentration minimale permettant d'avoir une action efficace sur le produit. We also know the incorporation in plastic films for packaging of active molecules based on chlorinated elements or containing metal ions such as silver and copper. However, all of these products present health risks with respect to packaged products, which limits their use, in particular for food products and cosmetic products, where the presence of metal ions or halogenated elements is at the origin. a lot of allergies. On the other hand, some of the substances tested are potentially extremely toxic by their very nature (generally arsenic-based compounds) and because of their minimum concentration allowing them to have an effective action on the product.
OBJET DE L'INVENTION Pour remédier à ces difficultés, la demanderesse a conféré au tube lui-même des caractéristiques lui permettant de jouer, en plus de son rôle passif de barrière contre les agressions venant de l'extérieur, un rôle actif tel qu'antiseptique, antifongique, OBJECT OF THE INVENTION To remedy these difficulties, the Applicant has given the tube itself characteristics enabling it to play, in addition to its passive role as a barrier against attacks from outside, an active role such as antiseptic, antifungal,
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antiviral ou bactéricide, c'est-à-dire inhibant la croissance, voire détruisant les microorganismes éventuellement présents, ou introduits au moment du remplissage ou même introduits à tout autre moment. Nous regrouperons par la suite l'ensemble de ces fonctions par le terme biocide)). antiviral or bactericidal, that is to say inhibiting growth or even destroying microorganisms possibly present, or introduced at the time of filling or even introduced at any other time. We will group all of these functions below by the term biocide)).
L'objet de l'invention est un tube souple comportant une jupe cylindrique et une tête munie d'un goulot et d'une épaule reliant ladite jupe audit goulot, caractérisé en ce que la paroi du tube comporte, au moins partiellement, une couche interne, destinée à être directement au contact du produit contenu par le tube, ladite couche interne étant en une matière organique comportant une substance biocide et un agent permettant et régulant la libération continue de ladite substance biocide. The object of the invention is a flexible tube comprising a cylindrical skirt and a head provided with a neck and a shoulder connecting said skirt to said neck, characterized in that the wall of the tube comprises, at least partially, a layer internal, intended to be directly in contact with the product contained by the tube, said internal layer being made of an organic material comprising a biocidal substance and an agent allowing and regulating the continuous release of said biocidal substance.
Le tube selon l'invention comporte en effet de préférence au moins deux couches et celle qui se trouve sur la face interne, au contact du produit, comporte une matière organique telle qu'une matière plastique contenant une faible proportion d'un agent biocide tel qu'un bactéricide ou un fongicide. La concentration moléculaire de cet agent est variable suivant sa nature, les propriétés de la matière plastique utilisée et les caractéristiques du produit à protéger. Elle peut varier de 1 ppm à 100 000 ppm. The tube according to the invention indeed preferably comprises at least two layers and the one which is on the internal face, in contact with the product, comprises an organic material such as a plastic material containing a small proportion of a biocidal agent such than a bactericide or fungicide. The molecular concentration of this agent is variable depending on its nature, the properties of the plastic used and the characteristics of the product to be protected. It can vary from 1 ppm to 100,000 ppm.
En général, elle est comprise entre 5 000 et 25 000 ppm. In general, it is between 5,000 and 25,000 ppm.
L'incorporation de l'agent biocide dans la couche interne du tube s'est révélée conférer audit tube des propriétés extrêmement intéressantes : tout d'abord, les risques de contamination des tubes vides au cours du stockage avant utilisation sont considérablement réduits. Ensuite, les opérations éventuelles de nettoyage ou même de stérilisation avant remplissage sont simplifiées, voire supprimées. Enfin, les risques de contamination au cours du remplissage ont pratiquement disparu. The incorporation of the biocidal agent into the inner layer of the tube has been shown to confer on said tube extremely advantageous properties: firstly, the risks of contamination of the empty tubes during storage before use are considerably reduced. Then, the possible cleaning or even sterilization operations before filling are simplified, or even eliminated. Finally, the risks of contamination during filling have practically disappeared.
