[go: up one dir, main page]

FR2611203B1 - Analogues gem-diphosphoniques d'amethopterine (methotrexate) et de derives deaza-n-10 amethopterine. leur preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Analogues gem-diphosphoniques d'amethopterine (methotrexate) et de derives deaza-n-10 amethopterine. leur preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR2611203B1
FR2611203B1 FR8702449A FR8702449A FR2611203B1 FR 2611203 B1 FR2611203 B1 FR 2611203B1 FR 8702449 A FR8702449 A FR 8702449A FR 8702449 A FR8702449 A FR 8702449A FR 2611203 B1 FR2611203 B1 FR 2611203B1
Authority
FR
France
Prior art keywords
amethopterine
amethopterin
deaza
diphosphonic
gem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8702449A
Other languages
English (en)
Other versions
FR2611203A1 (fr
Inventor
Georges Louis Edmond Sturtz
Patricia Cecile Marie-L Voisin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to FR8702449A priority Critical patent/FR2611203B1/fr
Priority to PCT/FR1988/000088 priority patent/WO1988006158A1/fr
Publication of FR2611203A1 publication Critical patent/FR2611203A1/fr
Application granted granted Critical
Publication of FR2611203B1 publication Critical patent/FR2611203B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/405—Esters of poly(thio)phosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8702449A 1987-02-20 1987-02-20 Analogues gem-diphosphoniques d'amethopterine (methotrexate) et de derives deaza-n-10 amethopterine. leur preparation et les compositions pharmaceutiques qui les contiennent Expired FR2611203B1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR8702449A FR2611203B1 (fr) 1987-02-20 1987-02-20 Analogues gem-diphosphoniques d'amethopterine (methotrexate) et de derives deaza-n-10 amethopterine. leur preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1988/000088 WO1988006158A1 (fr) 1987-02-20 1988-02-18 Analogues gem-diphosphoniques d'amethopterine et de deaza-n-10 amethopterine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8702449A FR2611203B1 (fr) 1987-02-20 1987-02-20 Analogues gem-diphosphoniques d'amethopterine (methotrexate) et de derives deaza-n-10 amethopterine. leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR2611203A1 FR2611203A1 (fr) 1988-08-26
FR2611203B1 true FR2611203B1 (fr) 1989-06-09

Family

ID=9348267

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8702449A Expired FR2611203B1 (fr) 1987-02-20 1987-02-20 Analogues gem-diphosphoniques d'amethopterine (methotrexate) et de derives deaza-n-10 amethopterine. leur preparation et les compositions pharmaceutiques qui les contiennent

Country Status (2)

Country Link
FR (1) FR2611203B1 (fr)
WO (1) WO1988006158A1 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5030634A (en) * 1990-03-29 1991-07-09 Krumdieck Carlos L 10-deazaaminopterin: a new arthritis remittive drug
FR2661179B1 (fr) * 1990-04-23 1992-08-21 Sturtz Georges Prodrogues gem-disphophoniques d'amethopterine (methotrexate) et de derives deaza-n-10 amethopterine, compositions pharmaceutiques contenant de tels prodrogues, procedes d'obtention et produits intermediaires.
ATE120753T1 (de) * 1990-08-21 1995-04-15 Upjohn Co Bisphosphonsäurederivate als antiarthritische mittel.
FR2683527A1 (fr) * 1991-11-12 1993-05-14 Bretagne Occidentale Universit Prodrogues gem-bisphosphonates de sterouides derives de la cortisone.
FR2683528A1 (fr) * 1991-11-12 1993-05-14 Bretagne Occidentale Universit Prodrogues et analogues gem-bisphosphoniques d'antiinflammatoires non-sterouidiens de type arylacetique ou arylpropionique.
JP2746041B2 (ja) * 1992-02-14 1998-04-28 三菱化学株式会社 新規なステロイド誘導体
AU4387893A (en) * 1992-07-16 1994-02-14 Upjohn Company, The Phosphono derivatives as antiinflammatory and antiarthritic agents
US5880111A (en) * 1995-06-07 1999-03-09 Farcasiu; Dan Therapeutic derivations of diphosphonates
IT1284070B1 (it) * 1996-06-26 1998-05-08 Boehringer Mannheim Italia Derivati di carbossi gem-difosfonati ad attivita' antitumorale, un processo per la loro preparazione e composizioni farmaceutiche che
IT1290444B1 (it) * 1997-03-27 1998-12-03 Boehringer Mannheim Italia Coniugati di bis-fosfonati con funzionalita' alchilanti aventi attivita' antitumorale
KR20040108756A (ko) 2002-04-26 2004-12-24 길리애드 사이언시즈, 인코포레이티드 비뉴클레오사이드 역전사 효소 억제제
JP2005527302A (ja) 2002-05-24 2005-09-15 アンジオテック インターナショナル アーゲー 医療用移植物をコーティングするための組成物および方法
ATE457716T1 (de) 2002-12-30 2010-03-15 Angiotech Int Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
SG182849A1 (en) 2003-04-25 2012-08-30 Gilead Sciences Inc Antiviral phosphonate analogs
US7432261B2 (en) 2003-04-25 2008-10-07 Gilead Sciences, Inc. Anti-inflammatory phosphonate compounds
EP1620109A2 (fr) 2003-04-25 2006-02-01 Gilead Sciences, Inc. Analogues de phosphonate inhibiteurs de kinase
US7407965B2 (en) 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
US7452901B2 (en) 2003-04-25 2008-11-18 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
WO2004096287A2 (fr) 2003-04-25 2004-11-11 Gilead Sciences, Inc. Composes de phosphonate inhibiteurs de l'inosine monophosphate deshydrogenase
US7300924B2 (en) 2003-04-25 2007-11-27 Gilead Sciences, Inc. Anti-infective phosphonate analogs
WO2005002626A2 (fr) 2003-04-25 2005-01-13 Gilead Sciences, Inc. Composes de phosphonate therapeutiques
US7470724B2 (en) 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
US7273717B2 (en) 2003-10-24 2007-09-25 Gilead Sciences, Inc. Methods and compositions for identifying therapeutic compounds with GS-9005 ester hydrolase B
US7432273B2 (en) 2003-10-24 2008-10-07 Gilead Sciences, Inc. Phosphonate analogs of antimetabolites
US7427624B2 (en) 2003-10-24 2008-09-23 Gilead Sciences, Inc. Purine nucleoside phosphorylase inhibitory phosphonate compounds
NZ547907A (en) 2003-12-22 2010-07-30 Gilead Sciences Inc 4'-Substituted carbovir-and abacavir-derivatives as well as related compounds with HIV and HCV antiviral activity
PL1778251T3 (pl) 2004-07-27 2011-09-30 Gilead Sciences Inc Koniugaty fosfonianowo-nukleozydowe jako środki przeciw wirusowi HIV
US20100093667A1 (en) 2008-07-08 2010-04-15 Gilead Sciences, Inc. Salts of hiv inhibitor compounds
EP3779446A1 (fr) 2013-12-11 2021-02-17 University of Massachusetts Compositions et procédés de traitement d'une maladie au moyen d'une protéine effectrice t3ss de salmonella (sipa)
PL3661937T3 (pl) 2017-08-01 2021-12-20 Gilead Sciences, Inc. Formy krystaliczne ((s)-((((2r,5r)-5-(6-amino-9h-puryn-9-ylo)-4-fluoro-2,5-dihydrofuran-2-ylo)oksy)metylo)(fenoksy)fosforylo)-l-alaninianu etylu (gs-9131) do leczenia zakażeń wirusowych

