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FR2624022B1 - Appareil de perfusion contenant des hepatocytes et procedes pour sa preparation et son utilisation - Google Patents

Appareil de perfusion contenant des hepatocytes et procedes pour sa preparation et son utilisation

Info

Publication number
FR2624022B1
FR2624022B1 FR8814280A FR8814280A FR2624022B1 FR 2624022 B1 FR2624022 B1 FR 2624022B1 FR 8814280 A FR8814280 A FR 8814280A FR 8814280 A FR8814280 A FR 8814280A FR 2624022 B1 FR2624022 B1 FR 2624022B1
Authority
FR
France
Prior art keywords
preparation
methods
infusion apparatus
apparatus containing
containing hepatocytes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR8814280A
Other languages
English (en)
Other versions
FR2624022A1 (fr
Inventor
Osvaldo Jauregui Hugo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhode Island Hospital
Original Assignee
Rhode Island Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhode Island Hospital filed Critical Rhode Island Hospital
Publication of FR2624022A1 publication Critical patent/FR2624022A1/fr
Application granted granted Critical
Publication of FR2624022B1 publication Critical patent/FR2624022B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/022—Artificial gland structures using bioreactors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1621—Constructional aspects thereof
    • A61M1/1623—Disposition or location of membranes relative to fluids
    • A61M1/1627—Dialyser of the inside perfusion type, i.e. blood flow inside hollow membrane fibres or tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3475—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate with filtrate treatment agent in the same enclosure as the membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
    • A61M1/3489—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents by biological cells, e.g. bioreactor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/10—Hollow fibers or tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/16—Hollow fibers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • External Artificial Organs (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
FR8814280A 1987-11-02 1988-11-02 Appareil de perfusion contenant des hepatocytes et procedes pour sa preparation et son utilisation Expired - Fee Related FR2624022B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/116,525 US5043260A (en) 1987-11-02 1987-11-02 Perfusion device with hepatocytes

Publications (2)

Publication Number Publication Date
FR2624022A1 FR2624022A1 (fr) 1989-06-09
FR2624022B1 true FR2624022B1 (fr) 1997-10-31

Family

ID=22367712

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8814280A Expired - Fee Related FR2624022B1 (fr) 1987-11-02 1988-11-02 Appareil de perfusion contenant des hepatocytes et procedes pour sa preparation et son utilisation

Country Status (6)

Country Link
US (1) US5043260A (fr)
JP (1) JPH01198559A (fr)
CA (1) CA1305935C (fr)
DE (1) DE3837226C2 (fr)
FR (1) FR2624022B1 (fr)
GB (1) GB2211857B (fr)

Families Citing this family (51)

