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FR2785537A1 - Antiseptic composition in gel form for disinfecting the skin without using water or soap comprises ethyl alcohol, isopropyl alcohol and a carbomer with gel-forming capability - Google Patents

Antiseptic composition in gel form for disinfecting the skin without using water or soap comprises ethyl alcohol, isopropyl alcohol and a carbomer with gel-forming capability Download PDF

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Publication number
FR2785537A1
FR2785537A1 FR9903790A FR9903790A FR2785537A1 FR 2785537 A1 FR2785537 A1 FR 2785537A1 FR 9903790 A FR9903790 A FR 9903790A FR 9903790 A FR9903790 A FR 9903790A FR 2785537 A1 FR2785537 A1 FR 2785537A1
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Prior art keywords
gel
skin
carbomer
water
disinfecting
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Granted
Application number
FR9903790A
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French (fr)
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FR2785537B1 (en
Inventor
Franck Lahmi
Eric Auday
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BLUE SKIN SA
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BLUE SKIN SA
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Publication date
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Priority to FR9903790A priority Critical patent/FR2785537B1/en
Publication of FR2785537A1 publication Critical patent/FR2785537A1/en
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Publication of FR2785537B1 publication Critical patent/FR2785537B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02Acyclic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • A61K8/042Gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Emergency Medicine (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Agronomy & Crop Science (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

An antiseptic composition for disinfecting the skin based on a mixture of ethyl alcohol and isopropyl alcohol gelled with a carbomer. Antiseptic composition for disinfecting the skin without using soap or water and which is evaporable, comprises 50-80 vol. % ethyl alcohol and 10-15 vol. % isopropyl alcohol together with a carbomer having gel-forming capability.

Description

1 27855371 2785537

COMPOSITION ET GEL ANTISEPTIQUE ADOUCISSANT ET LEUR UTILISATION  SOFTENING ANTISEPTIC COMPOSITION AND GEL AND THEIR USE

DANS DES PROCEDES DE DESINFECTION CUTANE  IN SKIN DISINFECTION PROCESSES

La présente invention concerne une composition antiseptique gélifiée notamment destinée à la désinfection de l'épiderme, notamment celui des mains. Le lavage des mains au savon traditionnel ou antibactérien implique la présence d'un point d'eau et la nécessité d'un séchage par divers procédés, notamment par  The present invention relates to a gelled antiseptic composition in particular intended for the disinfection of the epidermis, in particular that of the hands. Hand washing with traditional or antibacterial soap implies the presence of a water point and the need for drying by various methods, in particular by

l'emploi d'une serviette qui peut être cause d'une contamination à posteriori.  the use of a towel which can cause post-contamination.

La désinfection des mains pouvant aussi s'opérer à partir de liquides  Hand disinfection can also be carried out using liquids

antiseptiques, notamment à base d'alcool.  antiseptics, especially alcohol-based.

Les personnes amenées à être fréquemment au contact de germes, notamment dans les professions médicales et paramédicales, ont la nécessité de se désinfecter les i5 mains très régulièrement tout au long de la journéme afin de limiter les risques de  People who come into frequent contact with germs, especially in the medical and paramedical professions, need to disinfect their hands 15 very regularly throughout the day in order to limit the risk of

transmission de contamination à eux-mêmes ou à d'autres patients.  transmission of contamination to themselves or other patients.

Le problème se pose de façon identique pour les métiers de la restauration et de façon générale pour toute personne ayant un souci d'hygiène au quotidien, dans un  The problem arises identically for the catering trades and generally for anyone with a daily hygiene concern, in a

usage professionnel ou privé.professional or private use.

Or l'action du savon seul n'est pas suffisamment efficace et l'utilisation répétée  However, the action of soap alone is not sufficiently effective and repeated use

d'antiseptiques traditionnels, tel l'alcool liquide, agresse et dessèche l'épiderme.  traditional antiseptics, such as liquid alcohol, attack and dry out the epidermis.

La présente composition apporte une solution novatrice et permet de remédier à  The present composition provides an innovative solution and makes it possible to remedy

ces inconvénients.these disadvantages.

Sans utilisation d'eau, ni de savon, ni de serviette elle permet une désinfection de la peau, rapide et sans essuyage tout en exerçant une action hydratante et  Without the use of water, soap or towel, it allows rapid disinfection of the skin without wiping while exerting a hydrating and

adoucissantes sur l'épiderme, permettant ainsi un usage répété du produit.  softening on the epidermis, allowing repeated use of the product.

