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FR2816619B1 - Derives de benzimidazole, leur preparation et leur application en therapeutique - Google Patents

Derives de benzimidazole, leur preparation et leur application en therapeutique

Info

Publication number
FR2816619B1
FR2816619B1 FR0014696A FR0014696A FR2816619B1 FR 2816619 B1 FR2816619 B1 FR 2816619B1 FR 0014696 A FR0014696 A FR 0014696A FR 0014696 A FR0014696 A FR 0014696A FR 2816619 B1 FR2816619 B1 FR 2816619B1
Authority
FR
France
Prior art keywords
preparation
therapeutic application
benzimidazole derivatives
benzimidazole
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0014696A
Other languages
English (en)
Other versions
FR2816619A1 (fr
Inventor
Francis Barth
Daniel Bichon
Frank Bolkenius
Dorsselaer Viviane Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0014696A priority Critical patent/FR2816619B1/fr
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Priority to ES01960871T priority patent/ES2233671T3/es
Priority to US10/343,467 priority patent/US6794382B2/en
Priority to CN01813895A priority patent/CN1446218A/zh
Priority to JP2002518214A priority patent/JP2004505975A/ja
Priority to HU0301514A priority patent/HUP0301514A2/hu
Priority to DE60107859T priority patent/DE60107859T2/de
Priority to ARP010103751A priority patent/AR030121A1/es
Priority to EP01960871A priority patent/EP1309594B1/fr
Priority to CA002412368A priority patent/CA2412368A1/fr
Priority to PL01365080A priority patent/PL365080A1/xx
Priority to YU7203A priority patent/YU7203A/sh
Priority to SK158-2003A priority patent/SK1582003A3/sk
Priority to DK01960871T priority patent/DK1309594T3/da
Priority to PT01960871T priority patent/PT1309594E/pt
Priority to EA200201259A priority patent/EA005950B1/ru
Priority to SI200130300T priority patent/SI1309594T1/xx
Priority to EEP200300048A priority patent/EE200300048A/xx
Priority to PCT/FR2001/002556 priority patent/WO2002012239A1/fr
Priority to KR10-2003-7001760A priority patent/KR20030020450A/ko
Priority to AU2001282267A priority patent/AU2001282267A1/en
Priority to CZ2003354A priority patent/CZ294493B6/cs
Priority to BR0113046-3A priority patent/BR0113046A/pt
Priority to MXPA03000753A priority patent/MXPA03000753A/es
Priority to IL15370801A priority patent/IL153708A0/xx
Priority to AT01960871T priority patent/ATE284886T1/de
Publication of FR2816619A1 publication Critical patent/FR2816619A1/fr
Priority to IS6661A priority patent/IS6661A/is
Priority to BG107460A priority patent/BG107460A/bg
Application granted granted Critical
Publication of FR2816619B1 publication Critical patent/FR2816619B1/fr
Priority to NO20030596A priority patent/NO20030596L/no
Priority to HR20030081A priority patent/HRP20030081A2/hr
Priority to HK03105435A priority patent/HK1053118A1/xx
Priority to US10/939,910 priority patent/US20050032779A1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0014696A 2000-08-08 2000-11-15 Derives de benzimidazole, leur preparation et leur application en therapeutique Expired - Fee Related FR2816619B1 (fr)

Priority Applications (32)

