FR2598080A1 - Fluid for peritonial dialysis, containing, in particular, a compound of the verapamil type - Google Patents

Abstract

Fluids for peritonial dialysis, which contain a compound of formula I in which the substituents R<1> to R<5> are identical or different and represent hydrogen atoms or C1 to C4 alkoxy groups, or their enantiomers.

Description

People with kidney failure should undergo dialysis treatment. One such method is continuous ambulatory peritoneal dialysis (CAPD), which can be performed by those affected. It consists of introducing into the peritoneal cavity, via a peritoneal catheter, an appropriate dialysis fluid, contained in a bag, t i withdrawing it after a certain time. The fluid is then exchanged for fresh dialysis fluid and dialysis is continued.

However, it has been found that the dialysis conditions and the efficiency of the dialysis can be significantly improved by adding certain substances to the dialysis liquid.

dans laquelle les substitutants R1 à R3 sont identiques ou différents et représentent des atomes d'hydrogène ou des groupes alcoxy en C1 à C4, ou leurs énantiomères.The subject of the invention is liquids for peritoneal dialysis, characterized in that they contain, in addition to the usual components, 0.001 to 0.1% by weight of a compound of formula I

wherein the substitutes R1 to R3 are the same or different and represent hydrogen atoms or C1 to C4 alkoxy groups, or their enantiomers.

To prepare the liquids according to the invention are added customary peritoneal dialysis solutions of 0.001 to 0.09 *, preferably 0.001 to 0.01 *, by weight, of a compound of formula I, preferably in the form of a salt of a physiologically acceptable acid.

The compounds of formula I, as well as their physiologically acceptable diacid salts, are described in DE-PS 1 154 810, DE-PS 2 039 923, DE-PS 2 059 983 and EP-OS 147 707.

The addition of the compounds of formula I makes it possible to significantly increase the elimination of substances contained in the urine, in particular urea, so that the bags containing the dialysis liquid no longer have to be exchanged as often. In addition, the side effects which manifest themselves as a result of the loss of protein, due to peritoneal dialysis, are greatly reduced.

Example1
An aqueous solution is prepared containing 134mval / 1de
Na +, 3.5 mval / l of Ca +, 1.0 mval / l of Mg +, 103.5 mval / l of Cl-, 35.0 mval / l of lactate, 15 g / l of glucose and 10 mg / l of Verapamil - HCl (formula I, R = R = R4 = R5 = OCH3,
R = H), and introduced, under aseptic conditions, into 2 L plastic bags, which are then enclosed in sterilized envelopes.

Example 2
An aqueous solution is prepared containing 134 mval / l of Na +, 2.0 mwal / l of R +, 3.5 mval / l of Ca2 +, 1.0 mval / l of
Mg +, 105.5 mval / l of Cl-, 35.0 mval / l of lactate, 35 g / l of glucose and 2 mg / l of Gallopamil, HCl (formula I,
R-R5 = OCH3), and is introduced, under aseptic conditions, into 2 q plastic bags, which are then enclosed in sterilized envelopes.

Claims (1)

Claim Liquids for peritoneal dialysis, characterized in that they contain, in addition to the usual components, 0.001 & 0.1% by weight of a compound of formula I

wherein the substituents R1 & R5 are the same or different and represent hydrogen atoms or C1 to 64 alkoxy groups, or their enantiomers.