FR2599026A1 - Pulverulent compositions which generate an oxygenation biocatalyst for biocatalytic oxygenation - Google Patents

Abstract

A. By way of new industrial products, stable pulverulent compositions which generate an oxygenation biocatalyst for biocatalytic oxygenation, and a gas laden with this biocatalyst, consisting of a mixture of unsaturated terpenes and of one or more metals or metalloids (non-metals), as well as of an inorganic filler. B. Process for the manufacture of an oxygenation biocatalyst by autoxidation in the presence of oxygen or air of the composition defined under A.

Description

The present invention relates to pulverulent compositions generating a gas charged with an oxygenation biocatalyst for bio-catalytic oxygenation, as well as their preparation process, the compositions obtained by implementing said process, and their applications.

We know all the importance which, in the fields of therapy, nutrition and environmental health, sources of nascent oxide and especially peroxides of emerging terpenes which are oxygenation biocatalysts .

Several methods have already been proposed for preparing terpene peroxides.

Thus, in a first process, the terpenes are oxidized using a mixture of air and oxygen in the presence of a catalyst, such as cobalt III abietate passing over peroxides with stirring by "turning" while continuing to pass the gas stream under pressure until the heat given off by the oxidation has reached a temperature above 90 C.

The derivatives thus obtained are then separated by fractional distillation.

According to another known method, the oxidation is carried out by bubbling ozone through a terpene substrate.

The purpose of the present invention is to propose new pulverulent compositions, based on terpenes, generating an oxygenation bio-catalyst usable in the dwarfing state (terpene peroxides).

This process allows the increase of tissue oxygenations by better cellular assimilation of the breathed air.

This better assimilation of oxygen from the air is produced by the presence in the blood of the nascent oxygenation biocatalyst obtained according to the invention.

This biocatalyst is introduced into the bloodstream by the lungs, by respiratory act. It is of great oxygenating activity, probably in the form of a complex with hemoglobin.

It should be noted in this regard that the pulmonary route, for the introduction of these products into the blood is the most suave route. This is a first advantage according to the invention. But this advantage is negligible compared to that represented by the emerging quality of the catalyst obtained by this method.

Indeed, it is well known, in chemistry, that nascent products have actions and properties that the same products prepared in advance (non-nascent) do not often have, or to a lesser degree.

These particular and exalting properties of nascent products are due to the presence of very fleeting and unstable free radicals over time. For example, benzoyl peroxide, at the time of its decomposition generates an incipient oxide which is capable of causing catalytic phenomena of polymerization, whereas the same non-incipient oxide, derived from this same peroxide and prepared with antecedence before its use, has no catalytic action.

It is for identical reasons that the nascent products prepared according to the invention have a bio-catalytic oxygenation activity much greater than that. normal terpene oxides. This activity is probably a multiple. Thus this increased activity of oxygenating biocatalysis obtained according to the invention makes it possible to observe numerous results which the normal oxides of terpenes do not in any way give, and overcomes the faults of the prior art notably making it possible to carry out at will, on the place even from use and at the chosen time, the generation of a gas (or corona) charged with an oxygenation biocatalyst.

There is thus a source of biocatalyst always fresh, which makes it possible to avoid the storage of unstable peroxides of terpenes.

 The compositions according to the invention are characterized in that the terpenes are there in a dry and powdery form, and not in a liquid form, typical of the prior art which limited its applications; such terpene substances cannot, in their usual liquid form, be spread over the floors and surfaces of the premises without prejudice to the occupants and the materials.

The compositions according to the invention are characterized in that they are essentially composed of terpenes introduced by any means suitable for this purpose, in a powder (preferably one or more carbonates or / and one or more phosphates) . The porosity of these powders allows good adsorption of terpenes during their preparations as well as a good release of these terpenes for use in the form of gas (or corona) not particulate loaded with air or oxygen or another gas, and in oxygenation biocatalysts, by autoxidation of terpenes in contact with air, oxygen or another gas.

In the case of compositions according to the invention, metallic oxidation catalysts can usefully be used.

The inventor, in fact, unexpectedly determined that it was possible to improve qualitatively and quantitatively the production of biocatalysts (terpene peroxides) and especially the reaction rate of this production, by adding in the composition to metals generally used as an oxidation catalyst, a metalloid in an alkaline medium.