En effet, le produit lui-même est pratiquement toujours aseptique car il a subi pendant son élaboration des traitements à température suffisante pour détruire les microorganismes. Aussi, lorsque ceux-ci sont présents au remplissage, ils se trouvent en Indeed, the product itself is practically always aseptic because it has undergone, during its preparation, treatments at a temperature sufficient to destroy the microorganisms. Also, when these are present during filling, they are found in
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général à la surface du produit et/ou au voisinage de la paroi interne du tube. L'agent biocide, présent dans cette paroi, est en mesure d'avoir une action directe sur ces microorganismes. Par ailleurs, l'agent biocide qu'on incorpore dans la couche interne est choisi de façon à pouvoir diffuser lentement dans le produit à protéger. Il peut ainsi atteindre les bactéries qui ont déjà cheminé plus ou moins profondément à l'intérieur du produit. Un agent régulant la libération de la substance biocide permet de limiter la concentration de ladite substance dans le produit. general on the surface of the product and / or in the vicinity of the internal wall of the tube. The biocidal agent present in this wall is able to have a direct action on these microorganisms. Furthermore, the biocidal agent which is incorporated into the internal layer is chosen so as to be able to diffuse slowly into the product to be protected. It can thus reach bacteria that have already traveled more or less deeply inside the product. An agent regulating the release of the biocidal substance makes it possible to limit the concentration of the said substance in the product.
La substance biocide peut être de l'acide sorbique, de l'acide benzoïque, du diiodométhyl-p-tolyl sulfone, de la trichloromélamine, du triclosan ou du zinc pyrithione. Mais, de préférence, on la choisit issue d'extraits naturels non toxiques ou allergisants, en particulier d'origine végétale. Il s'agit par exemple de substances photosensibles d'origine naturelle choisies parmi l'extrait de poivre (oléorésine de capsicum), l'extrait de pépins de pamplemousse, l'huile de lemon grass, l'huile de théier, l'acide citrique ou encore issues des oléorésines végétales, plus particulièrement les oléorésines de conifères et d'agrumes, ou tout mélange desdites substances. The biocidal substance can be sorbic acid, benzoic acid, diiodomethyl-p-tolyl sulfone, trichloromelamine, triclosan or zinc pyrithione. But, preferably, it is chosen from non-toxic or allergenic natural extracts, in particular of plant origin. These are, for example, photosensitive substances of natural origin chosen from pepper extract (capsicum oleoresin), grapefruit seed extract, lemon grass oil, tea tree oil, acid citric or else derived from vegetable oleoresins, more particularly oleoresins from conifers and citrus fruits, or any mixture of said substances.
Si le tube est métallique, la matière organique de la couche interne est un vernis, typiquement une résine époxy, polyuréthane, polyester ou polyamide. Un tel vernis pourrait également être utilisé pour recouvrir la paroi interne des boîtiers métalliques de distributeurs sous pression de produits alimentaires ou cosmétiques, exposés aux mêmes problèmes sanitaires. If the tube is metallic, the organic material of the inner layer is a varnish, typically an epoxy, polyurethane, polyester or polyamide resin. Such a varnish could also be used to cover the internal wall of metal housings of pressure dispensers for food or cosmetic products, exposed to the same health problems.
Si le tube est plastique ou métalloplastique, la matière organique de la couche interne est une polyoléfine-typiquement du polyéthylène, du polypropylène ou un copolymère éthylène-acétate de vinyle (EVA)-, un polyester saturé-typiquement du polyéthylène téréphtalate (PET)-, ou encore un polyvinyl, une silicone, un polystyrène, un polyacrylate ou un polyuréthane. If the tube is plastic or metalloplastic, the organic material of the inner layer is a polyolefin - typically polyethylene, polypropylene or an ethylene-vinyl acetate copolymer (EVA) -, a saturated polyester - typically polyethylene terephthalate (PET) - , or else a polyvinyl, a silicone, a polystyrene, a polyacrylate or a polyurethane.
