FR2755010A1 - Dental care product, e.g. tooth paste, with enhanced fluoride effect - Google Patents
Dental care product, e.g. tooth paste, with enhanced fluoride effect Download PDFInfo
- Publication number
- FR2755010A1 FR2755010A1 FR9713484A FR9713484A FR2755010A1 FR 2755010 A1 FR2755010 A1 FR 2755010A1 FR 9713484 A FR9713484 A FR 9713484A FR 9713484 A FR9713484 A FR 9713484A FR 2755010 A1 FR2755010 A1 FR 2755010A1
- Authority
- FR
- France
- Prior art keywords
- sep
- oral care
- care product
- fluoride
- agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 title claims abstract description 19
- 239000000606 toothpaste Substances 0.000 title claims description 13
- 229940034610 toothpaste Drugs 0.000 title claims description 9
- 230000000694 effects Effects 0.000 title description 4
- 238000005498 polishing Methods 0.000 claims abstract description 11
- 229920001285 xanthan gum Polymers 0.000 claims abstract description 9
- 229920002554 vinyl polymer Polymers 0.000 claims abstract description 8
- 239000000230 xanthan gum Substances 0.000 claims abstract description 8
- 235000010493 xanthan gum Nutrition 0.000 claims abstract description 8
- 229940082509 xanthan gum Drugs 0.000 claims abstract description 8
- 239000002562 thickening agent Substances 0.000 claims abstract description 6
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 5
- 239000004088 foaming agent Substances 0.000 claims abstract 2
- 239000003795 chemical substances by application Substances 0.000 claims description 15
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 14
- 239000000126 substance Substances 0.000 claims description 8
- 239000011775 sodium fluoride Substances 0.000 claims description 7
- 235000013024 sodium fluoride Nutrition 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 108090000790 Enzymes Proteins 0.000 claims description 5
- 102000004190 Enzymes Human genes 0.000 claims description 5
- 239000002671 adjuvant Substances 0.000 claims description 5
- 239000002324 mouth wash Substances 0.000 claims description 5
- 239000000080 wetting agent Substances 0.000 claims description 5
- 229940051866 mouthwash Drugs 0.000 claims description 4
- 239000008365 aqueous carrier Substances 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 1
- 239000000975 dye Substances 0.000 claims 1
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- 230000000844 anti-bacterial effect Effects 0.000 abstract description 3
- 239000000654 additive Substances 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 238000005187 foaming Methods 0.000 abstract 1
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- 230000008719 thickening Effects 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 13
- 229940091249 fluoride supplement Drugs 0.000 description 13
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 12
- 150000001875 compounds Chemical class 0.000 description 10
- -1 alkaline earth metal salts Chemical class 0.000 description 9
- 230000009471 action Effects 0.000 description 6
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 5
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- JYIZNFVTKLARKT-UHFFFAOYSA-N phenol;1,3,5-triazine-2,4,6-triamine Chemical compound OC1=CC=CC=C1.NC1=NC(N)=NC(N)=N1 JYIZNFVTKLARKT-UHFFFAOYSA-N 0.000 description 1
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- 239000010452 phosphate Substances 0.000 description 1
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- 239000001508 potassium citrate Substances 0.000 description 1
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- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
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- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 229960001462 sodium cyclamate Drugs 0.000 description 1
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- 230000000638 stimulation Effects 0.000 description 1
- 159000000008 strontium salts Chemical class 0.000 description 1
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- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- 239000011135 tin Substances 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- AZJYLVAUMGUUBL-UHFFFAOYSA-A u1qj22mc8e Chemical compound [F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[F-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O=[Si]=O.O=[Si]=O.O=[Si]=O.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 AZJYLVAUMGUUBL-UHFFFAOYSA-A 0.000 description 1
- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/594—Mixtures of polymers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
Description
La présente invention est relative à un produit de soins buccaux contenant du fluorure, dans lequel l'efficacité du fluorure présent dans le produit est renforcée. The present invention relates to an oral care product containing fluoride, wherein the effectiveness of the fluoride present in the product is enhanced.
