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FR2652742A1 - Anallergic cosmetic and dermopharmaceutical compositions - Google Patents

Anallergic cosmetic and dermopharmaceutical compositions Download PDF

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Publication number
FR2652742A1
FR2652742A1 FR8913511A FR8913511A FR2652742A1 FR 2652742 A1 FR2652742 A1 FR 2652742A1 FR 8913511 A FR8913511 A FR 8913511A FR 8913511 A FR8913511 A FR 8913511A FR 2652742 A1 FR2652742 A1 FR 2652742A1
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Prior art keywords
cosmetic
compositions
fucose
anallergic
compositions according
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FR8913511A
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French (fr)
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FR2652742B1 (en
Inventor
Vacher Dominique
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004Monosaccharides having only carbon, hydrogen and oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02Preparations containing skin colorants, e.g. pigments
    • A61Q1/10Preparations containing skin colorants, e.g. pigments for eyes, e.g. eyeliner, mascara
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00Anti-perspirants or body deodorants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/70Biological properties of the composition as a whole

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

These compositions contain at least one saccharide capable of locally neutralising the effect of lymphokines produced by the immune system, thereby bringing about a failure to express the hypersensitivity or contact allergy reaction.

Description

La présente invention a pour objet des compositions cosmétiques et dermo-pharmaceutiques anallergiques. The present invention relates to anallergic cosmetic and dermo-pharmaceutical compositions.

Les compositions cosmétiques peuvent être définies comme des compositions destinées à traiter ou améliorer les propriétés élastiques de la peau, accélérer la régénération de ltépiderme, modifier les teintes ou l'aspect de la peau, ou capter ou neutraliser les sécrétions des glandes sudoripares. Cosmetic compositions can be defined as compositions intended to treat or improve the elastic properties of the skin, accelerate the regeneration of the epidermis, modify the hues or appearance of the skin, or capture or neutralize the secretions of the sweat glands.

Les compositions dermo-pharmaceutiques peuvent être définies comme étant des compositions destinées à réaliser le traitement d'un trouble cutané ou à améliorer les conditions d'une cicatrisation. The dermo-pharmaceutical compositions can be defined as being compositions intended to carry out the treatment of a skin disorder or to improve the conditions of scarring.

Lors de la préparation d'une composition cosmétique et dermo-pharmaceutique, il est tenu compte du toucher et de la stabilité de la composition, à laquelle on fait subir des tests d'inocuité (irritation, allergie) sur une population animale limitée. When preparing a cosmetic and dermo-pharmaceutical composition, account is taken of the feel and the stability of the composition, which is subjected to harmlessness tests (irritation, allergy) on a limited animal population.

Si ces tests d'allergie donnent des résultats négatifs chez ltanimal, aucune conclusion rigoureuse ne peut être sérieusement tirée quant au risque allergique dans une population humaine importante. En effet, aucune technique de formulation ne permet d'obtenir des préparations topiques non allergisantes dans une population humaine importante. If these allergy tests give negative results in animals, no rigorous conclusion can be seriously drawn as to the allergic risk in a large human population. Indeed, no formulation technique makes it possible to obtain topical non-allergenic preparations in a large human population.

Or, une utilisation répétée de compositions cosmétiques risque de développer et d'exprimer chez certains individus une réaction cutanée d'hypersensibilité ou d'allergie. However, repeated use of cosmetic compositions risks developing and expressing in certain individuals a skin reaction of hypersensitivity or allergy.

Une solution serait de donner aux compositions cosmétiques et dermo-pharmaceutiques un caractère anallergique. A cet effet, il conviendrait de bloquer l'effet des lymphokin-es sécrétées par les cellules immunitaires. A l'état physiologique, ces lymphokines conduisent à l'expression clinique de la réaction allergique par phénomènes de recrutement/amplification. Pour disposer d'une composition anallergique, il conviendrait de bloquer la production des lymphokines en jouant sur le système immunitaire. Une telle solution présente des dangers pour les utilisateurs, et est absolument inenvisageable dans le domaine de la cosmétique et de la dermo-pharmacie. One solution would be to give cosmetic and dermo-pharmaceutical compositions an anallergic character. To this end, the effect of lymphokines secreted by immune cells should be blocked. In the physiological state, these lymphokines lead to the clinical expression of the allergic reaction by recruitment / amplification phenomena. To have an anallergic composition, it would be necessary to block the production of lymphokines by playing on the immune system. Such a solution presents dangers for users, and is absolutely unthinkable in the field of cosmetics and dermo-pharmacy.