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L'agent de libération de la substance biocide est de préférence l'acide citrique ou la vitamine E. La vitamine E peut également être utilisée comme anti-oxydant. Dans certains cas, la substance biocide se libère elle-même par diffusion du polymère constitutif de la couche interne. Elle est en quelque sorte son propre agent de . libération. The release agent for the biocidal substance is preferably citric acid or vitamin E. Vitamin E can also be used as an antioxidant. In some cases, the biocidal substance releases itself by diffusion of the constituent polymer of the inner layer. She's sort of her own agent. release.
La paroi du tube peut être en un seul matériau, auquel cas elle est assimilée à la couche interne selon l'invention, c'est-à-dire constituée du matériau organique comportant une substance biocide. Mais, de préférence, la paroi du tube est multicouche, munie vers l'extérieur d'au moins une deuxième couche exempte de substance biocide et/ou faisant barrière à la diffusion de ladite substance. On empêche ainsi la migration vers l'extérieur de cet agent actif qui pourrait en particulier interférer avec les opérations d'impression qui sont généralement effectuées sur la surface externe des tubes souples. The wall of the tube can be made of a single material, in which case it is assimilated to the internal layer according to the invention, that is to say made of organic material comprising a biocidal substance. However, preferably, the wall of the tube is multilayer, provided towards the outside with at least one second layer free of biocidal substance and / or forming a barrier to the diffusion of said substance. This prevents migration to the outside of this active agent which could in particular interfere with the printing operations which are generally carried out on the external surface of the flexible tubes.
En général, le tube métallique doit posséder un vernis protecteur sur toute sa surface interne et il suffit donc d'employer un vernis additivé avec la substance biocide et un agent contrôlant la libération de ladite substance. In general, the metal tube must have a protective varnish over its entire internal surface and it is therefore sufficient to use a varnish additive with the biocidal substance and an agent controlling the release of said substance.
En ce qui concerne le tube plastique ou métalloplastique, il n'est pas nécessaire de recouvrir intégralement la surface interne. Le tube souple plastique est en effet rarement fabriqué en une pièce mais est obtenu par assemblage d'une jupe cylindrique soudée sur une tête injectée moulée ou comprimée moulée. La jupe cylindrique est elle-même réalisée par découpe de manchons cylindriques soit (co) extrudés, soit obtenus par roulage d'une bande multicouche laminée puis soudage suivant une génératrice des deux bords latéraux superposés de ladite bande roulée. With regard to the plastic or metalloplastic tube, it is not necessary to completely cover the internal surface. The flexible plastic tube is in fact rarely manufactured in one piece but is obtained by assembling a cylindrical skirt welded on an injected molded or compressed molded head. The cylindrical skirt is itself produced by cutting cylindrical sleeves either (co) extruded, or obtained by rolling a multilayer laminated strip and then welding along a generatrix of the two superimposed lateral edges of said rolled strip.
Le tube souple plastique peut donc ne comporter une couche interne biocide qu'au niveau de la jupe cylindrique, celle étant entièrement en une matière plastique The flexible plastic tube may therefore have an internal biocidal layer only at the level of the cylindrical skirt, that being entirely made of a plastic material.
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comportant une substance biocide ou étant multicouche (coextrudée ou laminée) et comportant ladite couche interne.
comprising a biocidal substance or being multilayer (coextruded or laminated) and comprising said internal layer.
Pour améliorer l'efficacité sanitaire du tube plastique selon l'invention, il est possible d'étendre la couche interne biocide au niveau de la tête, soit en moulant (par injection ou compression) la tête avec une matière plastique comportant une substance biocide, soit en coinjectant la tête-par exempte en suivant le procédé décrit par la demanderesse dans la demande internationale WOOO/23340-en utilisant pour la couche interne la matière plastique comportant une substance biocide. To improve the sanitary efficiency of the plastic tube according to the invention, it is possible to extend the internal biocidal layer at the level of the head, either by molding (by injection or compression) the head with a plastic material comprising a biocidal substance, either by co-injecting the head - for example by following the process described by the applicant in international application WOOO / 23340 - by using the plastic material comprising a biocidal substance for the internal layer.