Par produits de soins buccaux, il faut entendre les produits qui, lors d'un usage normal, ne sont pas ou à peine avalés, mais qui subsistent dans la cavité buccale pendant un certain temps, le produit venant en contact intense avec pratiquement toutes les surfaces des dents. Comme exemples de tels produits on peut citer des pâtes dentifrices, des produits de polissage des dents, des gommes à mâcher, des bains de bouche et des poudres pour la bouche. Oral care products are those products which, during normal use, are not or only slightly swallowed, but which remain in the oral cavity for a certain period of time, the product coming into intense contact with practically all surfaces of the teeth. Examples of such products include toothpastes, tooth polishes, chewing gums, mouthwashes and mouth powders.
Nettoyer et soigner régulièrement la cavité buccale en faisant usage d'un produit approprié tel qu'une pâte dentifrice ou un bain de bouche aident lors de l'apparition d'une rapide constitution de plaque et d'autres affections, mais même un nettoyage régulier n'est pas suffisant pour éliminer complètement la plaque et combattre des caries. Regular cleaning and care of the oral cavity using a suitable product such as toothpaste or mouthwash aids in rapid plaque formation and other conditions, but even regular cleaning is not enough to completely eliminate plaque and fight cavities.
II est connu qu'il est possible de contrecarrer la progression de caries par l'addition de divers composés aux produits de soins buccaux. La plupart des composés connus sont ceux qui fournissent des ions fluorés, comme du NaF, du fluorure d'étain, du fluorure d'amine à longues chaînes et du monofluorophosphate de sodium. L'action de tels composés fluorés repose sur une stimulation de transformations minérales dans l'émail dentaire. It is known that it is possible to counteract the progression of caries by the addition of various compounds to oral care products. Most of the known compounds are those which provide fluorinated ions, such as NaF, tin fluoride, long chain amine fluoride and sodium monofluorophosphate. The action of such fluorinated compounds is based on stimulation of mineral transformations in tooth enamel.
L'action de tels composés fluorés est toutefois limitée dans le temps et en efficacité, surtout lors de l'usage de fluorure de sodium comme source de fluorure. L'invention a par conséquent pour but de prévoir un produit de soins buccaux qui montre une action nettement renforcée du fluorure, en particulier en provenance de fluorure de sodium. The action of such fluorinated compounds is however limited in time and efficiency, especially when using sodium fluoride as a source of fluoride. The aim of the invention is therefore to provide an oral care product which shows a markedly enhanced action of fluoride, in particular from sodium fluoride.
D'une manière surprenante il est apparu que l'application d'une combinaison de gomme de xanthane et d'un polymère vinylique carboxylé dans des produits de soins buccaux contenant du fluorure montre un effet particulièrement bon en ce qui concerne l'action du fluorure. Cela vaut en particulier lors de l'application de fluorure de sodium comme source de fluorure. Surprisingly it has been found that the application of a combination of xanthan gum and a carboxylated vinyl polymer in fluoride-containing oral care products shows a particularly good effect with regard to the action of fluoride. . This is particularly true when applying sodium fluoride as a source of fluoride.
L'invention concerne par conséquent un produit de soins buccaux contenant du fluorure, qui comporte une combinaison de gomme de xanthane et d'un polymère vinylique carboxylé, ainsi que les adjuvants usuels. The invention therefore relates to an oral care product containing fluoride, which comprises a combination of xanthan gum and a carboxylated vinyl polymer, as well as the usual adjuvants.
Comme adjuvants usuels, on peut utiliser les substances courantes pour des produits de soins buccaux. Comme exemples on peut citer entre autres des agents antibactériens, des agents de polissage, des supports, des agents mouillants, des agents épaississants, des substances aromatisantes et sapides, des agents antitartre, des agents combattant la sensibilité des dents, des agents cicatrisants, ainsi que des agents accroissant l'activité tels que divers polymères. II peut aussi être nécessaire d'incorporer dans les produits des systèmes enzymatiques produisant du peroxyde d'hydrogène. As usual adjuvants, the usual substances can be used for oral care products. Examples which may be mentioned include antibacterial agents, polishing agents, carriers, wetting agents, thickeners, flavoring and flavoring substances, anti-scale agents, tooth sensitivity control agents, healing agents, and the like. as activity enhancing agents such as various polymers. It may also be necessary to incorporate into the products enzymatic systems producing hydrogen peroxide.