Par sa présentation gélifiée et ses qualités évaporatoires, la présente composition permet de plus une utilisation ambulatoire et autonome en tout lieu et en toute  By its gelled presentation and its evaporative qualities, the present composition also allows ambulatory and autonomous use anywhere and in any

circonstance.circumstance.

L'alcool éthylique et l'alcool isopropil sont les composants essentiels de cette composition. S'ils sont connus pour leur activité antiseptique, notamment efficace à des  Ethyl alcohol and isopropil alcohol are the essential components of this composition. If they are known for their antiseptic activity, especially effective at

concentrations proche de 70%, ils sont inappropriés à un emploi répété sur l'épiderme.  concentrations close to 70%, they are unsuitable for repeated use on the epidermis.

2 27855372,278,537

La présente composition a par ailleurs une action hydratante, venant compenser l'effet déssechant de l'alcool, grâce à l'addition d'un extrait végétal hydratant, à titre  The present composition also has a hydrating action, compensating for the drying effect of the alcohol, by virtue of the addition of a hydrating plant extract, by way of

d'exemple non limitatif un extrait d'Aloe Barbadensis.  nonlimiting example an extract of Aloe Barbadensis.

La fonction adoucissante du produit, venant aussi pallier à l'effet dessechant de l'alcool est apportée par une résine pseudo silicone, à l'effet surgraissant et  The softening function of the product, which also overcomes the drying effect of alcohol, is provided by a pseudo silicone resin, with a superfatting effect and

adoucissant, à titre d'exemple non limitatif le Neopentyl glycol diheptanoate.  softener, by way of nonlimiting example, Neopentyl glycol diheptanoate.

Le présent produit se conserve sous forme gélifiée, facilitant son transport en 1o flacon. Après dépose sur l'épiderme il se liquéfie afin de permettre le lavage des mains,  This product is stored in gelled form, facilitating its transport in 1o bottle. After depositing on the epidermis it liquefies in order to allow washing of the hands,

pendant une période durant de 10 à 30 secondes, puis s'évapore passé ce délai.  for a period of 10 to 30 seconds, then evaporates after this time.

Il laisse alors sur l'épiderme un film protecteur et hydratant non collant tout en  It then leaves a non-sticky protective and hydrating film on the epidermis while

dégageant une odeur agréable et procure une sensation de fraîcheur.  giving off a pleasant odor and providing a feeling of freshness.

Ce nettoyage peut s'opérer seul ou en complément d'un lavage au savon.  This cleaning can be done alone or in addition to washing with soap.

Un essuyage peut éventuellement être nécessaire si les mains sont particulièrement sales ou souillées afin d'opérer une action mécanique enlevant les  A wiping may possibly be necessary if the hands are particularly dirty or dirty in order to operate a mechanical action removing the

résidus du lavage.washing residue.

La présente composition est conçue pour conserver les mêmes qualités, et notamment la même consistance, sur tous les types d'épiderme. Ceux-ci pouvant  The present composition is designed to retain the same qualities, and in particular the same consistency, on all types of epidermis. These can

notamment présenter des taux d'acidité très différents.  in particular present very different acidity rates.

Au delà de sa facilité et sa rapidité d'emploi, les tests suivants ont mis en évidence  Beyond its ease and speed of use, the following tests have highlighted

les avantages de l'invention.the advantages of the invention.

Le but du premier test est de montrer l'activité bactéricide de la composition.  The purpose of the first test is to show the bactericidal activity of the composition.

Une solution contenant des bactéries est réalisée et une numération des  A solution containing bacteria is produced and a count of

microorganismes en suspension est effectuée.  suspended microorganisms is carried out.

Puis la composition est diluée dans la suspension dans une boîte de Petri.  Then the composition is diluted in the suspension in a Petri dish.

Apres un temps d'exposition d'une minute l'action de la composition est  After an exposure time of one minute the action of the composition is

neutralisée et on procède à une autre numérotation des bactéries.  neutralized and another numbering of the bacteria is carried out.

On constate une réduction très importante du nombre de bactérie sur les boîtes de Petri.  There is a very significant reduction in the number of bacteria on the Petri dishes.

La même procédure de test est applicable à d'autres microorganismes.  The same test procedure is applicable to other microorganisms.