Il est possible également d'injecter la tête avec une matière plastique ne comportant pas de substance biocide puis de recouvrir substantiellement la surface interne de l'épaule et du goulot par un insert monobloc constitué d'une matière plastique comportant une substance biocide ou encore par un insert multicouche-tel que celui décrit par la demanderesse dans la demande EP 0 524 897-qui comporterait comme couche interne la couche interne selon l'invention. It is also possible to inject the head with a plastic material containing no biocidal substance and then to substantially cover the internal surface of the shoulder and the neck with a monobloc insert made of a plastic material comprising a biocidal substance or even by a multi-layer insert - such as that described by the applicant in application EP 0 524 897 - which would include as internal layer the internal layer according to the invention.
Les risques de contamination étant situés surtout au voisinage de l'orifice de distribution, la couche interne selon l'invention du tube peut ne recouvrir que la surface intérieure de la tête et non celle de la jupe. En un tel cas, seule la tête, monocouche ou multi-couche ou encore munie d'un insert, aurait une couche interne comportant une substance biocide et un agent de libération de ladite substance biocide. De plus, on peut munir l'intérieur de la tête d'un insert à chicanes dans lequel on impose au produit de circuler au travers de canaux coudés de telle sorte qu'il doit rester plus longtemps au contact de ladite matière plastique comportant une substance biocide avant de sortir par l'orifice de distribution. The risks of contamination being located especially in the vicinity of the dispensing orifice, the internal layer according to the invention of the tube may cover only the internal surface of the head and not that of the skirt. In such a case, only the head, monolayer or multi-layer or even provided with an insert, would have an internal layer comprising a biocidal substance and an agent for releasing said biocidal substance. In addition, the inside of the head can be provided with a baffle insert in which the product is forced to circulate through bent channels so that it must remain longer in contact with said plastic containing a substance. biocide before exiting through the dispensing orifice.
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Enfin, le bouchon peut comporter également, en particulier dans sa partie intérieure qui se trouve au droit de l'orifice de distribution lorsque le bouchon obture le tube, une matière plastique comportant une substance biocide et un agent de libération. Finally, the stopper may also include, in particular in its inner part which is located in line with the dispensing orifice when the stopper closes the tube, a plastic material comprising a biocidal substance and a release agent.
5 EXEMPLE
La demanderesse a réalisé un tube souple destiné à stocker et distribuer un produit cosmétique spécialisé dans le traitement de la peau, par exemple un produit à base de cétrimide à 0,5 %. En général, un produit tel qu'une crème spécialisée dans le ) traitement de la peau est mélangé avec un agent conservateur, tel que le parahydroxybenzoate de méthyle et/ou de propyle. Le but est ici de savoir si un tube selon l'invention permettrait d'éviter l'ajout d'un tel agent conservateur. 5 EXAMPLE
The Applicant has produced a flexible tube intended for storing and distributing a cosmetic product specialized in the treatment of the skin, for example a product based on 0.5% cetrimide. In general, a product such as a cream specialized in the treatment of the skin is mixed with a preservative, such as methyl and / or propyl parahydroxybenzoate. The goal here is to know if a tube according to the invention would avoid the addition of such a preservative.