La présence d'agents produisant du fluorure dans les produits de soins buccaux suivant l'invention est importante. Des composés appropriés peuvent être compiètement ou quelque peu solubles dans l'eau. Comme composés appropriés on peut citer les fluorures inorganiques, tels que des sels de métal alcalin et alcalinoterreux solubles dans l'eau, par exemple du fluorure de sodium, du fluorure de potassium, du fluorure de baryum, du fluorure de calcium, du fluorure d'ammonium, du fluorure de cuivre ou du fluorure de zinc. Les fluorures de métal alcalin, tels que du fluorure de sodium, et le fluorure d'étain ont la préférence. The presence of fluoride-producing agents in the oral care products according to the invention is important. Suitable compounds can be fully or somewhat soluble in water. Suitable compounds include inorganic fluorides, such as water-soluble alkali and alkaline earth metal salts, for example sodium fluoride, potassium fluoride, barium fluoride, calcium fluoride, fluoride, and the like. ammonium, copper fluoride or zinc fluoride. Alkali metal fluorides, such as sodium fluoride, and tin fluoride are preferred.
La quantité de composé fournissant du fluorure est un tant soin peu dépendante du type des composés, de la solubilité et du type du produit de soins buccaux. Cela doit cependant être une quantité efficace, non-toxique. Pour des pâtes dentifrices, elle sera généralement comprise entre 0,005 et 3,0 %, cette quantité étant en état de fournir jusqu'à environ 5.000 ppm d'ions fluor. Une quantité minimale appropriée est de préférence de 300 ppm. En général, il est préférable d'appliquer une quantité qui mène à la présence de 300 jusqu'à environ 2.000, plus particulièrement de 800 jusqu'à environ 1.500 ppm d'ions fluor dans le produit de soins buccaux. Dans le cas où on fait usage de fluorures de métal alcalin et de fluorures d'étain, le composé fluorure est présent en une quantité allant jusqu'à environ 2 % en poids, plus particulièrement de 0,5 à 1 % en poids. The amount of fluoride-providing compound is so little dependent on the type of compounds, the solubility and the type of the oral care product. This must however be an effective, non-toxic amount. For toothpastes, it will generally be between 0.005 and 3.0%, this amount being able to provide up to about 5.000 ppm of fluorine ions. A suitable minimum amount is preferably 300 ppm. In general, it is preferable to apply an amount that leads to the presence of 300 up to about 2,000, more preferably from 800 up to about 1,500 ppm fluoride ion in the oral care product. In the case where alkali metal fluorides and tin fluorides are used, the fluoride compound is present in an amount of up to about 2% by weight, more preferably from 0.5 to 1% by weight.
Suivant l'invention, il est important qu'une combinaison d'une gomme de xanthane et d'une quantité efficace de polymère vinylique carboxylé soit présente. Cette quantité dépend de l'efficacité du polymère, ce qui est déterminé entre autres par la quantité de groupes carboxyles et par le poids moléculaire. Des quantités appropriées se trouvent entre 0,001 et 2 % en poids par rapport au poids des produits. La quantité de gomme de xanthane peut varier de 0,001 à 4 % en poids. According to the invention, it is important that a combination of a xanthan gum and an effective amount of carboxylated vinyl polymer is present. This amount depends on the effectiveness of the polymer, which is determined inter alia by the amount of carboxyl groups and by the molecular weight. Suitable amounts are between 0.001 and 2% by weight based on the weight of the products. The amount of xanthan gum can range from 0.001 to 4% by weight.
Des polymères vinyliques carboxylés de types appropriés sont disponibles sur le marché sous la dénomination commerciale de CarbopolE) chez la firme B.F. Goodrich. D'une manière plus particulière, les types 956, 980, 2984, 5984 et 974 sont appropriés, les trois derniers types jouissant d'une préférence particulière. Suitable carboxyl type vinyl polymers are commercially available under the trade name CarbopolE) from B.F. Goodrich. More particularly, types 956, 980, 2984, 5984 and 974 are suitable, with the last three types being particularly preferred.
Pour améliorer davantage l'action des produits de soins buccaux et pour renforcer l'efficacité du fluorure, il peut être souhaitable d'ajouter des cations bivalents ou trivalents. En exemples on peut citer des ions magnésium, calcium, titane, étain etlou aluminium, généralement sous la forme de sels solubles dans l'eau. Leurs quantités appropriées sont situées entre 0,1 et 5 % en poids, calcuiés sur la base de l'ion métallique par rapport au poids du produit de soins buccaux. To further enhance the action of oral care products and to enhance the effectiveness of fluoride, it may be desirable to add bivalent or trivalent cations. Examples that may be mentioned include magnesium, calcium, titanium, tin and / or aluminum ions, generally in the form of water-soluble salts. Their appropriate amounts are between 0.1 and 5% by weight, calculated on the basis of the metal ion based on the weight of the oral care product.