Indeed, if we examine for example, how cobalt, iron or manganese acts in the drying of drying oils, we quickly realize their re-reading and the limits of it. They break down the peroxides and reveal the oxygen oxide with additive properties. It is perhaps besides only this rible which is due to them and they act only very weakly as initiator of peroxidation.

This is why the inventor, in order to initiate and accelerate the peroxidation of terpenes in the compositions according to the invention, tested various metals and oxidizing mgtallopEdes and retained as particularly effective the iodine placed in an alkaline pulverulent medium. , calcium carbonate and / or magnesium, for example. In such a medium, iodine leads to the formation of hypo-iodite, a strongly oxidizing product which discolours the blue of
digo.

The compositions according to the invention are therefore also characterized in that they are composed in the form of a powder, of a mixture:
A - One or more terpenes, unsaturated substances which can easily fix oxygen.

B - Calcium carbonate and / or magnesium.

C - Of a strongly oxidizing metalloSde, iodine, which placed in the medium (B) leads to the formation of hypo-iodite de-stiné to oxidize the terpenes (A) at the level of the double bond (Hypo- iodite + terpenes = peroxides R = 0 ::: = 0)
D - Of metals or metallic salts such as Iron aVet Cobalt or / and Manganese which are decomposers of the peroxides formed in (C): (R = 0 ::: + 0 =) and which make the form appear oxygen oxonium: (R = 0 :::). This tetravalent oxygen having marked additive, biocatalytic and assimilating properties and is perfectly suitable for oxygenating bio-catalysis, the main application of the compositions according to the invention.

These compositions therefore generate, by progressive autoxidation, a non-particulate gas, or fragrance, of aromatic odor.

Gas charged with a dioxygenation biocatalyst for biocatalytic oxygenation.

According to a preferred embodiment of the invention, the terpenes are chosen from synthetic terpenes or those extracted from essential oils, such as hemiherpenes, terpenes strictly speaking, sesquiterpenes, diterpanas and among the main terpenes camphene, myrcene, limonene, Alphapinene, Beta-pinene, terpinene, salvene, phellandrene, caryophyllene.

Without departing from the scope of the invention, may be used as a source of terpenes, essential oils containing such as turpentine, pine, cloves, eucalyptus, lemon, etc.

The quantity of terpenes to be introduced into the mixture is between 1 and 75 O / oo by weight and preferably between 5 and 40 O / oo by weight, this in order to obtain, in the final mixture, a sufficient proportion of peroxidized terpenes .

The metals, metallords or metallic salts may be used in the form of macro or trace elements (traces).

It is however obvious that for each case of use of the catalyst formed, it will be necessary to terminate beforehand the optimum proportion of terpenes and of metals in the initial mixture.

Likewise, the particle size of the powder will be determined according to the case of use of the biocatalyst formed. It could be excessively fine (example: 400 sieve), medium (ex: AFNOR 26 to 90) or even in the form of large grains or granules.

The composition according to the invention transformable by autoxidation into a mixture of peroxides and oxides of terpenes with air or oxygen or another gas, as well as the gas charged with this biocatalyst is entirely suitable for use as a biocatalyst to breathe or ingest through the digestive tract.

The present invention will be better understood moreover and its advantages will emerge clearly from the description which follows, which illustrates it without limiting it.

Example 1
The following powdery compounds are mixed at a dose, per thousand, of approximately
Alpha-Pinene and Seta-pinene terpenes ......... 10.50
Carbonates (in C03) 560.00
Calcium (CA) 349.00
Magnesium (Mg) ............................ 60.00
Sodium (Na) ................................ 10.00
Sulfur (S) ............................... 5.00
Iron, 4.00
Iodine ........................................ 0.15
Copper,. D, 10
Manganese ................................... 1.00
Zinc s ..................... 0.22
Molybdenum .................................... 0.02
Cobalt ....................................... 0.01
We sprinkle the soil and the litter of animals in a room of intensive breeding. Under the action of the air and / or oxygen of the air, ambient, a gas emitted by the powder charged with terpe nes and composed of air and / or oxygen from the ambient air and terpene, peroxidizable and peroxidized effluents, will gradually rise and occupy the entire volume of the room treated for the benefit of animals which will breathe the oxygenation biocatalyst.