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US5605835A (en) * 1988-05-23 1997-02-25 Regents Of The University Of Minnesota Bioreactor device with application as a bioartificial liver
AU9031591A (en) * 1990-10-29 1992-05-26 Regents Of The University Of Minnesota A bioartificial liver
US5270192A (en) * 1991-02-07 1993-12-14 Monsanto Company Biological artificial liver
EP0579804B1 (fr) * 1992-02-07 1996-07-24 Monsanto Company Foie biologique artificiel
DE4230194C2 (de) * 1992-09-09 1995-07-27 Joerg Dr Med Gerlach Reaktor zur Züchtung und zur Nutzung von Stoffwechselleistungen und/oder zum Erhalt von Mikroorganismen
JPH10506806A (ja) * 1992-09-11 1998-07-07 ゼノジェネックス，インコーポレーテッド 人工肝臓装置および方法
US5368555A (en) * 1992-12-29 1994-11-29 Hepatix, Inc. Organ support system
US5866420A (en) * 1993-10-08 1999-02-02 The United States Of America As Represented By The Secretary Of Agriculture Artificial liver device
US5792603A (en) * 1995-04-27 1998-08-11 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing tissue, synthetic or native, vascular grafts
US6121042A (en) * 1995-04-27 2000-09-19 Advanced Tissue Sciences, Inc. Apparatus and method for simulating in vivo conditions while seeding and culturing three-dimensional tissue constructs
US5846828A (en) * 1995-06-07 1998-12-08 Advanced Tissue Sciences Apparatus and method for sterilizing, seeding, culturing, storing, shipping, and testing tissue, synthetic, or mechanical heart valves orvalve segments
US5843766A (en) * 1995-06-07 1998-12-01 Advanced Tissue Sciences, Inc. Apparatus for the growth and packaging of three dimensional tissue cultures
US6680166B1 (en) * 1995-06-07 2004-01-20 Claudy Jean Paul Mullon Dual fiber bioreactor
AU5931896A (en) * 1995-06-07 1996-12-30 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, st oring, shipping, and testing replacement cartilage tissue co nstructs
US6017760A (en) * 1995-10-10 2000-01-25 Rhode Island Hospital Isolation and culture of porcine hepatocytes
US5763267A (en) * 1996-04-16 1998-06-09 Advanced Tissue Sciences Apparatus for the large scale growth and packaging of cell suspensions and three-dimensional tissue cultures
US5827729A (en) * 1996-04-23 1998-10-27 Advanced Tissue Sciences Diffusion gradient bioreactor and extracorporeal liver device using a three-dimensional liver tissue
JP4177898B2 (ja) * 1996-10-22 2008-11-05 リーナル・ソリューションズ・インコーポレーテッド 腹腔内圧を制御した連続式フロースルー腹膜透析（ｃｆｐｄ）法
WO1998033581A1 (fr) 1997-02-04 1998-08-06 Akzo Nobel N.V. Module a fibres creuses d'au moins deux groupes, et mode de fabrication
US6723284B1 (en) * 1997-04-11 2004-04-20 University Of Pittsburgh Membrane apparatus with enhanced mass transfer, heat transfer and pumping capabilities via active mixing
US5993406A (en) 1997-05-14 1999-11-30 Cedars-Sinai Medical Center Artificial gut
US5955353A (en) * 1997-05-22 1999-09-21 Excorp Medical, Inc. Hollow fiber bioreactor with an extrafilament flow plug
JP3553858B2 (ja) * 1999-08-25 2004-08-11 東洋紡績株式会社 血管網類似構造体を有する細胞培養用モジュール
US6737270B1 (en) 1999-12-07 2004-05-18 University Of Pittsburgh Of The Commonwealth System Of Higher Education Long-term three dimensional tissue culture system
US20030096411A1 (en) * 1999-12-07 2003-05-22 George Michalopoulos Novel long-term three-dimensional tissue culture system
US6541243B1 (en) 2000-06-05 2003-04-01 Axon Instruments, Inc. Perfusion chamber for electrophysiological testing of oocytes
EP1234553A1 (fr) * 2001-02-14 2002-08-28 Boris-Wolfgang Hochleitner Dispositif bioartificiel
US20070037277A1 (en) * 2001-04-25 2007-02-15 Michael Shuler Pharmacokinetic-based culture system with biological barriers
US7288405B2 (en) * 2001-04-25 2007-10-30 Cornell Research Foundation, Inc. Devices and methods for pharmacokinetic-based cell culture system
US20070048727A1 (en) * 2001-04-25 2007-03-01 Michael Shuler Biliary barrier
IL164079A0 (en) * 2002-03-15 2005-12-18 Us Dept Veterans Affairs Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs
JP2006505554A (ja) * 2002-10-10 2006-02-16 デパートメント・オヴ・ヴェテランズ・アフェアズ 腫瘍特異的エピトープに向けられた、標識活性化リンパ球を使用した、腫瘍の検出、定位および染色
US20040151729A1 (en) * 2002-10-28 2004-08-05 George Michalopoulos Novel long-term three-dimensional culture system
US20050266393A1 (en) * 2003-10-01 2005-12-01 Baxter Gregory T Circulating flow device for assays of cell cultures, cellular components and cell products
CN101223268A (zh) * 2005-05-18 2008-07-16 康奈尔研究基金会（有限公司） 具有生物屏障的基于药代动力学的培养系统
WO2007023711A1 (fr) * 2005-08-22 2007-03-01 Waseda University Appareil de mise en culture de microbe, incubateur et procede de mise en culture
WO2007056355A2 (fr) * 2005-11-07 2007-05-18 Athena Capital Partners, Llc Dispositif et procede de culture, de preservation, de transport, de stockage, de reconstitution et de dosage de materiaux cellulaires
EP3693454A1 (fr) 2008-07-16 2020-08-12 Children's Medical Center Corporation Dispositif simulateur d'organe comportant des microcanaux et ses procédés d'utilisation et de fabrication
DE102009037015A1 (de) * 2009-08-07 2011-02-17 Michael Hajek Vorrichtung und Verfahren zur Eliminierung von bioschädlichen Stoffen aus Körperflüssigkeiten
EP2444478A1 (fr) 2010-10-22 2012-04-25 Gerlach, Jörg, Dr. med. Système d'échange de masses de fluide d'un corps tubulaire et dispositif d'échange de masses
JP6122388B2 (ja) 2011-02-28 2017-04-26 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 細胞培養システム
WO2013086486A1 (fr) 2011-12-09 2013-06-13 President And Fellows Of Harvard College Systèmes microphysiologiques d'organes-sur-puce humains intégrés
US9855554B2 (en) 2013-07-22 2018-01-02 President And Fellows Of Harvard College Microfluidic cartridge assembly
GB2583047B (en) 2013-12-20 2021-03-24 Harvard College Organomimetic devices and methods of use and manufacturing thereof
GB2538012A (en) 2013-12-20 2016-11-02 Harvard College Low shear microfluidic devices and methods of use and manufacturing thereof
AU2015289999B2 (en) 2014-07-14 2020-09-10 President And Fellows Of Harvard College Systems and methods for improved performance of fluidic and microfluidic systems
US10202569B2 (en) 2015-07-24 2019-02-12 President And Fellows Of Harvard College Radial microfluidic devices and methods of use
AU2016406837B2 (en) * 2016-05-19 2020-07-23 Koji Saito Culture device, culture method and cultured organ produced by culture method
CN106267397B (zh) * 2016-07-29 2019-02-05 武汉仝干医疗科技股份有限公司 毛绒线式生物反应器人工肝系统
AU2017326179B2 (en) 2016-09-13 2022-12-08 President And Fellows Of Harvard College Methods relating to intestinal organ-on-a-chip
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US4853324A (en) * 1985-12-02 1989-08-01 Viles Joseph M Liver assist device employing transformed cell lines
US4675002A (en) * 1985-12-02 1987-06-23 Viles Joseph M Liver assist device employing transformed cell lines
US4869826A (en) * 1987-09-01 1989-09-26 Process Biotechnology, Inc. Cellular adsorbents for removal of viral contaminants from blood and complex protein solutions

Also Published As

Publication number Publication date
DE3837226C2 (de) 1994-09-22
GB8825583D0 (en) 1988-12-07
DE3837226A1 (de) 1989-05-24
US5043260A (en) 1991-08-27
GB2211857A (en) 1989-07-12
FR2624022A1 (fr) 1989-06-09
CA1305935C (fr) 1992-08-04
JPH01198559A (ja) 1989-08-10
GB2211857B (en) 1991-10-30

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Legal Events

Date Code Title Description
ST Notification of lapse