Pour obtenir une action antibactérienne, on peut appliquer des agents antibactériens connus, tels que du xylitol, un éther diphénylique ou un dérivé de phénol, tel que du triclosan ou du bromochlorophène. Il est cependant aussi possible d'utiliser un des autres antibactériens. Plus particulièrement on peut envisager de faire usage d'un antibiotique, tel que de la nisine, éventuellement en combinaison avec du triclosan ou un des autres composés cités. For antibacterial action, known antibacterial agents such as xylitol, diphenyl ether or a phenol derivative such as triclosan or bromochlorophene can be applied. However, it is also possible to use one of the other antibacterials. More particularly, it is conceivable to use an antibiotic, such as nisin, optionally in combination with triclosan or one of the other compounds mentioned.
Dans le cas où le produit de soins buccaux a la forme d'une pâte dentifrice, celle-ci possède aussi un agent de polissage. Comme agents de polissage courants, on peut citer du métaphosphate de sodium insoluble dans l'eau, du métaphosphate de potassium, du métaphosphate tricalcique, du phosphate de calcium déshydraté, du phosphate dicalcique anhydre, du pyrophosphate de calcium, de l'orthophosphate de magnésium, du phosphate trimagnésien, de l'oxyde d'aluminium, de l'oxyde d'aluminium hydraté, du carbonate de calcium, du silicate d'aluminium, du silicate de zirconium, de la silice, de la bentonite et des mélanges de deux ou de plusieurs de ces agents de polissage. D'autres matières polissantes appropriées comprennent les résines thermodurcissables en forme de particules, telles que les résines de mélamine-phénol et d'urée-formaldéhyde, ainsi que des polyesters et polyépoxydes réticulés. Les agents de polissage préférés comprennent de la silice ayant une taille de particules allant jusqu'à environ 7 pm, une taille moyenne de particules d'environ 1,1 pm et une surface de maximum 5 cm2/g, du gel de silice ou de la silice colloïdale, ainsi qu'un complexe d'aluminosilicate de métal alcalin amorphe. In the case where the oral care product is in the form of a toothpaste, it also has a polishing agent. Common polishing agents include water-insoluble sodium metaphosphate, potassium metaphosphate, tricalcium metaphosphate, dehydrated calcium phosphate, anhydrous dicalcium phosphate, calcium pyrophosphate, magnesium orthophosphate, and the like. , trimagnesium phosphate, aluminum oxide, hydrated aluminum oxide, calcium carbonate, aluminum silicate, zirconium silicate, silica, bentonite and mixtures of two or more of these polishing agents. Other suitable polishing materials include particle-shaped thermosetting resins, such as melamine-phenol and urea-formaldehyde resins, as well as cross-linked polyesters and polyepoxides. Preferred polishing agents include silica having a particle size of up to about 7 μm, an average particle size of about 1.1 μm and a surface area of up to about 5 cm 2 / g, silica gel or silica gel. colloidal silica, as well as an amorphous alkali metal aluminosilicate complex.
Lorsque des gels visuellement clairs sont souhaités, on applique de préférence un agent de polissage à base de silice colloïdale, par exemple du Syloid 72 et du Syloid 74 ou du Santocel 100, ainsi que des complexes d'aluminosilicate de métal alcalin. Ces substances ont des indices de réfraction qui sont situés tout près de l'indice de réfraction des systèmes de gel qui sont utilisés pour cela. When visually clear gels are desired, a colloidal silica polishing agent is preferably applied, for example Syloid 72 and Syloid 74 or Santocel 100, as well as alkali metal aluminosilicate complexes. These substances have refractive indices that are located close to the refractive index of the gel systems that are used for this purpose.
L'agent de polissage est généralement présent dans la pâte dentifrice en des quantités de 10-99 % en poids. De préférence, elles sont cependant de 10-75 %. The polishing agent is generally present in the toothpaste in amounts of 10-99% by weight. Preferably, however, they are 10-75%.