La présente invention vise à remédier à ces inconvénients en fournissant de nouvelles compositions cosmétiques et dermo-pharmaceutiques non allergisantes, et pour lesquelles l'absence d'allergie est obtenue sans avoir à agir sur le système immunitaire. The present invention aims to remedy these drawbacks by providing new non-allergenic cosmetic and dermo-pharmaceutical compositions, for which the absence of an allergy is obtained without having to act on the immune system.

A cet effet, les compositions cosmétiques ou dermo-pharmaceutiques qu'elle concerne contiennent au moins un saccharide susceptible de neutraliser les lymphokines produites par le système immunitaire, provoquant ainsi une non expression de la réaction d'hypersensibilité ou allergie de contact. Cette technique est particulièrement intéressante car n'agissant pas sur le système immunitaire, on laisse celui-ci sécréter les lymphokines, ces dernières étant neutralisées au niveau de la peau par le ou les saccharides contenus dans la formulation cosmétique. To this end, the cosmetic or dermo-pharmaceutical compositions which it relates contain at least one saccharide capable of neutralizing the lymphokines produced by the immune system, thus causing non-expression of the hypersensitivity reaction or contact allergy. This technique is particularly interesting because it does not act on the immune system, it is allowed to secrete the lymphokines, the latter being neutralized in the skin by the saccharide (s) contained in the cosmetic formulation.

Selon une première forme de réalisation, les compositions selon l'invention contiennent des monosaccharides choisis parmi les fucose, galactose, xylose, ribose et rhamnose. Avantageusement, ces monosaccharides sont choisis parmi les L - OC - fucose, galactose, L-xylose, D-ribose, et
L-rhamnose.
According to a first embodiment, the compositions according to the invention contain monosaccharides chosen from fucose, galactose, xylose, ribose and rhamnose. Advantageously, these monosaccharides are chosen from L - OC - fucose, galactose, L-xylose, D-ribose, and
L-rhamnose.

I1 est également possible de mettre en oeuvre lesdits saccharides composés de ces sucres ou ces monosaccharides intégrés dans une structure polysaccharide. Conformément à une autre caractéristique de l'invention, la concentration en saccharide est inférieure à 10 % en poids et de préférence entre 2,5 et 5 %. It is also possible to use said saccharides composed of these sugars or these monosaccharides integrated into a polysaccharide structure. According to another characteristic of the invention, the concentration of saccharide is less than 10% by weight and preferably between 2.5 and 5%.

I1 est donné ci-après plusieurs exemples de réalisation de compositions selon l'invention. I1 is given below several embodiments of compositions according to the invention.

