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FR2724170B1 - Nouveaux derives de spiro(indole-pyrrolidine) agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament - Google Patents

Nouveaux derives de spiro(indole-pyrrolidine) agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament

Info

Publication number
FR2724170B1
FR2724170B1 FR9410558A FR9410558A FR2724170B1 FR 2724170 B1 FR2724170 B1 FR 2724170B1 FR 9410558 A FR9410558 A FR 9410558A FR 9410558 A FR9410558 A FR 9410558A FR 2724170 B1 FR2724170 B1 FR 2724170B1
Authority
FR
France
Prior art keywords
pyrrolidine
indole
medicaments
derivatives
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9410558A
Other languages
English (en)
Other versions
FR2724170A1 (fr
Inventor
Jean-Bernard Fourtillan
Marianne Fourtillan
Jean-Claude Jacquesy
Marie-Paule Jouannetaud
Bruno Violeau
Omar Karam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CEMAF
Original Assignee
CEMAF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9410558A priority Critical patent/FR2724170B1/fr
Application filed by CEMAF filed Critical CEMAF
Priority to JP7526122A priority patent/JPH09511514A/ja
Priority to US08/722,105 priority patent/US5763471A/en
Priority to CN95192961A priority patent/CN1047386C/zh
Priority to PCT/FR1995/000443 priority patent/WO1995027712A1/fr
Priority to EP95916720A priority patent/EP0754183A1/fr
Priority to AU23108/95A priority patent/AU2310895A/en
Priority to ZA959826A priority patent/ZA959826B/xx
Publication of FR2724170A1 publication Critical patent/FR2724170A1/fr
Application granted granted Critical
Publication of FR2724170B1 publication Critical patent/FR2724170B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR9410558A 1994-04-07 1994-09-02 Nouveaux derives de spiro(indole-pyrrolidine) agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament Expired - Fee Related FR2724170B1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
FR9410558A FR2724170B1 (fr) 1994-09-02 1994-09-02 Nouveaux derives de spiro(indole-pyrrolidine) agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament
US08/722,105 US5763471A (en) 1994-04-07 1995-04-06 Melatoninergic agonist spiro indolepyrrolidine! derivatives, process for their preparation and their use as medicinal products
CN95192961A CN1047386C (zh) 1994-04-07 1995-04-06 新型褪黑激素拮抗物螺旋[吲哚吡咯烷丁]衍生物,其制备方法及其作为药物产品的用途
PCT/FR1995/000443 WO1995027712A1 (fr) 1994-04-07 1995-04-06 Nouveaux derives de spiro[indole-pyrrolidine] agonistes melatoninergiques, leur procede de preparation et leur utilisation a titre de medicament
JP7526122A JPH09511514A (ja) 1994-04-07 1995-04-06 新規メラトニン作用性アゴニストのスピロ［インドールピロリジン］誘導体とその製造方法および医薬品としての用途
EP95916720A EP0754183A1 (fr) 1994-04-07 1995-04-06 Nouveaux derives de spiro[indole-pyrrolidine] agonistes melatoninergiques, leur procede de preparation et leur utilisation a titre de medicament
AU23108/95A AU2310895A (en) 1994-04-07 1995-04-06 Novel spiro{indole-pyrrolidine} derivatives as melatoninergic agonists, method for preparing same and use thereofas a drug
ZA959826A ZA959826B (en) 1994-04-07 1995-11-20 Novel melatoninergic agonist spiro [indolepyrrolidine] derivatives process for their preparation and their use as medicinal products

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9410558A FR2724170B1 (fr) 1994-09-02 1994-09-02 Nouveaux derives de spiro(indole-pyrrolidine) agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament

Publications (2)

Publication Number Publication Date
FR2724170A1 FR2724170A1 (fr) 1996-03-08
FR2724170B1 true FR2724170B1 (fr) 1997-05-30

Family

ID=9466655

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9410558A Expired - Fee Related FR2724170B1 (fr) 1994-04-07 1994-09-02 Nouveaux derives de spiro(indole-pyrrolidine) agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament

Country Status (1)

Country Link
FR (1) FR2724170B1 (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54109983A (en) * 1978-02-13 1979-08-29 Sumitomo Chem Co Ltd Novel spiroamine derivative and its preparation
AU616907B2 (en) * 1987-08-17 1991-11-14 Whitby Research, Inc. Melatonin analogues

Also Published As

Publication number Publication date
FR2724170A1 (fr) 1996-03-08

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TP Transmission of property
ST Notification of lapse