Dans une pâte dentifrice, le support fluide contiendra généralement de l'eau et un agent mouillant en des quantités de 1090 % en poids. De la glycérine, du propylèneglycol, du sorbitol, du polypropylèneglycol et'ou du polyéthylèneglycol sont par exemple des agents mouillantslsupports appropriés. II peut aussi être avantageux d'appliquer des mélanges fluides d'eau, de glycérine et de sorbitol. Pour les gels clairs, où l'indice de réfraction représente une donnée importante, on applique de préférence 3-30 % en poids d'eau, 0-80 % en poids de glycérine et environ 20-80 % en poids de sorbitol. In a toothpaste, the fluid carrier will generally contain water and a wetting agent in amounts of 1090% by weight. Glycerol, propylene glycol, sorbitol, polypropylene glycol and / or polyethylene glycol are, for example, suitable wetting agents. It may also be advantageous to apply fluid mixtures of water, glycerine and sorbitol. For clear gels, where the refractive index is an important data, preferably 3-30% by weight of water, 0-80% by weight of glycerin and about 20-80% by weight of sorbitol are applied.
II est connu d'ajouter des composés phosphatés à des produits de soins buccaux. Les composés phosphatés inorganiques connus sont du trimétaphosphate et du phosphate de calcium. On connaît également des composés phosphatés organiques à ajouter aux produits de soins buccaux. Ces substances adhèrent fortement à l'émail, la tension superficielie étant ainsi diminuée. Cela réduirait l'adhésion de la plaque à l'émail. De préférence on applique des polyphosphates, tels que des tripolyphosphates etlou tétrapolyphosphates linéaires, avantageusement en des quantités allant jusqu'à environ 15 % en poids, par rapport au poids du produit de soins buccaux. It is known to add phosphate compounds to oral care products. The known inorganic phosphate compounds are trimetaphosphate and calcium phosphate. Organic phosphate compounds are also known to add to oral care products. These substances adhere strongly to the enamel, the surface tension being thus diminished. This would reduce plaque adhesion to enamel. Polyphosphates, such as linear tripolyphosphates and / or tetrapolyphosphates, are preferably applied, preferably in amounts up to about 15% by weight, based on the weight of the oral care product.
Les pâtes dentifrices et les gels dentaires comportent en général un agent épaississant naturel ou synthétique ou un agent de gélification en des quantités d'environ 0,1 à 10, de préférence d'environ 0,5 à environ 5 % en poids. L'hectorite synthétique, une argile synthétique à base d'un complexe de silicate de magnésium-métal alcalin colloïdal, qui peut par exemple être obtenue sous le nom de
Laponite (par exemple CP, SP 2002, D) de Laporte Industries Limited, est un agent épaississant approprié.The toothpastes and dental gels generally comprise a natural or synthetic thickening agent or a gelling agent in amounts of about 0.1 to 10, preferably about 0.5 to about 5% by weight. Synthetic hectorite, a synthetic clay based on a complex of magnesium silicate-alkali metal colloid, which can for example be obtained under the name of
Laponite (eg CP, SP 2002, D) from Laporte Industries Limited, is a suitable thickening agent.
D'autres agents épaississants appropriés comprennent de la mousse d'lrlande, de la gomme adragante, de l'amidon, de la polyvinylpyrrolidone, de l'hydroxyéthylpropylcellulose, de l'hydroxybutylméthylcellulose, de l'hydroxypropylméthylcellulose, de l'hydroxyéthylcellulose (par exemple du Natrosol), de la carboxyméthylcellulose sodique et de la silice colloïdale. Other suitable thickening agents include Irish moss, gum tragacanth, starch, polyvinylpyrrolidone, hydroxyethylpropylcellulose, hydroxybutylmethylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose (e.g. Natrosol), sodium carboxymethylcellulose and colloidal silica.
Des substances sapides ou édulcorantes appropriées peuvent aussi être appliquées. Comme exemples de composants appropriés pour le goût, on peut citer les huiles gustatives, telles que de la menthe, de l'huile de menthe poivrée, de la pirole, du sassafras, du clou de girofle, du sagou, de l'eucalyptus, de la marjolaine, du citron, de l'orange et du salicylate de méthyle. Les édulcorants appropriés comprennent du saccharose, du lactose, du maltose, du sorbitol, du cyclamate de sodium, la périllartine, de l'aspartame, de la saccharine et des substances analogues. La quantité des substances sapides et édulcorantes combinées est de préférence de 0,1-5 % en poids de la préparation. Suitable flavoring or sweetening substances may also be applied. Examples of suitable components for the taste include taste oils, such as mint, peppermint oil, pirole, sassafras, clove, sago, eucalyptus, marjoram, lemon, orange and methyl salicylate. Suitable sweeteners include sucrose, lactose, maltose, sorbitol, sodium cyclamate, perillartine, aspartame, saccharin and the like. The amount of the combined flavoring and sweetening substances is preferably 0.1-5% by weight of the preparation.