This same gas charged with catalysts will exert a powerful deodorization by peroxidation of the smelly molecules.

This same gas will contribute to the disinfection and purification of the ambient air.

Soils and litter will not be moistened, but on the contrary, dried.

Example 2
The same mixture is used as in Example 1, but in the form of grains or granules of larger diameter. A certain quantity of these is placed in a screened or perforated boot on each of its faces and an air compressor is placed at the rear of the boot, or compressed air is sprayed onto it or oxygen or another oxidizing gas, such as ozone. This current of air will violently oxygenate the mixture according to the invention and constitute in the atmosphere of the room a disinfectant and sanitizing gas which is perfectly usable as an oxygenation biocatalyst by the presence of peroxides and terpene oxides ( subject to customary reservations regarding the use of ozone).

Example 3
The same mixture is used as in Example 1 in the form of a very fine powder and it is incorporated into the daily diet of livestock or domestic animals (eg compound granules, fodder). The peroxides formed in vivo will be broken down in the blood by the presence of iron, cobalt or manganese and transformed into nascent bio-catalytic oxides.

Indeed, the peroxide passes into the blood, gives up half of its oxygen (RO2 - RO + O) to generate the oxide again, returns to the lungs. next sterilize (RO + O - R02) or the oxide is peroxide and the cycle begins again. From the oxygenation point of view these oxygenation catalysts, whether they are formed exogenously as in examples 1 and 2, or endogenous as in this example 3, may other considered as very active artificial blood, breaking down into oxides nascent or transiently oxygen is tetravalent unsaturated; (oxonium form of oxygen).

The compositions according to the invention are very particularly useful in the treatment of contagious, microbial or viral diseases, in the cases of respiratory insufficiencies and of cardiopulmonary anomalies, as well as in general in all variations in metabolism for which the use of an oxygenation biocatalyst is required.

These compounds can also be used for other hygienic purposes intended to solve the problems of ochlopathology and ochloepidemiology in living quarters, public communities, care establishments as well as in the breeding of animals intended for sales, and laboratories.

It is quite obvious that, without departing from the scope of the invention, other active substances can, in addition, be added to the compositions according to the invention, whether to exploit the proper mode of action of these said substances or to exert an action synergistic on said compositions.

Claims (10)

- CLAIMS  1- Powder compositions based on terpenes or / and terpene essential oils, generating an oxygenation biocatalyst and its oxides and peroxides components of nascent terpenes, characterized in that they are essentially formed by one or several unsaturated terpenes and at least one filler in powder form as well as one or more metals or metalloids.  2- Compositions according to claim 1 characterized in that the terpenes are chosen from synthetic terpenes and those contained and / or extracts of terpene essential oils.  3- Compositions according to Claims 1 and 2, this characterized in that the terpenes are advantageously chosen from pinenes, camphene, limonene, salvene, caryophylene, terpinene, phellandrene, and in that the essential oils are advantageously chosen from essences of eucalyptus, turpentine, pine, lemon, niaouli, cejeput, cloves, juniper, camphor, alone or in mixture,  4- Compositions according to claim 1 characterized in that the pulverulent filler is chosen from natural or artificial products, alone or as a mixture.  5. Compositions according to claims 1 and 4, characterized in that the pulverulent filler is chosen by carbonates and / or phosphates, alone or as a mixture.  6- Compositions according to Claims 1, 4 and 5, characterized in that the carbonates are chosen from calcium, magnesium and sodium carbonates, alone or as a mixture.  7- Compositions according to claim 1, characterized in that the metals and / and metalloids or / and metallic salts chosen are of two categories of activity: a / oxidation initiators, b / peroxide decGmposers, used alone or in mixture.  B- Compositions according to Claims 1 and 7, characterized in that among the oxidation initiators, iodine, a metalloyde placed in the invention in an alkaline medium, was chosen as a priority to give strongly hypodiodite oxidant.  9- Compositions according to claims 1 and 7, characterized in that the metallic decomposers of peroxides chosen are cobalt, iron and manganese, alone or as a mixture.  10- Compositions and applications according to any one of claims 1 to 9, as a breathed or ingested oxygen biocatalyst.  11- Applications of the compositions according to any one of claims 1 to 9, as a disinfectant, deodorant and sanitizer.