Deux lots de 10 tubes sont réalisés : un lot de tubes témoins et un lot de tubes selon 5 l'invention. Tous les tubes possèdent une jupe multicouche laminée et une tête en
PE. BD qui a été injectée dans un moule contenant une extrémité de la jupe. La structure de la jupe multicouche est la suivante (description allant de l'intérieur vers
l'extérieur) : PE. BD (90 p)/PE. HD (40 p)/EMA (10p)/EVOH (20 p)/EMA (10 p)/PE. HD (50 P) PE. BD (180 p) où PE. BD signifie polyéthylène basse densité PE. HD signifie polyéthylène haute densité
EMA signifie copolymère (éthylène - acide méthacrylique)
EVOH signifie copolymère (éthylène-alcool vinylique) Pour les tubes témoins, la couche interne est une simple couche de 90p en PE. BD non additivé. Two batches of 10 tubes are produced: a batch of control tubes and a batch of tubes according to the invention. All tubes have a laminated multilayer skirt and a
EP. BD which was injected into a mold containing one end of the skirt. The structure of the multilayer skirt is as follows (description going from the interior to
outside): PE. BD (90 p) / EP. HD (40 p) / EMA (10p) / EVOH (20 p) / EMA (10 p) / PE. HD (50 P) PE. BD (180 p) where PE. BD stands for low density polyethylene PE. HD stands for high density polyethylene
EMA stands for copolymer (ethylene - methacrylic acid)
EVOH means copolymer (ethylene-vinyl alcohol) For the control tubes, the internal layer is a single layer of 90p made of PE. BD not additive.
Pour les tubes selon l'invention, la couche interne est en PE. BD additivé avec de l'extrait de pépins de pamplemousse en proportions de : 35 000 ppm. For the tubes according to the invention, the internal layer is made of PE. BD added with grapefruit seed extract in proportions of: 35,000 ppm.
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Tous les tubes sont remplis avec une solution nutritive et maintenus à une température de 370 pendant une semaine. Au bout d'une semaine 1 ml de solution est prélevé dans chaque tube et versé sur de la gélose nutritive dans une boîte de Petri. Au bout de 48h à 37 0 on observe entre 50 et 300 colonies de staphylococcus epidermidis dans les boîtes alimentées avec la solution extraite de tubes témoins et entre 0 et 2 colonies dans les boîtes alimentées avec la solution extraite de tubes selon l'invention. All the tubes are filled with a nutritive solution and kept at a temperature of 370 for one week. After one week, 1 ml of solution is taken from each tube and poured onto nutritive agar in a Petri dish. After 48 hours at 37 0, between 50 and 300 colonies of staphylococcus epidermidis are observed in the dishes supplied with the solution extracted from control tubes and between 0 and 2 colonies in the dishes supplied with the solution extracted from tubes according to the invention.
. AVANTAGES action protectrice positive tout au long de la vie (stockage et utilisation) du tube a meilleure protection des crèmes assez visqueuses . ADVANTAGES positive protective action throughout the life (storage and use) of the tube for better protection of fairly viscous creams
Claims (20)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0015520A FR2817242B1 (en) | 2000-11-30 | 2000-11-30 | FLEXIBLE TUBES CONTAINING BIOCIDAL AGENTS |
| AU2002222066A AU2002222066A1 (en) | 2000-11-30 | 2001-11-28 | Containers comprising a wall containing biocidal agents |
| CN 01805743 CN1406194A (en) | 2000-11-30 | 2001-11-28 | Containers comprising a wall containing biocidal agents |
| BR0107882-8A BR0107882A (en) | 2000-11-30 | 2001-11-28 | Containers that have a wall containing biocidal agents |
| JP2002546005A JP2004514617A (en) | 2000-11-30 | 2001-11-28 | Container having an inner wall containing a biocide |
| PCT/FR2001/003755 WO2002044055A1 (en) | 2000-11-30 | 2001-11-28 | Containers comprising a wall containing biocidal agents |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0015520A FR2817242B1 (en) | 2000-11-30 | 2000-11-30 | FLEXIBLE TUBES CONTAINING BIOCIDAL AGENTS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2817242A1 true FR2817242A1 (en) | 2002-05-31 |