Dans les produits de soins buccaux suivant l'invention, des composants peuvent être présents qui diminuent la sensibilité des dents, comme des sels spécifiques de métal alcalin (sels de strontium et/ou nitrate de potassium et/ou citrate de potassium). Des agents cicatrisants peuvent aussi être présents, comme de l'alantoïne, de la chlorophylle, du tocophérol et des extraits de plantes. Les agents accroissant l'activité, c'est-à-dire les agents qui prolongent le temps de séjour des composants actifs dans la cavité buccale, sont spécialement toutes sortes de polymères tels que du Gantrez et des phophonates. In the oral care products according to the invention, components may be present which decrease the sensitivity of the teeth, such as specific alkali metal salts (strontium salts and / or potassium nitrate and / or potassium citrate). Healing agents may also be present, such as alantoin, chlorophyll, tocopherol and plant extracts. Activity enhancing agents, i.e. agents which prolong the residence time of the active components in the oral cavity, are especially all kinds of polymers such as Gantrez and phophonates.
Suivant une forme de réalisation préférée, les produits de soins buccaux comportent également un système enzymatique tel que décrit dans les US-A4.150.113 et 4.871.532. Les systèmes enzymatiques produisant du peroxyde d'hydrogène ici décrits ont également une action avantageuse sur la réduction de l'activité bactérienne dans la cavité buccale L'enzyme la plus efficace est l'oxydoréductase appelée glucose-oxydase. Cette enzyme peut être présente en combinaison avec d'autres enzymes, comme de l'amyloglucosidase, de la dextranase et/ou de la mutanase, éventuellement en combinaison avec des composés fournissant des ions de zinc et/ou des dérivés de 8-hydroxyquinoline. In a preferred embodiment, oral care products also include an enzymatic system as described in US-A4.150113 and US-4,871,532. The enzymatic systems producing hydrogen peroxide described here also have an advantageous action on the reduction of bacterial activity in the oral cavity. The most effective enzyme is the oxidoreductase called glucose oxidase. This enzyme may be present in combination with other enzymes, such as amyloglucosidase, dextranase and / or mutanase, optionally in combination with compounds providing zinc ions and / or 8-hydroxyquinoline derivatives.
D'autres enzymes, tels que de la lactoperoxydase, de la lactoferrine et du lysozyme, peuvent aussi être présentes et procurer un produit de soins buccaux ayant des propriétés supplémentaires attirantes. Other enzymes, such as lactoperoxidase, lactoferrin and lysozyme, may also be present and provide an oral care product having attractive additional properties.
Dans les produits de soins buccaux, il peut aussi y avoir des substances tensioactives, plus particulièrement des substances tensioactives non ionogènes, bien qu'on puisse aussi utiliser des substances tensioactives anioniques. Comme exemples de telles substances tensioactives, qui peuvent être présentes en des quantités comprises entre 0,01 et 5 % en poids, on peut citer entre autres des alcools éthoxylés et des matières analogues. In oral care products, there may also be surfactants, more particularly nonionic surfactants, although anionic surfactants may also be used. Examples of such surfactants which may be present in amounts of from 0.01 to 5% by weight are, inter alia, ethoxylated alcohols and the like.
Dans le cas où le produit de soins buccaux est un bain de bouche, on ajoute de préférence de l'eau comme support, éventuellement en combinaison avec un agent mouillant, comme du glycérol. In the case where the oral care product is a mouthwash, water is preferably added as a carrier, optionally in combination with a wetting agent, such as glycerol.
La préparation de produits de soins buccaux suivant l'invention comprend les procédés courants qui sont connus de l'homme de métier. The preparation of oral care products according to the invention comprises the common methods which are known to those skilled in the art.
L'invention va être expliquée dans la suite à l'aide de quelques exemples non limitatifs. The invention will be explained hereinafter with the aid of some nonlimiting examples.