3 27855373,278,537

Le but du second test est de démontrer la bonne tolérance cutanée du produit et  The purpose of the second test is to demonstrate the good skin tolerance of the product and

son action hydratante.its hydrating action.

Les tests ont été effectués sur un panel expert composé de 11 individus.  The tests were carried out on an expert panel made up of 11 individuals.

Le produit a été appliqué, à raison de deux fois par jour, sur la face interne d'un avant bras pendant 15 jours.  The product was applied, twice a day, to the inner side of a forearm for 15 days.

Aucun signe clinique d'allergie ou d'irritation n'est constate.  No clinical sign of allergy or irritation is noted.

L'hydratation cutanée est jugée bonne ou assez bonne par l'ensemble du panel et une mesure cornéométrique signale une légère augmentation de l'indice d'hydratation  The skin hydration is considered good or fairly good by the entire panel and a corneometric measurement signals a slight increase in the hydration index

des avants bras traités.treated forearms.

Ces précédents test sont donnés à titre illustratif et non limitatif.  These previous tests are given by way of illustration and without limitation.

La présente invention, qui se caractérise par son aspect gélifié, son action antiseptique et adoucissante et sa capacité d'évaporation, est illustrée par les exemples s5 non limitatifs suivants: Composition: A/ Alcool éthylique denature entre 50% et 80% en volume B/ alcool Isopropyl entre 10% et 15% en volume C/ Aloe barbadensis entre 0,5% et 2% en volume D/ Parfum entre 0,1% et 0,5% en volume E/ Neopentyl glycol diheptanoate 0,1% à 0,8% en volume F/Carbomer entre 0,1% et 0,5% en volume G/Eau en complément du volume H/Amino- 2-methyl- 2- propanol entre 0,05% et 0,1% en volume Fabrication:  The present invention, which is characterized by its gelled appearance, its antiseptic and softening action and its evaporation capacity, is illustrated by the following non-limiting examples s5: Composition: A / Ethyl alcohol denature between 50% and 80% by volume B / Isopropyl alcohol between 10% and 15% by volume C / Aloe barbadensis between 0.5% and 2% by volume D / Perfume between 0.1% and 0.5% by volume E / Neopentyl glycol diheptanoate 0.1% to 0.8% by volume F / Carbomer between 0.1% and 0.5% by volume G / Water in addition to the volume H / Amino- 2-methyl- 2-propanol between 0.05% and 0.1% by Manufacturing volume:

Les composants A à E sont ajoutés un à un dans une cuve de fabrication.  Components A to E are added one by one to a manufacturing tank.

Dans une seconde cuve constituant F est solubilisé dans l'eau (G).  In a second tank constituting F is dissolved in water (G).

Après agitation, le précédent mélange est versé dans la première cuve.  After stirring, the previous mixture is poured into the first tank.

Après agitation la solution est neutralisée par le composant H, puis agitée jusqu'à  After stirring the solution is neutralized by component H, then stirred until

disparition complète des bulles.complete disappearance of bubbles.

4 27855374 2785537

Claims (3)

REVENDICATIONS 1/ Composition antiseptique gélifiée, destinée à la désinfection de l'épiderme, s'utilisant sans eau ni savon et évaporable, caractérisée en ce qu'elle comprend 50 à  1 / Gelled antiseptic composition, intended for the disinfection of the epidermis, used without water or soap and evaporable, characterized in that it comprises 50 to % en volume d'alcool éthylique et 10 à 15% en volume d'alcool isopropyl, et un carbomer ayant une action gélifiante.  % by volume of ethyl alcohol and 10 to 15% by volume of isopropyl alcohol, and a carbomer having a gelling action. 2/ Composition selon revendication 1/ qui s'évapore tout en hydratant la peau,  2 / Composition according to Claim 1 / which evaporates while hydrating the skin, caractérisée en ce qu'elle contient de plus un extrait végétal hydratant, à titre d'exemple non limitatif un extrait d'Aloe Barbadensis.  characterized in that it additionally contains a hydrating plant extract, by way of nonlimiting example an extract of Aloe Barbadensis. 3/ Composition selon revendication 1/ caractérisée en ce qu'elle contient de plus une résine pseudo silicone, à effet surgraissant et adoucissant, à titre d'exemple non  3 / Composition according to claim 1 / characterized in that it additionally contains a pseudo silicone resin, with a superfatting and softening effect, by way of example not limitatif le Neopentyl Glycol Diheptanoate. limitatif le Neopentyl Glycol Diheptanoate.  limiting Neopentyl Glycol Diheptanoate. limiting Neopentyl Glycol Diheptanoate.
FR9903790A 1999-03-26 1999-03-26 SOFTENING ANTISEPTIC COMPOSITION AND GEL AND THEIR USE IN SKIN DISINFECTION PROCESSES Expired - Fee Related FR2785537B1 (en)