COMPOSITIONS COSMETIQUES
1 - Antiperspirant
- Réhydrol antiperspirant 14
- Acide stéarique 2
- Arlamol E émollient / solvant 2
- Silicone volatile 19
- L - < - fucose 3
- Alcool 60
2 - Base pour crème de maquillage d'yeux
- Acide stéarique 30
- Petrolatum 6
- Lanoline 5
- Propylène glycol 5 - Triéthanolamine 4 - L - < - fucose 5 - Eau 45 3 - Crème protectrice - Dimethicone et trimethoxysilicate 2 - Dimethicone 2 - Acide stéarique 6 - Alcool cétylique 1,5 - Huile minérale légère 2,2 - Triéthanolamine 1,5 - Glycérine 2 - L - - fucose 2,5 - Eau qsp 100
COMPOSITIONS DERMO-PHARMACEUTIQUES 1 - Pommade antibactérienne - Monostéarate de glycérine 12 - Alcool cétylstéarylique 3 - Huile de paraffine 5 - Sulfate de néomycine 0,5 - Triglycéride d'acide caprylique/ caprique 5 - L - (- - fucose 3,5 - Eau 71 2 - Pommade antimycosique % - Cutina MD 6 (Glycérides d'acides palmitique et stéarique) - Alcool cétylstéarylique 1 - Esters d'acide oléique 5 - Monoéthanolamine d'acide undécylénique 2 - L - &alpha;- fucose 5 - Carbopol 940 1 - Triéthanolamine 0,6
- Alcool éthylique 46
- Eau 33,4
Comme il ressort de ce qui précède, l'invention apporte une grande amélioration à la technique existante en fournissant des compositions cosmétiques et dermo-pharmaceutiques possédant des propriétés non allergisantes, ce caractère non allergisant étant obtenu par mise en oeuvre de produits totalement naturels.
COSMETIC COMPOSITIONS
1 - Antiperspirant
- Antiperspirant rehydrol 14
- Stearic acid 2
- Arlamol E emollient / solvent 2
- Volatile silicone 19
- L - <- fucose 3
- Alcohol 60
2 - Base for eye makeup cream
- Stearic acid 30
- Petrolatum 6
- Lanolin 5
- Propylene glycol 5 - Triethanolamine 4 - L - <- fucose 5 - Water 45 3 - Protective cream - Dimethicone and trimethoxysilicate 2 - Dimethicone 2 - Stearic acid 6 - Cetyl alcohol 1.5 - Light mineral oil 2.2 - Triethanolamine 1, 5 - Glycerin 2 - L - - fucose 2,5 - Water qs 100
DERMO-PHARMACEUTICAL COMPOSITIONS 1 - Antibacterial ointment - Glycerin monostearate 12 - Cetylstearyl alcohol 3 - Paraffin oil 5 - Neomycin sulfate 0.5 - Caprylic / capric acid triglyceride 5 - L - (- - fucose 3.5 - Water 71 2 - Antimycotic ointment% - Cutina MD 6 (Glycerides of palmitic and stearic acids) - Cetylstearyl alcohol 1 - Oleic acid esters 5 - Monoethanolamine undecylenic acid 2 - L - &alpha; - fucose 5 - Carbopol 940 1 - Triethanolamine 0.6
- Ethyl alcohol 46
- Water 33.4
As is apparent from the above, the invention provides a great improvement to the existing technique by providing cosmetic and dermo-pharmaceutical compositions having non-allergenic properties, this non-allergenic nature being obtained by using completely natural products.

Comme il va de soi, l'invention ne se limite pas aux seules compositions décrites ci-dessus à titre d'exemples ; elle en embrasse au contraire toutes les variantes.  It goes without saying that the invention is not limited to the compositions described above by way of examples only; on the contrary, it embraces all its variants.

Claims (5)

REVENDICATIONS 1 - Compositions cosmétiques et dermo-pharmaceutiques, caractérisées en ce qu'elles contiennent au moins un saccharide susceptible de neutraliser localement l'effet de lymphokines produites par le système immunitaire, provoquant ainsi une non expression de la réaction d'hypersensibilité ou d'allergie de contact. 1 - Cosmetic and dermo-pharmaceutical compositions, characterized in that they contain at least one saccharide capable of locally neutralizing the effect of lymphokines produced by the immune system, thus causing a non-expression of the hypersensitivity or allergy reaction of contact. 2 - Compositions selon la revendication 1, caractérisées en ce qu'elles contiennent des monosaccharides choisis parmi les fucose, galactose, xylose, ribose et rhamnose. 2 - Compositions according to claim 1, characterized in that they contain monosaccharides chosen from fucose, galactose, xylose, ribose and rhamnose. 3 - Compositions selon la revendication 2, caractérisées en ce qu'elles contiennent des monosaccharides choisis parmi les L - Oc - fucose, galactose, L-xylose, D-ribose et L-rhamnose. 3 - Compositions according to claim 2, characterized in that they contain monosaccharides chosen from L - Oc - fucose, galactose, L-xylose, D-ribose and L-rhamnose. 4 - Compositions selon l'une quelconque des revendications 1 à 3, caractérisées en ce que les saccharides sont intégrés dans une structure polysaccharide. 4 - Compositions according to any one of claims 1 to 3, characterized in that the saccharides are integrated into a polysaccharide structure. 5 - Compositions selon l'une quelconque des revendications 1 à 4, caractérisées en ce que la concentration en saccharide est inférieure à 10 % en poids et de préférence entre 2,5 et 5 %.  5 - Compositions according to any one of claims 1 to 4, characterized in that the concentration of saccharide is less than 10% by weight and preferably between 2.5 and 5%.
FR8913511A 1989-10-11 1989-10-11 COSMETIC AND DERMO-PHARMACEUTICAL ANALLERGIC COMPOSITIONS. Expired - Fee Related FR2652742B1 (en)

Priority Applications (1)

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FR8913511A FR2652742B1 (en) 1989-10-11 1989-10-11 COSMETIC AND DERMO-PHARMACEUTICAL ANALLERGIC COMPOSITIONS.