Exemple 1
Une pâte dentifrice est préparée d'une manière courante pour des pâtes dentifrices. Les compositions sont les suivantes
A toothpaste is commonly prepared for toothpastes. The compositions are as follows
<tb> <SEP> Composant <SEP> % <SEP> en <SEP> poids
<tb> Silice <SEP> 20,0 <SEP> 20 <SEP> 20 <SEP> 20
<tb> Fluorure <SEP> de <SEP> sodium <SEP> 0,32 <SEP> 0,32 <SEP> 0,32 <SEP> 0,32
<tb> Sorbitol <SEP> 10 <SEP> 42 <SEP> 36 <SEP> 20
<tb> Glycérol <SEP> 3 <SEP> - <SEP> 3 <SEP> 5
<tb> Polyol <SEP> 4,5 <SEP> 2,0
<tb> PEG <SEP> 3 <SEP> 2,5 <SEP> 2,5 <SEP> 3
<tb> Xylitol <SEP> 10 <SEP>
<tb> Gomme <SEP> de <SEP> xanthane <SEP> 1,0 <SEP> 0,4 <SEP> 0,6 <SEP> 1,0
<tb> Carbopol <SEP> 0,2 <SEP> 0,2 <SEP> 0,2 <SEP> 0,2
<tb> Dioxyde <SEP> de <SEP> titane <SEP> 0,5 <SEP> - <SEP> - <SEP> 0,5
<tb> Tampon <SEP> de <SEP> phosphate <SEP> 1 <SEP> 1 <SEP> 1 <SEP> 1
<tb> Sulfonate <SEP> de <SEP> a-oléfine <SEP> 1,5 <SEP> 1,5 <SEP> 1,5 <SEP> 1,5
<tb> Eau <SEP> jusqu'à <SEP> 100 <SEP> 100 <SEP> 100 <SEP> 100
<tb> <tb><SEP> Component <SEP>% <SEP> in <SEP> Weight
<tb> Silica <SEP> 20.0 <SEP> 20 <SEP> 20 <SEP> 20
<tb> Fluoride <SEP> of <SEP> sodium <SEP> 0.32 <SEP> 0.32 <SEP> 0.32 <SEP> 0.32
<tb> Sorbitol <SEP> 10 <SEP> 42 <SEP> 36 <SEP> 20
<tb> Glycerol <SEP> 3 <SEP> - <SEP> 3 <SEP> 5
<tb> Polyol <SEP> 4.5 <SEP> 2.0
<tb> PEG <SEP> 3 <SEP> 2.5 <SEP> 2.5 <SEP> 3
<tb> Xylitol <SEP> 10 <SEP>
<tb> Gum <SEP> of <SEP> xanthan <SEP> 1.0 <SEP> 0.4 <SEP> 0.6 <SEP> 1.0
<tb> Carbopol <SEP> 0.2 <SEP> 0.2 <SEP> 0.2 <SEP> 0.2
<tb> Dioxide <SEP> of <SEP> Titanium <SEP> 0.5 <SEP> - <SEP> - <SEP> 0.5
<tb> Buffer <SEP> of <SEP> phosphate <SEP> 1 <SEP> 1 <SEP> 1 <SEP> 1
<tb> Sulfonate <SEP> of <SEP> α-olefin <SEP> 1.5 <SEP> 1.5 <SEP> 1.5 <SEP> 1.5
<tb> Water <SEP> up to <SEP> 100 <SEP> 100 <SEP> 100 <SEP> 100
<Tb>
Claims (10)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL1004386A NL1004386C2 (en) | 1996-10-30 | 1996-10-30 | Oral care product. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2755010A1 true FR2755010A1 (en) | 1998-04-30 |
| FR2755010B1 FR2755010B1 (en) | 2001-03-02 |
Family
ID=19763763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR9713484A Expired - Lifetime FR2755010B1 (en) | 1996-10-30 | 1997-10-28 | ORAL CARE PRODUCT |
Country Status (3)
| Country | Link |
|---|---|
| BE (1) | BE1011379A3 (en) |
| FR (1) | FR2755010B1 (en) |
| NL (1) | NL1004386C2 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008155345A1 (en) * | 2007-06-21 | 2008-12-24 | Glaxo Group Limited | Mouthwash composition comprising xanthan gum and sodium fluoride |
| WO2009117644A1 (en) * | 2008-03-21 | 2009-09-24 | Colgate-Palmolive Company | High fluoride ion recovery compositions |
| WO2010037701A3 (en) * | 2008-09-30 | 2011-05-12 | Glaxo Group Limited | Dentifrice composition comprising fluoride ions and a thickening system |
| WO2015106915A1 (en) * | 2014-01-14 | 2015-07-23 | Unilever Plc | Oral care compositions |
| WO2021179014A1 (en) * | 2020-03-06 | 2021-09-10 | Colgate-Palmolive Company | Toothpastes containing calcium carbonate, xanthan gum and polyacrylic acid polymer |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0102200A2 (en) * | 1982-08-02 | 1984-03-07 | JOHNSON & JOHNSON DENTAL PRODUCTS COMPANY | Neutral topical sodium fluoride gel |