| FR2817242B1 FR2817242B1 (en) | 2003-06-27 |
Family
ID=8857089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR0015520A Expired - Fee Related FR2817242B1 (en) | 2000-11-30 | 2000-11-30 | FLEXIBLE TUBES CONTAINING BIOCIDAL AGENTS |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2817242B1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2880619A1 (en) * | 2005-01-10 | 2006-07-14 | Cebal Sas Soc Par Actions Simp | PLASTIC PACKAGES, IN PARTICULAR FLEXIBLE TUBES, CONTAINING REACTIVE SUBSTANCES ASSOCIATED WITH A PRESENCE WITNESS |
| WO2017001591A1 (en) * | 2015-06-30 | 2017-01-05 | Courtin Karine | Container having a bactericidal insert |
| US10123861B2 (en) | 2014-11-04 | 2018-11-13 | Imv Technologies | Bag for packaging diluted animal semen suitable for artificial insemination, in particular of porcine species; and system comprising same |
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| US4705708A (en) * | 1982-03-04 | 1987-11-10 | American Can Company | Multi-laminate structure containing a scrap layer and containers made therefrom |
| EP0423604A1 (en) * | 1989-10-20 | 1991-04-24 | Mitsubishi Petrochemical Co., Ltd. | Method for producing an antibacterial molded article of polyolefin resin |
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| EP0875463A1 (en) * | 1996-10-02 | 1998-11-04 | Taisei Kako Co., Ltd., | Metallic extruded tube, aerosol can and method of manufacturing metallic extruded tube |
| GB2337035A (en) * | 1998-05-08 | 1999-11-10 | Courtaulds Packaging Ltd | Containers |
| FR2784657A1 (en) * | 1998-10-19 | 2000-04-21 | Cebal | Polyolefin head for e.g. plastic toothpaste tube contains intermediate, fully encapsulated vapor barrier layer coinjected onto prefabricated skirt forming tube wall |
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|---|---|---|---|---|
| US4705708A (en) * | 1982-03-04 | 1987-11-10 | American Can Company | Multi-laminate structure containing a scrap layer and containers made therefrom |
| EP0423604A1 (en) * | 1989-10-20 | 1991-04-24 | Mitsubishi Petrochemical Co., Ltd. | Method for producing an antibacterial molded article of polyolefin resin |
| EP0524897A1 (en) | 1991-07-25 | 1993-01-27 | Cebal S.A. | Plastic tube head with barrier effect inner layer and part forming this layer |
| DE19612340A1 (en) * | 1995-03-31 | 1996-11-07 | Schuer Joerg Peter Prof | Process for improving the durability and / or stabilization of microbially perishable products |
| EP0875463A1 (en) * | 1996-10-02 | 1998-11-04 | Taisei Kako Co., Ltd., | Metallic extruded tube, aerosol can and method of manufacturing metallic extruded tube |
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| FR2784657A1 (en) * | 1998-10-19 | 2000-04-21 | Cebal | Polyolefin head for e.g. plastic toothpaste tube contains intermediate, fully encapsulated vapor barrier layer coinjected onto prefabricated skirt forming tube wall |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2880619A1 (en) * | 2005-01-10 | 2006-07-14 | Cebal Sas Soc Par Actions Simp | PLASTIC PACKAGES, IN PARTICULAR FLEXIBLE TUBES, CONTAINING REACTIVE SUBSTANCES ASSOCIATED WITH A PRESENCE WITNESS |
| WO2006075072A1 (en) * | 2005-01-10 | 2006-07-20 | Cebal Sas | Plastic packaging, particularly flexible tubes, containing reactive substances associated with a presence indicator |
| US10123861B2 (en) | 2014-11-04 | 2018-11-13 | Imv Technologies | Bag for packaging diluted animal semen suitable for artificial insemination, in particular of porcine species; and system comprising same |
| WO2017001591A1 (en) * | 2015-06-30 | 2017-01-05 | Courtin Karine | Container having a bactericidal insert |
| FR3038302A1 (en) * | 2015-06-30 | 2017-01-06 | Karine Courtin | CONTAINER COMPRISING A BACTERICIDE INSERT |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2817242B1 (en) | 2003-06-27 |
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