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FR8913511A FR2652742B1 (en) 1989-10-11 1989-10-11 COSMETIC AND DERMO-PHARMACEUTICAL ANALLERGIC COMPOSITIONS.

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FR2652742B1 FR2652742B1 (en) 1993-10-29

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2756735A1 (en) * 1996-12-11 1998-06-12 Thorel Jean Noel Agent for treating or preventing contact allergy
WO1998034589A1 (en) * 1997-02-07 1998-08-13 Henkel Kommanditgesellschaft Auf Aktien Skin care product
EP0937454A3 (en) * 1998-02-13 2000-03-15 Beiersdorf Aktiengesellschaft Cosmetic or dermatological compositions containing polysaccharides for the protection of sensitive skin against irritations
FR2853539A1 (en) * 2003-04-08 2004-10-15 Ind E Com De Cosmeticos Natura Cosmetic composition with anti-aging effect on the skin contains rhamnose and fucose compounds and excipients, protects hyaluronic acid against decomposition induced by free radicals
WO2005041983A1 (en) 2003-10-31 2005-05-12 Pierre Fabre Dermo-Cosmetique Medicament comprising a reducing alkyl-sugar monomer for the treatment of inflammatory disorders
FR2912055A1 (en) * 2007-02-06 2008-08-08 Idenov Lab Cosmetic composition useful for soothing skin irritations comprises mono- and polysaccharides, glycerol, sorbitol, yeast extract, olive oil extract and a shea extract
WO2019129823A1 (en) * 2017-12-29 2019-07-04 L'oreal Use of fucose derivatives as deodorants

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH368267A (en) * 1957-07-22 1963-03-31 Chem Fab Promonta Ges Mit Besc Skin care products
DE1948990A1 (en) * 1968-10-02 1970-05-27 Kolmar Laboratories Means for topical treatment of the skin
EP0074264A2 (en) * 1981-09-08 1983-03-16 Unilever Plc Shampoo
EP0141732A2 (en) * 1983-10-25 1985-05-15 L'oreal Cosmetic cleansing composition, particularly eye make-up remover
JPS62412A (en) * 1985-06-25 1987-01-06 Shiseido Co Ltd Cosmetic
EP0221728A2 (en) * 1985-10-22 1987-05-13 Anthony N. Silvetti, Sr. Monosaccharide containing wound healing preparation
FR2609397A1 (en) * 1988-02-23 1988-07-15 Serobiologiques Lab Sa Use of a substance or composition of carbohydrate nature as active principle of a dermatological and/or cosmetological and/or pharmaceutical and/or cell-stimulating composition, and composition containing such a substance or composition of carbohydrate nature
EP0287876A1 (en) * 1987-04-08 1988-10-26 Henkel Kommanditgesellschaft auf Aktien Hair-regenerating compositions

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH368267A (en) * 1957-07-22 1963-03-31 Chem Fab Promonta Ges Mit Besc Skin care products
DE1948990A1 (en) * 1968-10-02 1970-05-27 Kolmar Laboratories Means for topical treatment of the skin
EP0074264A2 (en) * 1981-09-08 1983-03-16 Unilever Plc Shampoo
EP0141732A2 (en) * 1983-10-25 1985-05-15 L'oreal Cosmetic cleansing composition, particularly eye make-up remover
JPS62412A (en) * 1985-06-25 1987-01-06 Shiseido Co Ltd Cosmetic
EP0221728A2 (en) * 1985-10-22 1987-05-13 Anthony N. Silvetti, Sr. Monosaccharide containing wound healing preparation
EP0287876A1 (en) * 1987-04-08 1988-10-26 Henkel Kommanditgesellschaft auf Aktien Hair-regenerating compositions
FR2609397A1 (en) * 1988-02-23 1988-07-15 Serobiologiques Lab Sa Use of a substance or composition of carbohydrate nature as active principle of a dermatological and/or cosmetological and/or pharmaceutical and/or cell-stimulating composition, and composition containing such a substance or composition of carbohydrate nature