| GB2240473A (en) * | 1990-01-31 | 1991-08-07 | Lion Corp | Liquid dentifrice compositions |
| US5213789A (en) * | 1990-08-02 | 1993-05-25 | The Procter & Gamble Company | Use of a carboxy-containing copolymer to inhibit plaque formation without tooth staining |
| US5320830A (en) * | 1992-12-30 | 1994-06-14 | The Procter & Gamble Company | Oral compositions |
-
1996
- 1996-10-30 NL NL1004386A patent/NL1004386C2/en not_active IP Right Cessation
-
1997
- 1997-10-28 FR FR9713484A patent/FR2755010B1/en not_active Expired - Lifetime
- 1997-10-28 BE BE9700860A patent/BE1011379A3/en not_active IP Right Cessation
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0102200A2 (en) * | 1982-08-02 | 1984-03-07 | JOHNSON & JOHNSON DENTAL PRODUCTS COMPANY | Neutral topical sodium fluoride gel |
| GB2240473A (en) * | 1990-01-31 | 1991-08-07 | Lion Corp | Liquid dentifrice compositions |
| US5213789A (en) * | 1990-08-02 | 1993-05-25 | The Procter & Gamble Company | Use of a carboxy-containing copolymer to inhibit plaque formation without tooth staining |
| US5320830A (en) * | 1992-12-30 | 1994-06-14 | The Procter & Gamble Company | Oral compositions |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010530399A (en) * | 2007-06-21 | 2010-09-09 | グラクソ グループ リミテッド | Mouthwash composition containing xanthan gum and sodium fluoride |
| WO2008155345A1 (en) * | 2007-06-21 | 2008-12-24 | Glaxo Group Limited | Mouthwash composition comprising xanthan gum and sodium fluoride |
| US8568697B2 (en) | 2008-03-21 | 2013-10-29 | Colgate-Palmolive Company | High fluoride ion recovery compositions |
| WO2009117644A1 (en) * | 2008-03-21 | 2009-09-24 | Colgate-Palmolive Company | High fluoride ion recovery compositions |
| CN101977584B (en) * | 2008-03-21 | 2014-01-08 | 高露洁-棕榄公司 | High fluoride ion recovery compositions |
| US8623333B2 (en) | 2008-09-30 | 2014-01-07 | Glaxo Group Limited | Composition |
| CN102368994A (en) * | 2008-09-30 | 2012-03-07 | 葛兰素集团有限公司 | Novel composition |
| WO2010037701A3 (en) * | 2008-09-30 | 2011-05-12 | Glaxo Group Limited | Dentifrice composition comprising fluoride ions and a thickening system |
| RU2526148C2 (en) * | 2008-09-30 | 2014-08-20 | Глаксо Груп Лимитед | Toothpaste composition |
| AU2009299913B2 (en) * | 2008-09-30 | 2014-09-18 | Glaxo Group Limited | Dentifrice composition comprising fluoride ions and a thickening system |
| CN102368994B (en) * | 2008-09-30 | 2014-12-17 | 葛兰素集团有限公司 | Teeth cleaning composition containing fluorinion and thickening system |
| WO2015106915A1 (en) * | 2014-01-14 | 2015-07-23 | Unilever Plc | Oral care compositions |
| WO2021179014A1 (en) * | 2020-03-06 | 2021-09-10 | Colgate-Palmolive Company | Toothpastes containing calcium carbonate, xanthan gum and polyacrylic acid polymer |
| US11648190B2 (en) | 2020-03-06 | 2023-05-16 | Colgate-Palmolive Company | Toothpastes containing calcium carbonate, xanthan gum and polyacrylic acid polymer |
Also Published As
| Publication number | Publication date |
|---|---|
| NL1004386A1 (en) | 1998-05-08 |
| FR2755010B1 (en) | 2001-03-02 |
| NL1004386C2 (en) | 1998-08-06 |
| BE1011379A3 (en) | 1999-08-03 |
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