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds

Also Published As

Publication number Publication date
WO1988006158A1 (fr) 1988-08-25
FR2611203A1 (fr) 1988-08-26

Similar Documents

Publication Publication Date Title
FR2611203B1 (fr) Analogues gem-diphosphoniques d'amethopterine (methotrexate) et de derives deaza-n-10 amethopterine. leur preparation et les compositions pharmaceutiques qui les contiennent
FR2679230B1 (fr) Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent.
MC1743A1 (fr) Nouveaux dérivés de la xanthine leur préparation et médicaments qui en contiennent
EP0315978A3 (en) New use of 11,28-dioxa-4-azatricyclo û22.3.1.0 4,9¨octacos-18-ene derivatives and pharmaceutical compositions containing them
IL67103A (en) Ester and amide derivatives of 13,14-didehydroprostaglandins,their preparation and pharmaceutical compositions containing them
IL86798A (en) 2,2-dimethylchroman-3-ol derivatives, their preparation and pharmaceutical compositions containing them
IL88670A0 (en) 2,5-diaryl-tetrahydrofurans and analogs thereof and pharmaceutical compositions containing them
FR2599742B1 (fr) Composes antibiotiques, leur preparation et les compositions pharmaceutiques qui les contiennent
IL87089A (en) Derivatives of n-aminobutyl-n- phenylarylamides, their preparation and pharmaceutical compositions containing them
FR2687151B1 (fr) Nouveaux derives de la baccatine iii et de la desacetyl-10 baccatine iii, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2607502B1 (fr) Derives de l'imidazole, leur preparation et compositions medicamenteuses les contenant
IL86890A0 (en) Thiourea derivatives,their preparation and pharmaceutical compositions containing them
IL88002A0 (en) 2,2-dimethylchromene derivatives,their preparation and pharmaceutical compositions containing them
FR2574407B1 (fr) Nouveaux derives de la pyrrolo(2,3-d) pyrimidine, leur preparation et les compositions pharmaceutiques qui les contiennent
PT87024A (pt) Process for the preparation of propiolophenone derivatives and of pharmaceutical compositions containing the same
FR2602771B1 (fr) Nouveaux derives de la benzyl-4 piperazine, leur preparation et les compositions pharmaceutiques qui les contiennent
PT87550A (pt) Process for the preparation of pyrimidine derivatives and of pharmaceutical compositions containing the same
IL80658A0 (en) 6,7,8,9-tetrahydro-10-methyl-pyrido(1,2-a)indol-9-amines and derivatives thereof,their preparation and pharmaceutical compositions containing them
BE888472A (fr) Compositions pharmaceutiques a base de derives d'adenosine et leur preparation,
PT84933B (fr) Procede de preparation de cyclodepsipeptides et compositions pharmaceutiques qui les contiennent
FR2641276B1 (fr) Derives du benzene, leur preparation et les compositions pharmaceutiques en contenant
PT84184A (pt) Process for the preparation of 8 alpha-acylaminoergolines and of pharmaceutical compositions containing them
FR2532310B1 (fr) Nouveaux derives de la benzamide, leur preparation et les compositions pharmaceutiques qui les contiennent
IL85738A0 (en) Nucleoside derivatives,their preparation and pharmaceutical compositions containing them
LU81182A1 (fr) Nouveaux derives de l'isoquinoleine,leur preparation et les compositions pharmaceutiques qui les contiennent

Legal Events

Date Code Title Description
ST Notification of lapse