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, vol. 46, no. 6, novembre 1968, pages 859-864; G.E. THOMPSON et al.: "The influence of sugars upon hypersensitivity reactions" *
DIALOG INFORMATION SERVICES, INC., BASE DE DONNEES 155: MEDLINE 66-90, numéro d'accés: 05504537; M. CASTELAIN et al.: "Les competitions antigeniques et les phenomenes d'extinction antigenique en allergie de contact", & ANN. DERMATOL. VENEREOL. 1984, vol. 111, no. 11, 1984, pages 1029-37 *
PATENT ABSTRACTS OF JAPAN, vol. 11, no. 167 (C-425)[2614], 28 mai 1987; & JP-A-62 412 (SHISEIDO CO., LTD) 06-01-1987 *
THE JOURNAL OF IMMUNOLOGY, vol. 120, no. 2, février 1978, pages 542-549, The Williams & Wilkins Co., US; A. AMSDEN et al.: "Studies on cellular receptors for lymphokines" *
THE JOURNAL OF IMMUNOLOGY, vol. 122, no. 3, mars 1979, pages 838-841, The Williams & Wilkins Co., US; T. BABA et al.: "Suppression of cell-mediated immune reactions by monosaccharides" *
THE JOURNAL OF INVESTIGATIONS DERMATOLOGY, vol. 75, no. 3, septembre 1980, pages 284-287, The Williams & Wilkins Co., US; S. HASEGAWA et al.: "Suppression of allergic contact dermatitis by alpha-L-fucose" *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2756735A1 (en) * 1996-12-11 1998-06-12 Thorel Jean Noel Agent for treating or preventing contact allergy
WO1998034589A1 (en) * 1997-02-07 1998-08-13 Henkel Kommanditgesellschaft Auf Aktien Skin care product
EP0937454A3 (en) * 1998-02-13 2000-03-15 Beiersdorf Aktiengesellschaft Cosmetic or dermatological compositions containing polysaccharides for the protection of sensitive skin against irritations
FR2853539A1 (en) * 2003-04-08 2004-10-15 Ind E Com De Cosmeticos Natura Cosmetic composition with anti-aging effect on the skin contains rhamnose and fucose compounds and excipients, protects hyaluronic acid against decomposition induced by free radicals
WO2004091568A3 (en) * 2003-04-08 2005-05-06 Ind E Com De Cosmeticos Natura Cosmetic composition of two polysaccharides based on fucose and rhamnose
WO2005041983A1 (en) 2003-10-31 2005-05-12 Pierre Fabre Dermo-Cosmetique Medicament comprising a reducing alkyl-sugar monomer for the treatment of inflammatory disorders
US7666847B2 (en) 2003-10-31 2010-02-23 Pierre Fabre Dermo-Cosmetique Medicament comprising a reducing alkyl-sugar monomer for the treatment of inflammatory disorders
EP2266580A1 (en) * 2003-10-31 2010-12-29 Pierre Fabre Dermo-Cosmétique Medicament comprising a reducing alkyl-sugar monomer for the treatment of inflammatory disorders
US9163049B2 (en) 2003-10-31 2015-10-20 Pierre Fabre Dermo-Cosmetique Medicament comprising a reducing alkyl-sugar monomer for the treatment of inflammatory disorders
FR2912055A1 (en) * 2007-02-06 2008-08-08 Idenov Lab Cosmetic composition useful for soothing skin irritations comprises mono- and polysaccharides, glycerol, sorbitol, yeast extract, olive oil extract and a shea extract
WO2019129823A1 (en) * 2017-12-29 2019-07-04 L'oreal Use of fucose derivatives as deodorants
FR3076216A1 (en) * 2017-12-29 2019-07-05 L'oreal USE OF FUCOSE DERIVATIVES AS DEODORANT AGENTS

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