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FR2731355B1 - Nouveaux immunogenes, nouveaux anticorps, procede de preparation et compositions pharmaceutiques les renfermant - Google Patents

Nouveaux immunogenes, nouveaux anticorps, procede de preparation et compositions pharmaceutiques les renfermant

Info

Publication number
FR2731355B1
FR2731355B1 FR9502708A FR9502708A FR2731355B1 FR 2731355 B1 FR2731355 B1 FR 2731355B1 FR 9502708 A FR9502708 A FR 9502708A FR 9502708 A FR9502708 A FR 9502708A FR 2731355 B1 FR2731355 B1 FR 2731355B1
Authority
FR
France
Prior art keywords
novel
preparation
pharmaceutical compositions
compositions containing
immunogens
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9502708A
Other languages
English (en)
Other versions
FR2731355A1 (fr
Inventor
Jean Francois Zagury
Bernard Bizzini
Daniel Zagury
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neovacs SA
Original Assignee
Neovacs SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9502708A priority Critical patent/FR2731355B1/fr
Application filed by Neovacs SA filed Critical Neovacs SA
Priority to BR9607659A priority patent/BR9607659A/pt
Priority to PL96322143A priority patent/PL322143A1/xx
Priority to AT96906795T priority patent/ATE196255T1/de
Priority to KR1019970706241A priority patent/KR100309856B1/ko
Priority to EP96906795A priority patent/EP0814834B2/fr
Priority to JP8526669A priority patent/JPH11501310A/ja
Priority to PT96906795T priority patent/PT814834E/pt
Priority to ES96906795T priority patent/ES2150107T5/es
Priority to CNB961931914A priority patent/CN1226046C/zh
Priority to DE69610295T priority patent/DE69610295T3/de
Priority to US08/913,221 priority patent/US6132721A/en
Priority to AU50071/96A priority patent/AU710626B2/en
Priority to PCT/FR1996/000357 priority patent/WO1996027389A1/fr
Priority to CA2215483A priority patent/CA2215483C/fr
Priority to DK96906795T priority patent/DK0814834T4/da
Publication of FR2731355A1 publication Critical patent/FR2731355A1/fr
Application granted granted Critical
Publication of FR2731355B1 publication Critical patent/FR2731355B1/fr
Priority to OA70071A priority patent/OA10615A/fr
Priority to GR20000402673T priority patent/GR3034970T3/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1072—Regulatory proteins, e.g. tat, rev, vpt
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/826—Viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
FR9502708A 1995-03-08 1995-03-08 Nouveaux immunogenes, nouveaux anticorps, procede de preparation et compositions pharmaceutiques les renfermant Expired - Fee Related FR2731355B1 (fr)

Priority Applications (18)

Application Number Priority Date Filing Date Title
FR9502708A FR2731355B1 (fr) 1995-03-08 1995-03-08 Nouveaux immunogenes, nouveaux anticorps, procede de preparation et compositions pharmaceutiques les renfermant
US08/913,221 US6132721A (en) 1995-03-08 1996-03-07 Non-Toxic immunogens derived from a retroviral regulatory protein, antibodies, preparation method therefor, and pharmaceutical compositions containing same
AT96906795T ATE196255T1 (de) 1995-03-08 1996-03-07 Von einem retroviralen regulationsprotein abstammende, detoxifierte immunogene, dagegen gerichtete antikörper, verfahren zur deren herstellung und diese immunogene oder antikörper enthaltende, pharmazeutische zusammensetzungen.
KR1019970706241A KR100309856B1 (ko) 1995-03-08 1996-03-07 레트로바이러스조절단백질로부터유래된비독성면역원,항체,그들의제조방법,및그들을함유한제약조성물
EP96906795A EP0814834B2 (fr) 1995-03-08 1996-03-07 Immunogenes denues de toxicite derivant d'une proteine de regulation retrovirale, anticorps diriges contre ces immunogenes, procede pour leur preparation et compositions pharmaceutiques les renfermant
JP8526669A JPH11501310A (ja) 1995-03-08 1996-03-07 レトロウイルスの調節タンパク質から誘導された無毒の免疫原、抗体、製造方法およびそれらを含んでなる医薬組成物
PT96906795T PT814834E (pt) 1995-03-08 1996-03-07 Imunogenes desprovidos de toxicidade derivados de uma proteina de regulacao retroviral anticorpos destinados a combater os referidos imunogenes processo de preparacao e composicoes farmaceuticas englobando-os
ES96906795T ES2150107T5 (es) 1995-03-08 1996-03-07 Inmunogenos no toxicos que proceden de una proteina de regulacion retroviral, anticuerpos dirigidos contra estos inmunogenos, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
CNB961931914A CN1226046C (zh) 1995-03-08 1996-03-07 来自逆转录病毒调节蛋白的无毒免疫原、抗体、其制备方法和含有它们的药物组合物
PCT/FR1996/000357 WO1996027389A1 (fr) 1995-03-08 1996-03-07 Immunogenes denues de toxicite derivant d'une proteine de regulation retrovirale, anticorps, procede de preparation et compositions pharmaceutiques les renfermant
BR9607659A BR9607659A (pt) 1995-03-08 1996-03-07 Composto imunogênio composição processos para preparação de um composto imunogênico de um anticorpo anti-proteína e de um fragmento anticorpo anti-proteína e fragmento
PL96322143A PL322143A1 (en) 1995-03-08 1996-03-07 Non-topxic immunogenes originating frommretroviral regulator protein, antibodies as such, method of preparing them and pharmaceutic compositions containing them
DE69610295T DE69610295T3 (de) 1995-03-08 1996-03-07 Von einem retroviralen regulationsprotein abstammende, detoxifierte immunogene, dagegen gerichtete antikörper, verfahren zur deren herstellung und diese immunogene oder antikörper enthaltende, pharmazeutische zusammensetzungen.
CA2215483A CA2215483C (fr) 1995-03-08 1996-03-07 Immunogenes denues de toxicite derivant d'une proteine de regulation retrovirale, anticorps, procede de preparation et compositions pharmaceutiques les renfermant
DK96906795T DK0814834T4 (da) 1995-03-08 1996-03-07 Immunogener, der er blottet for toksicitet, afledt af et retroviralt regulatorprotein, antistoffer, der er rettet mod disse immunogener, fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger, der indeholder dem
AU50071/96A AU710626B2 (en) 1995-03-08 1996-03-07 Non-toxic immunogens derived from a retroviral regulatory protein, antibodies, preparation process and pharmaceutical compositions comprising them
OA70071A OA10615A (fr) 1995-03-08 1997-09-08 Immunogènes dénués de toxicité dérivant d'une protéine de régulation rétrovirale anticorps procédé de préparation et compositions pharmaceutiques les renfermant
GR20000402673T GR3034970T3 (en) 1995-03-08 2000-11-30 Non-toxic immunogens derived from a retroviral regulatory protein, antibodies, preparation method therefor, and pharmaceutical compositions containing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9502708A FR2731355B1 (fr) 1995-03-08 1995-03-08 Nouveaux immunogenes, nouveaux anticorps, procede de preparation et compositions pharmaceutiques les renfermant