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FR9903790A FR2785537B1 (en) 1999-03-26 1999-03-26 SOFTENING ANTISEPTIC COMPOSITION AND GEL AND THEIR USE IN SKIN DISINFECTION PROCESSES

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Application Number Priority Date Filing Date Title
FR9903790A FR2785537B1 (en) 1999-03-26 1999-03-26 SOFTENING ANTISEPTIC COMPOSITION AND GEL AND THEIR USE IN SKIN DISINFECTION PROCESSES

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10132382A1 (en) * 2001-07-06 2003-02-06 Stockhausen Chem Fab Gmbh Process for the production of disinfectant skin and hand care gels
EP1769824A1 (en) * 2005-09-22 2007-04-04 Nof Corporation Quick-drying disinfectant gel for hands

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1023895A (en) * 1964-06-03 1966-03-30 Plough Alcoholic compositions
GB2017491A (en) * 1978-03-31 1979-10-10 Landstingens Inkopscentral Ointments containing alcohols
DE3543918A1 (en) * 1985-12-12 1987-06-19 Fresenius Ag Disinfectant solution for washing the skin and hands
EP0425398A1 (en) * 1989-10-23 1991-05-02 Camille Isnard Aloe solution, preparation process and compositions containing it
US5167950A (en) * 1991-03-28 1992-12-01 S. C. Johnson & Son High alcohol content aerosol antimicrobial mousse
EP0604848A2 (en) * 1992-12-28 1994-07-06 Toko Yakuhin Kogyo Kabushiki Kaisha Quick-drying gel-type disinfectant for hands and fingers
US5376366A (en) * 1992-11-12 1994-12-27 John Petchul Composition and process for forming isopropyl alcohol gel with water-soluble vinyl polymer neutralizing agent
US5516506A (en) * 1993-11-19 1996-05-14 Bernel Chemical Co. Emollients for sunscreens and other dermatological products
JPH10152433A (en) * 1996-09-27 1998-06-09 Shiseido Co Ltd Film-forming antifungal composition

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1023895A (en) * 1964-06-03 1966-03-30 Plough Alcoholic compositions
GB2017491A (en) * 1978-03-31 1979-10-10 Landstingens Inkopscentral Ointments containing alcohols
DE3543918A1 (en) * 1985-12-12 1987-06-19 Fresenius Ag Disinfectant solution for washing the skin and hands
EP0425398A1 (en) * 1989-10-23 1991-05-02 Camille Isnard Aloe solution, preparation process and compositions containing it
US5167950A (en) * 1991-03-28 1992-12-01 S. C. Johnson & Son High alcohol content aerosol antimicrobial mousse
US5376366A (en) * 1992-11-12 1994-12-27 John Petchul Composition and process for forming isopropyl alcohol gel with water-soluble vinyl polymer neutralizing agent
US5508029A (en) * 1992-11-12 1996-04-16 John Petchul Isopropyl alcohol gel composition and process for preparing same
EP0604848A2 (en) * 1992-12-28 1994-07-06 Toko Yakuhin Kogyo Kabushiki Kaisha Quick-drying gel-type disinfectant for hands and fingers
US5516506A (en) * 1993-11-19 1996-05-14 Bernel Chemical Co. Emollients for sunscreens and other dermatological products
JPH10152433A (en) * 1996-09-27 1998-06-09 Shiseido Co Ltd Film-forming antifungal composition

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 1998, no. 11 30 September 1998 (1998-09-30) *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10132382A1 (en) * 2001-07-06 2003-02-06 Stockhausen Chem Fab Gmbh Process for the production of disinfectant skin and hand care gels
EP1769824A1 (en) * 2005-09-22 2007-04-04 Nof Corporation Quick-drying disinfectant gel for hands
US7824665B2 (en) 2005-09-22 2010-11-02 Nof Corporation Disinfectant gel for hands

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Publication number Publication date
FR2785537B1 (en) 2001-01-05

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