Application Number Priority Date Filing Date Title
FR0014696A FR2816619B1 (fr) 2000-11-15 2000-11-15 Derives de benzimidazole, leur preparation et leur application en therapeutique
US10/343,467 US6794382B2 (en) 2000-08-08 2001-08-06 Benzimidazole derivatives, preparation and therapeutic use thereof
CN01813895A CN1446218A (zh) 2000-08-08 2001-08-06 苯并咪唑衍生物,它们的制备方法以及它们的治疗应用
JP2002518214A JP2004505975A (ja) 2000-08-08 2001-08-06 ベンズイミダゾール誘導体、その製造及び治療上の使用
HU0301514A HUP0301514A2 (hu) 2000-08-08 2001-08-06 Benzimidazol származékok, elżállításuk és ezeket tartalmazó gyógyszerkészítmények
DE60107859T DE60107859T2 (de) 2000-08-08 2001-08-06 Benzimidazolderivate, ihre herstellung und therapeutische verwendung
ARP010103751A AR030121A1 (es) 2000-08-08 2001-08-06 Derivados de benzimidazol, su preparacion y su aplicacion en terapeutica
EP01960871A EP1309594B1 (fr) 2000-08-08 2001-08-06 Derives de benzimidazole, leur preparation et leur application en therapeutique
CA002412368A CA2412368A1 (fr) 2000-08-08 2001-08-06 Derives de benzimidazole, leur preparation et leur application en therapeutique
PL01365080A PL365080A1 (en) 2000-08-08 2001-08-06 Benzimidazole derivatives, preparation and therapeutic use thereof
YU7203A YU7203A (sh) 2000-08-08 2001-08-06 Derivati benzimidazola, njihovo dobijanje i terapeutska primena
SK158-2003A SK1582003A3 (en) 2000-08-08 2001-08-06 Benzimidazole derivatives, preparation and therapeutic use thereof
DK01960871T DK1309594T3 (da) 2000-08-08 2001-08-06 Benzimidazolderivater, fremstilling heraf og terapeutisk anvendelse heraf
PT01960871T PT1309594E (pt) 2000-08-08 2001-08-06 Derivados de benzimidazole a sua preparacao e a sua aplicacao em terapeutica
EA200201259A EA005950B1 (ru) 2000-08-08 2001-08-06 Производные бензимидазола, их получение и терапевтическое применение
SI200130300T SI1309594T1 (en) 2000-08-08 2001-08-06 Benzimidazole derivatives, preparation and therapeutic use thereof
ES01960871T ES2233671T3 (es) 2000-08-08 2001-08-06 Derivados de benzimidazol, su preparacion y aplicacion en terapeutica.
EEP200300048A EE200300048A (et) 2000-08-08 2001-08-06 Bensimidasooli derivaadid, nende valmistamine ja terapeutiline kasutamine
PCT/FR2001/002556 WO2002012239A1 (fr) 2000-08-08 2001-08-06 Derives de benzimidazole, leur preparation et leur application en therapeutique
AU2001282267A AU2001282267A1 (en) 2000-08-08 2001-08-06 Benzimidazole derivatives, preparation and therapeutic use thereof
CZ2003354A CZ294493B6 (cs) 2000-08-08 2001-08-06 Deriváty benzimidazolu, způsob jejich přípravy a léčebné prostředky s jejich obsahem
BR0113046-3A BR0113046A (pt) 2000-08-08 2001-08-06 Derivados de benzimidazol, preparação dos mesmos e aplicação dos mesmos em terapia
MXPA03000753A MXPA03000753A (es) 2000-08-08 2001-08-06 Derivados de benzimidazola, su preparacion y su aplicacion terapeutica.
IL15370801A IL153708A0 (en) 2000-08-08 2001-08-06 Benzimidazole derivatives, preparation and therapeutic use thereof
AT01960871T ATE284886T1 (de) 2000-08-08 2001-08-06 Benzimidazolderivate, ihre herstellung und therapeutische verwendung
KR10-2003-7001760A KR20030020450A (ko) 2000-08-08 2001-08-06 벤지미다졸 유도체, 그의 제조 방법 및 치료적 용도
IS6661A IS6661A (is) 2000-08-08 2002-12-19 Bensimídasólafleiður, framleiðsla þeirra og meðferðarleg notkun
BG107460A BG107460A (bg) 2000-08-08 2003-01-14 Производни на бензимидазола, тяхното получаване иприложението им в терапията
NO20030596A NO20030596L (no) 2000-08-08 2003-02-06 Benzimidazolderivater, deres fremstilling og terapeutiske anvendelse
HR20030081A HRP20030081A2 (en) 2000-08-08 2003-02-06 Benzimidazole derivatives, preparation and therapeutic use thereof
HK03105435A HK1053118A1 (en) 2000-08-08 2003-07-28 Benzimidazole derivatives, preparation and therapeutic use thereof.
US10/939,910 US20050032779A1 (en) 2000-08-08 2004-09-13 Benzimidazole derivatives, preparation and therapeutic use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0014696A FR2816619B1 (fr) 2000-11-15 2000-11-15 Derives de benzimidazole, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2816619A1 FR2816619A1 (fr) 2002-05-17
FR2816619B1 true FR2816619B1 (fr) 2003-01-31

Family

ID=8856477

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0014696A Expired - Fee Related FR2816619B1 (fr) 2000-08-08 2000-11-15 Derives de benzimidazole, leur preparation et leur application en therapeutique

Country Status (1)

Country Link
FR (1) FR2816619B1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12227502B2 (en) 2023-05-31 2025-02-18 Incyte Corporation 1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c] pyridin-7(6H)-ones as inhibitors of BET proteins

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3581576B1 (fr) 2013-03-15 2022-01-26 Incyte Holdings Corporation Hétérocycles tricycliques en tant qu'inhibiteurs de protéine bet utiles pour le traitement d'une maladie proliférante en combinaison avec un inhibiteur de kinase janus
TWI735002B (zh) 2014-04-23 2021-08-01 美商英塞特公司 作為BET蛋白抑制劑之1H-吡咯并[2,3-c]吡啶-7(6H)-酮及吡唑并[3,4-c]吡啶-7(6H)-酮
TWI786050B (zh) 2016-06-20 2022-12-11 美商英塞特公司 Ｂｅｔ抑制劑之結晶固體形式
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2710915B1 (fr) * 1993-10-04 1995-11-24 Synthelabo Dérivés de pipéridine, leur préparation et leur utilisation en thérapeutique.
FR2731708B1 (fr) * 1995-03-13 1997-04-30 Synthelabo Derives de piperidine, leur procede de preparation et leur application en therapeutique

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12227502B2 (en) 2023-05-31 2025-02-18 Incyte Corporation 1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c] pyridin-7(6H)-ones as inhibitors of BET proteins

Also Published As

Publication number Publication date
FR2816619A1 (fr) 2002-05-17

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Legal Events

Date Code Title Description
CD Change of name or company name
ST Notification of lapse

Effective date: 20120731