Publications (2)

Publication Number Publication Date
FR2731355A1 FR2731355A1 (fr) 1996-09-13
FR2731355B1 true FR2731355B1 (fr) 1997-05-30

Family

ID=9476864

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9502708A Expired - Fee Related FR2731355B1 (fr) 1995-03-08 1995-03-08 Nouveaux immunogenes, nouveaux anticorps, procede de preparation et compositions pharmaceutiques les renfermant

Country Status (6)

Country Link
KR (1) KR100309856B1 (fr)
CN (1) CN1226046C (fr)
ES (1) ES2150107T5 (fr)
FR (1) FR2731355B1 (fr)
OA (1) OA10615A (fr)
PT (1) PT814834E (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60044303D1 (de) * 1999-08-12 2010-06-10 Inist Inc Nicht-immunsuppresives hiv tat-protein
US8323928B2 (en) 1999-08-12 2012-12-04 Pin Pharma, Inc. Vaccines and immunotherapeutics derived from the human immunodeficiency virus (HIV) transactivator of transcription protein for the treatment and prevention of HIV disease
FR2844514B1 (fr) * 2002-09-16 2007-10-19 Neovacs Produit immunogene stable comprenant des heterocomplexes antigeniques, compositions les contenant et procede de preparation
EP3077417A1 (fr) * 2013-12-08 2016-10-12 Peptcell Limited Antigènes et anticorps anti-vih, compositions, méthodes et utilisations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3756789A (en) * 1988-06-16 1990-01-12 St. Louis University Antagonists of viral transactivating proteins
WO1991015224A1 (fr) * 1990-03-30 1991-10-17 Smithkline Beecham Corporation Inhibition de la maladie associee a l'infection due au virus de l'immunodeficience
WO1991018454A1 (fr) * 1990-05-18 1991-11-28 Centre National De La Recherche Scientifique Compositions capables de bloquer la cytotoxicite de proteines regulatrices de virus et les symptomes neurotoxiques associes aux infections par retrovirus
WO1992014755A1 (fr) * 1991-02-14 1992-09-03 La Jolla Cancer Research Foundation NOUVELLE SPECIFICITE DE L'INTEGRINE POUR LA PROTEINE Tat DE L'HIV
CA2134080C (fr) * 1992-04-24 2004-07-13 Toby C. Rodman Anticorps igm reagissant a la protamine
WO1993025235A1 (fr) * 1992-06-09 1993-12-23 President And Fellows Of Harvard College Procedes therapeutiques destines au sida, a base de peptides vpx d'hiv-2
WO1994015634A1 (fr) * 1992-12-30 1994-07-21 Matthias Rath Oligopeptide tat et rev utilises pour le traitement du vih
FR2700169B1 (fr) * 1993-01-04 1995-03-24 Transgene Sa Nouveaux variants trans-dominants TAT du virus de l'immunodéficience humaine.
AU7263994A (en) * 1993-08-06 1995-02-28 Kai Juhani Ernst Krohn Novel mutated human and simian immunodeficiency viruses and vaccines containing said viruses

Also Published As

Publication number Publication date
CN1181020A (zh) 1998-05-06
PT814834E (pt) 2001-01-31
ES2150107T5 (es) 2009-08-05
ES2150107T3 (es) 2000-11-16
CN1226046C (zh) 2005-11-09
OA10615A (fr) 2002-08-30
KR19980702834A (ko) 1998-08-05
FR2731355A1 (fr) 1996-09-13
KR100309856B1 (ko) 2003-03-06

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Legal Events

Date Code Title Description
CD Change of name or company name
CL Concession to grant licences
ST Notification of lapse

Effective date: 20131129